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ORIGINAL ARTICLE: CELLULAR AND MOLECULAR BIOLOGY

Silibinin-Induced Apoptosis in MCF7 and T47D Human Breast Carcinoma Cells Involves Caspase-8 Activation and Mitochondrial Pathway

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Pages 12-20 | Published online: 17 Dec 2010

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Prabha Tiwari & Kaushala Prasad Mishra. (2023) Role of Plant-Derived Flavonoids in Cancer Treatment. Nutrition and Cancer 75:2, pages 430-449.
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Prabha Tiwari & Kaushala Prasad Mishra. (2020) Flavonoids sensitize tumor cells to radiation: molecular mechanisms and relevance to cancer radiotherapy. International Journal of Radiation Biology 96:3, pages 360-369.
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Jen-Yang Tang, Chih-Wen Shu, Chun-Lin Wang, Sheng-Chieh Wang, Meng-Yang Chang, Li-Ching Lin & Hsueh-Wei Chang. (2019) Sulfonyl chromen-4-ones (CHW09) shows an additive effect to inhibit cell growth of X-ray irradiated oral cancer cells, involving apoptosis and ROS generation. International Journal of Radiation Biology 95:9, pages 1226-1235.
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Seyede Elmira Yazdi Rouholamini, Saeid Moghassemi, Zahra Maharat, Amirhossien Hakamivala, Susan Kashanian & Kobra Omidfar. (2018) Effect of silibinin-loaded nano-niosomal coated with trimethyl chitosan on miRNAs expression in 2D and 3D models of T47D breast cancer cell line. Artificial Cells, Nanomedicine, and Biotechnology 46:3, pages 524-535.
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Articles from other publishers (23)

Vanina S. Vachetta, Mariel Marder, María F. Troncoso & María T. Elola. (2022) Opportunities, obstacles and current challenges of flavonoids for luminal and triple-negative breast cancer therapy. European Journal of Medicinal Chemistry Reports 6, pages 100077.
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Qiuchan Wu, Jiang Zeng & Jinfu Dong. (2022) Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups. Medicinal Chemistry Research 31:4, pages 533-544.
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Hardeep Singh Tuli, Sonam Mittal, Diwakar Aggarwal, Gaurav Parashar, Nidarshana Chaturvedi Parashar, Sushil Kumar Upadhyay, Tushar Singh Barwal, Aklank Jain, Ginpreet Kaur, Raj Savla, Katrin Sak, Manoj Kumar, Mehmet Varol, Ashif Iqubal & Anil Kumar Sharma. (2021) Path of Silibinin from diet to medicine: A dietary polyphenolic flavonoid having potential anti-cancer therapeutic significance. Seminars in Cancer Biology 73, pages 196-218.
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Hua Luo, Chi Teng Vong, Hanbin Chen, Yan Gao, Peng Lyu, Ling Qiu, Mingming Zhao, Qiao Liu, Zehua Cheng, Jian Zou, Peifen Yao, Caifang Gao, Jinchao Wei, Carolina Oi Lam Ung, Shengpeng Wang, Zhangfeng Zhong & Yitao Wang. (2019) Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine. Chinese Medicine 14:1.
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Samaneh Hossainzadeh, Najmeh Ranji, Alireza Naderi Sohi & Farhood Najafi. (2019) Silibinin encapsulation in polymersome: A promising anticancer nanoparticle for inducing apoptosis and decreasing the expression level of miR‐125b/miR‐182 in human breast cancer cells. Journal of Cellular Physiology 234:12, pages 22285-22298.
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Ashkan Hassankhani Rad, Farshid Asiaee, Sevda Jafari, Ali Shayanfar, Afsaneh Lavasanifar & Ommoleila Molavi. (2019) Poly(ethylene glycol)-poly(ε-caprolactone)-based micelles for solubilization and tumor-targeted delivery of silibinin. BioImpacts 10:2, pages 87-95.
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Zohreh Jahanafrooz, Nasrin Motamed, Beate Rinner, Ahad Mokhtarzadeh & Behzad Baradaran. (2018) Silibinin to improve cancer therapeutic, as an apoptotic inducer, autophagy modulator, cell cycle inhibitor, and microRNAs regulator. Life Sciences 213, pages 236-247.
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Arpit Dheeraj, Dhanir Tailor, Surya P. Singh & Rana P. Singh. 2018. Role of Nutraceuticals in Chemoresistance to Cancer. Role of Nutraceuticals in Chemoresistance to Cancer 199 220 .
Zohreh Jahanafrooz, Nasrin Motamed & Behnaz Bakhshandeh. (2017) Effects of miR-21 downregulation and silibinin treatment in breast cancer cell lines. Cytotechnology 69:4, pages 667-680.
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D Bayram, ES Çetin, M Kara, M Özgöçmen & IA Candan. (2016) The apoptotic effects of silibinin on MDA-MB-231 and MCF-7 human breast carcinoma cells. Human & Experimental Toxicology 36:6, pages 573-586.
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Min Li, Mao Zhang, Zhi-lang Zhang, Ning Liu, Xiao-yu Han, Qin-cheng Liu, Wei-jun Deng & Cai-xian Liao. (2017) Induction of Apoptosis by Berberine in Hepatocellular Carcinoma HepG2 Cells via Downregulation of NF-κB. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 25:2, pages 233-239.
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Navaneethakrishnan Polachi, Guirong Bai, Tingyang Li, Yang Chu, Xiangyang Wang, Shuming Li, Ning Gu, Jiang Wu, Wei Li, Yanjun Zhang, Shuiping Zhou, He Sun & Changxiao Liu. (2016) Modulatory effects of silibinin in various cell signaling pathways against liver disorders and cancer – A comprehensive review. European Journal of Medicinal Chemistry 123, pages 577-595.
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Masoud Maleki ZadehNasrin MotamedNajmeh RanjiMohammad MajidiFahimeh Falahi. (2016) Silibinin-Induced Apoptosis and Downregulation of MicroRNA-21 and MicroRNA-155 in MCF-7 Human Breast Cancer Cells. Journal of Breast Cancer 19:1, pages 45.
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Mingjie Zhang, Yunhui Liu, Yun Gao & Shaoyi Li. (2015) Silibinin-induced glioma cell apoptosis by PI3K-mediated but Akt-independent downregulation of FoxM1 expression. European Journal of Pharmacology 765, pages 346-354.
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Pegah Abdollahi, Marzieh Ebrahimi, Nasrin Motamed & Fazel S. Samani. (2015) Silibinin affects tumor cell growth because of reduction of stemness properties and induction of apoptosis in 2D and 3D models of MDA-MB-468. Anti-Cancer Drugs 26:5, pages 487-497.
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Tahsin F. Kellici, Dimitrios Ntountaniotis, Georgios Leonis, Maria Chatziathanasiadou, Alexandra V. Chatzikonstantinou, Johanna Becker-Baldus, Clemens Glaubitz, Andreas G. Tzakos, Kyriakos Viras, Petros Chatzigeorgiou, Stavros Tzimas, Evangelia Kefala, Georgia Valsami, Helen Archontaki, Manthos G. Papadopoulos & Thomas Mavromoustakos. (2015) Investigation of the Interactions of Silibinin with 2-Hydroxypropyl-β-cyclodextrin through Biophysical Techniques and Computational Methods. Molecular Pharmaceutics 12:3, pages 954-965.
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Thae Hyun Kim, Jae Suk Woo, Yong Keun Kim & Ki Hyung Kim. (2014) Silibinin Induces Cell Death through Reactive Oxygen Species–Dependent Downregulation of Notch-1/ERK/Akt Signaling in Human Breast Cancer Cells. Journal of Pharmacology and Experimental Therapeutics 349:2, pages 268-278.
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Khaled Khazim, Yves Gorin, Rita Cassia Cavaglieri, Hanna E. Abboud & Paolo Fanti. (2013) The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivo. American Journal of Physiology-Renal Physiology 305:5, pages F691-F700.
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Xinxin Yang, Xiaoyu Li, Liangxiang An, Bo Bai & Jing Chen. (2013) Silibinin induced the apoptosis of Hep-2 cells via oxidative stress and down-regulating survivin expression. European Archives of Oto-Rhino-Laryngology 270:8, pages 2289-2297.
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Kazem Nejati-Koshki, Nosratollah Zarghami, Mohammad Pourhassan-Moghaddam, Mohammad Rahmati-Yamchi, Mahdie Mollazade, Marzieh Nasiri, Rana Jahanban Esfahlan, Amin Barkhordari & Hamid Tayefi-Nasrabadi. (2012) Inhibition of leptin gene expression and secretion by silibinin: possible role of estrogen receptors. Cytotechnology 64:6, pages 719-726.
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Shi-Xiu Feng, Qiunong Guan, Tao Chen & Caigan Du. (2012) In vitro activities of 3-hydroxy-1,5,6-trimethoxy-2-methyl-9,10-anthraquinone against non-small cell lung carcinoma. Archives of Pharmacal Research 35:7, pages 1251-1258.
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Dhanir Tailor & Rana P. Singh. 2012. Nutrition, Diet and Cancer. Nutrition, Diet and Cancer 585 622 .
Wen Tan, Jinjian Lu, Mingqing Huang, Yingbo Li, Meiwan Chen, Guosheng Wu, Jian Gong, Zhangfeng Zhong, Zengtao Xu, Yuanye Dang, Jiajie Guo, Xiuping Chen & Yitao Wang. (2011) Anti-cancer natural products isolated from chinese medicinal herbs. Chinese Medicine 6:1.
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