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Research Article

PKCα negatively regulates in vitro proplatelet formation and in vivo platelet production in mice

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Pages 62-68 | Received 31 Oct 2012, Accepted 18 Dec 2012, Published online: 12 Feb 2013

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Qi Wang, Tao You, Hongqiong Fan, Yinyan Wang, Tinatian Chu, Mortimer Poncz & Li Zhu. (2017) Rapamycin and bafilomycin A1 alter autophagy and megakaryopoiesis. Platelets 28:1, pages 82-89.
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John C. Kostyak & Satya P. Kunapuli. (2015) PKCθ is dispensable for megakaryopoiesis. Platelets 26:6, pages 610-611.
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Xiaodong Zhou, Sung-Hoon Kim, Ling Shen, Hyo-Jung Lee & Changyan Chen. (2014) Induction of mitotic catastrophe by PKC inhibition in Nf1-deficient cells. Cell Cycle 13:15, pages 2340-2348.
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Zakaria Louadi, Maria L. Elkjaer, Melissa Klug, Chit Tong Lio, Amit Fenn, Zsolt Illes, Dario Bongiovanni, Jan Baumbach, Tim Kacprowski, Markus List & Olga Tsoy. (2021) Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases. Genome Biology 22:1.
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Rui-Jie Sun, Dai Yuan, Shu-yan Liu, Jing-jing Zhu & Ning-ning Shan. (2020) Rapamycin induces megakaryocytic differentiation through increasing autophagy in Dami cells. Blood Coagulation & Fibrinolysis 31:5, pages 310-316.
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Guiliang Shi, Xiangjun Yang, Min Pan, Jianhui Sun, Haiyan Ke, Chi Zhang & Haihua Geng. (2018) Apixaban attenuates ischemia-induced myocardial fibrosis by inhibition of Gq/PKC signaling. Biochemical and Biophysical Research Communications 500:3, pages 550-556.
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Anthony M. Battram, Tom N. Durrant, Ejaife O. Agbani, Kate J. Heesom, David S. Paul, Raymond Piatt, Alastair W. Poole, Peter J. Cullen, Wolfgang Bergmeier, Samantha F. Moore & Ingeborg Hers. (2017) The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling. Journal of Biological Chemistry 292:5, pages 1691-1704.
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Jiaqian Qi, Tao You, Tingting Pan, Qi Wang, Li Zhu & Yue Han. (2017) Downregulation of hypoxia-inducible factor-1α contributes to impaired megakaryopoiesis in immune thrombocytopenia. Thrombosis and Haemostasis 117:10, pages 1875-1886.
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Suthakar Ganapathy, Johan B Fagman, Ling Shen, Tianqi Yu, Xiaodong Zhou, Wei Dai, Alexandros Makriyannis & Changyan Chen. (2016) Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C . Oncotarget 7:51, pages 84326-84337.
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Valentina Iotchkova, Jie Huang, John A Morris, Deepti Jain, Caterina Barbieri, Klaudia Walter, Josine L Min, Lu Chen, William Astle, Massimilian Cocca, Patrick Deelen, Heather Elding, Aliki-Eleni Farmaki, Christopher S Franklin, Mattias Franberg, Tom R Gaunt, Albert Hofman, Tao Jiang, Marcus E Kleber, Genevieve Lachance, Jian'an Luan, Giovanni Malerba, Angela Matchan, Daniel Mead, Yasin Memari, Ioanna Ntalla, Kalliope Panoutsopoulou, Raha Pazoki, John R B Perry, Fernando Rivadeneira, Maria Sabater-Lleal, Bengt Sennblad, So-Youn Shin, Lorraine Southam, Michela Traglia, Freerk van Dijk, Elisabeth M van Leeuwen, Gianluigi Zaza, Weihua Zhang, Najaf Amin, Adam Butterworth, John C Chambers, George Dedoussis, Abbas Dehghan, Oscar H Franco, Lude Franke, Mattia Frontini, Giovanni Gambaro, Paolo Gasparini, Anders Hamsten, Aaron Issacs, Jaspal S Kooner, Charles Kooperberg, Claudia Langenberg, Winfried Marz, Robert A Scott, Morris A Swertz, Daniela Toniolo, Andre G Uitterlinden, Cornelia M van Duijn, Hugh Watkins, Eleftheria Zeggini, Mathew T Maurano, Nicholas J Timpson, Alexander P Reiner, Paul L Auer & Nicole Soranzo. (2016) Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. Nature Genetics 48:11, pages 1303-1312.
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Kellie R. Machlus, Stephen K. WuDeborah J. StumpoThomas S. SoussouDavid S. PaulRobert A. CampbellHermann Kalwa, Thomas Michel, Wolfgang BergmeierAndrew S. WeyrichPerry J. BlackshearJohn H. HartwigJoseph E. ItalianoJrJr. (2016) Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood 127:11, pages 1468-1480.
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Y. Zaid, N. Senhaji, A. Naya, C. Fadainia & K. Kojok. (2015) PKCs in thrombus formation. Pathologie Biologie 63:6, pages 268-271.
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Dheeraj Bhavanasi, Rachit Badolia, Bhanu Kanth Manne, Sumalaxmi Janapati, Carol Dangelmaier, Alexandra Mazharian, Jianguo Jin, Soochong Kim, Xiaoying Zhang, Xiongwen Chen, Yotis Senis & Satya Kunapuli. (2017) Cross talk between serine/threonine and tyrosine kinases regulates ADP-induced thromboxane generation in platelets. Thrombosis and Haemostasis 114:09, pages 558-568.
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John C. KostyakDheeraj BhavanasiElisabeta LiveraniSteven E. McKenzieSatya P. Kunapuli. (2014) Protein Kinase C δ Deficiency Enhances Megakaryopoiesis and Recovery From Thrombocytopenia. Arteriosclerosis, Thrombosis, and Vascular Biology 34:12, pages 2579-2585.
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Gabriel L. Galea, Lee B. Meakin, Christopher M. Williams, Sarah L. Hulin-Curtis, Lance E. Lanyon, Alastair W. Poole & Joanna S. Price. (2014) Protein Kinase Cα (PKCα) Regulates Bone Architecture and Osteoblast Activity. Journal of Biological Chemistry 289:37, pages 25509-25522.
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