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Review Article

Phyto-oestrogens and Western Diseases

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Pages 95-120 | Published online: 30 Oct 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Patricia A. Janulewicz, Jeffrey M. Carlson, Amelia K. Wesselink, Lauren A. Wise, Elizabeth E. Hatch, Lariah M. Edwards & Junenette L. Peters. (2021) Urinary Isoflavones Levels in Relation to Serum Thyroid Hormone Concentrations in Female and Male Adults in the U.S. General Population. International Journal of Environmental Health Research 31:4, pages 389-400.
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Giorgio I. Russo, Marina Di Mauro, Federica Regis, Giulio Reale, Daniele Campisi, Marina Marranzano, Arturo Lo Giudice, Tatiana Solinas, Massimo Madonia, Sebastiano Cimino & Giuseppe Morgia. (2018) Association between dietary phytoestrogens intakes and prostate cancer risk in Sicily. The Aging Male 21:1, pages 48-54.
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Yukyung Go, Minsung Chung & Yongsoon Park. (2016) Dietary Patterns for Women With Triple-negative Breast Cancer and Dense Breasts. Nutrition and Cancer 68:8, pages 1281-1288.
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Xiang-Yang Xiong, Xiao-Juan Hu, Yong Li & Cheng-Mei Liu. (2015) Inhibitory Effects of Enterolactone on Growth and Metastasis in Human Breast Cancer. Nutrition and Cancer 67:8, pages 1326-1334.
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Mina Fujitani, Takafumi Mizushige, Keshab Bhattarai, Asami Iwahara, Ryojiro Aida, Tomomi Segawa & Taro Kishida. (2015) Dynamics of appetite-mediated gene expression in daidzein-fed female rats in the meal-feeding method. Bioscience, Biotechnology, and Biochemistry 79:8, pages 1342-1349.
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Mina Fujitani, Takafumi Mizushige, Keshab Bhattarai, Asami Iwahara, Ryojiro Aida & Taro Kishida. (2015) The daidzein- and estradiol- induced anorectic action in CCK or leptin receptor deficiency rats. Bioscience, Biotechnology, and Biochemistry 79:7, pages 1164-1171.
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Aliya Ahmad, Kalavathy Ramasamy, Abu Bakar Abdul Majeed & Vasudevan Mani. (2015) Enhancement of β-secretase inhibition and antioxidant activities of tempeh, a fermented soybean cake through enrichment of bioactive aglycones. Pharmaceutical Biology 53:5, pages 758-766.
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Niki Mourouti, Meropi D. Kontogianni, Christos Papavagelis & Demosthenes B. Panagiotakos. (2015) Diet and breast cancer: a systematic review. International Journal of Food Sciences and Nutrition 66:1, pages 1-42.
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A. Durazzo, M. Carcea, H. Adlercreutz, E. Azzini, A. Polito, L. Olivieri, M. Zaccaria, C. Meneghini, F. Maiani, G. Bausano, F. Martiri, A. Samaletdin, A. Fumagalli, A. Raguzzini, E. Venneria, M. S. Foddai, D. Ciarapica, B. Mauro, F. Volpe & G. Maiani. (2014) Effects of consumption of whole grain foods rich in lignans in healthy postmenopausal women with moderate serum cholesterol: a pilot study. International Journal of Food Sciences and Nutrition 65:5, pages 637-645.
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Joseph F. Gonzales, Neal D. Barnard, David J.A. Jenkins, Amy J. Lanou, Brenda Davis, Gordon Saxe & Susan Levin. (2014) Applying the Precautionary Principle to Nutrition and Cancer. Journal of the American College of Nutrition 33:3, pages 239-246.
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Kyungsil Yoon, Seung Jun Kwack, Hyung Sik Kim & Byung-Mu Lee. (2014) Estrogenic Endocrine-Disrupting Chemicals: Molecular Mechanisms of Actions on Putative Human Diseases. Journal of Toxicology and Environmental Health, Part B 17:3, pages 127-174.
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Dagmar Richter, Sibylle Abarzua, Mareike Chrobak, Thomas Vrekoussis, Tobias Weissenbacher, Christina Kuhn, Sandra Schulze, MarkusS. Kupka, Klaus Friese, Volker Briese, Birgit Piechulla, Antonis Makrigiannakis, Udo Jeschke & Darius Dian. (2013) Effects of Phytoestrogen Extracts Isolated from Pumpkin Seeds on Estradiol Production and ER/PR Expression in Breast Cancer and Trophoblast Tumor Cells. Nutrition and Cancer 65:5, pages 739-745.
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J. Hernandez-Elizondo, C. Monteagudo, M.A. Murcia, N. Olea, F. Olea-Serrano & M. Mariscal-Arcas. (2013) Assessment of the estrogenicity of the diet of a healthy female Spanish population based on its isoflavone content. Food Additives & Contaminants: Part A 30:4, pages 627-633.
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Ombretta Marconi, Heidi Mayer, Francesco Chiacchieroni, Eros Ricci, Giuseppe Perretti & Paolo Fantozzi. (2013) The Influence of Glumes on Malting and Brewing of Hulled Wheats. Journal of the American Society of Brewing Chemists 71:1, pages 41-48.
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Manhai Long, Tanja Krüger, Mandana Ghisari & Eva Cecilie Bonefeld-Jørgensen. (2012) Effects of Selected Phytoestrogens and Their Mixtures on the Function of the Thyroid Hormone and the Aryl Hydrocarbon Receptor. Nutrition and Cancer 64:7, pages 1008-1019.
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Aida Karina Zaineddin, Katharina Buck, Alina Vrieling, Judith Heinz, Dieter Flesch-Janys, Jakob Linseisen & Jenny Chang-Claude. (2012) The Association Between Dietary Lignans, Phytoestrogen-Rich Foods, and Fiber Intake and Postmenopausal Breast Cancer Risk: A German Case-Control Study. Nutrition and Cancer 64:5, pages 652-665.
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Hanan A. Al-Ashaal, Maha A. Fahmy, Farouk R. Melek, Nagwa H. Aly & Zenab M. Hasan. (2012) Effect of supplemented soybean (Glycine max L) diet and extracts on aluminum sulfate-induced genotoxicity. Toxicological & Environmental Chemistry 94:5, pages 965-986.
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L. Malashree, Priti Mudgil, Sumit Singh Dagar, Sanjay Kumar & Anil Kumar Puniya. (2012) β-Glucosidase Activity of Lactobacilli for Biotransformation of Soy Isoflavones. Food Biotechnology 26:2, pages 154-163.
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Mei-Hua Huang, Jean Norris, Weijuan Han, Torin Block, Ellen Gold, Sybil Crawford & GailA. Greendale. (2012) Development of an Updated Phytoestrogen Database for Use With the SWAN Food Frequency Questionnaire: Intakes and Food Sources in a Community-Based, Multiethnic Cohort Study. Nutrition and Cancer 64:2, pages 228-244.
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M. Gossell-Williams, C. Hyde, T. Hunter, D. Simms-Stewart, H. Fletcher, D. McGrowder & C. A. Walters. (2011) Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study. Climacteric 14:5, pages 558-564.
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Susanne Andres, Klaus Abraham, Klaus Erich Appel & Alfonso Lampen. (2011) Risks and benefits of dietary isoflavones for cancer. Critical Reviews in Toxicology 41:6, pages 463-506.
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Neal Okarter & Rui Hai Liu. (2010) Health Benefits of Whole Grain Phytochemicals. Critical Reviews in Food Science and Nutrition 50:3, pages 193-208.
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Anna Rossini, Laura Zanobbio, Marco Palazzo, Lucia Sfondrini, Daniele Morelli, Elda Tagliabue, Andrea Balsari & Cristiano Rumio. (2010) Influence of Lignans Depletion on Murine Mammary Gland Morphology. Nutrition and Cancer 62:2, pages 237-242.
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S Kawakita, F Marotta, Y Naito, U Gumaste, S Jain, J Tsuchiya & E Minelli. (2009) Effect of an isoflavones-containing red clover preparation and alkaline supplementation on bone metabolism in ovariectomized rats. Clinical Interventions in Aging 4, pages 91-100.
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Mark Messina & Leena Hilakivi-Clarke. (2009) Early Intake Appears to Be the Key to the Proposed Protective Effects of Soy Intake Against Breast Cancer. Nutrition and Cancer 61:6, pages 792-798.
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Seung Jun Kwack, Kyu-Bong Kim, Hyung Sik Kim, Kyung Sil Yoon & Byung Mu Lee. (2009) Risk Assessment of Soybean-Based Phytoestrogens. Journal of Toxicology and Environmental Health, Part A 72:21-22, pages 1254-1261.
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Qingxi Zhang & Qipeng Yuan. (2009) Modeling of Nanofiltration Process for Solvent Recovery from Aqueous Ethanol Solution of Soybean Isoflavones. Separation Science and Technology 44:13, pages 3239-3257.
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Gertraud Maskarinec. (2009) Cancer Protective Properties of Cocoa: A Review of the Epidemiologic Evidence. Nutrition and Cancer 61:5, pages 573-579.
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GunterG. C. Kuhnle, Caterina Dell'Aquila, SueM. Aspinall, ShirleyA. Runswick, AngelaA. Mulligan & SheilaA. Bingham. (2009) Phytoestrogen Content of Cereals and Cereal-Based Foods Consumed in the UK. Nutrition and Cancer 61:3, pages 302-309.
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AdrianA. Franke, BrunhildM. Halm & LeslieA. Ashburn. (2008) Urinary Isoflavones Are Increased in Adults, But Decreased in Children, Consuming Soy When on Oral Antibiotic Therapy. Nutrition and Cancer 60:5, pages 627-635.
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Mi Kyung Kim, Jin Hee Kim, Seok Jin Nam, Seungho Ryu & Gu Kong. (2008) Dietary Intake of Soy Protein and Tofu in Association With Breast Cancer Risk Based on a Case-Control Study. Nutrition and Cancer 60:5, pages 568-576.
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Evagelos Gikas, Alexandra Alesta, Garifalia Economou, Andreas Karamanos & Anthony Tsarbopoulos. (2008) Determination of Isoflavones in the Aerial Part of Red Clover by HPLC–Diode Array Detection. Journal of Liquid Chromatography & Related Technologies 31:8, pages 1181-1194.
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BrunhildM. Halm, AdrianA. Franke, LeslieA. Ashburn, SandraM. Hebshi & LynneR. Wilkens. (2007) Oral Antibiotics Decrease Urinary Isoflavonoid Excretion in Children After Soy Consumption. Nutrition and Cancer 60:1, pages 14-22.
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DebraA. Tonetti, Yiyun Zhang, Huiping Zhao, Sok-Bee Lim & AndreasI. Constantinou. (2007) The Effect of the Phytoestrogens Genistein, Daidzein, and Equol on the Growth of Tamoxifen-Resistant T47D/PKCα. Nutrition and Cancer 58:2, pages 222-229.
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KristineR. Monroe, SuzanneP. Murphy, BrianE. Henderson, LaurenceN. Kolonel, FrankZ. Stanczyk, Herman Adlercreutz & MalcolmC. Pike. (2007) Dietary Fiber Intake and Endogenous Serum Hormone Levels in Naturally Postmenopausal Mexican American Women: The Multiethnic Cohort Study. Nutrition and Cancer 58:2, pages 127-135.
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Min Hee Do, Sang Sun Lee, Pa Jong Jung & Min Hyuk Lee. (2007) Intake of Fruits, Vegetables, and Soy Foods in Relation to Breast Cancer Risk in Korean Women: A Case-Control Study. Nutrition and Cancer 57:1, pages 20-27.
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Herman Adlercreutz. (2007) Lignans and Human Health. Critical Reviews in Clinical Laboratory Sciences 44:5-6, pages 483-525.
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Yue-Wern Huang, Jacob R. Phillips & Loretta D. Hunter. (2007) Human exposure to medicinal, dietary, and environmental estrogens. Toxicological & Environmental Chemistry 89:1, pages 141-160.
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Timothy G Whitsett Jr & Coral A Lamartiniere. (2006) Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Review of Anticancer Therapy 6:12, pages 1699-1706.
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C. Haines, A. James, D. Sahota, Z. Y. Chen, N. Panesar, B. Tomlinson, L. Chow, I. Benzie & A. Husband. (2006) Comparison between phytoestrogens and estradiol in the preventionof atheroma in ovariectomized cholesterol-fed rabbits. Climacteric 9:6, pages 430-436.
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Takuya Watanabe, Yoichi Arai, Yuki Mitsui, Tatsuya Kusaura, Wataru Okawa, Yasushi Kajihara & Ikuo Saito. (2006) The Blood Pressure-Lowering Effect and Safety of Chlorogenic Acid from Green Coffee Bean Extract in Essential Hypertension. Clinical and Experimental Hypertension 28:5, pages 439-449.
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Annalidia Sammartino, Giovanni Antonio Tommaselli, Virginia Gargano, Costantino di Carlo, Wanda Attianese & Carmine Nappi. (2006) Short-term effects of a combination of isoflavones, lignans and Cimicifuga racemosa on climacteric-related symptoms in postmenopausal women: A double-blind, randomized, placebo-controlled trial. Gynecological Endocrinology 22:11, pages 646-650.
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Pernilla Wikstrom, Annika Bylund, Jie-Xian Zhang, Goran Hallmans, Par Stattin & Anders Bergh. (2005) Rye Bran Diet Increases Epithelial Cell Apoptosis and Decreases Epithelial Cell Volume in TRAMP (transgenic adenocarcinoma of the mouse prostate) Tumors. Nutrition and Cancer 53:1, pages 111-116.
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Mark J. McCann, Chris I. R. Gill, Hugh McGlynn & Ian R. Rowland. (2005) Role of Mammalian Lignans in the Prevention and Treatment of Prostate Cancer. Nutrition and Cancer 52:1, pages 1-14.
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Marina S. Touillaud, Patricia C. Pillow, Jelena Jakovljevic, Melissa L. Bondy, S. Eva Singletary, Donghui Li & Shine Chang. (2005) Effect of Dietary Intake of Phytoestrogens on Estrogen Receptor Status in Premenopausal Women With Breast Cancer. Nutrition and Cancer 51:2, pages 162-169.
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Barry R. Goldin, Edgard Brauner, Herman Adlercreutz, Lynne M. Ausman & Alice H. Lichtenstein. (2005) Hormonal Response to Diets High in Soy or Animal Protein Without and With Isoflavones in Moderately Hypercholesterolemic Subjects. Nutrition and Cancer 51:1, pages 1-6.
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P. Albertazzi, S. A. Steel & M. Bottazzi. (2005) Effect of pure genistein on bone markers and hot flushes. Climacteric 8:4, pages 371-379.
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Udo Jeschke, Volker Briese, Dagmar-Ulrike Richter, Gunther Bruer, Dirk Plessow, Juliane Waldschläger, Ioannis Mylonas & Klaus Friese. (2005) Effects of phytoestrogens genistein and daidzein on production of human chorionic gonadotropin in term trophoblast cells in vitro. Gynecological Endocrinology 21:3, pages 180-184.
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Cesare R. Sirtori, Anna Arnoldi & Stuart K. Johnson. (2005) Phytoestrogens: End of a tale?. Annals of Medicine 37:6, pages 423-438.
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Adrian A. Franke, Laurie J. Custer & Scott A. Hundahl. (2004) Determinants for Urinary and Plasma Isoflavones in Humans After Soy Intake. Nutrition and Cancer 50:2, pages 141-154.
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D. B. Clarke , K. A. Barnes & A. S. Lloyd. (2004) Determination of unusual soya and non-soya phytoestrogen sources in beer, fish products and other foods. Food Additives & Contaminants 21:10, pages 949-962.
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Min Zhang, Xing Xie, Andy H. Lee & Colin W. Binns. (2004) Soy and Isoflavone Intake Are Associated With Reduced Risk of Ovarian Cancer in Southeast China. Nutrition and Cancer 49:2, pages 125-130.
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Anna N. C. Lam, Maryanne Demasi, Michael J. James, Alan J. Husband & Catherine Walker. (2004) Effect of Red Clover Isoflavones on Cox-2 Activity in Murine and Human Monocyte/Macrophage Cells. Nutrition and Cancer 49:1, pages 89-93.
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D. B. Clarke & A. S. Lloyd. (2004) Dietary exposure estimates of isoflavones from the 1998 UK Total Diet Study. Food Additives & Contaminants 21:4, pages 305-316.
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Elsa J. Frische, Andrea M. Hutchins, Margaret C. Martini, William Thomas & Joanne L. Slavin. (2003) Effect of Flaxseed and Wheat Bran on Serum Hormones and Lignan Excretion in Premenopausal Women. Journal of the American College of Nutrition 22:6, pages 550-554.
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Henk J. van Kranen, Alicja Mortensen, Ilona K. Sorensen, Jolanda van den Berg-Wijnands, Rudolf Beems, Tarja Nurmi, Herman Adlercreutz & Coen F. van Kreijl. (2003) Lignan Precursors From Flaxseed or Rye Bran Do Not Protect Against the Development of Intestinal Neoplasia in ApcMin Mice. Nutrition and Cancer 45:2, pages 203-210.
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Yutaka KONISHI, Kazuo KUBO & Makoto SHIMIZU. (2003) Structural Effects of Phenolic Acids on the Transepithelial Transport of Fluorescein in Caco-2 Cell Monolayers. Bioscience, Biotechnology, and Biochemistry 67:9, pages 2014-2017.
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A. Sammartino, C. Di Carlo, V. D. Mandato, G. Bifulco, M. Di Stefano & C. Nappi. (2003) Effects of genistein on the endometrium: ultrasonographic evaluation. Gynecological Endocrinology 17:1, pages 45-49.
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A. P. Wilkinson, J. M. Gee, M. S. Dupont, P. W. Needs, F. A. Mellon, G. Williamson & I. T. Johnson. (2003) Hydrolysis by lactase phlorizin hydrolase is the first step in the uptake of daidzein glucosides by rat small intestine in vitro. Xenobiotica 33:3, pages 255-264.
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Gabriela Cimpan & Simion Gocan. (2002) ANALYSIS OF MEDICINAL PLANTS BY HPLC: RECENT APPROACHES. Journal of Liquid Chromatography & Related Technologies 25:13-15, pages 2225-2292.
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Yutaka KONISHI, Keiko HAGIWARA & Makoto SHIMIZU. (2002) Transepithelial Transport of Fluorescein in Caco-2 Cell Monolayers and Use of Such Transport in In Vitro Evaluation of Phenolic Acid Availability. Bioscience, Biotechnology, and Biochemistry 66:11, pages 2449-2457.
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Young-Joo Park, Hesook Suzie Kim, Pyong-Sahm Ku, Hyun-Choel Kang & Sook-Hee Chun. (2001) A Survey on the Climacteric Symptoms in Korean Women. Women & Health 34:1, pages 17-28.
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DavidG. Himelrick. (2001) Wild Berries in Finland. Small Fruits Review 1:3, pages 83-94.
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Pia K. Verkasalo, Paul N. Appleby, Gwyneth K. Davey & Timothy J. Key. (2001) Soy Milk Intake and Plasma Sex Hormones: A Cross-Sectional Study in Pre- and Postmenopausal Women (EPIC-Oxford). Nutrition and Cancer 40:2, pages 79-86.
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Benson T Akingbemi & Matthew P Hardy. (2001) Oestrogenic and antiandrogenic chemicals in the environment: effects on male reproductive health. Annals of Medicine 33:6, pages 391-403.
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Andrea M. Hutchins, Margaret C. Martini, B. Amy Olson, William Thomas & Joanne L. Slavin. (2001) Flaxseed Consumption Influences Endogenous Hormone Concentrations in Postmenopausal Women. Nutrition and Cancer 39:1, pages 58-65.
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Joanne L. Slavin, David Jacobs & Len Marquart. (2001) Grain Processing and Nutrition. Critical Reviews in Biotechnology 21:1, pages 49-66.
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Wendy E. Ward, Fanny O. Jiang & Lilian U. Thompson. (2000) Exposure to Flaxseed or Purified Lignan During Lactation Influences Rat Mammary Gland Structures. Nutrition and Cancer 37:2, pages 187-192.
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Y. S. Choi & K. H. Row. (2000) PREPARATIVE SEPARATION OF ISOFLAVONES FROM SOYBEAN BY REVERSED-PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY. Journal of Liquid Chromatography & Related Technologies 23:11, pages 1671-1679.
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Joanne L. Slavin. (2000) Mechanisms for the Impact of Whole Grain Foods on Cancer Risk. Journal of the American College of Nutrition 19:sup3, pages 300S-307S.
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S. Widyarini, N. Spinks & V.E. Reeve. (2000) Protective effect of isoflavone derivative against photocarcinogenesis in a mouse model. Redox Report 5:2-3, pages 156-158.
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J. R. Guthrie, M. Ball, A. Murkies & L. Dennerstein. (2000) Dietary phytoestrogen intake in mid-life Australian-born women: relationship to health variables. Climacteric 3:4, pages 254-261.
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Margaret C. Martini, Betsy B. Dancisak, Carol J. Haggans, William Thomas & Joanne L. Slavin. (1999) Effects of Soy Intake on Sex Hormone Metabolism in Premenopausal Women. Nutrition and Cancer 34:2, pages 133-139.
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Carol J. Haggans, Andrea M. Hutchins, B. Amy Olson, William Thomas, Margaret C. Martini & Joanne L. Slavin. (1999) Effect of Flaxseed Consumption on Urinary Estrogen Metabolites in Postmenopausal Women. Nutrition and Cancer 33:2, pages 188-195.
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Mazda Jenab, Sharon E. Rickard, Lindy J. Orcheson & Lilian U. Thompson. (1999) Flaxseed and Lignans Increase Cecal β-Glucuronidase Activity in Rats. Nutrition and Cancer 33:2, pages 154-158.
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R. J. Baber, C. Templeman, T. Morton, G. E. Kelly & L. West. (1999) Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric 2:2, pages 85-92.
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Zhi Chen, Wei Zheng, LaurieJ. Custer, Qi Dai, Xiao‐Ou Shu, Fan Jin & AdrianA. Franke. (1999) Usual dietary consumption of soy foods and its correlation with the excretion rate of isoflavonoids in overnight urine samples among Chinese women in shanghai. Nutrition and Cancer 33:1, pages 82-87.
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PatriciaC. Pillow, CherieM. Duphorne, Shine Chang, JohnH. Contois, SaraS. Strom, MargaretR. Spitz & StephenD. Hursting. (1999) Development of a database for assessing dietary phytoestrogen intake. Nutrition and Cancer 33:1, pages 3-19.
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