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Review Article

Inflammatory bowel disease—From mechanisms to treatment strategies

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Pages 463-477 | Received 01 Feb 2010, Accepted 03 Feb 2010, Published online: 14 Apr 2010

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Read on this site (12)

Li-Ze Zhang, Hui Xue, Cui-Xia Qiao, Wen-Li You, Ai-Ting Di & Gang Zhao. (2021) MiR-223 promotes pyroptosis of enteritis cells through activating NF-κB signalling pathway by targeting SNIP1 in inflammatory bowel disease. Autoimmunity 54:6, pages 362-372.
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Qingping Yao, Ellen Li & Bo Shen. (2019) Autoinflammatory disease with focus on NOD2-associated disease in the era of genomic medicine. Autoimmunity 52:2, pages 48-56.
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Christine McDonald, Min Shen, Erin E. Johnson, Amrita Kabi & Qingping Yao. (2018) Alterations in nucleotide-binding oligomerization domain-2 expression, pathway activation, and cytokine production in Yao syndrome. Autoimmunity 51:2, pages 53-61.
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Tejaswini Prakash, Avinash Veerappa & Nallur B. Ramachandra. (2017) Complex interaction between HNRNPD mutations and risk polymorphisms is associated with discordant Crohn’s disease in monozygotic twins. Autoimmunity 50:5, pages 275-276.
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Eleni Kontaki, Dimitrios T. Boumpas, Maria Tzardi, Ioannis A. Mouzas, Konstantinos A. Papadakis & Panayotis Verginis. (2017) Aberrant function of myeloid-derived suppressor cells (MDSCs) in experimental colitis and in inflammatory bowel disease (IBD) immune responses. Autoimmunity 50:3, pages 170-181.
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Mousa Mohammadnia-Afrouzi, Ahmad Zavaran Hosseini, Ali Khalili, Saeid Abediankenari, Vahid Hosseini & Iradj Maleki. (2015) Decrease of CD4+ CD25+ CD127low FoxP3+ regulatory T cells with impaired suppressive function in untreated ulcerative colitis patients. Autoimmunity 48:8, pages 556-561.
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Jacek Karczewski, Barbara Poniedziałek, Zygmunt Adamski & Piotr Rzymski. (2014) The effects of the microbiota on the host immune system. Autoimmunity 47:8, pages 494-504.
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Jixiang Zhang, Jihui Zhang, Dandan Wu, Jun Wang & Weiguo Dong. (2014) Associations between TNFSF15 polymorphisms and susceptibility to ulcerative colitis and Crohn's disease: A meta-analysis. Autoimmunity 47:8, pages 512-518.
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Li Zeng, Juncheng Cui, Haijing Wu & Qianjin Lu. (2014) The emerging role of circulating microRNAs as biomarkers in autoimmune diseases. Autoimmunity 47:7, pages 419-429.
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Liwei Zou, Longsheng Wang, Xijun Gong, Hong Zhao, Anhong Jiang & Suisheng Zheng. (2014) The association between three promoter polymorphisms of IL-10 and inflammatory bowel diseases (IBD): A meta-analysis. Autoimmunity 47:1, pages 27-39.
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Bo Xiao & Didier Merlin. (2012) Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease. Expert Opinion on Drug Delivery 9:11, pages 1393-1407.
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Articles from other publishers (29)

Jiryeon Jang & Sehoon Jeong. (2023) Inflammatory Bowel Disease: Pathophysiology, Treatment, and Disease Modeling. BioChip Journal.
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Julia Eckenberger, James C. Butler, Charles N. Bernstein, Fergus Shanahan & Marcus J. Claesson. (2022) Interactions between Medications and the Gut Microbiome in Inflammatory Bowel Disease. Microorganisms 10:10, pages 1963.
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Mengchi Sun, Weiyue Ban, Hao Ling, Xiang Yu, Zhonggui He, Qikun Jiang & Jin Sun. (2022) Emerging nanomedicine and prodrug delivery strategies for the treatment of inflammatory bowel disease. Chinese Chemical Letters 33:10, pages 4449-4460.
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Antonio Speciale, Romina Bashllari, Claudia Muscarà, Maria Sofia Molonia, Antonella Saija, Shikha Saha, Peter J. Wilde & Francesco Cimino. (2022) Anti-Inflammatory Activity of an In Vitro Digested Anthocyanin-Rich Extract on Intestinal Epithelial Cells Exposed to TNF-α. Molecules 27:17, pages 5368.
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Sanaz Keshavarz Shahbaz, Khadijeh Koushki, Seyed Hassan Ayati, Abigail R. Bland, Evgeny E. Bezsonov & Amirhossein Sahebkar. (2021) Inflammasomes and Colorectal Cancer. Cells 10:9, pages 2172.
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Daniela Marotto, Fabiola Atzeni, Sandro Ardizzone, Giovanni Monteleone, Valeria Giorgi & Piercarlo Sarzi-Puttini. (2020) Extra-intestinal manifestations of inflammatory bowel diseases. Pharmacological Research 161, pages 105206.
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Qingdong Guan. (2019) A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease. Journal of Immunology Research 2019, pages 1-16.
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Lisa Kaly, Michael Rozenbaum, Doron Rimar, Gleb Slobodin, Nina Boulman, Abid Awisat, Shira Ginsberg, Nizar Jiries & Itzhak Rosner. (2019) Ulcerative Colitis and Familial Mediterranean Fever: Can Anakinra Treat Both?. ACG Case Reports Journal 6:7, pages e00143.
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Maebh Kelleher, Raminder Singh, Caitriona M. O’Driscoll & Silvia Melgar. (2019) Carcinoembryonic antigen (CEACAM) family members and Inflammatory Bowel Disease. Cytokine & Growth Factor Reviews 47, pages 21-31.
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Stig Purup, Søren D. Nielsen, Thao T. Le, Hans Bertelsen, John Sørensen & Lotte B. Larsen. (2018) Wound Healing Properties of Commercial Milk Hydrolysates in Intestinal Cells. International Journal of Peptide Research and Therapeutics 25:2, pages 483-491.
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Søren Nielsen, Stig Purup & Lotte Larsen. (2019) Effect of Casein Hydrolysates on Intestinal Cell Migration and Their Peptide Profiles by LC-ESI/MS/MS. Foods 8:3, pages 91.
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Andreia Almeida, Helena Macedo, José das Neves & Bruno Sarmento. 2018. Stimuli-responsive Drug Delivery Systems. Stimuli-responsive Drug Delivery Systems 83 108 .
Zhao Peng, Liangkai Chen, Jie Xiao, Xiaoqi Zhou, Andreas K. Nüssler, Liegang Liu, Jinping Liu & Wei Yang. (2017) Review of mechanisms of deoxynivalenol-induced anorexia: The role of gut microbiota. Journal of Applied Toxicology 37:9, pages 1021-1029.
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Donjete Statovci, Mònica Aguilera, John MacSharry & Silvia Melgar. (2017) The Impact of Western Diet and Nutrients on the Microbiota and Immune Response at Mucosal Interfaces. Frontiers in Immunology 8.
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Yangyang Xiong, Yan Lou, Han Su, Yu Fu & Juan Kong. (2016) Cholecalciterol cholesterol emulsion ameliorates experimental colitis via down-regulating the pyroptosis signaling pathway. Experimental and Molecular Pathology 100:3, pages 386-392.
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Ke Ren, Hongjiang Yuan, Yijia Zhang, Xin Wei & Dong Wang. (2015) Macromolecular glucocorticoid prodrug improves the treatment of dextran sulfate sodium-induced mice ulcerative colitis. Clinical Immunology 160:1, pages 71-81.
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Mònica Aguilera, Trevor Darby & Silvia Melgar. (2014) The complex role of inflammasomes in the pathogenesis of Inflammatory Bowel Diseases – Lessons learned from experimental models. Cytokine & Growth Factor Reviews 25:6, pages 715-730.
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Margarita Martinez-Medina, Jérémy Denizot, Nicolas Dreux, Frédéric Robin, Elisabeth Billard, Richard Bonnet, Arlette Darfeuille-Michaud & Nicolas Barnich. (2014) Western diet induces dysbiosis with increased E coli in CEABAC10 mice , alters host barrier function favouring AIEC colonisation . Gut 63:1, pages 116-124.
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Barbara Renga, Claudio D’Amore, Sabrina Cipriani, Andrea Mencarelli, Adriana Carino, Valentina Sepe, Angela Zampella, Eleonora Distrutti & Stefano Fiorucci. (2013) FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents. Pharmacological Research 77, pages 1-10.
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J. McCarthy, M.J. O'Neill, L. Bourre, D. Walsh, A. Quinlan, G. Hurley, J. Ogier, F. Shanahan, S. Melgar, R. Darcy & C.M. O'Driscoll. (2013) Gene silencing of TNF-alpha in a murine model of acute colitis using a modified cyclodextrin delivery system. Journal of Controlled Release 168:1, pages 28-34.
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David Walsh, Joanna McCarthy, Caitriona O’Driscoll & Silvia Melgar. (2013) Pattern recognition receptors—Molecular orchestrators of inflammation in inflammatory bowel disease. Cytokine & Growth Factor Reviews 24:2, pages 91-104.
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Eleanora Anna Margaretha Festen, Cisca Wijmenga & Rinse K Weersma. 2013. Genomic and Personalized Medicine. Genomic and Personalized Medicine 863 878 .
Peter Holzer, Florian Reichmann & Aitak Farzi. (2012) Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut–brain axis. Neuropeptides 46:6, pages 261-274.
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Fergus Shanahan. (2012) The microbiota in inflammatory bowel disease: friend, bystander, and sometime-villain. Nutrition Reviews 70, pages S31-S37.
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Pauline D. Scanlan. (2012) Blastocystis: past pitfalls and future perspectives. Trends in Parasitology 28:8, pages 327-334.
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E. Øines, R. Murison, J. Mrdalj, J. Grønli & A.M. Milde. (2012) Neonatal maternal separation in male rats increases intestinal permeability and affects behavior after chronic social stress. Physiology & Behavior 105:4, pages 1058-1066.
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Carola T. Murphy, Kenneth Nally, Fergus Shanahan & Silvia Melgar. (2012) Shining a Light on Intestinal Traffic. Clinical and Developmental Immunology 2012, pages 1-14.
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P. Marteau & M. Camus. (2011) Probiotiques et maladies inflammatoires cryptogénétiques de l’intestinProbiotics and inflammatory bowel disease. Phytothérapie 9:2, pages 113-116.
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Martin J. O’Neill, Ludovic Bourre, Silvia Melgar & Caitriona M. O’Driscoll. (2011) Intestinal delivery of non-viral gene therapeutics: physiological barriers and preclinical models. Drug Discovery Today 16:5-6, pages 203-218.
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