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Drug Development and Industrial Pharmacy Volume 42, 2016 - Issue 2
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Research Article

Designing of the fixed-dose gastroretentive bilayer tablet for sustained release of metformin and immediate release of atorvastatin

Ju-Hee OhDepartment of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea and
,
Ji Eun LeeR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
,
Yu Jeong KimR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
,
Tack-Oon OhR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
,
SungKyun HanR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
,
Eun Kyung JeonR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
,
Kyungmin ShinR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
,
Dong-Hyun KimR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
,
Chi Hye ParkR&D Center, CJ HealthCare Co., Ltd., Gyeonggi-Do, Republic of Korea
&
Young-Joo LeeDepartment of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea and Correspondence[email protected]
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Pages 340-349 | Received 29 Apr 2015, Accepted 15 Sep 2015, Published online: 15 Oct 2015

Citations (13)

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Read on this site (3)

Amit Porwal, Harinath Dwivedi & Kamla Pathak. (2020) Gastroretentive bilayer film for sustained release of atorvastatin calcium and immediate release of amlodipine besylate: pharmaceutical, pharmacokinetic evaluation, and IVIVC. Pharmaceutical Development and Technology 25:4, pages 416-431.
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Syaiful Choiri, T. N. Saifullah Sulaiman & Abdul Rohman. (2020) Assessment of the effect of polymers combination and effervescent component on the drug release of swellable gastro-floating tablet formulation through compartmental modeling-based approach. Drug Development and Industrial Pharmacy 46:1, pages 146-158.
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Hugh D. C. Smyth. (2016) Recent advances in solid dispersions and the formulation of poorly absorbed drugs. Drug Development and Industrial Pharmacy 42:3, pages 351-352.
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Articles from other publishers (10)

Dong Han Won, Heejun Park, Jeong-Woong Seo, Sun Woo Jang, Eun-Sol Ha & Min-Soo Kim. (2022) Active coating of immediate-release evogliptin tartrate to prepare fixed dose combination tablet with sustained-release metformin HCl. International Journal of Pharmaceutics 623, pages 121927.
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Xin Jin, Chengxiong Wei, Chengwei Wu & Wei Zhang. (2022) Gastroretentive core–shell hydrogel assembly for sustained release of metformin hydrochloride. European Polymer Journal 170, pages 111155.
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Sabu Mandumpal Chacko & Priya Thambi Thekkekara. 2021. Metformin - Pharmacology and Drug Interactions. Metformin - Pharmacology and Drug Interactions.
Napoleon-Nikolaos Vrettos, Clive J. Roberts & Zheying Zhu. (2021) Gastroretentive Technologies in Tandem with Controlled-Release Strategies: A Potent Answer to Oral Drug Bioavailability and Patient Compliance Implications. Pharmaceutics 13:10, pages 1591.
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Dong Han Won, Heejun Park, Eun-Sol Ha, Hwan-Ho Kim, Sun Woo Jang & Min-Soo Kim. (2021) Optimization of bilayer tablet manufacturing process for fixed dose combination of sustained release high-dose drug and immediate release low-dose drug based on quality by design (QbD). International Journal of Pharmaceutics 605, pages 120838.
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Amit Porwal, Harinath Dwivedi & Kamla Pathak. (2020) Predicting pharmacokinetic parameters by convolution: An in vitro approach for investigating bifunctional capsulated dosage form. Journal of Drug Delivery Science and Technology 60, pages 102078.
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Bart Hens, Maura Corsetti, Marival Bermejo, Raimar Löbenberg, Pablo M. González, Amitava Mitra, Divyakant Desai, Dakshina Murthy Chilukuri & Alexis Aceituno. (2019) “Development of Fixed Dose Combination Products” Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy. The AAPS Journal 21:4.
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Mariël F. van Stee, Albert A. de Graaf & Albert K. Groen. (2018) Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy. Cardiovascular Diabetology 17:1.
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Young-Kyung ChoiSung-Eun ParkEun-Young KimHyo Ju ParkEun-Ji KimGeun Seog SongJong-Lyul Ghim. (2017) Pharmacokinetics of atorvastatin and sustained-release metformin fixed-dose combination tablets: two randomized, open-label, 2-way crossover studies in healthy male subjects under fed conditions. Translational and Clinical Pharmacology 25:4, pages 190.
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Madhusudhan Malladi & Raju Jukanti. (2016) Formulation development and evaluation of a novel bi-dependent clarithromycin gastroretentive drug delivery system using Box-Behnken design. Journal of Drug Delivery Science and Technology 35, pages 134-145.
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