729
Views
46
CrossRef citations to date
0
Altmetric
Studies in Humans

Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial

, , , , , , , & show all
Pages 7-15 | Received 15 Feb 2012, Accepted 03 Jun 2012, Published online: 29 Jun 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Amirhossein Sahebkar, Matteo Pirro, Maciej Banach, Dimitri P. Mikhailidis, Stephen L. Atkin & Arrigo F. G. Cicero. (2018) Lipid-lowering activity of artichoke extracts: A systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition 58:15, pages 2549-2556.
Read now
Engy M. El Morsy & Rehab Kamel. (2015) Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats. Pharmaceutical Biology 53:2, pages 167-173.
Read now

Articles from other publishers (44)

Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Mariem Achour, Rosa M. Lamuela-Raventós, Ramon Estruch, Rikard Landberg, Sabine E. Kulling, David Wishart, Ana Rodriguez-Mateos, Michael N. Clifford, Alan Crozier, Claudine Manach & Daniele Del Rio. (2023) A Systematic Review and Comprehensive Evaluation of Human Intervention Studies to Unravel the Bioavailability of Hydroxycinnamic Acids. Antioxidants & Redox Signaling.
Crossref
Fabien Wauquier, Line Boutin-Wittrant, Stéphanie Krisa, Josep Valls, Cedric Langhi, Yolanda F. Otero, Pascal Sirvent, Sébastien Peltier, Maxime Bargetto, Murielle Cazaubiel, Véronique Sapone, Annie Bouchard-Mercier, Véronique Roux, Nicolas Macian, Gisèle Pickering & Yohann Wittrant. (2023) Circulating Human Metabolites Resulting from TOTUM-070 Absorption (a Plant-Based, Polyphenol-Rich Ingredient) Improve Lipid Metabolism in Human Hepatocytes: Lessons from an Original Ex Vivo Clinical Trial. Nutrients 15:8, pages 1903.
Crossref
Manfredi Rizzo, Alessandro Colletti, Peter E. Penson, Niki Katsiki, Dimitri P. Mikhailidis, Peter P. Toth, Ioanna Gouni-Berthold, John Mancini, David Marais, Patrick Moriarty, Massimiliano Ruscica, Amirhossein Sahebkar, Dragos Vinereanu, Arrigo Francesco Giuseppe Cicero, Maciej Banach, Julio Acosta, Mutaz Al-Khnifsawi, Fahad Alnouri, Fahma Amar, Atanas G. Atanasov, Gani Bajraktari, Maciej Banach, Ioanna Gouni-Berthold, Sonu Bhaskar, Agata Bielecka-Dąbrowa, Bojko Bjelakovic, Eric Bruckert, Ibadete Bytyçi, Alberto Cafferata, Richard Ceska, Arrigo F.G. Cicero, Krzysztof Chlebus, Xavier Collet, Magdalena Daccord, Olivier Descamps, Dragan Djuric, Ronen Durst, Marat V. Ezhov, Zlatko Fras, Dan Gaita, Ioanna Gouni-Berthold, Adrian V. Hernandez, Steven R. Jones, Jacek Jozwiak, Nona Kakauridze, Amani Kallel, Niki Katsiki, Amit Khera, Karam Kostner, Raimondas Kubilius, Gustavs Latkovskis, G.B. John Mancini, A. David Marais, Seth S. Martin, Julio Acosta Martinez, Mohsen Mazidi, Dimitri P. Mikhailidis, Erkin Mirrakhimov, Andre R. Miserez, Olena Mitchenko, Natalya P. Mitkovskaya, Patrick M. Moriarty, Seyed Mohammad Nabavi, Devaki Nair, Demosthenes B. Panagiotakos, György Paragh, Daniel Pella, Peter E. Penson, Zaneta Petrulioniene, Matteo Pirro, Arman Postadzhiyan, Raman Puri, Ashraf Reda, Željko Reiner, Dina Radenkovic, Michał Rakowski, Jemaa Riadh, Dimitri Richter, Manfredi Rizzo, Massimiliano Ruscica, Amirhossein Sahebkar, Maria-Corina Serban, Abdullah M.A Shehab, Aleksandr B. Shek, Cesare R. Sirtori, Claudia Stefanutti, Tomasz Tomasik, Peter P. Toth, Margus Viigimaa, Pedro Valdivielso, Dragos Vinereanu, Branislav Vohnout, Stephan von Haehling, Michal Vrablik, Nathan D. Wong, Hung-I Yeh, Jiang Zhisheng & Andreas Zirlik. (2023) Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP). Pharmacological Research 189, pages 106679.
Crossref
Jessica Maiuolo, Rocco Mollace, Francesca Bosco, Federica Scarano, Francesca Oppedisano, Saverio Nucera, Stefano Ruga, Lorenza Guarnieri, Roberta Macri, Irene Bava, Cristina Carresi, Micaela Gliozzi, Vincenzo Musolino, Antonio Cardamone, Anna Rita Coppoletta, Andrea Barillaro, Virginia Simari, Daniela Salvemini, Ernesto Palma & Vincenzo Mollace. (2023) The Phytochemical Synergistic Properties of Combination of Bergamot Polyphenolic Fraction and Cynara cardunculus Extract in Non-Alcoholic Fatty Liver Disease. Agriculture 13:2, pages 249.
Crossref
Lorenzo ARNABOLDI, Alberto CORSINI & Stefano BELLOSTA. (2022) Artichoke and bergamot extracts: a new opportunity for the management of dyslipidemia and related risk factors. Minerva Medica 113:1.
Crossref
Luís R. Silva, Telma A. Jacinto & Paula Coutinho. (2022) Bioactive Compounds from Cardoon as Health Promoters in Metabolic Disorders. Foods 11:3, pages 336.
Crossref
Maite Domínguez-Fernández, Paul Young Tie Yang, Iziar A. Ludwig, Michael N. Clifford, Concepción Cid & Ana Rodriguez-Mateos. (2022) In vivo study of the bioavailability and metabolic profile of (poly)phenols after sous-vide artichoke consumption. Food Chemistry 367, pages 130620.
Crossref
Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Simone Perna, Attilio Giacosa, Gabriella Peroni, Milena Anna Faliva, Maurizio Naso & Mariangela Rondanelli. (2021) Artichoke and Bergamot Phytosome Alliance: A Randomized Double Blind Clinical Trial in Mild Hypercholesterolemia. Nutrients 14:1, pages 108.
Crossref
Hossein Shahinfar, Elham Bazshahi, Mohammad Reza Amini, Nastaran Payandeh, Sanaz Pourreza, Zahra Noruzi & Sakineh Shab‐Bidar. (2021) Effects of artichoke leaf extract supplementation or artichoke juice consumption on lipid profile: A systematic review and dose–response meta‐analysis of randomized controlled trials. Phytotherapy Research 35:12, pages 6607-6623.
Crossref
Mohammad Bagher Majnooni, Mari Ataee, Gholamreza Bahrami, Fatemeh Heydarpour, Ina Yosifova Aneva, Mohammad Hosein Farzaei & Touraj Ahmadi‐Juoibari. (2021) The effects of co‐administration of artichoke leaf extract supplementation with metformin and vitamin E in patients with nonalcoholic fatty liver disease: A randomized clinical trial. Phytotherapy Research 35:11, pages 6324-6334.
Crossref
Guo-Chen Liao, Jia-Hua Jhuang & Hsien-Tsung Yao. (2021) Artichoke leaf extract supplementation lowers hepatic oxidative stress and inflammation and increases multidrug resistance-associated protein 2 in mice fed a high-fat and high-cholesterol diet. Food & Function 12:16, pages 7239-7249.
Crossref
Fabien Wauquier, Line Boutin-Wittrant, Aurélien Viret, Laure Guilhaudis, Hassan Oulyadi, Asma Bourafai-Aziez, Gwladys Charpentier, Guillaume Rousselot, Emmanuel Cassin, Stéphane Descamps, Véronique Roux, Nicolas Macian, Gisèle Pickering & Yohann Wittrant. (2021) Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial. Nutrients 13:8, pages 2653.
Crossref
Şaziment KILIÇTAŞ. (2021) ENGİNAR (CYNARA SCOLYMUS): BESİN DEĞERİ VE OLASI SAĞLIK ETKİLERİARTICHOKE (CYNARA SCOLYMUS): NUTRITIONAL VALUE AND POSSIBLE HEALTH EFFECTS. Uluslararası Sosyal Bilimler Akademi Dergisi:5, pages 6-22.
Crossref
Mukaddas Sobirova & Sayyora Murodova. (2021) Effects of biopraparites on cynara scolymus L., micro and macroelements, and quantity of flavonoids . E3S Web of Conferences 258, pages 04025.
Crossref
Dorota Woźniak, Izabela Nawrot-Hadzik, Weronika Kozłowska, Sylwester Ślusarczyk & Adam Matkowski. 2021. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 1065 1104 .
Elske M. Brouwer-Brolsma, Beate Brandl, Marion E. C. Buso, Thomas Skurk & Claudine Manach. (2020) Food intake biomarkers for green leafy vegetables, bulb vegetables, and stem vegetables: a review. Genes & Nutrition 15:1.
Crossref
Mariangela Rondanelli, Antonella Riva, Giovanna Petrangolini, Pietro Allegrini, Luisa Bernardinelli, Teresa Fazia, Gabriella Peroni, Clara Gasparri, Mara Nichetti, Milena Anna Faliva, Maurizio Naso & Simone Perna. (2020) The Metabolic Effects of Cynara Supplementation in Overweight and Obese Class I Subjects with Newly Detected Impaired Fasting Glycemia: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial. Nutrients 12:11, pages 3298.
Crossref
Ahmed Zayed, Ahmed Serag & Mohamed A. Farag. (2020) Cynara cardunculus L.: Outgoing and potential trends of phytochemical, industrial, nutritive and medicinal merits. Journal of Functional Foods 69, pages 103937.
Crossref
Francesca Oppedisano, Carolina Muscoli, Vincenzo Musolino, Cristina Carresi, Roberta Macrì, Caterina Giancotta, Francesca Bosco, Jessica Maiuolo, Federica Scarano, Sara Paone, Saverio Nucera, Maria Caterina Zito, Miriam Scicchitano, Stefano Ruga, Monica Ragusa, Ernesto Palma, Annamaria Tavernese, Rocco Mollace, Ezio Bombardelli & Vincenzo Mollace. (2020) The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily. Nutrients 12:5, pages 1435.
Crossref
Vincenzo Musolino, Micaela Gliozzi, Ezio Bombardelli, Saverio Nucera, Cristina Carresi, Jessica Maiuolo, Rocco Mollace, Sara Paone, Francesca Bosco, Federica Scarano, Miriam Scicchitano, Roberta Macrì, Stefano Ruga, Maria Caterina Zito, Ernesto Palma, Santo Gratteri, Monica Ragusa, Maurizio Volterrani, Massimo Fini & Vincenzo Mollace. (2020) The synergistic effect of Citrus bergamia and Cynara cardunculus extracts on vascular inflammation and oxidative stress in non-alcoholic fatty liver disease. Journal of Traditional and Complementary Medicine 10:3, pages 268-274.
Crossref
Wioletta Biel, Robert Witkowicz, Ewa Piątkowska & Cezary Podsiadło. (2019) Proximate Composition, Minerals and Antioxidant Activity of Artichoke Leaf Extracts. Biological Trace Element Research 194:2, pages 589-595.
Crossref
Lía Noemi Gerschenson, Eliana Noemi Fissore, Ana María Rojas, Dana Cecilia Bernhardt & Cinthia Santo Domingo. 2020. Nutritional Composition and Antioxidant Properties of Fruits and Vegetables. Nutritional Composition and Antioxidant Properties of Fruits and Vegetables 55 69 .
Dorota Woźniak, Izabela Nawrot-Hadzik, Weronika Kozłowska, Sylwester Ślusarczyk & Adam Matkowski. 2020. Handbook of Dietary Phytochemicals. Handbook of Dietary Phytochemicals 1 40 .
Wioletta Florkiewicz, Dagmara Malina, Klaudia Pluta, Karolina Rudnicka, Adrian Gajewski, Ewa Olejnik, Bożena Tyliszczak & Agnieszka Sobczak‐Kupiec. (2019) Assessment of cytotoxicity and immune compatibility of phytochemicals‐mediated biosynthesised silver nanoparticles using Cynara scolymus . IET Nanobiotechnology 13:7, pages 726-735.
Crossref
Daniela Martini, Laura Chiavaroli, Antonio González-Sarrías, Letizia Bresciani, Susana A. Palma-Duran, Margherita Dall’Asta, Georgia-Eirini Deligiannidou, Marika Massaro, Egeria Scoditti, Emilie Combet, Viktorija Maksimova, Mireia Urpi-Sarda, Christos A. Kontogiorgis, Cristina Andrés-Lacueva, Eileen R. Gibney, Daniele Del Rio, Christine Morand, Mar Garcia-Aloy, Ana Rodriguez-Mateos & Pedro Mena. (2019) Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability. Nutrients 11:8, pages 1805.
Crossref
Saverio M. Lepore, Valentina Maggisano, Giovanni E. Lombardo, Jessica Maiuolo, Vincenzo Mollace, Stefania Bulotta, Diego Russo & Marilena Celano. (2019) Antiproliferative Effects of Cynaropicrin on Anaplastic Thyroid Cancer Cells. Endocrine, Metabolic & Immune Disorders - Drug Targets 19:1, pages 59-66.
Crossref
María José Frutos, Domingo Ruiz-Cano, Estefanía Valero-Cases, Salvador Zamora & Francisca Pérez-Llamas. 2019. Nonvitamin and Nonmineral Nutritional Supplements. Nonvitamin and Nonmineral Nutritional Supplements 135 138 .
Heitor Oliveira Santos, Allain Amador Bueno & João Felipe Mota. (2018) The effect of artichoke on lipid profile: A review of possible mechanisms of action. Pharmacological Research 137, pages 170-178.
Crossref
Mehranghiz Ebrahimi-Mameghani, Mohammad Asghari-Jafarabadi & Khatereh Rezazadeh. (2018) TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial. Journal of Integrative Medicine 16:5, pages 329-334.
Crossref
Yunes Panahi, Parisa Kianpour, Reza Mohtashami, Stephen L. Atkin, Alexandra E. Butler, Ramezan Jafari, Roghayeh Badeli & Amirhossein Sahebkar. (2018) Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytotherapy Research 32:7, pages 1382-1387.
Crossref
Paola Crinò & Mario Pagnotta. (2017) Phenotyping, Genotyping, and Selections within Italian Local Landraces of Romanesco Globe Artichoke. Diversity 9:1, pages 14.
Crossref
Arrigo Francesco Giuseppe Cicero, Alessandro Colletti, Federica Fogacci, Marilisa Bove, Martina Rosticci & Claudio Borghi. (2016) Effects of a Combined Nutraceutical on Lipid Pattern, Glucose Metabolism and Inflammatory Parameters in Moderately Hypercholesterolemic Subjects: A Double-blind, Cross-over, Randomized Clinical Trial. High Blood Pressure & Cardiovascular Prevention 24:1, pages 13-18.
Crossref
. 2017. Phytotherapie. Phytotherapie 493 504 .
Alfredo Cassano, Walter Cabri, Giacomo Mombelli, Federico Peterlongo & Lidietta Giorno. (2016) Recovery of bioactive compounds from artichoke brines by nanofiltration. Food and Bioproducts Processing 98, pages 257-265.
Crossref
Mariangela Rondanelli, Attilio Giacosa, Paolo Morazzoni, Davide Guido, Mario Grassi, Gabriella Morandi, Chiara Bologna, Antonella Riva, Pietro Allegrini & Simone Perna. (2016) MediterrAsian Diet Products That Could Raise HDL-Cholesterol: A Systematic Review. BioMed Research International 2016, pages 1-15.
Crossref
Imma Pagano, Anna Lisa Piccinelli, Rita Celano, Luca Campone, Patrizia Gazzerro, Enrica De Falco & Luca Rastrelli. (2016) Chemical profile and cellular antioxidant activity of artichoke by-products. Food & Function 7:12, pages 4841-4850.
Crossref
Luana M. Cercato, Pollyanna A.S. White, Fernando K. Nampo, Márcio R.V. Santos & Enilton A. Camargo. (2015) A systematic review of medicinal plants used for weight loss in Brazil: Is there potential for obesity treatment?. Journal of Ethnopharmacology 176, pages 286-296.
Crossref
Hassan I.H. El-Sayyad. (2015) Cholesterol overload impairing cerebellar function: The promise of natural products. Nutrition 31:5, pages 621-630.
Crossref
Sarah E. Edwards, Inês da Costa Rocha, Elizabeth M. Williamson & Michael Heinrich. 2015. Phytopharmacy. Phytopharmacy 29 31 .
Y. V. Vereshchagina, V. P. Bulgakov, V. P. Grigorchuk, V. G. Rybin, G. N. Veremeichik, G. K. Tchernoded, T. Y. Gorpenchenko, O. G. Koren, N. H. T. Phan, N. T. Minh, L. T. Chau & Y. N. Zhuravlev. (2014) The rolC gene increases caffeoylquinic acid production in transformed artichoke cells. Applied Microbiology and Biotechnology 98:18, pages 7773-7780.
Crossref
Arshag D. Mooradian & Michael J. Haas. (2014) The Effect of Nutritional Supplements on Serum High-Density Lipoprotein Cholesterol and Apolipoprotein A-I. American Journal of Cardiovascular Drugs 14:4, pages 253-274.
Crossref
Daniela Borgognone, Mariateresa Cardarelli, Elvira Rea, Luigi Lucini & Giuseppe Colla. (2014) Salinity source-induced changes in yield, mineral composition, phenolic acids and flavonoids in leaves of artichoke and cardoon grown in floating system. Journal of the Science of Food and Agriculture 94:6, pages 1231-1237.
Crossref
Ning Xia, Andrea Pautz, Ursula Wollscheid, Gisela Reifenberg, Ulrich Förstermann & Huige Li. (2014) Artichoke, Cynarin and Cyanidin Downregulate the Expression of Inducible Nitric Oxide Synthase in Human Coronary Smooth Muscle Cells. Molecules 19:3, pages 3654-3668.
Crossref
T. K. LimT. K. Lim. 2014. Edible Medicinal And Non-Medicinal Plants. Edible Medicinal And Non-Medicinal Plants 291 328 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.