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Platelets Volume 22, 2011 - Issue 7
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Research Article

P2Y12 and EP3 antagonists promote the inhibitory effects of natural modulators of platelet aggregation that act via cAMP

David IyúCardiovascular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK
,
Jackie R. GlennCardiovascular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK
,
Ann E. WhiteCardiovascular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK
,
Sue C. FoxCardiovascular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK
,
Natalia DovlatovaCardiovascular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UK
&
Stan HeptinstallCardiovascular Medicine, University of Nottingham, Queen's Medical Centre, Nottingham, UKCorrespondence[email protected]
Pages 504-515 | Received 03 Mar 2011, Accepted 25 Mar 2011, Published online: 12 Oct 2011

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Natalia Dovlatova & Stan Heptinstall. (2018) Platelet aggregation measured by single-platelet counting and using PFA-100 devices. Platelets 29:7, pages 656-661.
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Mark R. Thomas & Robert F. Storey. (2015) The future of P2Y12 receptor antagonists. Platelets 26:5, pages 392-398.
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Rolf P. Kreutz, Perry Nystrom, Yvonne Kreutz, Jia Miao, Richard Kovacs, Zeruesenay Desta, David A. Flockhart & Yan Jin. (2013) Inhibition of platelet aggregation by prostaglandin E1 (PGE1) in diabetic patients during therapy with clopidogrel and aspirin. Platelets 24:2, pages 145-150.
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Yanushi Dullewe Wijeyeratne, Rashi Joshi & Stan Heptinstall. (2012) Ticagrelor: a P2Y12 antagonist for use in acute coronary syndromes. Expert Review of Clinical Pharmacology 5:3, pages 257-269.
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Articles from other publishers (20)

Claire Normand, Billy Breton, Marine Salze, Eric Barbeau, Arturo Mancini & Martin Audet. (2022) A systematic analysis of prostaglandin E2 type 3 receptor isoform signaling reveals isoform- and species-dependent L798106 Gαz-biased agonist responses. European Journal of Pharmacology 927, pages 175043.
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Fakilahyel S. Mshelbwala, Daniel W. Hugenberg & Rolf P. Kreutz. (2020) Intensified P2Y12 inhibition for high-on treatment platelet reactivity. Journal of Thrombosis and Thrombolysis 50:3, pages 619-627.
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Liyuan ZhuYuze ZhangZiyi GuoMiao Wang. (2020) Cardiovascular Biology of Prostanoids and Drug Discovery. Arteriosclerosis, Thrombosis, and Vascular Biology 40:6, pages 1454-1463.
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Sören Twarock, Saghar Bagheri, Sayeh Bagheri & Thomas Hohlfeld. (2016) Platelet–vessel wall interactions and drug effects. Pharmacology & Therapeutics 167, pages 74-84.
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Nathan E. K. Procter, Nicola L. Hurst, Vivek B. Nooney, Hasan Imam, Raffaele De Caterina, Yuliy Y. Chirkov & John D. Horowitz. (2016) New Developments in Platelet Cyclic Nucleotide Signalling: Therapeutic Implications. Cardiovascular Drugs and Therapy 30:5, pages 505-513.
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Rossella Marcucci, Elisa Grifoni & Betti Giusti. (2016) On-treatment platelet reactivity: State of the art and perspectives. Vascular Pharmacology 77, pages 8-18.
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Eitan A. Friedman, Martin L. Ogletree, Elias V. Haddad & Olivier Boutaud. (2015) Understanding the role of prostaglandin E2 in regulating human platelet activity in health and disease. Thrombosis Research 136:3, pages 493-503.
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Nicola L. Hurst, Vivek B. Nooney, Yuliy Y. Chirkov, Raffaele De Caterina & John D. Horowitz. (2015) Determinants of subacute response to clopidogrel: relative impact of CYP2C19 genotype and PGE1/adenylate cyclase signalling. Thrombosis Research 136:2, pages 308-314.
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V.B. Nooney, N.L. Hurst, Y.Y. Chirkov, R. De Caterina & J.D. Horowitz. (2015) Post receptor determinants of acute platelet response to clopidogrel in patients with symptomatic myocardial ischemia. Vascular Pharmacology 65-66, pages 17-22.
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Katharina Hubertus, Marcel Mischnik, Jens Timmer, Sabine Herterich, Regina Mark, Maxime Moulard, Ulrich Walter & Joerg Geiger. (2014) Reciprocal regulation of human platelet function by endogenous prostanoids and through multiple prostanoid receptors. European Journal of Pharmacology 740, pages 15-27.
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Eduardo Fuentes & Iván Palomo. (2014) Regulatory mechanisms of cAMP levels as a multiple target for antiplatelet activity and less bleeding risk. Thrombosis Research 134:2, pages 221-226.
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N.L. Hurst, V.B. Nooney, B. Raman, Y.Y. Chirkov, R. De Caterina & J.D. Horowitz. (2013) Clopidogrel “resistance”: Pre- vs post-receptor determinants. Vascular Pharmacology 59:5-6, pages 152-161.
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Knut Fälker, Marc Nazare, Peter Wonerow & Detlef H. Kozian. (2013) Targeting Platelet G Protein-Coupled Receptors for Antithrombotic Therapy. Drug Development Research 74:7, pages 440-449.
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Nicholas S. Kirkby, Martina H. Lundberg, Melissa V. Chan, Ivana Vojnovic, Antonia B. Solomon, Michael Emerson, Jane A. Mitchell & Timothy D. Warner. (2013) Blockade of the purinergic P2Y 12 receptor greatly increases the platelet inhibitory actions of nitric oxide . Proceedings of the National Academy of Sciences 110:39, pages 15782-15787.
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Takahiro Uchida, Mai Hazekawa, Miyako Yoshida, Kunio Matsumoto & Yoshiki Sakai. (2013) A Novel Long-Acting Prostacyclin Agonist (ONO-1301) With an Angiogenic Effect: Promoting Synthesis of Hepatocyte Growth Factor and Increasing Cyclic AMP Concentration via IP-Receptor Signaling. Journal of Pharmacological Sciences 123:4, pages 392-401.
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Marcel Mischnik, Desislava Boyanova, Katharina Hubertus, Jörg Geiger, Nicole Philippi, Marcus Dittrich, Gaby Wangorsch, Jens Timmer & Thomas Dandekar. (2013) A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation. Molecular BioSystems 9:6, pages 1326.
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Stan Heptinstall. 2013. Antiplatelet and Anticoagulation Therapy. Antiplatelet and Anticoagulation Therapy 1 44 .
Fatemeh Moheimani & Denise E. Jackson. (2012) P2Y12 receptor: platelet thrombus formation and medical interventions. International Journal of Hematology 96:5, pages 572-587.
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Andreas G. Tzakos, Vassiliki G. Kontogianni, Maria Tsoumani, Eleni Kyriakou, John Hwa, Francisco A. Rodrigues & Alexandros D. Tselepis. (2012) Exploration of the Antiplatelet Activity Profile of Betulinic Acid on Human Platelets. Journal of Agricultural and Food Chemistry 60:28, pages 6977-6983.
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Yanushi Dullewe Wijeyeratne & Stan Heptinstall. (2011) Anti-platelet therapy: ADP receptor antagonists. British Journal of Clinical Pharmacology 72:4, pages 647-657.
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