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Review Article

The complex role of DNA, histones and HMGB1 in the pathogenesis of SLE

Pages 487-493 | Received 06 Feb 2014, Accepted 03 May 2014, Published online: 11 Jun 2014

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Ulf Andersson, Huan Yang & Helena Harris. (2018) Extracellular HMGB1 as a therapeutic target in inflammatory diseases. Expert Opinion on Therapeutic Targets 22:3, pages 263-277.
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Lina Tan, Haijing Wu, Ying Liu, Ming Zhao, Duo Li & Qianjin Lu. (2016) Recent advances of exosomes in immune modulation and autoimmune diseases. Autoimmunity 49:6, pages 357-365.
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Fatma A Hisham, Samar Tharwat, Nouran E Samra, Nora Mostafa, Mohammed K Nassar & Manal M. El-Desoky. (2022) High mobility group box protein 1 (HMGB1) serum and urinary levels and gene polymorphism in Egyptian patients with systemic lupus erythematosus: A possible relation to lupus nephritis. Lupus 31:14, pages 1777-1785.
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Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang & Jinlong Li. (2022) Receptor for Advanced Glycation End Products (RAGE): A Pivotal Hub in Immune Diseases. Molecules 27:15, pages 4922.
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Ulf Andersson & Huan Yang. (2022) HMGB1 is a critical molecule in the pathogenesis of Gram-negative sepsis. Journal of Intensive Medicine 2:3, pages 156-166.
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Lauren E. Fritsch, Jing Ju, Erwin Kristobal Gudenschwager Basso, Eman Soliman, Swagatika Paul, Jiang Chen, Alexandra M. Kaloss, Elizabeth A. Kowalski, Taylor C. Tuhy, Rachana Deven Somaiya, Xia Wang, Irving Coy Allen, Michelle H. Theus & Alicia M. Pickrell. (2022) Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury. Frontiers in Molecular Neuroscience 15.
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Ole Petter Rekvig. (2022) The Anti-DNA Antibodies: Their Specificities for Unique DNA Structures and Their Unresolved Clinical Impact—A System Criticism and a Hypothesis. Frontiers in Immunology 12.
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Johannes Hartl, Lee Serpas, Yueyang Wang, Ali Rashidfarrokhi, Oriana A. Perez, Benjamin Sally, Vanja Sisirak, Chetna Soni, Alireza Khodadadi-Jamayran, Aristotelis Tsirigos, Ivan Caiello, Claudia Bracaglia, Stefano Volpi, Gian Marco Ghiggeri, Asiya Seema Chida, Ignacio Sanz, Mimi Y. Kim, H. Michael Belmont, Gregg J. Silverman, Robert M. Clancy, Peter M. Izmirly, Jill P. Buyon & Boris Reizis. (2021) Autoantibody-mediated impairment of DNASE1L3 activity in sporadic systemic lupus erythematosus. Journal of Experimental Medicine 218:5.
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Haruka Takata, Taro Shimizu, Yoshino Kawaguchi, Hiro Ueda, Nehal E. Elsadek, Hidenori Ando, Yu Ishima & Tatsuhiro Ishida. (2021) Nucleic acids delivered by PEGylated cationic liposomes in systemic lupus erythematosus-prone mice: A possible exacerbation of lupus nephritis in the presence of pre-existing anti-nucleic acid antibodies. International Journal of Pharmaceutics 601, pages 120529.
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Patricia Mondelo-Macía, Patricia Castro-Santos, Adrián Castillo-García, Laura Muinelo-Romay & Roberto Diaz-Peña. (2021) Circulating Free DNA and Its Emerging Role in Autoimmune Diseases. Journal of Personalized Medicine 11:2, pages 151.
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Ji-Na Zheng, Yang Li, Yue-Mei Yan, Yong Yu, Wen-Qi Shao & Qiang Wang. (2020) Increased serum calpain activity is associated with HMGB1 levels in systemic sclerosis. Arthritis Research & Therapy 22:1.
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Ole Petter Rekvig. (2020) Autoimmunity and SLE: Factual and Semantic Evidence-Based Critical Analyses of Definitions, Etiology, and Pathogenesis. Frontiers in Immunology 11.
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Zhi Zhao, Zhizhi Hu, Rui Zeng & Ying Yao. (2020) HMGB1 in kidney diseases. Life Sciences 259, pages 118203.
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Michal Mego, Katarina Kalavska, Marian Karaba, Gabriel Minarik, Juraj Benca, Tatiana Sedlackova, Paulina Gronesova, Dana Cholujova, Daniel Pindak, Jozef Mardiak & Peter Celec. (2020) Plasma Nucleosomes in Primary Breast Cancer. Cancers 12:9, pages 2587.
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Tianye Liu, Myoungsun Son & Betty Diamond. (2020) HMGB1 in Systemic Lupus Erythematosus. Frontiers in Immunology 11.
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Izabela Dybowska-Gołota, Agnieszka Owczarczyk-Saczonek, Magdalena Krajewska-Włodarczyk & Zbigniew Żuber. (2020) Psoriasis and systemic lupus erythematosus in children – literature review based on case report. Rheumatology 58:1, pages 48-55.
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Chuanxin Zhang, Xinfeng Gu, Guangyi Zhao, Wang Wang, Jiahua Shao, Jun Zhu, Ting Yuan, Jiuyi Sun, Daibang Nie & Yiqin Zhou. (2020) Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues. Therapeutic Advances in Chronic Disease 11, pages 204062232095642.
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Ruochan Chen, Shan Zhu, Ling Zeng, Qingde Wang, Yi Sheng, Borong Zhou, Daolin Tang & Rui Kang. (2019) AGER-Mediated Lipid Peroxidation Drives Caspase-11 Inflammasome Activation in Sepsis. Frontiers in Immunology 10.
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A Tanaka, T Ito, K Kibata, N Inagaki-Katashiba, H Amuro, T Nishizawa, Y Son, Y Ozaki & S Nomura. (2019) Serum high-mobility group box 1 is correlated with interferon-α and may predict disease activity in patients with systemic lupus erythematosus. Lupus 28:9, pages 1120-1127.
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Carolina M. Gorgulho, Graziela G. Romagnoli, Rosh Bharthi & Michael T. Lotze. (2019) Johnny on the Spot-Chronic Inflammation Is Driven by HMGB1. Frontiers in Immunology 10.
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Ole Petter Rekvig. (2019) The dsDNA, Anti-dsDNA Antibody, and Lupus Nephritis: What We Agree on, What Must Be Done, and What the Best Strategy Forward Could Be. Frontiers in Immunology 10.
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Jonathan Delgado-Hernández, Nieves León-Gómez & Alejandra Jiménez-Álvarez. (2019) Diagnostic accuracy of the Smoothed Cepstral Peak Prominence (CPPS) in the detection of dysphonia in the Spanish language. Loquens 6:1, pages 058.
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David S. Pisetsky. 2019. Dubois' Lupus Erythematosus and Related Syndromes. Dubois' Lupus Erythematosus and Related Syndromes 631 639 .
Yalan Xu, Yijun Song, Jiazhen Chang, Xiya Zhou, Qingwei Qi, Xinping Tian, Mengtao Li, Xiaofeng Zeng, Mengnan Xu, Wenjuan Zhang, David S Cram & Juntao Liu. (2018) High levels of circulating cell-free DNA are a biomarker of active SLE. European Journal of Clinical Investigation 48:11, pages e13015.
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Yu Guo, Zheng Xiao, Yanan Wang, Weihua Yao, Shun Liao, Bo Yu, Jianqiang Zhang, Yanxiang Zhang, Bing Zheng, Boxu Ren & Quan Gong. (2018) Sodium Butyrate Ameliorates Streptozotocin-Induced Type 1 Diabetes in Mice by Inhibiting the HMGB1 Expression. Frontiers in Endocrinology 9.
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Ulf Andersson, Huan Yang & Helena Harris. (2018) High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells. Seminars in Immunology 38, pages 40-48.
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Donald E. Olins & Ada L. Olins. (2018) Epichromatin and chromomeres: a ‘fuzzy’ perspective. Open Biology 8:6.
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Stefan Vordenbäumen, Paloma Böhmer, Ralph Brinks, Rebecca Fischer-Betz, Jutta Richter, Ellen Bleck, Petra Rengers, Heike Göhler, Hans-Dieter Zucht, Petra Budde, Peter Schulz-Knappe & Matthias Schneider. (2018) High diagnostic accuracy of histone H4-IgG autoantibodies in systemic lupus erythematosus. Rheumatology 57:3, pages 533-537.
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Dmytro Fishman, Kai Kisand, Christina Hertel, Mike Rothe, Anu Remm, Maire Pihlap, Priit Adler, Jaak Vilo, Aleksandr Peet, Antonella Meloni, Katarina Trebusak Podkrajsek, Tadej Battelino, Øyvind Bruserud, Anette S. B. Wolff, Eystein S. Husebye, Nicolas Kluger, Kai Krohn, Annamari Ranki, Hedi Peterson, Adrian Hayday & Pärt Peterson. (2017) Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Frontiers in Immunology 8.
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Francesco Di Virgilio & Anna Lisa Giuliani. (2016) Purinergic signalling in autoimmunity: A role for the P2X7R in systemic lupus erythematosus?. Biomedical Journal 39:5, pages 326-338.
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Mariele Gatto, Luca Iaccarino, Anna Ghirardello, Leonardo Punzi & Andrea Doria. (2016) Clinical and pathologic considerations of the qualitative and quantitative aspects of lupus nephritogenic autoantibodies: A comprehensive review. Journal of Autoimmunity 69, pages 1-11.
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David S. Pisetsky. (2015) Anti-DNA antibodies — quintessential biomarkers of SLE. Nature Reviews Rheumatology 12:2, pages 102-110.
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Lina Wirestam, Hanna Schierbeck, Thomas Skogh, Iva Gunnarsson, Lars Ottosson, Helena Erlandsson-Harris, Jonas Wetterö & Christopher Sjöwall. (2015) Antibodies against High Mobility Group Box protein-1 (HMGB1) versus other anti-nuclear antibody fine-specificities and disease activity in systemic lupus erythematosus. Arthritis Research & Therapy 17:1.
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M. Magna & D. S. Pisetsky. (2015) The Role of Cell Death in the Pathogenesis of SLE: Is Pyroptosis the Missing Link?. Scandinavian Journal of Immunology 82:3, pages 218-224.
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Shu Man Fu, Chao Dai, Zhenhuan Zhao & Felicia Gaskin. (2015) Anti-dsDNA Antibodies are one of the many autoantibodies in systemic lupus erythematosus. F1000Research 4, pages 939.
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