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Consensus Conf: Myo- and D-chiro-inositol

Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology – assisted reproduction technology

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Pages 441-446 | Received 11 Dec 2014, Accepted 08 Jan 2015, Published online: 02 Jun 2015

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Zahra Bashiri, Nadia Sheibak, Fatemehsadat Amjadi & Zahra Zandieh. (2022) The role of myo-inositol supplement in assisted reproductive techniques. Human Fertility 0:0, pages 1-17.
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Mariano Bizzarri, Patrizia Logoteta, Giovanni Monastra & Antonio Simone Laganà. (2022) An innovative approach to polycystic ovary syndrome. Journal of Obstetrics and Gynaecology 42:4, pages 546-556.
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Oliver C. Watkins, Hannah E. J. Yong, Neha Sharma & Shiao-Yng Chan. (2022) A review of the role of inositols in conditions of insulin dysregulation and in uncomplicated and pathological pregnancy. Critical Reviews in Food Science and Nutrition 62:6, pages 1626-1673.
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Marta Santoro, Saveria Aquila & Giampiero Russo. (2021) Sperm performance in oligoasthenoteratozoospermic patients is induced by a nutraceuticals mix, containing mainly myo-inositol. Systems Biology in Reproductive Medicine 67:1, pages 50-63.
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Fabio Facchinetti, Marialuisa Appetecchia, Cesare Aragona, Arturo Bevilacqua, Maria Salome Bezerra Espinola, Mariano Bizzarri, Rosario D’Anna, Didier Dewailly, Evanthia Diamanti-Kandarakis, Imelda Hernández Marín, Zdravko A. Kamenov, Eleni Kandaraki, Antonio Simone Laganà, Giovanni Monastra, Mario Montanino Oliva, John E. Nestler, Francesco Orio, Ali Cenk Ozay, Olga Papalou, Lali Pkhaladze, Giusy Porcaro, Nikos Prapas, Christophe O. Soulage, Annarita Stringaro, Artur Wdowiak & Vittorio Unfer. (2020) Experts’ opinion on inositols in treating polycystic ovary syndrome and non-insulin dependent diabetes mellitus: a further help for human reproduction and beyond. Expert Opinion on Drug Metabolism & Toxicology 16:3, pages 255-274.
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Antoaneta Gateva, Vittorio Unfer & Zdravko Kamenov. (2018) The use of inositol(s) isomers in the management of polycystic ovary syndrome: a comprehensive review. Gynecological Endocrinology 34:7, pages 545-550.
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Vittorio Unfer, Beatrice Orrù & Giovanni Monastra. (2016) Inositols: from physiology to rational therapy in gynecological clinical practice. Expert Opinion on Drug Metabolism & Toxicology 12:10, pages 1129-1131.
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Ewa M. Milewska, Adam Czyzyk, Blazej Meczekalski & Alessandro D. Genazzani. (2016) Inositol and human reproduction. From cellular metabolism to clinical use. Gynecological Endocrinology 32:9, pages 690-695.
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Cristiana Paul, Antonio Simone Laganà, Paolo Maniglio, Onofrio Triolo & David M. Brady. (2016) Inositol’s and other nutraceuticals’ synergistic actions counteract insulin resistance in polycystic ovarian syndrome and metabolic syndrome: state-of-the-art and future perspectives. Gynecological Endocrinology 32:6, pages 431-438.
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John E. Nestler & Vittorio Unfer. (2015) Reflections on inositol(s) for PCOS therapy: steps toward success. Gynecological Endocrinology 31:7, pages 501-505.
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Articles from other publishers (47)

Amir Hosein Moslehi, Fatemeh Hoseinpour, Amir Saber, Maryam Akhavan Taheri & Amir Hossein Hashemian. (2023) Fertility-enhancing effects of inositol & vitamin C on cisplatin induced ovarian and uterine toxicity in rats via suppressing oxidative stress and apoptosis. Food and Chemical Toxicology 179, pages 113995.
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Ali Jawad, Dongjin Oh, Hyerin Choi, Mirae Kim, Lian Cai, Joohyeong Lee & Sang-Hwan Hyun. (2023) Myo-inositol improves the viability of boar sperm during liquid storage. Frontiers in Veterinary Science 10.
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Zdravko Kamenov, Antoaneta Gateva, Simona Dinicola & Vittorio Unfer. (2023) Comparing the Efficacy of Myo-Inositol Plus α-Lactalbumin vs. Myo-Inositol Alone on Reproductive and Metabolic Disturbances of Polycystic Ovary Syndrome. Metabolites 13:6, pages 717.
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Ahmad Yar Qamar, Muhammad Ilyas Naveed, Sanan Raza, Xun Fang, Pantu Kumar Roy, Seonggyu Bang, Bereket Molla Tanga, Islam M. Saadeldin, Sanghoon Lee & Jongki Cho. (2023) Role of antioxidants in fertility preservation of sperm — A narrative review. Animal Bioscience 36:3, pages 385-403.
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Carmen Concerto, Cecilia Chiarenza, Antonio Di Francesco, Antimo Natale, Ivan Privitera, Alessandro Rodolico, Antonio Trovato, Andrea Aguglia, Francesco Fisicaro, Manuela Pennisi, Rita Bella, Antonino Petralia, Maria Salvina Signorelli & Giuseppe Lanza. (2023) Neurobiology and Applications of Inositol in Psychiatry: A Narrative Review. Current Issues in Molecular Biology 45:2, pages 1762-1778.
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Maria Salomé Bezerra Espinola, Artur Wdowiak & Tony Chiu Tak Yu. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 167 174 .
Arturo Bevilacqua, Simona Dinicola & Mariano Bizzarri. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 53 64 .
Lali Pkhaladze, Vittorio Unfer & Didier Dewailly. 2023. A Clinical Guide to Inositols. A Clinical Guide to Inositols 151 165 .
Elisabeth Reiser, Julia Lanbach, Bettina Böttcher & Bettina Toth. (2022) Non-Hormonal Treatment Options for Regulation of Menstrual Cycle in Adolescents with PCOS. Journal of Clinical Medicine 12:1, pages 67.
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Garima Kachhawa, Krithika V. Senthil Kumar, Vidushi Kulshrestha, Rajesh Khadgawat, Reeta Mahey & Neerja Bhatla. (2021) Efficacy of myo‐inositol and d ‐chiro‐inositol combination on menstrual cycle regulation and improving insulin resistance in young women with polycystic ovary syndrome: A randomized open‐label study . International Journal of Gynecology & Obstetrics 158:2, pages 278-284.
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Ling-Hui Zeng, Saba Rana, Liaqat Hussain, Muhammad Asif, Malik Hassan Mehmood, Imran Imran, Anam Younas, Amina Mahdy, Fakhria A. Al-Joufi & Shaymaa Najm Abed. (2022) Polycystic Ovary Syndrome: A Disorder of Reproductive Age, Its Pathogenesis, and a Discussion on the Emerging Role of Herbal Remedies. Frontiers in Pharmacology 13.
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Wiep de Ligny, Roos M Smits, Rebecca Mackenzie-Proctor, Vanessa Jordan, Kathrin Fleischer, Jan Peter de Bruin & Marian G Showell. (2022) Antioxidants for male subfertility. Cochrane Database of Systematic Reviews 2022:5.
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K.V. Krasnopolskaya, A.O. Garina, F.F. Burumkulova, K.M. Isakova & K.Sh. Kalseidova. (2022) The role of myo-inositol and calcium L-methylfolate in complex therapy of polycystic ovary syndrome. Problemy reproduktsii 28:6, pages 147.
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Maria Nunzia De Luca, Marisa Colone, Riccardo Gambioli, Annarita Stringaro & Vittorio Unfer. (2021) Oxidative Stress and Male Fertility: Role of Antioxidants and Inositols. Antioxidants 10:8, pages 1283.
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Feriel Yasmine Mahiddine & Min-Jung Kim. (2021) Overview on the Antioxidants, Egg Yolk Alternatives, and Mesenchymal Stem Cells and Derivatives Used in Canine Sperm Cryopreservation. Animals 11:7, pages 1930.
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V.Yu. Prilutskaya, O.S. Alyautdina & N.A. Sosna. (2021) The effect of the combination of myoinositol and D-chiroinositol in a ratio of 5:1 on the psychoemotional state and manifestations of androgen-dependent dermopathy in patients with polycystic ovary syndrome. Problemy reproduktsii 27:4, pages 97.
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Singh P. Shivakumar & G.M. Vidyasagar. 2021. Preparation of Phytopharmaceuticals for the Management of Disorders. Preparation of Phytopharmaceuticals for the Management of Disorders 287 296 .
Chiara Novielli, Gaia M. Anelli, Fabrizia Lisso, Anna Marzorati, Bina Parrilla, Monica Oneta, Valeria M. Savasi, Irene Cetin & Chiara Mandò. (2020) Effects of α-lipoic acid and myo-inositol supplementation on the oocyte environment of infertile obese women: A preliminary study. Reproductive Biology 20:4, pages 541-546.
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Г. О. Ісламова. (2020) Pregravid preparation of women with polycystic ovary syndrome.. REPRODUCTIVE ENDOCRINOLOGY:53, pages 30-34.
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Lauro González-Fernández, María Jesús Sánchez-Calabuig, Violeta Calle-Guisado, Luis Jesús García-Marín, María Julia Bragado, Pablo Fernández-Hernández, Alfonso Gutiérrez-Adán & Beatriz Macías-García. (2020) Stage-specific metabolomic changes in equine oviductal fluid: New insights into the equine fertilization environment. Theriogenology 143, pages 35-43.
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Ahmad Yar Qamar, Xung Fang, Min Jung Kim & Jongki Cho. (2019) Myoinositol Supplementation of Freezing Medium Improves the Quality-Related Parameters of Dog Sperm. Animals 9:12, pages 1038.
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Anna Wojciechowska, Adam Osowski, Marcin Jóźwik, Ryszard Górecki, Andrzej Rynkiewicz & Joanna Wojtkiewicz. (2019) Inositols’ Importance in the Improvement of the Endocrine–Metabolic Profile in PCOS. International Journal of Molecular Sciences 20:22, pages 5787.
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Arturo Bevilacqua, Jessica Dragotto, Alessandro Giuliani & Mariano Bizzarri. (2018) Myo‐inositol and D‐chiro‐inositol (40:1) reverse histological and functional features of polycystic ovary syndrome in a mouse model. Journal of Cellular Physiology 234:6, pages 9387-9398.
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Т. Л. Архипкина & Л. П. Любимова. (2019) Efficiency of the D-chiro-inositol for the polycystic ovary syndrome. Reproductive Endocrinology 0:45, pages 57-62.
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Roos M Smits, Rebecca Mackenzie-Proctor, Anusch Yazdani, Marcin T Stankiewicz, Vanessa Jordan & Marian G Showell. (2019) Antioxidants for male subfertility. Cochrane Database of Systematic Reviews 2019:3.
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F. Mohammadi, N. Varanloo, M. Heydari Nasrabadi, A. Vatannejad, F. S. Amjadi, M. Javedani Masroor, L. Bajelan, M. Mehdizadeh, R. Aflatoonian & Z. Zandieh. (2019) Supplementation of sperm freezing medium with myoinositol improve human sperm parameters and protects it against DNA fragmentation and apoptosis. Cell and Tissue Banking 20:1, pages 77-86.
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Christian Egarter. (2018) Myo-InositolMyo-inositol. Gynäkologische Endokrinologie 17:1, pages 11-15.
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Arturo Bevilacqua & Mariano Bizzarri. (2018) Inositols in Insulin Signaling and Glucose Metabolism. International Journal of Endocrinology 2018, pages 1-8.
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Natasha A M Jackson, Angelina M Flores, Elizabeth D Eldon & Lisa S Klig. (2018) Disruption of INOS , a Gene Encoding myo -Inositol Phosphate Synthase, Causes Male Sterility in Drosophila melanogaster . G3 Genes|Genomes|Genetics 8:9, pages 2913-2922.
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Robert H. Michell. (2018) Do inositol supplements enhance phosphatidylinositol supply and thus support endoplasmic reticulum function?. British Journal of Nutrition 120:3, pages 301-316.
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Xiangqin Zheng, Danmei Lin, Yulong Zhang, Yuan Lin, Jianrong Song, Suyu Li & Yan Sun. (2017) Inositol supplement improves clinical pregnancy rate in infertile women undergoing ovulation induction for ICSI or IVF-ET. Medicine 96:49, pages e8842.
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Bobo Zhang, Xudan Guo, Yunlong Li, Qiang Peng, Jinfeng Gao, Baolin Liu & Min Wang. (2017) d -Chiro inositol ameliorates endothelial dysfunction via inhibition of oxidative stress and mitochondrial fission . Molecular Nutrition & Food Research 61:8, pages 1600710.
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Juan Manuel Jiménez Tuñón, Paloma Piqueras Trilles, Miguel Gallardo Molina, María Hebles Duvison, Beatriz Migueles Pastor, Pascual Sánchez Martín, Fernando Sánchez Martín & Rafael Sánchez-Borrego. (2017) A Double-Blind, Randomized Prospective Study to Evaluate the Efficacy of Previous Therapy With Melatonin, Myo-inositol, Folic Acid, and Selenium in Improving the Results of an Assisted Reproductive Treatment. Clinical Medicine Insights: Therapeutics 9, pages 1179559X1774290.
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Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas & Fabio Facchinetti. (2017) Inositol(s) from Bench to Bedside in Endocrinology and Gynecology. International Journal of Endocrinology 2017, pages 1-2.
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Salvatore Benvenga & Alessandro Antonelli. (2016) Inositol(s) in thyroid function, growth and autoimmunity. Reviews in Endocrine and Metabolic Disorders 17:4, pages 471-484.
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Arturo Bevilacqua & Mariano Bizzarri. (2016) Physiological role and clinical utility of inositols in polycystic ovary syndrome. Best Practice & Research Clinical Obstetrics & Gynaecology 37, pages 129-139.
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Pavel Trávník. (2016) Influence of myo-inositol on the development and functions of spermatozoa. Praktické lékárenství 12:5, pages 173-174.
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Pavel Trávník. (2016) Effect of myo-inositol on the development of oocytes and embryos. Praktické lékárenství 12:3, pages 90-92.
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Kathrine Birch Petersen, Nina Gros Pedersen, Anette Tønnes Pedersen, Mette Petri Lauritsen & Nina la Cour Freiesleben. (2016) Mono-ovulation in women with polycystic ovary syndrome: a clinical review on ovulation induction. Reproductive BioMedicine Online 32:6, pages 563-583.
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Mario Mancini, Alice Andreassi, Michela Salvioni, Fiore Pelliccione, Gianna Mantellassi & Giuseppe Banderali. (2016) Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data. International Journal of Endocrinology 2016, pages 1-5.
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Artur Wdowiak. (2016) Myoinositol Improves Embryo Development in PCOS Patients Undergoing ICSI. International Journal of Endocrinology 2016, pages 1-8.
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Elena Benelli, Scilla Del Ghianda, Caterina Di Cosmo & Massimo Tonacchera. (2016) A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. International Journal of Endocrinology 2016, pages 1-5.
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Nilay Kuşcu, Mariano Bizzarri & Arturo Bevilacqua. (2016) Myo-Inositol Safety in Pregnancy: From Preimplantation Development to Newborn Animals. International Journal of Endocrinology 2016, pages 1-10.
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Vittorio Unfer, John E. Nestler, Zdravko A. Kamenov, Nikos Prapas & Fabio Facchinetti. (2016) Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials. International Journal of Endocrinology 2016, pages 1-12.
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Lali Pkhaladze, Ludmila Barbakadze & Nana Kvashilava. (2016) Myo-Inositol in the Treatment of Teenagers Affected by PCOS. International Journal of Endocrinology 2016, pages 1-6.
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Fabio Facchinetti, Giulia Dante & Isabella Neri. 2016. Frontiers in Gynecological Endocrinology. Frontiers in Gynecological Endocrinology 103 109 .
Fabio Facchinetti, Mariano Bizzarri, Salvatore Benvenga, Rosario D’Anna, Antonio Lanzone, Christophe Soulage, Gian Carlo Di Renzo, Moshe Hod, Pietro Cavalli, Tony T. Chiu, Zdravko A. Kamenov, Arturo Bevilacqua, Gianfranco Carlomagno, Sandro Gerli, Mario Montanino Oliva & Paul Devroey. (2015) Results from the International Consensus Conference on Myo-inositol and d-chiro-inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS. European Journal of Obstetrics & Gynecology and Reproductive Biology 195, pages 72-76.
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