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Immunopharmacology and Immunotoxicology Volume 35, 2013 - Issue 4
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Research Article

A study on the immunomodulation of polysaccharopeptide through the TLR4-TIRAP/MAL-MyD88 signaling pathway in PBMCs from breast cancer patients

Jing WangDepartment of Clinical Laboratory
,
Bing DongDepartment of Breasts, Thyroid and Pancreatic Surgery, the Second Affiliated Hospital of Chongqing Medical University ChongqingChina
,
Yi TanDepartment of Breasts, Thyroid and Pancreatic Surgery, the Second Affiliated Hospital of Chongqing Medical University ChongqingChina
,
Shuang YuDepartment of Clinical Laboratory
&
Yi-Xi BaoDepartment of Clinical LaboratoryCorrespondence[email protected]
Pages 497-504 | Received 08 Jan 2013, Accepted 11 May 2013, Published online: 27 Jun 2013

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Tomasz Jedrzejewski, Jakub Piotrowski, Malgorzata Kowalczewska, Sylwia Wrotek & Wieslaw Kozak. (2015) Polysaccharide peptide from Coriolus versicolor induces interleukin 6-related extension of endotoxin fever in rats. International Journal of Hyperthermia 31:6, pages 626-634.
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Articles from other publishers (22)

Tomasz Jędrzejewski, Małgorzata Pawlikowska, Justyna Sobocińska & Sylwia Wrotek. (2023) COVID-19 and Cancer Diseases—The Potential of Coriolus versicolor Mushroom to Combat Global Health Challenges. International Journal of Molecular Sciences 24:5, pages 4864.
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Zhicheng He, Jian Lin, Yingying He & Shubai Liu. (2022) Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment. Biomedicines 10:11, pages 2841.
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Temitope A. Oyedepo, Adetoun E. Morakinyo & Samuel O. Babarinde. 2022. Immunomodulators and Human Health. Immunomodulators and Human Health 71 100 .
Solomon Habtemariam. (2020) Trametes versicolor (Synn. Coriolus versicolor) Polysaccharides in Cancer Therapy: Targets and Efficacy. Biomedicines 8:5, pages 135.
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Khara Lucius & Jacob Hill. (2019) Combining immunotherapy and natural immune stimulants: mechanisms and clinical implications. Journal of Cancer Research and Clinical Oncology 145:10, pages 2633-2635.
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Oluwaseun Adebayo Bamodu, Kuang-Tai Kuo, Chun-Hua Wang, Wen-Chien Huang, Alexander T.H. Wu, Jo-Ting Tsai, Kang-Yun Lee, Chi-Tai Yeh & Liang-Shun Wang. (2019) Astragalus polysaccharides (PG2) Enhances the M1 Polarization of Macrophages, Functional Maturation of Dendritic Cells, and T Cell-Mediated Anticancer Immune Responses in Patients with Lung Cancer. Nutrients 11:10, pages 2264.
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Wen-Chien Huang, Kuang-Tai Kuo, Oluwaseun Adebayo Bamodu, Yen-Kuang Lin, Chun-Hua Wang, Kang-Yun Lee, Liang-Shun Wang, Chi-Tai Yeh & Jo-Ting Tsai. (2019) Astragalus polysaccharide (PG2) Ameliorates Cancer Symptom Clusters, as well as Improves Quality of Life in Patients with Metastatic Disease, through Modulation of the Inflammatory Cascade. Cancers 11:8, pages 1054.
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Tomasz Jędrzejewski, Jakub Piotrowski, Małgorzata Pawlikowska, Sylwia Wrotek & Wieslaw Kozak. (2019) Extract from Coriolus versicolor fungus partially prevents endotoxin tolerance development by maintaining febrile response and increasing IL-6 generation. Journal of Thermal Biology 83, pages 69-79.
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Jack Ho Wong, Stephen Cho Wing Sze, Tzi Bun Ng, Randy Chi Fai Cheung, Chit Tam, Kalin Yanbo Zhang, Xiuli Dan, Yau Sang Chan, William Chi Shing Cho, Charlene Cheuk Wing Ng, Mary Miu Yee Waye, Weicheng Liang, Jinfang Zhang, Jie Yang, Xiuyun Ye, Juan Lin, Xiujuan Ye, Hexiang Wang, Fang Liu, David Wai Chan, Hextan Yuen Sheung Ngan, Ou Sha, Guohui Li, Ryan Tse, Tak Fu Tse & Helen Chan. (2019) Apoptosis and Anti-cancer Drug Discovery: The Power of Medicinal Fungi and Plants. Current Medicinal Chemistry 25:40, pages 5613-5630.
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Kunlin Wu, Huihao Zhang, Yajuan Fu, Youzhi Zhu, Lingjun Kong, Ling Chen, Feng Zhao, Liangfei Yu & Xiangjin Chen. (2018) TLR4/MyD88 signaling determines the metastatic potential of breast cancer cells. Molecular Medicine Reports.
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Madeline Rodríguez-Valentín, Sheila López, Mariela Rivera, Eddy Ríos-Olivares, Luis Cubano & Nawal M. Boukli. (2018) Naturally Derived Anti-HIV Polysaccharide Peptide (PSP) Triggers a Toll-Like Receptor 4-Dependent Antiviral Immune Response. Journal of Immunology Research 2018, pages 1-14.
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Artem Blagodatski, Margarita Yatsunskaya, Valeriia Mikhailova, Vladlena Tiasto, Alexander Kagansky & Vladimir L. Katanaev. (2018) Medicinal mushrooms as an attractive new source of natural compounds for future cancer therapy. Oncotarget 9:49, pages 29259-29274.
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Sha Li, Ning Wang, Ming Hong, Hor-Yue Tan, Guofeng Pan & Yibin Feng. (2018) Hepatoprotective Effects of a Functional Formula of Three Chinese Medicinal Herbs: Experimental Evidence and Network Pharmacology-Based Identification of Mechanism of Action and Potential Bioactive Components. Molecules 23:2, pages 352.
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Wei Li, Hongxiu Zhang, Mingxiu Nie, Wei Wang, Zongtao Liu, Ceshi Chen, Haijun Chen, Rong Liu, Zulqarnain Baloch & Ke Ma. (2017) A novel synthetic ursolic acid derivative inhibits growth and induces apoptosis in breast cancer cell lines. Oncology Letters.
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Mohammad H. Saleh, Iran Rashedi & Armand Keating. (2017) Immunomodulatory Properties of Coriolus versicolor: The Role of Polysaccharopeptide. Frontiers in Immunology 8.
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Zhixue Wang, Zijing Liu, Lijng Zhou, Tingting Long, Xing Zhou & Yixi Bao. (2017) Immunomodulatory effect of APS and PSP is mediated by Ca2 + -cAMP and TLR4/NF-κB signaling pathway in macrophage. International Journal of Biological Macromolecules 94, pages 283-289.
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Małgorzata Pawlikowska, Tomasz Jędrzejewski, Jakub Piotrowski & Wiesław Kozak. (2016) Fever-range hyperthermia inhibits cells immune response to protein-bound polysaccharides derived from Coriolus versicolor extract. Molecular Immunology 80, pages 50-57.
Crossref
Tomasz Jędrzejewski, Małgorzata Pawlikowska, Jakub Piotrowski & Wiesław Kozak. (2016) Protein-bound polysaccharides from Coriolus versicolor attenuate LPS-induced synthesis of pro-inflammatory cytokines and stimulate PBMCs proliferation. Immunology Letters 178, pages 140-147.
Crossref
Xiaorui Zhang, Chunhui Qi, Yan Guo, Wenxia Zhou & Yongxiang Zhang. (2016) Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models. Carbohydrate Polymers 149, pages 186-206.
Crossref
Małgorzata Kowalczewska, Jakub Piotrowski, Tomasz Jędrzejewski & Wiesław Kozak. (2016) Polysaccharide peptides from Coriolus versicolor exert differential immunomodulatory effects on blood lymphocytes and breast cancer cell line MCF-7 in vitro. Immunology Letters 174, pages 37-44.
Crossref
Zifang Feng, Zhixue Wang, Min Yang, Lijing Zhou & Yixi Bao. (2016) Polysaccharopeptide exerts immunoregulatory effects via MyD88-dependent signaling pathway. International Journal of Biological Macromolecules 82, pages 201-207.
Crossref
Zhixue Wang, Bing Dong, Zifang Feng, Shuang Yu & Yixi Bao. (2015) A study on immunomodulatory mechanism of Polysaccharopeptide mediated by TLR4 signaling pathway. BMC Immunology 16:1.
Crossref

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