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Immunopharmacology and Immunotoxicology Volume 32, 2010 - Issue 4
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Research Article

Immunomodulatory effects of polysaccharopeptide (PSP) in human PBMC through regulation of TRAF6/TLR immunosignal-transduction pathways

Wenwen LiDepartment of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Manran LiuMolecular Medicine and Cancer Research Centre, Chongqing Medical University, Chongqing, China
,
Sihan LaiDepartment of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Can XuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Fang LuDepartment of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China
,
Xiaoqiu XiaoInstitute of Life Sciences, Chongqing Medical University, Chongqing, China
&
Yixi BaoDepartment of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaCorrespondence[email protected]
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Pages 576-584 | Received 29 Sep 2009, Accepted 31 Dec 2009, Published online: 04 Feb 2010

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Tomasz Jedrzejewski, Jakub Piotrowski, Malgorzata Kowalczewska, Sylwia Wrotek & Wieslaw Kozak. (2015) Polysaccharide peptide from Coriolus versicolor induces interleukin 6-related extension of endotoxin fever in rats. International Journal of Hyperthermia 31:6, pages 626-634.
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Jing Wang, Bing Dong, Yi Tan, Shuang Yu & Yi-Xi Bao. (2013) A study on the immunomodulation of polysaccharopeptide through the TLR4-TIRAP/MAL-MyD88 signaling pathway in PBMCs from breast cancer patients. Immunopharmacology and Immunotoxicology 35:4, pages 497-504.
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Articles from other publishers (19)

Tomasz Jędrzejewski, Małgorzata Pawlikowska, Justyna Sobocińska & Sylwia Wrotek. (2023) COVID-19 and Cancer Diseases—The Potential of Coriolus versicolor Mushroom to Combat Global Health Challenges. International Journal of Molecular Sciences 24:5, pages 4864.
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Zhicheng He, Jian Lin, Yingying He & Shubai Liu. (2022) Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment. Biomedicines 10:11, pages 2841.
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Hong-Bo Fan, Qian-Wang Zheng, Qing Han, Yuan Zou, Ying-Li Liu, Li-Qiong Guo & Jun-Fang Lin. (2021) Effect and mechanism of a novel Cordyceps militaris immunomodulatory protein on the differentiation of macrophages. Food Bioscience 43, pages 101268.
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Solomon Habtemariam. (2020) Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy. Biomedicines 8:5, pages 135.
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Tomasz Jędrzejewski, Jakub Piotrowski, Małgorzata Pawlikowska, Sylwia Wrotek & Wieslaw Kozak. (2019) Extract from Coriolus versicolor fungus partially prevents endotoxin tolerance development by maintaining febrile response and increasing IL-6 generation. Journal of Thermal Biology 83, pages 69-79.
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Wing-Fu Lai, Marie Lin & Guping Tang. (2018) A Phytochemical-Based Copolymer Derived from Coriolus versicolor Polysaccharopeptides for Gene Delivery. Molecules 23:9, pages 2273.
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Mohammad H. Saleh, Iran Rashedi & Armand Keating. (2017) Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide. Frontiers in Immunology 8.
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Lijing Zhou, Zijing Liu, Zhixue Wang, Shuang Yu, Tingting Long, Xing Zhou & Yixi Bao. (2017) Astragalus polysaccharides exerts immunomodulatory effects via TLR4-mediated MyD88-dependent signaling pathway in vitro and in vivo. Scientific Reports 7:1.
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Zhixue Wang, Zijing Liu, Lijng Zhou, Tingting Long, Xing Zhou & Yixi Bao. (2017) Immunomodulatory effect of APS and PSP is mediated by Ca2 + -cAMP and TLR4/NF-κB signaling pathway in macrophage. International Journal of Biological Macromolecules 94, pages 283-289.
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Tomasz Jędrzejewski, Małgorzata Pawlikowska, Jakub Piotrowski & Wiesław Kozak. (2016) Protein-bound polysaccharides from Coriolus versicolor attenuate LPS-induced synthesis of pro-inflammatory cytokines and stimulate PBMCs proliferation. Immunology Letters 178, pages 140-147.
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Zifang Feng, Zhixue Wang, Min Yang, Lijing Zhou & Yixi Bao. (2016) Polysaccharopeptide exerts immunoregulatory effects via MyD88-dependent signaling pathway. International Journal of Biological Macromolecules 82, pages 201-207.
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Tomasz Jedrzejewski, Jakub Piotrowski, Sylwia Wrotek & Wieslaw Kozak. (2014) Polysaccharide peptide induces a tumor necrosis factor-α-dependent drop of body temperature in rats. Journal of Thermal Biology 44, pages 1-4.
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Yan Zhou, Song Chen, Ran Ding, Wenbing Yao & Xiangdong Gao. (2014) Inflammatory Modulation Effect of Glycopeptide from Ganoderma capense (Lloyd) Teng . Mediators of Inflammation 2014, pages 1-8.
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Rodrigo Fernandez-Gonzalo, José A. De Paz, Paula Rodriguez-Miguelez, María J. Cuevas & Javier González-Gallego. (2014) TLR4-Mediated Blunting of Inflammatory Responses to Eccentric Exercise in Young Women. Mediators of Inflammation 2014, pages 1-11.
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RUI HUANG, JUN ZHANG, YONG LIU, YINGYING HAO, CHENCHEN YANG, KANGKANG WU, SHUFENG CAO & CHAO WU. (2013) Immunomodulatory effects of polysaccharopeptide in immunosuppressed mice induced by cyclophosphamide. Molecular Medicine Reports 8:2, pages 669-675.
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Rodrigo Fernandez-Gonzalo, José A. De Paz, Paula Rodriguez-Miguelez, María J. Cuevas & Javier González-Gallego. (2012) Effects of eccentric exercise on toll-like receptor 4 signaling pathway in peripheral blood mononuclear cells. Journal of Applied Physiology 112:12, pages 2011-2018.
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John H.K. Yeung & Penelope M.Y. Or. (2012) Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes. Phytomedicine 19:5, pages 457-463.
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Stanislava Stošić-Grujičić, Sanja Mijatović & Danijela Maksimović-Ivanić. 2011. Evidence-based Anticancer Materia Medica. Evidence-based Anticancer Materia Medica 265 302 .
Susu M Zughaier. (2011) Neisseria meningitidis capsular polysaccharides induce inflammatory responses via TLR2 and TLR4-MD-2 . Journal of Leukocyte Biology 89:3, pages 469-480.
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