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In vitro and animal studies

Digestive stability of hydroxytyrosol, hydroxytyrosyl acetate and alkyl hydroxytyrosyl ethers

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Pages 703-707 | Published online: 24 Jan 2012

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Marlene Costa, Vânia Costa, Margarida Lopes & Fátima Paiva-Martins. (2022) A biochemical perspective on the fate of virgin olive oil phenolic compounds in vivo. Critical Reviews in Food Science and Nutrition 0:0, pages 1-26.
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Articles from other publishers (43)

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Oznur Saroglu, Berkay Tav, Rusen Metin Yildirim & Ayse Karadag. (2023) Microencapsulation of olive mill wastewater in Saccharomyces cerevisiae cells by spray drying and in vitro bioaccessibility of phenolic compounds . Food & Function 14:8, pages 3746-3759.
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Vincenzo De Leo, Anna Maria Maurelli, Livia Giotta, Valeria Daniello, Sante Di Gioia, Massimo Conese, Chiara Ingrosso, Fulvio Ciriaco & Lucia Catucci. (2023) Polymer Encapsulated Liposomes for Oral Co-Delivery of Curcumin and Hydroxytyrosol. International Journal of Molecular Sciences 24:1, pages 790.
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Filipa Paulo, Loleny Tavares & Lúcia Santos. (2022) In vitro digestion, bioaccessibility, and release kinetics studies of encapsulated bioactive compounds obtained from olive mill pomace. Journal of Food Measurement and Characterization 16:6, pages 4880-4895.
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Marisol Villalva, Jose Manuel Silvan, Esperanza Guerrero-Hurtado, Alba Gutierrez-Docio, Joaquín Navarro del Hierro, Teresa Alarcón-Cavero, Marin Prodanov, Diana Martin & Adolfo J. Martinez-Rodriguez. (2022) Influence of In Vitro Gastric Digestion of Olive Leaf Extracts on Their Bioactive Properties against H. pylori. Foods 11:13, pages 1832.
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Athena Stergiou, Panagiota Binou, Panagiotis E. Igoumenidis, Antonia Chiou, Konstantina Yannakopoulou & Vaios Τ. Karathanos. (2022) Host–guest inclusion complexes of hydroxytyrosol with cyclodextrins: Development of a potential functional ingredient for food application. Journal of Food Science 87:6, pages 2678-2691.
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Thaís Jordânia Silva, Patricia Ramírez-Carrasco, Patricio Romero-Hasler, Eduardo Soto-Bustamante, Daniel Barrera-Arellano, Paz Robert & Begoña Giménez. (2022) Soybean oil organogelled emulsions as oral delivery systems of hydroxytyrosol and hydroxytyrosol alkyl esters. Food Chemistry 379, pages 132182.
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Maria Eleni Sakavitsi, Annelies Breynaert, Theodora Nikou, Stef Lauwers, Luc Pieters, Nina Hermans & Maria Halabalaki. (2022) Availability and Metabolic Fate of Olive Phenolic Alcohols Hydroxytyrosol and Tyrosol in the Human GI Tract Simulated by the In Vitro GIDM–Colon Model. Metabolites 12:5, pages 391.
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Christina Fytili, Theodora Nikou, Nikolaos Tentolouris, Ioulia K. Tseti, Charilaos Dimosthenopoulos, Petros P. Sfikakis, Dimitrios Simos, Alexandros Kokkinos, Alexios L. Skaltsounis, Nikolaos Katsilambros & Maria Halabalaki. (2022) Effect of Long-Term Hydroxytyrosol Administration on Body Weight, Fat Mass and Urine Metabolomics: A Randomized Double-Blind Prospective Human Study. Nutrients 14:7, pages 1525.
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Xinmiao Wang, Kefan Chen, Sijia Wang, Qian Wang, Yuanyuan Hu, Fawen Yin, Xiaoyang Liu & Dayong Zhou. (2022) Distribution of tyrosol fatty acid esters in the gastrointestinal tracts of mice and their hydrolysis characteristics by gut microbiota. Food & Function 13:5, pages 2998-3008.
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Xinmiao Wang, Kefan Chen, Jin Qiu, Yuanyuan Hu, Fawen Yin, Xiaoyang Liu & Dayong Zhou. (2022) Gastrointestinal Distribution of Tyrosol Acyl Esters in Orally Infected Mice and Their Hydrolysis by Lactobacillus Species Isolated from the Feces of Mice . Journal of Agricultural and Food Chemistry 70:4, pages 1316-1326.
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Carolina Alemán-Jiménez, Raúl Domínguez-Perles, Juana I. Gallego-Gómez, Agustín Simonelli-Muñoz, Espérance Moine, Thierry Durand, Céline Crauste, Federico Ferreres, Ángel Gil-Izquierdo & Sonia Medina. (2021) Fatty Acid Hydroxytyrosyl Esters of Olive Oils Are Bioaccessible According to Simulated In Vitro Gastrointestinal Digestion: Unraveling the Role of Digestive Enzymes on Their Stability . Journal of Agricultural and Food Chemistry 69:47, pages 14165-14175.
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Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Elena Martínez-Carballo, Noelia Cambeiro-Pérez, Raquel Rial-Otero, María Figueiredo-González & Beatriz Cancho-Grande. (2021) Applicability of an In-Vitro Digestion Model to Assess the Bioaccessibility of Phenolic Compounds from Olive-Related Products. Molecules 26:21, pages 6667.
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Xinmiao Wang, Kefan Chen, Xiumin Zhang, Yuanyuan Hu, Zixu Wang, Fawen Yin, Xiaoyang Liu, Jianghua Zhang, Lei Qin & Dayong Zhou. (2021) Effect of carbon chain length on the hydrolysis and transport characteristics of alkyl gallates in rat intestine. Food & Function 12:21, pages 10581-10588.
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P. Reboredo-Rodríguez, L. Olmo-García, M. Figueiredo-González, C. González-Barreiro, A. Carrasco-Pancorbo & B. Cancho-Grande. (2021) Application of the INFOGEST Standardized Method to Assess the Digestive Stability and Bioaccessibility of Phenolic Compounds from Galician Extra-Virgin Olive Oil. Journal of Agricultural and Food Chemistry 69:39, pages 11592-11605.
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Antonio J. León-González, Prudencio Sáez-Martínez, Juan M. Jiménez-Vacas, Vicente Herrero-Aguayo, Antonio J. Montero-Hidalgo, Enrique Gómez-Gómez, Andrés Madrona, Justo P. Castaño, José L. Espartero, Manuel D. Gahete & Raúl M. Luque. (2021) Comparative Cytotoxic Activity of Hydroxytyrosol and Its Semisynthetic Lipophilic Derivatives in Prostate Cancer Cells. Antioxidants 10:9, pages 1348.
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Maria Bellumori, Laura De Marchi, Federica Mainente, Francesca Zanoni, Lorenzo Cecchi, Marzia Innocenti, Nadia Mulinacci & Gianni Zoccatelli. (2021) A by‐product from virgin olive oil production (pâté) encapsulated by fluid bed coating: evaluation of the phenolic profile after shelf‐life test and in vitro gastrointestinal digestion . International Journal of Food Science & Technology 56:8, pages 3773-3783.
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Andreia F. R. Silva, Daniela Resende, Mariana Monteiro, Manuel A. Coimbra, Artur M. S. Silva & Susana M. Cardoso. (2020) Application of Hydroxytyrosol in the Functional Foods Field: From Ingredient to Dietary Supplements. Antioxidants 9:12, pages 1246.
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Paloma Rodríguez-López, Jesús Lozano-Sanchez, Isabel Borrás-Linares, Tatiana Emanuelli, Javier A. Menéndez & Antonio Segura-Carretero. (2020) Structure–Biological Activity Relationships of Extra-Virgin Olive Oil Phenolic Compounds: Health Properties and Bioavailability. Antioxidants 9:8, pages 685.
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Jon Alberdi-Cedeño, María L. Ibargoitia & María D. Guillén. (2020) Study of the In Vitro Digestion of Olive Oil Enriched or Not with Antioxidant Phenolic Compounds. Relationships between Bioaccessibility of Main Components of Different Oils and Their Composition. Antioxidants 9:6, pages 543.
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Jon Alberdi-Cedeño, María L. Ibargoitia & María D. Guillén. (2020) A Global Study by 1H NMR Spectroscopy and SPME-GC/MS of the in Vitro Digestion of Virgin Flaxseed Oil Enriched or not with Mono-, Di- or Tri-Phenolic Derivatives. Antioxidant Efficiency of These Compounds. Antioxidants 9:4, pages 312.
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Fawen Yin, Xinmiao Wang, Yuanyuan Hu, Hongkai Xie, Xiaoyang Liu, Lei Qin, Jianghua Zhang, Dayong Zhou & Fereidoon Shahidi. (2020) Evaluation of Absorption and Plasma Pharmacokinetics of Tyrosol Acyl Esters in Rats. Journal of Agricultural and Food Chemistry 68:5, pages 1248-1256.
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Shengnan Shen, Hua Yu, Lishe Gan, Yang Ye & Ligen Lin. (2019) Natural constituents from food sources: potential therapeutic agents against muscle wasting. Food & Function 10:11, pages 6967-6986.
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Fawen Yin, Xiaopei Hu, Dayong Zhou, Xiaochi Ma, Xiangge Tian, Xiaokui Huo, Kanyasiri Rakariyatham, Fereidoon Shahidi & Beiwei Zhu. (2018) Hydrolysis and Transport Characteristics of Tyrosol Acyl Esters in Rat Intestine. Journal of Agricultural and Food Chemistry 66:47, pages 12521-12526.
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Aurélia Malapert, Valérie Tomao, Marielle Margier, Marion Nowicki, Béatrice Gleize, Olivier Dangles & Emmanuelle Reboul. (2018) β-Cyclodextrin Does not Alter the Bioaccessibility and the Uptake by Caco-2 Cells of Olive By-Product Phenolic Compounds. Nutrients 10:11, pages 1653.
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Zebin Guo, Xiangze Jia, Zhichang Zheng, Xu Lu, Yafeng Zheng, Baodong Zheng & Jianbo Xiao. (2017) Chemical composition and nutritional function of olive (Olea europaea L.): a review. Phytochemistry Reviews 17:5, pages 1091-1110.
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Angélica Quintero-Flórez, Gema Pereira-Caro, Cristina Sánchez-Quezada, José Manuel Moreno-Rojas, José J. Gaforio, Antonio Jimenez & Gabriel Beltrán. (2017) Effect of olive cultivar on bioaccessibility and antioxidant activity of phenolic fraction of virgin olive oil. European Journal of Nutrition 57:5, pages 1925-1946.
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Aurélia Malapert, Valérie Tomao, Olivier Dangles & Emmanuelle Reboul. (2018) Effect of Foods and β-Cyclodextrin on the Bioaccessibility and the Uptake by Caco-2 Cells of Hydroxytyrosol from Either a Pure Standard or Alperujo. Journal of Agricultural and Food Chemistry 66:18, pages 4614-4620.
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Gema Baeza, Beatriz Sarriá, Laura Bravo & Raquel Mateos. (2018) Polyphenol content, in vitro bioaccessibility and antioxidant capacity of widely consumed beverages . Journal of the Science of Food and Agriculture 98:4, pages 1397-1406.
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Fa-Wen Yin, Xiao-Pei Hu, Da-Yong Zhou, Xiao-Chi Ma, Xiang-Ge Tian, Xiao-Kui Huo, Kanyasiri Rakariyatham, Fereidoon Shahidi & Bei-Wei Zhu. (2018) Evaluation of the stability of tyrosol esters during in vitro gastrointestinal digestion . Food & Function 9:7, pages 3610-3616.
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Rosa García-Rodríguez, Angjelina Belaj, Carmen Romero-Segura, Carlos Sanz & Ana G. Pérez. (2017) Exploration of genetic resources to improve the functional quality of virgin olive oil. Journal of Functional Foods 38, pages 1-8.
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Susana Cofrades, Ricard Bou, Linda Flaiz, Alba Garcimartín, Juana Benedí, Raquel Mateos, Francisco J. Sánchez-Muniz, Raúl Olivero-David & Francisco Jiménez-Colmenero. (2017) Bioaccessibility of hydroxytyrosol and n-3 fatty acids as affected by the delivery system: simple, double and gelled double emulsions. Journal of Food Science and Technology 54:7, pages 1785-1793.
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Leyre Sánchez-Barrionuevo, Alejandro González-Benjumea, Almudena Escobar-Niño, María Teresa García, Óscar López, Inés Maya, José G. Fernández-Bolaños, David Cánovas & Encarnación Mellado. (2016) A Straightforward Access to New Families of Lipophilic Polyphenols by Using Lipolytic Bacteria. PLOS ONE 11:11, pages e0166561.
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Raquel Mateos, Sara Martínez-López, Gema Baeza Arévalo, Miryam Amigo-Benavent, Beatriz Sarriá & Laura Bravo-Clemente. (2016) Hydroxytyrosol in functional hydroxytyrosol-enriched biscuits is highly bioavailable and decreases oxidised low density lipoprotein levels in humans. Food Chemistry 205, pages 248-256.
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Roberta Bernini, Maria Saveria Gilardini Montani, Nicolò Merendino, Annalisa Romani & Francesca Velotti. (2015) Hydroxytyrosol-Derived Compounds: A Basis for the Creation of New Pharmacological Agents for Cancer Prevention and Therapy. Journal of Medicinal Chemistry 58:23, pages 9089-9107.
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Susana Sánchez-Fidalgo, Isabel Villegas, Marina Aparicio-Soto, Ana Cárdeno, Ma. Ángeles Rosillo, Alejandro González-Benjumea, Azucena Marset, Óscar López, Inés Maya, José G. Fernández-Bolaños & Catalina Alarcón de la Lastra. (2015) Effects of dietary virgin olive oil polyphenols: hydroxytyrosyl acetate and 3, 4-dihydroxyphenylglycol on DSS-induced acute colitis in mice. The Journal of Nutritional Biochemistry 26:5, pages 513-520.
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Marta Navarro & Francisco J. Morales. (2015) Mechanism of reactive carbonyl species trapping by hydroxytyrosol under simulated physiological conditions. Food Chemistry 175, pages 92-99.
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Diana Martin, Maria I. Moran-Valero, Víctor Casado, Guillermo Reglero & Carlos F. Torres. (2014) Phosphatidyl Derivative of Hydroxytyrosol. In Vitro Intestinal Digestion, Bioaccessibility, and Its Effect on Antioxidant Activity . Journal of Agricultural and Food Chemistry 62:40, pages 9751-9759.
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Ana G. Pérez, Lorenzo León, Mar Pascual, Carmen Romero-Segura, Araceli Sánchez-Ortiz, Raúl de la Rosa & Carlos Sanz. (2014) Variability of Virgin Olive Oil Phenolic Compounds in a Segregating Progeny from a Single Cross in Olea europaea L. and Sensory and Nutritional Quality Implications. PLoS ONE 9:3, pages e92898.
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Javier Muñoz-Marín, José Pedro De La Cruz, José Julio Reyes, Juan Antonio López-Villodres, Ana Guerrero, Inmaculada López-Leiva, José Luis Espartero, María Teresa Labajos & José Antonio González-Correa. (2013) Hydroxytyrosyl alkyl ether derivatives inhibit platelet activation after oral administration to rats. Food and Chemical Toxicology 58, pages 295-300.
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G. Pereira-Caro, R. Mateos, M.H. Traka, J.R. Bacon, R. Bongaerts, B. Sarriá, L. Bravo & P.A. Kroon. (2013) Hydroxytyrosyl ethyl ether exhibits stronger intestinal anticarcinogenic potency and effects on transcript profiles compared to hydroxytyrosol. Food Chemistry 138:2-3, pages 1172-1182.
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José Manuel Calderón-Montaño, Andrés Madrona, Estefanía Burgos-Morón, Manuel Luis Orta, Santiago Mateos, José Luis Espartero & Miguel López-Lázaro. (2013) Selective Cytotoxic Activity of New Lipophilic Hydroxytyrosol Alkyl Ether Derivatives. Journal of Agricultural and Food Chemistry 61:21, pages 5046-5053.
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Raquel Mateos, Gema Pereira-Caro, James R. BaconRoy BongaertsBeatriz Sarriá, Laura Bravo & Paul A. Kroon. (2013) Anticancer Activity of Olive Oil Hydroxytyrosyl Acetate in Human Adenocarcinoma Caco-2 Cells. Journal of Agricultural and Food Chemistry 61:13, pages 3264-3269.
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