1,205
Views
71
CrossRef citations to date
0
Altmetric
Research Article

Amygdalin induces apoptosis in human cervical cancer cell line HeLa cells

, , , , , , & show all
Pages 43-51 | Received 30 Sep 2012, Accepted 08 Oct 2012, Published online: 09 Nov 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Papisetti Venkatesham, Perugu Shyam, Pooja, Raju Chedupaka & Rajeswar Rao Vedula. (2023) Facile One-Pot Multi-Component Synthesis, Characterization, Molecular Docking Studies, Biological Evaluation of 1,2,4-Triazolo Isoindoline-1,3-Diones and Their DFT Calculations. Polycyclic Aromatic Compounds 43:3, pages 2283-2301.
Read now
Khattab Al-Khafaji & Tugba Taskin Tok. (2021) Understanding the mechanism of amygdalin’s multifunctional anti-cancer action using computational approach. Journal of Biomolecular Structure and Dynamics 39:5, pages 1600-1610.
Read now
Radoslav Omelka, Veronika Kovacova, Vladimira Mondockova, Birgit Grosskopf, Adriana Kolesarova & Monika Martiniakova. (2021) Cyanogenic glycoside amygdalin influences functions of human osteoblasts in vitro. Journal of Environmental Science and Health, Part B 56:2, pages 109-116.
Read now
Iveta Boháčová, Simona Procházková & Radoslav Halko. (2019) Separation and determination of amygdalin and unnatural neoamygdalin in natural food supplements by HPLC-DAD. Food Additives & Contaminants: Part A 36:10, pages 1445-1452.
Read now
Sevcan Mamur, Deniz Yuzbasioglu, Serkan Yılmaz, Esra Erikel & Fatma Unal. (2018) Assessment of cytotoxic and genotoxic effects of enniatin-A in vitro. Food Additives & Contaminants: Part A 35:8, pages 1633-1644.
Read now
Ji-Yoon Moon, Sang-Won Kim, Gi-Mok Yun, Hyeon-Sik Lee, Yoon-Dong Kim, Gie-Joon Jeong, Imran Ullah, Gyu-Jin Rho & Byeong-Gyun Jeon. (2015) Inhibition of cell growth and down-regulation of telomerase activity by amygdalin in human cancer cell lines. Animal Cells and Systems 19:5, pages 295-304.
Read now
Shailendra Kapoor. (2014) Safety of studies analysing clinical benefit of amygdalin. Immunopharmacology and Immunotoxicology 36:1, pages 87-87.
Read now

Articles from other publishers (64)

Ahmed Mohammed Alwan & Jalil Tavakol Afshari. (2023) Investigating the Protective Role of Rhodanese Enzyme against Cyanide, the Cytotoxic by-product of Amygdalin, in HDF and L929 Cell Lines. Letters in Drug Design & Discovery 20:9, pages 1295-1307.
Crossref
Decai Zhang, Jianfen Ye, Yu Song, Yingying Wei, Shu Jiang, Yi Chen & Xingfeng Shao. (2023) Isomerization and Stabilization of Amygdalin from Peach Kernels. Molecules 28:11, pages 4550.
Crossref
Serap Ayaz Seyhan, Dilek Bilgic Alkaya, Sumeyye Cesur & Ali Sahin. (2023) Investigation of the antitumor effect on breast cancer cells of the electrospun amygdalin-loaded poly(l-lactic acid)/poly(ethylene glycol) nanofibers. International Journal of Biological Macromolecules 239, pages 124201.
Crossref
Esra Erikel, Deniz Yuzbasioglu & Fatma Unal. (2023) A study on Amygdalin's genotoxicological safety and modulatory activity in human peripheral lymphocytes in vitro . Environmental and Molecular Mutagenesis 64:5, pages 291-308.
Crossref
Mohammed Helmy Faris Shalayel, Ghassab M. Al-Mazaideh, Abdulkareem A. Alanezi, Afaf F. Almuqati & Meshal Alotaibi. (2023) The Potential Anti-Cancerous Activity of Prunus amygdalus var. amara Extract. Processes 11:4, pages 1277.
Crossref
Mabu L. Matlou, Hitler Louis, Destiny E. Charlie, Ernest C. Agwamba, Ismail O. Amodu, Vuyelwa J. Tembu & Amanda-Lee E. Manicum. (2023) Anticancer Activities of Re(I) Tricarbonyl and Its Imidazole-Based Ligands: Insight from a Theoretical Approach. ACS Omega 8:11, pages 10242-10252.
Crossref
Ahmed Mohammed Alwan, Dinesh Rokaya, Goma Kathayat & Jalil Tavakol Afshari. (2023) Onco-immunity and therapeutic application of amygdalin: A review. Journal of Oral Biology and Craniofacial Research 13:2, pages 155-163.
Crossref
Shahida Anusha Siddiqui, Sidra Anwar, Bello Mohammed Yunusa, Gulzar Ahmad Nayik & Amin Mousavi Khaneghah. (2023) The potential of apricot seed and oil as functional food: Composition, biological properties, health benefits & safety. Food Bioscience 51, pages 102336.
Crossref
Marwa Mohamed Ellithy, Heba Elsayed Tarek & Heba Nader Shalash. (2023) Nutraceutical with a promising oral anticancer effect: in vitro study on apricot oil extract. Bulletin of the National Research Centre 47:1.
Crossref
Alpaslan ÖZTÜRK, Aybüke Afra KESKİNER, Berna KOCAMAN & Ece AVULOĞLU YILMAZ. (2022) DETERMINATION OF CYTOTOXIC EFFECT OF AMYGDALIN IN DLD-1 CELL LINE AND ANTICYTOTOXIC EFFECT IN CCD-18CO CELL LINE. Cumhuriyet Medical Journal.
Crossref
Vadivelan RamachandranKirankumar Rapindra HosalliInbakumar VijayakumarLalithkumar ManiRuchi TiwariGaurav Tiwari. (2022) A review on antitumor action of amygdalin on various types of cancers. Research Journal of Pharmacy and Technology, pages 5373-5380.
Crossref
Valentina Cecarini, Salima Selmi, Massimiliano Cuccioloni, Chunmei Gong, Laura Bonfili, Yadong Zheng, Manuela Cortese, Mauro Angeletti, Soumaya Kilani & Anna Maria Eleuteri. (2022) Targeting Proteolysis with Cyanogenic Glycoside Amygdalin Induces Apoptosis in Breast Cancer Cells. Molecules 27:21, pages 7591.
Crossref
Hassan Barakat, Thamer Aljutaily, Mona S. Almujaydil, Reham M. Algheshairy, Raghad M. Alhomaid, Abdulkarim S. Almutairi, Saleh I. Alshimali & Ahmed A. H. Abdellatif. (2022) Amygdalin: A Review on Its Characteristics, Antioxidant Potential, Gastrointestinal Microbiota Intervention, Anticancer Therapeutic and Mechanisms, Toxicity, and Encapsulation. Biomolecules 12:10, pages 1514.
Crossref
Abdul Halim Farawahida, Jon Palmer & Steve Flint. (2022) Monascus spp. and citrinin: Identification, selection of Monascus spp. isolates, occurrence, detection and reduction of citrinin during the fermentation of red fermented rice. International Journal of Food Microbiology 379, pages 109829.
Crossref
Abozer Y. Elderdery, Badr Alzahrani, Siddiqa M. A. Hamza, Gomaa Mostafa-Hedeab, Pooi Ling Mok & Suresh Kumar Subbiah. (2022) Synthesis, Characterization, and Antiproliferative Effect of CuO-TiO2-Chitosan-Amygdalin Nanocomposites in Human Leukemic MOLT4 Cells. Bioinorganic Chemistry and Applications 2022, pages 1-13.
Crossref
Panayiota Christodoulou, Panagiotis Boutsikos, Christiana M. Neophytou, Theodora-Christina Kyriakou, Maria-Ioanna Christodoulou, Panagiotis Papageorgis, Anastasis Stephanou & Ioannis Patrikios. (2022) Amygdalin as a chemoprotective agent in co-treatment with cisplatin. Frontiers in Pharmacology 13.
Crossref
Arpita Roy, Shreeja Datta, Karanpreet Singh Bhatia, Bhumika, Priyanka Jha & Ram Prasad. (2022) Role of plant derived bioactive compounds against cancer. South African Journal of Botany 149, pages 1017-1028.
Crossref
XueZhen Wang, PeiWei Su, Qian Hao, XiaoYu Zhang, Lei Xia & YaNan Zhang. (2022) A Chinese classical prescription Guizhi-Fuling Wan in treatment of ovarian cancer: An overview. Biomedicine & Pharmacotherapy 153, pages 113401.
Crossref
Sajad Fakhri, Seyed Zachariah Moradi, Mohammad Hosein Farzaei & Anupam Bishayee. (2022) Modulation of dysregulated cancer metabolism by plant secondary metabolites: A mechanistic review. Seminars in Cancer Biology 80, pages 276-305.
Crossref
Abdul Waheed Khan, Mariya Farooq, Muhammad Haseeb & Sangdun Choi. (2022) Role of Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action. Cells 11:8, pages 1326.
Crossref
Vasil Tsanov & Hristo Tsanov. (2022) Theoretical Analysis of Anticancer Cellular Effects of Glycoside Amides. Anti-Cancer Agents in Medicinal Chemistry 22:6, pages 1171-1200.
Crossref
Maryam Abdolahi-Majd, Gholamhossein Hassanshahi, Mahboubeh Vatanparast & Mojgan Noroozi Karimabad. (2022) Investigation of the Effect of Prunus Amygdalus Amara on the Expression of some Genes of Apoptosis and Immortality in Breast Cancer Cells (MCF- 7). Current Drug Research Reviews 14:1, pages 73-79.
Crossref
Jana Kopčeková, Anna Kolesárová, Marianna Schwarzová, Anton Kováčik, Jana Mrázová, Martina Gažarová, Petra Lenártová, Peter Chlebo & Adriana Kolesárová. (2022) Phytonutrients of Bitter Apricot Seeds Modulate Human Lipid Profile and LDL Subfractions in Adults with Elevated Cholesterol Levels. International Journal of Environmental Research and Public Health 19:2, pages 857.
Crossref
Hai Xin & Sina Naficy. (2022) Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review. Gels 8:1, pages 45.
Crossref
Aleksandra Zielińska, Justyna Płonka-Czerw, Agnieszka Nowak & Dariusz Kuśmierz. (2022) Effect of amygdalin on MCF-7, MDA-MB-231 and T-47D breast cancer cells in the in vitro study. Postępy Higieny i Medycyny Doświadczalnej 76:1, pages 132-142.
Crossref
Shumeng Lin, Jing Wen, Xiao Xu, Jiamin Shi, Wen Zhang, Tiansheng Zheng, Yaqin Hou, Yanfei Zhang, Ziye Li, Kai Wang, Jing Jin, Liduo Yue, Baigenzhin Abay, Ming Li, Qingxi Yue & Lihong Fan. (2022) Amygdalin Induced Mitochondria-Mediated Apoptosis of Lung Cancer Cells via Regulating NFκB-1/NFκB Signaling Cascade in Vitro and in Vivo . The American Journal of Chinese Medicine 50:05, pages 1361-1386.
Crossref
Alexander V. Sirotkin & Adriana Kolesarova. 2022. Environmental Contaminants and Medicinal Plants Action on Female Reproduction. Environmental Contaminants and Medicinal Plants Action on Female Reproduction 81 243 .
Joseph T.Sreejith S.Joseph X.Sangeetha V.P.Prajitha N.Vandana U.Jayaprakas C.A.Mohanan P.V.. (2021) Effect of cyanide ions (CN-) extracted from cassava (Manihotesculenta Crantz) on Alveolar Epithelial Cells (A549 cells). Toxicology 464, pages 153019.
Crossref
Ahmed M. Mamdouh, Dina M. Khodeer, Mohamed A. Tantawy & Yasser M. Moustafa. (2021) In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma. Life Sciences 285, pages 119961.
Crossref
Ewa Jaszczak-Wilke, Żaneta Polkowska, Marek Koprowski, Krzysztof Owsianik, Alyson E. Mitchell & Piotr Bałczewski. (2021) Amygdalin: Toxicity, Anticancer Activity and Analytical Procedures for Its Determination in Plant Seeds. Molecules 26:8, pages 2253.
Crossref
Min Liu, Hongqiu Zhu, Ying Zhu & Xiaodan Hu. (2021) Guizhi Fuling Wan reduces autophagy of granulosa cell in rats with polycystic ovary syndrome via restoring the PI3K/AKT/mTOR signaling pathway. Journal of Ethnopharmacology 270, pages 113821.
Crossref
Peter U. Amadi, Emmanuel N. Agomuo & Chiamaka Adumekwe. (2020) Vascular Effects of Avocado Seed Glycosides during Diabetes-induced Endothelial Damage. Cardiovascular & Hematological Disorders-Drug Targets 20:3, pages 202-213.
Crossref
Esra Erikel, Deniz Yuzbasioglu & Fatma Unal. (2020) Genotoxic and antigenotoxic potential of amygdalin on isolated human lymphocytes by the comet assay. Journal of Food Biochemistry 44:10.
Crossref
Bahman Moradipoodeh, Mostafa Jamalan, Majid Zeinali, Masood Fereidoonnezhad & Ghorban Mohammadzadeh. (2020) Specific targeting of HER2-positive human breast carcinoma SK-BR-3 cells by amygdaline-ZHER2 affibody conjugate. Molecular Biology Reports 47:9, pages 7139-7151.
Crossref
Eleonora Marian, Narcis Duteanu, Laura Vicas, Gerlinde Rusu, Tunde Jurca, Mariana Muresan, Otilia Micle, Adriana Corina Hangan, Roxana Liana Stan, Corina Ionescu, Bogdan Sevastre & Emöke Páll. (2020) Synthesis, characterization of inclusion compounds of amygdalin with β-cyclodextrin and sod-like activity and cytotoxicity on hela tumor cells. Arabian Journal of Chemistry 13:8, pages 6828-6837.
Crossref
Vasil Tsanov & Hristo Tsanov. (2020) Theoretical Analysis for the Safe Form and Dosage of Amygdalin Product. Anti-Cancer Agents in Medicinal Chemistry 20:7, pages 897-908.
Crossref
Rabia Sohail & Shah Rukh Abbas. (2020) Evaluation of amygdalin-loaded alginate-chitosan nanoparticles as biocompatible drug delivery carriers for anticancerous efficacy. International Journal of Biological Macromolecules 153, pages 36-45.
Crossref
Mohamed A. El-Desouky, Abdelgawad A. Fahmi, Ibrahim Y. Abdelkader & Karima M. Nasraldin. (2020) Anticancer Effect of Amygdalin (Vitamin B-17) on Hepatocellular Carcinoma Cell Line (HepG2) in the Presence and Absence of Zinc. Anti-Cancer Agents in Medicinal Chemistry 20:4, pages 486-494.
Crossref
Xiao-Yan He, Li-Juan Wu, Wen-Xiang Wang, Pei-Jun Xie, Yun-Hui Chen & Fei Wang. (2020) Amygdalin - A pharmacological and toxicological review. Journal of Ethnopharmacology 254, pages 112717.
Crossref
Thulfiqar F. Mutar, Ehab Tousson, Ezar Hafez, Maha Abo Gazia & Seham B. Salem. (2019) Ameliorative effects of vitamin B17 on the kidney against Ehrlich ascites carcinoma induced renal toxicity in mice. Environmental Toxicology 35:4, pages 528-537.
Crossref
Ehab Tousson, Ezar Hafez, Maha Mohamed Abo Gazia, Siham Bayomi Salem & Thulfiqar Fawwaz Mutar. (2020) Hepatic ameliorative role of vitamin B17 against Ehrlich ascites carcinoma–induced liver toxicity. Environmental Science and Pollution Research 27:9, pages 9236-9246.
Crossref
Fatemeh Aamazadeh, Alireza Ostadrahimi, Yalda Rahbar Saadat & Jaleh Barar. (2020) Bitter apricot ethanolic extract induces apoptosis through increasing expression of Bax/Bcl-2 ratio and caspase-3 in PANC-1 pancreatic cancer cells. Molecular Biology Reports 47:3, pages 1895-1904.
Crossref
Wagheda Cassiem & Maryna de Kock. (2019) The anti-proliferative effect of apricot and peach kernel extracts on human colon cancer cells in vitro. BMC Complementary and Alternative Medicine 19:1.
Crossref
Bahman Moradipoodeh, Mostafa Jamalan, Majid Zeinali, Masood Fereidoonnezhad & Ghorban Mohammadzadeh. (2019) In vitro and in silico anticancer activity of amygdalin on the SK-BR-3 human breast cancer cell line. Molecular Biology Reports 46:6, pages 6361-6370.
Crossref
Kathleen Mikkelsen, Monica D. Prakash, Nyanbol Kuol, Kulmira Nurgali, Lily Stojanovska & Vasso Apostolopoulos. (2019) Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells. International Journal of Molecular Sciences 20:15, pages 3763.
Crossref
Gopi Kalaiyarasan, Murugan Veerapandian, Gnanasekaran JebaMercy, Krishnaswamy Balamurugan & James Joseph. (2019) Amygdalin-Functionalized Carbon Quantum Dots for Probing β-Glucosidase Activity for Cancer Diagnosis and Therapeutics. ACS Biomaterials Science & Engineering 5:6, pages 3089-3099.
Crossref
Jiamin Shi, Qianqian Chen, Meng Xu, Qing Xia, Tiansheng Zheng, Junliang Teng, Ming Li & Lihong Fan. (2019) Recent updates and future perspectives about amygdalin as a potential anticancer agent: A review. Cancer Medicine 8:6, pages 3004-3011.
Crossref
Asghar Arshi, Sayed Mostafa Hosseini, Fataneh Saleh Khaje Hosseini, Zahra Yousefnejad Amiri, Fatemeh Sadat Hosseini, Mahsa Sheikholia Lavasani, Hossein Kerdarian & Maryam Safarpour Dehkordi. (2019) The anti-cancer effect of amygdalin on human cancer cell lines. Molecular Biology Reports 46:2, pages 2059-2066.
Crossref
Huajie Tian, Lin Liu, Zhixiong Li, Wei Liu, Zhaolin Sun, Yongbin Xu, Shunchun Wang, Chungeng Liang, Yamei Hai, Qin Feng, Yu Zhao, Yiyang Hu & Jinghua Peng. (2019) Chinese medicine CGA formula ameliorates liver fibrosis induced by carbon tetrachloride involving inhibition of hepatic apoptosis in rats. Journal of Ethnopharmacology 232, pages 227-235.
Crossref
Mi-Ran Go, Hyeon-Jin Kim, Jin Yu & Soo-Jin Choi. (2018) Toxicity and Toxicokinetics of Amygdalin in Maesil ( Prunus mume ) Syrup: Protective Effect of Maesil against Amygdalin Toxicity . Journal of Agricultural and Food Chemistry 66:43, pages 11432-11440.
Crossref
V. D. Ravichandra, C. Ramesh, Mallappa Kumara Swamy, B. Purushotham & Gudepalya Renukaiah Rudramurthy. 2018. Anticancer plants: Properties and Application. Anticancer plants: Properties and Application 485 515 .
Inamul Haque, Arvind Subramanian, Chao Huang, Andrew Godwin, Peter Van Veldhuizen, Snigdha Banerjee & Sushanta Banerjee. (2017) The Role of Compounds Derived from Natural Supplement as Anticancer Agents in Renal Cell Carcinoma: A Review. International Journal of Molecular Sciences 19:1, pages 107.
Crossref
Atanaska TodorovaMargarita PeshevaIvan IlievKrum BardarovTeodora Todorova. (2017) Antimutagenic, Antirecombinogenic, and Antitumor Effect of Amygdalin in a Yeast Cell–Based Test and Mammalian Cell Lines. Journal of Medicinal Food 20:4, pages 360-366.
Crossref
Kathleen Mikkelsen, Lily Stojanovska, Monica Prakash & Vasso Apostolopoulos. (2017) The effects of vitamin B on the immune/cytokine network and their involvement in depression. Maturitas 96, pages 58-71.
Crossref
Roman A. Blaheta, Karen Nelson, Axel Haferkamp & Eva Juengel. (2016) Amygdalin, quackery or cure?. Phytomedicine 23:4, pages 367-376.
Crossref
EVA JUENGEL, ANITA THOMAS, JOCHEN RUTZ, JASMINA MAKAREVIC, IGOR TSAUR, KAREN NELSON, AXEL HAFERKAMP & ROMAN A. BLAHETA. (2016) Amygdalin inhibits the growth of renal cell carcinoma cells in vitro. International Journal of Molecular Medicine 37:2, pages 526-532.
Crossref
Jasmina Makarević, Igor Tsaur, Eva Juengel, Hendrik Borgmann, Karen Nelson, Christian Thomas, Georg Bartsch, Axel Haferkamp & Roman A. Blaheta. (2016) Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro. Life Sciences 147, pages 137-142.
Crossref
Shuai Song, Qinhai Ma, Qingfa Tang, Feilong Chen, Xuefeng Xing, Yang Guo, Shenshen Guo, Xiaomei Tan & Jiabo Luo. (2016) Stereoselective metabolism of amygdalin-based study of detoxification of Semen Armeniacae Amarum in the Herba Ephedrae–Semen Armeniacae Amarum herb pair. Journal of Ethnopharmacology 179, pages 356-366.
Crossref
Hye Min Lee & Aree Moon. (2016) Amygdalin Regulates Apoptosis and Adhesion in Hs578T Triple-Negative Breast Cancer Cells. Biomolecules & Therapeutics 24:1, pages 62-66.
Crossref
Yuanyuan Cheng, Chuanbin Yang, Jia Zhao, Hung Fat Tse & Jianhui Rong. (2015) Proteomic identification of calcium-binding chaperone calreticulin as a potential mediator for the neuroprotective and neuritogenic activities of fruit-derived glycoside amygdalin. The Journal of Nutritional Biochemistry 26:2, pages 146-154.
Crossref
Feng Zhang, Yin Lu, Wenhui Qian & Zifan Pei. 2015. Dietary Chinese Herbs. Dietary Chinese Herbs 477 482 .
Jasmina Makarević, Jochen Rutz, Eva Juengel, Silke Kaulfuss, Michael Reiter, Igor Tsaur, Georg Bartsch, Axel Haferkamp & Roman A. Blaheta. (2014) Amygdalin Blocks Bladder Cancer Cell Growth In Vitro by Diminishing Cyclin A and cdk2. PLoS ONE 9:8, pages e105590.
Crossref
Jianwu Zhou, Guanzhen Gao, Qiuping Chu, Huiqin Wang, Pingfan Rao & Lijing Ke. (2014) Chromatographic isolation of nanoparticles from Ma-Xing-Shi-Gan-Tang decoction and their characterization. Journal of Ethnopharmacology 151:3, pages 1116-1123.
Crossref
ThierryF Vandamme. (2014) Use of rodents as models of human diseases. Journal of Pharmacy And Bioallied Sciences 6:1, pages 2.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.