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Inhalation Toxicology
International Forum for Respiratory Research
Volume 25, 2013 - Issue 12
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Research Article

Toxicity of lunar dust assessed in inhalation-exposed rats

Chiu-wing LamSpace Toxicology Office, NASA Johnson Space Center Houston, TXUSA;Wyle Science, Technology & Engineering Group Houston, TXUSA;Department of Pathology and Laboratory Medicine, University of Texas Medical School Houston, TXUSACorrespondence[email protected]
,
Robert R. ScullySpace Toxicology Office, NASA Johnson Space Center Houston, TXUSA;Wyle Science, Technology & Engineering Group Houston, TXUSA
,
Ye ZhangWyle Science, Technology & Engineering Group Houston, TXUSA;Bioanalytical Core Laboratories, NASA Johnson Space Center Houston, TXUSA
,
Roger A. RenneRoger Renne ToxPath Consulting Inc. Sumner, WAUSA
,
Robert L. HunterDepartment of Pathology and Laboratory Medicine, University of Texas Medical School Houston, TXUSA
,
Richard A. McCluskeyNaval Hospital Pensacola Pensacola, FLUSA
,
Bean T. ChenHealth Effects Laboratory Division, National Institute for Occupational Safety and Health Morgantown, WVUSA
,
Vincent CastranovaHealth Effects Laboratory Division, National Institute for Occupational Safety and Health Morgantown, WVUSA
,
Kevin E. DriscollPGT Healthcare GenevaSwitzerland
,
Donald E. GardnerInhalation Toxicology Associates Savannah, GAUSA
,
Roger O. McClellanToxicology and Human Health Risk Analysis Albuquerque, NMUSA
,
Bonnie L. CooperAstromaterials Research and Exploration Systems, NASA Johnson Space Center Houston, TX 77058USA;Oceaneering Space Systems Houston, TXUSA
,
David S. McKayAstromaterials Research and Exploration Systems, NASA Johnson Space Center Houston, TX 77058USA
,
Linda MarshallWyle Science, Technology & Engineering Group Houston, TXUSA;Clinical Laboratory, NASA Johnson Space Center Houston, TXUSA
&
John T. JamesSpace Toxicology Office, NASA Johnson Space Center Houston, TXUSA
 show all
Pages 661-678 | Received 06 Jun 2013, Accepted 02 Aug 2013, Published online: 09 Oct 2013

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Chiu-wing Lam, Vincent Castranova, Kevin Driscoll, David Warheit, Valerie Ryder, Ye Zhang, Patti Zeidler-Erdely, Robert Hunter, Robert Scully, William Wallace, John James, Brian Crucian, Mayra Nelman, Richard McCluskey, Donald Gardner, Roger Renne & Roger McClellan. (2023) A review of pulmonary neutrophilia and insights into the key role of neutrophils in particle-induced pathogenesis in the lung from animal studies of lunar dusts and other poorly soluble dust particles. Critical Reviews in Toxicology 53:8, pages 441-479.
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Ye Zhang, Michael Story, Samrawit Yeshitla, Xiaoyu Wang, Robert R. Scully, Corey Theriot, Honglu Wu, Valerie E. Ryder & Chiu-wing Lam. (2023) Persistent changes in expression of genes involved in inflammation and fibrosis in the lungs of rats exposed to airborne lunar dust. Inhalation Toxicology 35:5-6, pages 139-156.
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Chiu-wing Lam, Vincent Castranova, Patti C. Zeidler-Erdely, Roger Renne, Robert Hunter, Richard McCluskey, Robert R. Scully, William T. Wallace, Ye Zhang, Valerie E. Ryder, Bonnie Cooper, David McKay, Roger O. McClellan, Kevin E. Driscoll, Donald E. Gardner, Mark Barger, Terence Meighan & John T. James. (2022) Comparative pulmonary toxicities of lunar dusts and terrestrial dusts (TiO2 & SiO2) in rats and an assessment of the impact of particle-generated oxidants on the dusts’ toxicities. Inhalation Toxicology 34:3-4, pages 51-67.
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Articles from other publishers (34)

Xinguang Cui, Wei Song, Yuan Xue, Hao Jing, Ming Lei, Honglei Ma, Xinxing He, Pengfei Zou, Bin Wu & Jintao Wang. (2024) Numerical analysis of micro lunar dust deposition in the human nasal airway. Journal of Hazardous Materials 461, pages 132682.
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Chen Gu, Yuhang Yin, Yan Sun, Jinguo Liu, Xiongyao Li & Xiaoping Zhang. (2023) Exploring the mechanism of lung injury induced by lunar dust simulant in rats based on metabolomic analysis. Environmental Toxicology.
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Silvana Miranda, Shannon Marchal, Lina Cumps, Jenne Dierckx, Marcus Krüger, Daniela Grimm, Sarah Baatout, Kevin Tabury & Bjorn Baselet. (2023) A Dusty Road for Astronauts. Biomedicines 11:7, pages 1921.
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E.L. Kordyum. (2023) SPACE BIOLOGY PROJECTS IN UKRAINE: NOWADAYS TRENDS. Kosmìčna nauka ì tehnologìâ 29:1, pages 36-51.
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Nima Gharib, Javad Farrokhi Derakhshandeh & Peter Radziszewski. 2023. Electrostatic Dust Mitigation and Manipulation Techniques for Planetary Dust. Electrostatic Dust Mitigation and Manipulation Techniques for Planetary Dust 35 69 .
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Michael Pohlen, Danielle Carroll, G. Kim Prisk & Aenor J. Sawyer. (2022) Overview of lunar dust toxicity risk. npj Microgravity 8:1.
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Robert Mulcahy, Grace Douglas, Torin McCoy & Erik Antonsen. 2020. Handbook of Lunar Base Design and Development. Handbook of Lunar Base Design and Development 1 28 .
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Donald A. Hendrix, Joel A. Hurowitz, Timothy D. Glotch & Martin A. A. Schoonen. (2021) Olivine Dissolution in Simulated Lung and Gastric Fluid as an Analog to the Behavior of Lunar Particulate Matter Inside the Human Respiratory and Gastrointestinal Systems. GeoHealth 5:11.
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A.E. Chumikov, V.S. Cheptsov, P. Wurz, D. Lasi, J. Jost & N.G. Managadze. (2021) Design, characteristics and scientific tasks of the LASMA-LR laser ionization mass spectrometer onboard Luna-25 and Luna-27 space missions. International Journal of Mass Spectrometry 469, pages 116676.
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Yan Sun, Lu Zhang, Jinguo Liu, Xiaoping Zhang, Yan Su, Quanling Yin & Shuangxi He. (2019) Effects of lunar dust simulant on cardiac function and fibrosis in rats. Toxicology Research 8:4, pages 499-508.
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D. W. Beaty, M. M. Grady, H. Y. McSween, E. Sefton‐Nash, B. L. Carrier, F. Altieri, Y. Amelin, E. Ammannito, M. Anand, L. G. Benning, J. L. Bishop, L. E. Borg, D. Boucher, J. R. Brucato, H. Busemann, K. A. Campbell, A. D. Czaja, V. Debaille, D. J. Des Marais, M. Dixon, B. L. Ehlmann, J. D. Farmer, D. C. Fernandez‐Remolar, J. Filiberto, J. Fogarty, D. P. Glavin, Y. S. Goreva, L. J. Hallis, A. D. Harrington, E. M. Hausrath, C. D. K. Herd, B. Horgan, M. Humayun, T. Kleine, J. Kleinhenz, R. Mackelprang, N. Mangold, L. E. Mayhew, J. T. McCoy, F. M. McCubbin, S. M. McLennan, D. E. Moser, F. Moynier, J. F. Mustard, P. B. Niles, G. G. Ori, F. Raulin, P. Rettberg, M. A. Rucker, N. Schmitz, S. P. Schwenzer, M. A. Sephton, R. Shaheen, Z. D. Sharp, D. L. Shuster, S. Siljeström, C. L. Smith, J. A. Spry, A. Steele, T. D. Swindle, I. L. ten Kate, N. J. Tosca, T. Usui, M. J. Van Kranendonk, M. Wadhwa, B. P. Weiss, S. C. Werner, F. Westall, R. M. Wheeler, J. Zipfel & M. P. Zorzano. (2019) The potential science and engineering value of samples delivered to Earth by Mars sample return. Meteoritics & Planetary Science 54:S1.
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Tatiana Borisova. (2019) Express assessment of neurotoxicity of particles of planetary and interstellar dust. npj Microgravity 5:1.
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Yan Sun, Jinguo Liu, Xiaoping Zhang, Xiongyao Li, Baichu Zhou & Zengjing Lv. (2018) Mechanisms involved in inflammatory pulmonary fibrosis induced by lunar dust simulant in rats. Environmental Toxicology 34:2, pages 131-140.
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John T. James & Valerie E. Ryder. 2019. Principles of Clinical Medicine for Space Flight. Principles of Clinical Medicine for Space Flight 153 174 .
Michael R. Barratt. 2019. Principles of Clinical Medicine for Space Flight. Principles of Clinical Medicine for Space Flight 3 37 .
Sun Yan, Liu Jin Guo, Kong Yi Di, Hu Jia Sen & Zhang Xiao Ping. (2018) Effects of Lunar Soil Simulant on Systemic Oxidative Stress and Immune Response in Acute Rat Lung Injury. International Journal of Pharmacology 14:6, pages 766-772.
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Rachel Caston, Katie Luc, Donald Hendrix, Joel A. Hurowitz & Bruce Demple. (2018) Assessing Toxicity and Nuclear and Mitochondrial DNA Damage Caused by Exposure of Mammalian Cells to Lunar Regolith Simulants. GeoHealth 2:4, pages 139-148.
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Yan Sun, Jin-Guo Liu, Yong-Chun Zheng, Chun-Ling Xiao, Bing Wan, Li Guo, Xu-Guang Wang & Wei Bo. (2018) Research on rat's pulmonary acute injury induced by lunar soil simulant. Journal of the Chinese Medical Association 81:2, pages 133-140.
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Jon Rask. 2018. Encyclopedia of Lunar Science. Encyclopedia of Lunar Science 1 3 .
Hong Tang, Xiongyao Li, Sensen Zhang, Shijie Wang, Jianzhong Liu, Shijie Li, Yang Li & Yanxue Wu. (2017) A lunar dust simulant: CLDS-i. Advances in Space Research 59:4, pages 1156-1160.
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Jasmeet Kaur, Douglas Rickman & Martin A. Schoonen. (2016) Reactive Oxygen Species (ROS) generation by lunar simulants. Acta Astronautica 122, pages 196-208.
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James T.F. WiseHong XieJohn Pierce WiseJr.Jr., Michael MasonAntony JeevarajanWilliam Wallace & John Pierce WiseSr.Sr.. (2015) Comparative Toxicity of Lunar, Martian Dust Simulants, and Urban Dust in Human Skin Fibroblast Cells. Gravitational and Space Research 3:1, pages 51-58.
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Francesco TurciIngrid CorazzariGabriele AlbertoGianmario MartraBice Fubini. (2015) Free-Radical Chemistry as a Means to Evaluate Lunar Dust Health Hazard in View of Future Missions to the Moon. Astrobiology 15:5, pages 371-380.
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D.S. McKay, B.L. Cooper, L.A. Taylor, J.T. James, K. Thomas-Keprta, C.M. Pieters, S.J. Wentworth, W.T. Wallace & T.S. Lee. (2015) Physicochemical properties of respirable-size lunar dust. Acta Astronautica 107, pages 163-176.
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