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Drug Development and Industrial Pharmacy Volume 42, 2016 - Issue 2
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Research Article

Topical delivery of leflunomide for rheumatoid arthritis treatment: evaluation of local tissue deposition of teriflunomide and its anti-inflammatory effects in an arthritis rat model

Joonho BaeAmorepacific Corporation R&D Center, Yongin-si, Gyeonggi-do, Republic of Korea and
&
Jin Woo ParkCollege of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Muan-gun, Jeonnam, Republic of KoreaCorrespondence[email protected]
Pages 254-262 | Received 03 Dec 2014, Accepted 20 Apr 2015, Published online: 26 May 2015

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Mariam Zewail, Passent M. E. Gaafar, Mai M. Ali & Haidy Abbas. (2022) Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management. Drug Delivery 29:1, pages 1663-1674.
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Articles from other publishers (13)

Bazla Siddiqui, Asim ur Rehman, Rabia Gul, Iqra Chaudhery, Kifayat Ullah Shah & Naveed Ahmed. (2023) Folate decorated chitosan-chondroitin sulfate nanoparticles loaded hydrogel for targeting macrophages against rheumatoid arthritis. Carbohydrate Polymers, pages 121683.
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Hongtao Shang, Ayesha Younas & Nan Zhang. (2022) Recent advances on transdermal delivery systems for the treatment of arthritic injuries: From classical treatment to nanomedicines. WIREs Nanomedicine and Nanobiotechnology 14:3.
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Gholamhossein Sodeifian, Loubna Nasri, Fariba Razmimanesh & Mohammadamin Abadian. (2022) CO2 utilization for determining solubility of teriflunomide (immunomodulatory agent) in supercritical carbon dioxide: Experimental investigation and thermodynamic modeling. Journal of CO2 Utilization 58, pages 101931.
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Ning Xiao, Feng Xiao, Jinzhang Gao, Zhengkun Xu, Qianlei Wang, Jiajie Kuai, Wei Wei & Chun Wang. (2021) Effects of paeoniflorin‐6′‐O‐benzene sulfonate on the pharmacokinetics, excretion and tissue distribution of leflunomide in rats. Basic & Clinical Pharmacology & Toxicology 130:3, pages 364-374.
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Cláudia Veloso, Romeu A. Videira, Paula B. Andrade, Catarina Cardoso & Carla Vitorino. (2022) In vivo methodologies to assist preclinical development of topical fixed-dose combinations for pain management. International Journal of Pharmaceutics 616, pages 121530.
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Stavroula G. Nanaki, Sophia Andrianidou, Panagiotis Barmpalexis, Evi Christodoulou & Dimitrios N. Bikiaris. (2021) Leflunomide Loaded Chitosan Nanoparticles for the Preparation of Aliphatic Polyester Based Skin Patches. Polymers 13:10, pages 1539.
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Stavroula G. Nanaki, Evi Christodoulou, Nikolaos D. Bikiaris, Afroditi Kapourani, Konstantinos N. Kontogiannopoulos, Souzan Vergkizi-Nikolakaki & Panagiotis Barmpalexis. (2021) Leflunomide Sustained Skin Delivery Based on Sulfobetaine-Modified Chitosan Nanoparticles Embedded in Biodegradable Polyesters Films. Polymers 13:6, pages 960.
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Irina Terekhova, Iliya Kritskiy, Mikhail Agafonov, Roman Kumeev, Carlos Martínez-Cortés & Horacio Pérez-Sánchez. (2020) Selective Binding of Cyclodextrins with Leflunomide and Its Pharmacologically Active Metabolite Teriflunomide. International Journal of Molecular Sciences 21:23, pages 9102.
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Gong Mei-jiao, Li Shi-fang, Chang Yan-yan, Shao Jun-jun, Sun Yue-feng, Ren Ting-ting, Zhang Yong-guang & Chang Hui-yun. (2019) Antiviral effects of selected IMPDH and DHODH inhibitors against foot and mouth disease virus. Biomedicine & Pharmacotherapy 118, pages 109305.
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Mariam Zewail, Noha Nafee, Maged W. Helmy & Nabila Boraie. (2019) Coated nanostructured lipid carriers targeting the joints – An effective and safe approach for the oral management of rheumatoid arthritis. International Journal of Pharmaceutics 567, pages 118447.
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Iliya Kritskiy, Tatyana Volkova, Artem Surov & Irina Terekhova. (2019) γ-Cyclodextrin-metal organic frameworks as efficient microcontainers for encapsulation of leflunomide and acceleration of its transformation into teriflunomide. Carbohydrate Polymers 216, pages 224-230.
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Xiong-Bin Hu, Rong-Rong Kang, Tian-Tian Tang, Yong-Jiang Li, Jun-Yong Wu, Jie-Min Wang, Xin-Yi Liu & Da-Xiong Xiang. (2018) Topical delivery of 3,5,4′-trimethoxy-trans-stilbene-loaded microemulsion-based hydrogel for the treatment of osteoarthritis in a rabbit model. Drug Delivery and Translational Research 9:1, pages 357-365.
Crossref
Rong Wang, Hong Wu, Jian Chen, Shu-Ping Li, Li Dai, Zheng-Rong Zhang & Wen-Yu Wang. (2017) Antiinflammation Effects and Mechanisms Study of Geniposide on Rats with Collagen-Induced Arthritis. Phytotherapy Research 31:4, pages 631-637.
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