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Cancer Investigation Volume 28, 2010 - Issue 5
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ORIGINAL ARTICLEClinical Translational Therapeutics

Mesenchymal Stem Cells Contribute to Tumor Cell Proliferation by Direct Cell-Cell Contact Interactions

Berber D. RoordaDepartment of Pediatric Hematology/Oncology, University Medical Center Groningen, Hanzeplein, Groningen, The Netherlands
,
Arja ter ElstDepartment of Pediatric Hematology/Oncology, University Medical Center Groningen, Hanzeplein, Groningen, The Netherlands
,
Tiny G. J. Meeuwsen-de BoerDepartment of Pediatric Hematology/Oncology, University Medical Center Groningen, Hanzeplein, Groningen, The Netherlands
,
Willem A. KampsDepartment of Pediatric Hematology/Oncology, University Medical Center Groningen, Hanzeplein, Groningen, The Netherlands
&
Eveline S. J. M. de BontDepartment of Pediatric Hematology/Oncology, University Medical Center Groningen, Hanzeplein, Groningen, The Netherlands
Pages 526-534 | Published online: 08 Mar 2010

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Zhi-Gang Zhao, Zeng Cao, Wen Xu, Li Sun, Yong You, Fang Li, Qiu-Bai Li & Ping Zou. (2012) Immune Protection Function of Multipotent Mesenchymal Stromal Cells: Role of Transforming Growth Factor-β1. Cancer Investigation 30:9, pages 646-656.
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Articles from other publishers (36)

Cuihua Qi, Huiying Shi, Mengke Fan, Weigang Chen, Hailing Yao, Chen Jiang, Lingjun Meng, Suya Pang & Rong Lin. (2023) Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2. Cell Communication and Signaling 21:1.
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Shohreh Azadi, Elham Torkashvand, Ehsan Mohammadi & Mohammad Tafazzoli-Shadpour. (2023) Analysis of EMT induction in a non-invasive breast cancer cell line by mesenchymal stem cell supernatant: Study of 2D and 3D microfluidic based aggregate formation and migration ability, and cytoskeleton remodeling. Life Sciences 320, pages 121545.
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Biao-Qi Chen, Yi Zhao, Yang Zhang, Yu-Jing Pan, Hong-Ying Xia, Ranjith Kumar Kankala, Shi-Bin Wang, Gang Liu & Ai-Zheng Chen. (2023) Immune-regulating camouflaged nanoplatforms: A promising strategy to improve cancer nano-immunotherapy. Bioactive Materials 21, pages 1-19.
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Huaiyu Zhang, Shujun Dong, Zhongmin Li, Xiangru Feng, Weiguo Xu, Catrina Mae S. Tulinao, Yang Jiang & Jianxun Ding. (2020) Biointerface engineering nanoplatforms for cancer-targeted drug delivery. Asian Journal of Pharmaceutical Sciences 15:4, pages 397-415.
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Yael Lupu‐Haber, Tomer Bronshtein, Hagit Shalom‐Luxenburg, Domenico D'Atri, Jacopo Oieni, Limor Kaneti, Alona Shagan, Shani Hamias, Liat Amram, Galoz Kaneti, Noa Cohen Anavy & Marcelle Machluf. (2019) Pretreating Mesenchymal Stem Cells with Cancer Conditioned‐Media or Proinflammatory Cytokines Changes the Tumor and Immune Targeting by Nanoghosts Derived from these Cells. Advanced Healthcare Materials 8:10, pages 1801589.
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Nitzan Letko Khait, Natali Malkah, Galoz Kaneti, Lital Fried, Noa Cohen Anavy, Tomer Bronshtein & Marcelle Machluf. (2019) Radiolabeling of cell membrane-based nano-vesicles with 14C-linoleic acid for robust and sensitive quantification of their biodistribution. Journal of Controlled Release 293, pages 215-223.
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Youwei Wang. 2019. Perinatal Stem Cells. Perinatal Stem Cells 47 55 .
Toni Celià-Terrassa & Yibin Kang. (2018) Metastatic niche functions and therapeutic opportunities. Nature Cell Biology 20:8, pages 868-877.
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Alessia Farinazzo, Stefano Angiari, Ermanna Turano, Edoardo Bistaffa, Silvia Dusi, Serena Ruggieri, Roberta Bonafede, Raffaella Mariotti, Gabriela Constantin & Bruno Bonetti. (2018) Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis. Scientific Reports 8:1.
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Biyu Xu & Ting Wang. (2017) Intimate cross-talk between cancer cells and the tumor microenvironment of B-cell lymphomas: The key role of exosomes. Tumor Biology 39:6, pages 101042831770622.
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Pratika Y. Hernanda, Maikel P. Peppelenbosch & Qiuwei Pan. 2016. The Biology and Therapeutic Application of Mesenchymal Cells. The Biology and Therapeutic Application of Mesenchymal Cells 415 425 .
Limor Kaneti, Tomer Bronshtein, Natali Malkah Dayan, Inna Kovregina, Nitzan Letko Khait, Yael Lupu-Haber, Miguel Fliman, Beth W. Schoen, Galoz Kaneti & Marcelle Machluf. (2016) Nanoghosts as a Novel Natural Nonviral Gene Delivery Platform Safely Targeting Multiple Cancers. Nano Letters 16:3, pages 1574-1582.
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Diana Dehaini, Ronnie H. Fang & Liangfang Zhang. (2016) Biomimetic strategies for targeted nanoparticle delivery. Bioengineering & Translational Medicine 1:1, pages 30-46.
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Lei Zhang, Xiao San Su, Jun Song Ye, Yi Yin Wang, Zheng Guan & Yan Feng Yin. (2015) Bone marrow mesenchymal stem cells suppress metastatic tumor development in mouse by modulating immune system. Stem Cell Research & Therapy 6:1.
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Anne S. Cornelissen, Marijke W. Maijenburg, Martijn A. Nolte & Carlijn Voermans. (2015) Organ-specific migration of mesenchymal stromal cells: Who, when, where and why?. Immunology Letters 168:2, pages 159-169.
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Yuanyuan YangAnna OtteRalf Hass. (2015) Human Mesenchymal Stroma/Stem Cells Exchange Membrane Proteins and Alter Functionality During Interaction with Different Tumor Cell Lines. Stem Cells and Development 24:10, pages 1205-1222.
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Alessia Farinazzo, Ermanna Turano, Silvia Marconi, Edoardo Bistaffa, Elena Bazzoli & Bruno Bonetti. (2015) Murine adipose-derived mesenchymal stromal cell vesicles: in vitro clues for neuroprotective and neuroregenerative approaches. Cytotherapy 17:5, pages 571-578.
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Vicki Plaks, Niwen Kong & Zena Werb. (2015) The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?. Cell Stem Cell 16:3, pages 225-238.
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Xiaoming Li, Qing Luo, Jinghui Sun & Guanbin Song. (2014) Conditioned medium from mesenchymal stem cells enhances the migration of hepatoma cells through CXCR4 up-regulation and F-actin remodeling. Biotechnology Letters 37:3, pages 511-521.
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Younghun JungJingcheng WangEunsohl LeeSamantha McGeeJanice E. BerryKenji YumotoJinlu DaiEvan T. KellerYusuke ShiozawaRussell S. Taichman. (2015) Annexin 2–CXCL12 Interactions Regulate Metastatic Cell Targeting and Growth in the Bone Marrow. Molecular Cancer Research 13:1, pages 197-207.
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Quansheng Li, Ping Yu, Wei Wang, Peng Zhang, Haiqing Yang, Shengfu Li & Li Zhang. (2014) Gene expression profiles of various cytokines in mesenchymal stem cells derived from umbilical cord tissue and bone marrow following infection with human cytomegalovirus. Cellular and Molecular Biology Letters 19:1.
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Katharina MandelYuanyuan YangAxel SchambachSilke GlageAnna OtteRalf Hass. (2013) Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth In Vitro and In Vivo. Stem Cells and Development 22:23, pages 3114-3127.
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Ludovic Zimmerlin, Tea Soon Park, Elias T. Zambidis, Vera S. Donnenberg & Albert D. Donnenberg. (2013) Mesenchymal stem cell secretome and regenerative therapy after cancer. Biochimie 95:12, pages 2235-2245.
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Ruizhu Lin, Shihua Wang & Robert Chunhua Zhao. (2013) Exosomes from human adipose-derived mesenchymal stem cells promote migration through Wnt signaling pathway in a breast cancer cell model. Molecular and Cellular Biochemistry 383:1-2, pages 13-20.
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Ting Zhang, Yuk Wai Lee, Yun Feng Rui, Tin Yan Cheng, Xiao Hua Jiang & Gang Li. (2013) Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. Stem Cell Research & Therapy 4:3.
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Naama E. Toledano Furman, Yael Lupu-Haber, Tomer Bronshtein, Limor Kaneti, Nitzan Letko, Eyal Weinstein, Limor Baruch & Marcelle Machluf. (2013) Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform. Nano Letters 13:7, pages 3248-3255.
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Dan Luo, Xiuping Yan, Dengqun Liu, Xiangdong Zhou & Guoxiang Liu. (2013) Differential effects of mesenchymal stem cells on a heterogeneous cell population within lung cancer cell lines. Molecular and Cellular Biochemistry 378:1-2, pages 107-116.
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Anja Torsvik & Rolf Bjerkvig. (2013) Mesenchymal stem cell signaling in cancer progression. Cancer Treatment Reviews 39:2, pages 180-188.
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HUAPING XIN, FANG XIN, SHAOQIONG ZHOU & SIMING GUAN. (2013) The Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification. International Journal of Molecular Medicine 31:3, pages 583-588.
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Cihui Yan, Shuangjing Li, Zhenzhen Li, Hongwei Peng, Xiangfei Yuan, Linlin Jiang, Yanjun Zhang, Dongmei Fan, Xiao Hu, Ming Yang & Dongsheng Xiong. (2012) Human Umbilical Cord Mesenchymal Stem Cells as Vehicles of CD20-Specific TRAIL Fusion Protein Delivery: A Double-Target Therapy against Non-Hodgkin’s Lymphoma. Molecular Pharmaceutics 10:1, pages 142-151.
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Minoo Battiwalla & A. John Barrett. 2013. Mesenchymal Stromal Cells. Mesenchymal Stromal Cells 377 387 .
Florian E. Tögel & Christof Westenfelder. (2012) Kidney Protection and Regeneration Following Acute Injury: Progress Through Stem Cell Therapy. American Journal of Kidney Diseases 60:6, pages 1012-1022.
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Wei Zhu, Ling Huang, Yahong Li, Xu Zhang, Jianmei Gu, Yongmin Yan, Xiaomeng Xu, Mei Wang, Hui Qian & Wenrong Xu. (2012) Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Letters 315:1, pages 28-37.
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Ralf Hass & Anna Otte. (2012) Mesenchymal stem cells as all-round supporters in a normal and neoplastic microenvironment. Cell Communication and Signaling 10:1, pages 26.
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R.M. DwyerM.J. Kerin. (2010) Mesenchymal Stem Cells and Cancer: Tumor-Specific Delivery Vehicles or Therapeutic Targets?. Human Gene Therapy 21:11, pages 1506-1512.
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Cuihua Qi, Huiying Shi, Mengke Fan, Weigang Chen, Hailing Yao, Chen Jiang, Lingjun Meng, Suya Pang & Rong Lin. (2022) Microvesicles from Bone Marrow-Derived Mesenchymal Stem Cells Promote <i>Helicobacter Pylori</i>-Associated Gastric Cancer Progression by Transferring Thrombospondin-2. SSRN Electronic Journal.
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