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Stress
The International Journal on the Biology of Stress
Volume 14, 2011 - Issue 2
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Original Research Reports

Eugenol as an anti-stress agent: Modulation of hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in a rat model of stress

Debapriya Garabadu Neurotherapeutics Lab, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, UP, India
,
Ankit Shah Neurotherapeutics Lab, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, UP, India
,
Ausaf Ahmad Division of Pharmacology, Central Drug Research Institute, P.O. Box 173, Lucknow, 226001, UP, India
,
Vijaya B. Joshi Neurotherapeutics Lab, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, UP, India
,
Bhagawati Saxena Neurotherapeutics Lab, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, UP, India
,
Gautam Palit Division of Pharmacology, Central Drug Research Institute, P.O. Box 173, Lucknow, 226001, UP, India
&
Sairam Krishnamurthy Neurotherapeutics Lab, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, UP, IndiaCorrespondence[email protected] [email protected]
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Pages 145-155 | Received 23 May 2009, Accepted 02 Aug 2010, Published online: 31 Oct 2010

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Debapriya Garabadu, Ankit Shah, Sanjay Singh & Sairam Krishnamurthy. (2015) Protective effect of eugenol against restraint stress-induced gastrointestinal dysfunction: Potential use in irritable bowel syndrome. Pharmaceutical Biology 53:7, pages 968-974.
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Sairam Krishnamurthy, Debapriya Garabadu & Nagannathahalli Ranga Reddy. (2013) Asparagus racemosus modulates the hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in rats. Nutritional Neuroscience 16:6, pages 255-261.
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Articles from other publishers (54)

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Ashwani Sharma, Talever Singh, Devender Pathak, Tarun Virmani, Girish Kumar & Abdulsalam Alhalmi. (2022) Antidepressive-Like Effect of Aegle marmelos Leaf Extract in Chronic Unpredictable Mild Stress-Induced Depression-Like Behaviour in Rats. BioMed Research International 2022, pages 1-16.
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Hebatullah Helmy, Nermin Abdel Hamid Sadik, Laila Badawy & Noha H. Sayed. (2022) Mechanistic insights into the protective role of eugenol against stress-induced reproductive dysfunction in female rat model. Chemico-Biological Interactions 367, pages 110181.
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Fatemeh Parvizi, Soraya Mehrabi, Ayeh Naghizadeh, Mohammad Kamalinejad‬, Sepide Goudarzi & ‬‬‬‬‬‬‬‬‬‬ Maryam Farahmandfar. (2022) Comparison of intranasal and intraperitoneal administration of Eugenia caryophyllata (clove) essential oil on spatial memory, anxiety-like behavior and locomotor activity in a pilocarpine-induced status epilepticus rat model. BMC Complementary Medicine and Therapies 22:1.
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Victor Hugo S. Rodrigues, Rafael N. Almeida, Rubem M.F. Vargas & Eduardo Cassel. (2022) Vapor pressure and vapor-liquid equilibrium data for eugenol/caryophyllene binary system at low pressures by experimental and predictive methods. The Journal of Chemical Thermodynamics 168, pages 106725.
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Karol Rojek, Anna Serefko, Ewa Poleszak, Aleksandra Szopa, Andrzej Wróbel, Małgorzata Guz, Jianbo Xiao & Krystyna Skalicka-Woźniak. (2021) Neurobehavioral properties of Cymbopogon essential oils and its components. Phytochemistry Reviews 21:2, pages 327-338.
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Yan Li, Jing-Wen Wang, Qiu-Shi Dong, Bao-Chang Zhao, Ji-Mei Zhang, Yan-Ling Li, Zhi-Guo Lu & Xin Zhang. (2022) Dual pH and Temperature-Sensitive Nanogels Loaded with Eugenol for Regulating Central Nervous System. Journal of Biomedical Nanotechnology 18:3, pages 860-867.
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Ajay Sharma, Garima Bhardwaj, Harvinder Singh Sohal & Apurba Gohain. 2022. Nutraceuticals and Health Care. Nutraceuticals and Health Care 177 198 .
Adrian Isaza. 2022. Functional Foods and Nutraceuticals in Metabolic and Non-Communicable Diseases. Functional Foods and Nutraceuticals in Metabolic and Non-Communicable Diseases 771 782 .
Muhammad Farrukh Nisar, Mahnoor Khadim, Muhammad Rafiq, Jinyin Chen, Yali Yang & Chunpeng Craig Wan. (2021) Pharmacological Properties and Health Benefits of Eugenol: A Comprehensive Review. Oxidative Medicine and Cellular Longevity 2021, pages 1-14.
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Jeetprakash Barot & Bhagawati Saxena. (2021) Therapeutic effects of eugenol in a rat model of traumatic brain injury: A behavioral, biochemical, and histological study. Journal of Traditional and Complementary Medicine 11:4, pages 318-327.
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T. T. Podvigina, O. Yu. Morozova, O. P. Komkova & L. P. Filaretova. (2021) Involvement of Hypothalamo-Hypophyseal-Adrenocortical System Hormones in Gastroprotection in Rats on Sensitization and Desensitization of Capsaicin-Sensitive Afferent Neurons. Neuroscience and Behavioral Physiology 51:6, pages 784-792.
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Mohammed A. Jahangir, Mohamad Taleuzzaman, Sarwar Beg, Surajpal Verma, Sadaf J. Gilani & Perwaiz Alam. (2021) A Review of Eugenol-based Nanomedicine: Recent Advancements. Current Bioactive Compounds 17:3, pages 214-219.
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Fang Lu, Yurong Ma, Hui Huang, Yue Zhang, Hui Kong, Yan Zhao, Huihua Qu, Qingguo Wang, Yang Liu & Zhenhui Kang. (2021) Edible and highly biocompatible nanodots from natural plants for the treatment of stress gastric ulcers. Nanoscale 13:14, pages 6809-6818.
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Yan-Ling Qiao, Jun-Jun Zhou, Jia-Hao Liang, Xiao-Peng Deng, Zhan-Jun Zhang, Hui-Lian Huang, Song Li, Shu-Fang Dai, Chun-Qing Liu, Zhi-Lin Luan, Zhen-Long Yu, Cheng-Peng Sun & Xiao-Chi Ma. (2021) Uncaria rhynchophylla ameliorates unpredictable chronic mild stress-induced depression in mice via activating 5-HT1A receptor: Insights from transcriptomics. Phytomedicine 81, pages 153436.
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Kyung-A. Hwang, Hye-Jeong Hwang, Yu Jin Hwang & Young Jun Kim. (2020) Mustard Leaf Extract Suppresses Psychological Stress in Chronic Restraint Stress-Subjected Mice by Regulation of Stress Hormone, Neurotransmitters, and Apoptosis. Nutrients 12:12, pages 3640.
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Salomeh Ghaffari, Ali Ghobadi, Amir Hossein Jamshidi, Seyyed Hosein Mortazavi, Sina Naderi, Ali Aqamolaei, Amirhosein Mortezaei, Erfan Sahebolzamani, Ahmad Shamabadi, Shakiba Jalilvand, Bahram Daraei, Mohammad Reza Shalbafan & Shahin Akhondzadeh. (2020) Cinnamomum tamala as an adjuvant therapy in the treatment of major depressive disorder: A double-blind, randomized, placebo-controlled clinical trial with placebo control. Advances in Integrative Medicine 7:3, pages 141-147.
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Debapriya Garabadu & Nidhi Agrawal. (2020) Naringin Exhibits Neuroprotection Against Rotenone-Induced Neurotoxicity in Experimental Rodents. NeuroMolecular Medicine 22:2, pages 314-330.
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R. K. Romana, A. Sharma, V. Gupta, R. Kaur, S. Kumar & P. Bansal. (2017) Was Hawan Designed to Fight Anxiety-Scientific Evidences?. Journal of Religion and Health 59:1, pages 505-521.
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Debapriya Garabadu, Neha Srivastava & Yogesh Murti. (2019) Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals. Metabolic Brain Disease 34:6, pages 1635-1647.
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Santosh Kumar Prajapati, Durgesh Singh Dangi & Sairam Krishnamurthy. (2019) Repeated caffeine administration aggravates post-traumatic stress disorder-like symptoms in rats. Physiology & Behavior 211, pages 112666.
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Debapriya Garabadu & Mahima Sharma. (2019) Eugenol Attenuates Scopolamine-Induced Hippocampal Cholinergic, Glutamatergic, and Mitochondrial Toxicity in Experimental Rats. Neurotoxicity Research 35:4, pages 848-859.
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Debapriya Garabadu & Vivek Kumar. (2019) Celecoxib potentiates the antianxiety and anticompulsive-like activity of fluoxetine against chronic unpredictable mild stress in experimental animals. Behavioural Pharmacology 30:2 and 3, pages 251-259.
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Guangming Xu, Yingmin Li, Chunling Ma, Chuan Wang, Zhaoling Sun, Yiwen Shen, Li Liu, Shujin Li, Xiaojing Zhang & Bin Cong. (2019) Restraint Stress Induced Hyperpermeability and Damage of the Blood-Brain Barrier in the Amygdala of Adult Rats. Frontiers in Molecular Neuroscience 12.
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Saeedeh Bahramzadeh Zoeram, Mahmoud Elahdadi Salmani, Taghi Lashkarbolouki & Iran Goudarzi. (2019) Hippocampal orexin receptor blocking prevented the stress induced social learning and memory deficits. Neurobiology of Learning and Memory 157, pages 12-23.
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Bing Liu, Abulimiti Yili, Haji Akber Aisa & Maihesu Aikemu. (2018) Gastroprotective effect of the protease-rich extract from sheep abomasum against stress-induced gastric ulcers in rats. Journal of Food Biochemistry 42:5, pages e12558.
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Ajeet Kumar Singh, Sanjay Kumar & Manjula Vinayak. (2018) Recent development in antihyperalgesic effect of phytochemicals: anti-inflammatory and neuro-modulatory actions. Inflammation Research 67:8, pages 633-654.
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Yusuf Hussain & Sairam Krishnamurthy. (2018) Piracetam attenuates binge eating disorder related symptoms in rats. Pharmacology Biochemistry and Behavior 169, pages 35-47.
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Negar Jamshidi, Cliff Da Costa & Marc Cohen. (2018) Holybasil (tulsi) lowers fasting glucose and improves lipid profile in adults with metabolic disease: A meta-analysis of randomized clinical trials. Journal of Functional Foods 45, pages 47-57.
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M.P. Venuprasad, Hemanth Kumar Kandikattu, Sakina Razack, Narayanappa Amruta & Farhath Khanum. (2017) Chemical composition of Ocimum sanctum by LC-ESI–MS/MS analysis and its protective effects against smoke induced lung and neuronal tissue damage in rats. Biomedicine & Pharmacotherapy 91, pages 1-12.
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Rajendra K. Shukla, Yogesh K. Dhuriya, Lalit P. Chandravanshi, Richa Gupta, Pranay Srivastava, Aditya B. Pant, Ajay Kumar, Chandra M. Pandey, M. Haris Siddiqui & Vinay K. Khanna. (2017) Influence of immobilization and forced swim stress on the neurotoxicity of lambda-cyhalothrin in rats: Effect on brain biogenic amines and BBB permeability. NeuroToxicology 60, pages 187-196.
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Santosh Kumar Prajapati, Debapriya Garabadu & Sairam Krishnamurthy. (2017) Coenzyme Q10 Prevents Mitochondrial Dysfunction and Facilitates Pharmacological Activity of Atorvastatin in 6-OHDA Induced Dopaminergic Toxicity in Rats. Neurotoxicity Research 31:4, pages 478-492.
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Mahmoud M. Said & Marwa M. Abd Rabo. (2017) Neuroprotective effects of eugenol against aluminiuminduced toxicity in the rat brain. Archives of Industrial Hygiene and Toxicology 68:1, pages 27-37.
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Mohamed Saleem Abdul Shukkoor, Mohamad Taufik Hidayat Bin Baharuldin, Abdul Manan Mat Jais, Mohamad Aris Mohamad Moklas, Sharida Fakurazi & Rusliza Basir. (2017) Antidepressant-Like Effect of Lipid Extract of Channa striatus in Postpartum Model of Depression in Rats . Evidence-Based Complementary and Alternative Medicine 2017, pages 1-15.
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Anees Ahmed Khalil, Ubaid ur Rahman, Moazzam Rafiq Khan, Amna Sahar, Tariq Mehmood & Muneeb Khan. (2017) Essential oil eugenol: sources, extraction techniques and nutraceutical perspectives. RSC Advances 7:52, pages 32669-32681.
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Omar J. Mohammed, Roseanna McAlpine, Phasawee Chiewhatpong, Muhammad Liaque Latif & Margaret K. Pratten. (2016) Assessment of developmental cardiotoxic effects of some commonly used phytochemicals in mouse embryonic D3 stem cell differentiation and chick embryonic cardiomyocyte micromass culture models. Reproductive Toxicology 64, pages 86-97.
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Edwin Jothie Richard, Ramanaiah Illuri, Bharathi Bethapudi, Senthilkumar Anandhakumar, Anirban Bhaskar, Chandrasekaran Chinampudur Velusami, Deepak Mundkinajeddu & Amit Agarwal. (2016) Anti-stress Activity of Ocimum sanctum : Possible Effects on Hypothalamic-Pituitary-Adrenal Axis . Phytotherapy Research 30:5, pages 805-814.
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Debapriya Garabadu, Ausaf Ahmad & Sairam Krishnamurthy. (2015) Risperidone Attenuates Modified Stress–Re-stress Paradigm-Induced Mitochondrial Dysfunction and Apoptosis in Rats Exhibiting Post-traumatic Stress Disorder-Like Symptoms. Journal of Molecular Neuroscience 56:2, pages 299-312.
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Debapriya Garabadu, B. C. M. Harshavardhan Reddy & Sairam Krishnamurthy. (2014) Citalopram Protects Against Cold-Restraint Stress-Induced Activation of Brain-Derived Neurotrophic Factor and Expression of Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells in Rats. Journal of Molecular Neuroscience 55:2, pages 355-366.
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Keith Singletary. (2014) Clove. Nutrition Today 49:4, pages 207-224.
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Debapriya Garabadu & Sairam Krishnamurthy. (2014) Asparagus racemosus Attenuates Anxiety-Like Behavior in Experimental Animal Models. Cellular and Molecular Neurobiology 34:4, pages 511-521.
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Milind Geed, Debapriya Garabadu, Ausaf Ahmad & Sairam Krishnamurthy. (2014) Silibinin pretreatment attenuates biochemical and behavioral changes induced by intrastriatal MPP+ injection in rats. Pharmacology Biochemistry and Behavior 117, pages 92-103.
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Donglin Zhu, Qiang Tong, Wei Liu, Minjie Tian, Wei Xie, Li Ji & Jingping Shi. (2014) Angiotensin (1–7) protects against stress-induced gastric lesions in rats. Biochemical Pharmacology 87:3, pages 467-476.
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Debapriya Garabadu & Sairam Krishnamurthy. (2014) Diazepam Potentiates the Antidiabetic, Antistress and Anxiolytic Activities of Metformin in Type-2 Diabetes Mellitus with Cooccurring Stress in Experimental Animals. BioMed Research International 2014, pages 1-15.
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Sairam Krishnamurthy, Debapriya Garabadu & Keerikkattil P. Joy. (2013) Risperidone ameliorates post-traumatic stress disorder-like symptoms in modified stress re-stress model. Neuropharmacology 75, pages 62-77.
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Aleksandra Owczarek, Jan Gudej & Agnieszka Kicel. (2013) Composition of Essential Oil from Aerial and Underground Parts of Geum rivale and G. urbanum Growing in Poland . Natural Product Communications 8:4, pages 1934578X1300800.
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Nazmun Lyle, Shrabana Chakrabarti, Tapas Sur, Antony Gomes & Dipankar Bhattacharyya. (2012) Nardostachys jatamansi Protects Against Cold Restraint Stress Induced Central Monoaminergic and Oxidative Changes in Rats. Neurochemical Research 37:12, pages 2748-2757.
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Guy P. Kamatou, Ilze Vermaak & Alvaro M. Viljoen. (2012) Eugenol—From the Remote Maluku Islands to the International Market Place: A Review of a Remarkable and Versatile Molecule. Molecules 17:6, pages 6953-6981.
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M. Fukada, E. Kano, M. Miyoshi, R. Komaki & T. Watanabe. (2011) Effect of "Rose Essential Oil" Inhalation on Stress-Induced Skin-Barrier Disruption in Rats and Humans. Chemical Senses 37:4, pages 347-356.
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Sairam Krishnamurthy, Debapriya Garabadu, Nagannathahalli Ranga Reddy & Keerikkattil P. Joy. (2011) Risperidone in Ultra Low Dose Protects Against Stress in the Rodent Cold Restraint Model by Modulating Stress Pathways. Neurochemical Research 36:10, pages 1750-1758.
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