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Stress
The International Journal on the Biology of Stress
Volume 14, 2011 - Issue 2
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Original Research Reports

Eugenol as an anti-stress agent: Modulation of hypothalamic–pituitary–adrenal axis and brain monoaminergic systems in a rat model of stress

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Pages 145-155 | Received 23 May 2009, Accepted 02 Aug 2010, Published online: 31 Oct 2010

References

  • Akirav I, Richter-Levin G. 1999. Biphasic modulation of hippocampal plasticity by behavioral stress and basolateral amygdala stimulation in the rat. J Neurosci. 19 23: 10530–10535.
  • Ardjmand A, Fathollahi Y, Sayyah M, Kamalinejad M, Omrani A. 2006. Eugenol depresses synaptic transmission but does not prevent the induction of long-term potentiation in the CA1 region of rat hippocampal slices. Phytomedicine. 13:146–151.
  • Auerbach SB, Minzeberg MJ, Wilkinson LO. 1989. Extracellular serotonin and 5-hydroxyindoleacetic acid in hypothalamus of the anaesthetized rat measured by in vivo dialysis coupled to high-performance liquid chromatography with electrochemical detection: Dialysate serotonin reflects neuronal release. Brain Res. 499:281–290.
  • Brady KT, Sinha R. 2005. Co-occurring mental and substance use disorders: The neurobiological effects of chronic stress. Am J Psychiatry. 162:1483–1493.
  • Brodin P, Roed A. 1984. Effects of eugenol on rat phrenic nerve and phrenic nerve-diaphragm preparations. Arch Oral Biol. 29:611–615.
  • Burchfield SR. 1979. The stress response: A new perspective. Psychosom Med. 41 8: 661–672.
  • Charney DS. 2004. Psychobiological mechanisms of resilience and vulnerability: Implications for successful adaptation to extreme stress. Am J Psychiatry. 161:195–216.
  • Corley KC, Phan TH, Daugherty WP, Boadle-Biber MC. 2002. Stress-induced activation of median raphe serotonergic neurons in rats is potentiated by the neurotensin antagonist, SR 48692. Neurosci Lett. 319 1: 1–4.
  • Czéh C, Perez-Cruz C, Fuchs E, Flügge G. 2008. Chronic stress-induced cellular changes in the medial prefrontal cortex and their potential clinical implications: Does hemisphere location matter?. Behav Brain Res. 190:1–13.
  • Feldman S, Weidenfeld J. 1995. Neural mechanisms involved in the corticosteroid feedback effects on the hypothalamo–pituitary–adrenocortical axis. Prog Neurobiol. 45:129–141.
  • Floresco SB, Grace AA. 2003. Gating of hippocampal-evoked activity in prefrontal cortical neurons by inputs from the mediodorsal thalamus and ventral tegmental area. J Neurosci. 23 9: 3930–3943.
  • Gavrilovic L, Dronjak S. 2005. Activation of rat pituitary–adrenocortical and sympatho-adrenomedullary system in response to different stressors. Neuro Endocrinol Lett. 26 5: 515–520.
  • Graeff FG, Guimarães FS, De Andrade TG, Deakin JF. 1996. Role of 5-HT in stress, anxiety, and depression. Pharmacol Biochem Behav. 54:129–141.
  • Gregory AO, Violetta K, John JM. 2002. Neurocircuitry of mood disorders. Neuropsychopharmacology. 73:1051–1064.
  • Hasler G, Drevets WC, Manji HK, Charney DS. 2004. Discovering endophenotypes for major depression. Neuropsychopharmacology. 29:1765–1781.
  • Hennessy MB, Levine S. 1979. Sensitive pituitary–adrenal responsiveness to varying intensities of psychological stimulation. Physiol Behav. 21 3: 295–297.
  • Herman JP, Cullinan WE. 1997. Neurocircuitry of stress: Central control of the hypothalamo–pituitary–adrenocortical axis. Trends Neurosci. 20:78–84.
  • Herman JP, Ostrander MM, Mueller NK, Figueiredo H. 2005. Limbic system mechanisms of stress regulation: Hypothalamo–pituitary–adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry. 29:1201–1213.
  • Inglis FM, Moghaddam B. 1999. Dopaminergic innervation of the amygdala is highly responsive to stress. J Neurochem. 72 3: 1088–1094.
  • Irie Y, Keung WM. 2003. Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-β peptide. Brain Res. 963:282–289.
  • Irie Y, Itokazu N, Anjiki N, Ishige A, Watanabe K, Keung WM. 2004. Eugenol exhibits antidepressant-like activity in mice and induces expression of metallothionein-III in the hippocampus. Brain Res. 1011 2: 243–246.
  • Jacobson L, Sapolsky R. 1991. The role of the hippocampus in feedback regulation of the hypothalamic–pituitary–adrenocortical axis. Endocr Rev. 12 2: 118–134.
  • Jankord R, Herman JP. 2008. Limbic regulation of hypothalamo–pituitary–adrenocortical function during acute and chronic stress. Ann N Y Acad Sci. 1148:64–73.
  • Joca SR, Ferreira FR, Guimarães FS. 2007. Modulation of stress consequences by hippocampal monoaminergic, glutamatergic and nitrergic neurotransmitter systems. Stress. 10:227–249.
  • Kim C, Speisky MB, Kharouba SN. 1987. Rapid and sensitive method for measuring norepinephrine, dopamine, 5-hydroxytryptamine and their major metabolites in rat brain by high-performance liquid chromatography. Differential effect of probenecid, haloperidol and yohimbine on the concentrations of biogenic amines and metabolites in various regions of rat brain. J Chromatogr. 386:25–35.
  • Kirby LG, Chou-Green JM, Davis K, Lucki I. 1997. The effects of different stressors on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res. 760 1–2: 218–230.
  • Koob GF. 1999. Stress, corticotropin-releasing factor, and drug addiction. Ann N Y Acad Sci. 897:27–45.
  • Kurata K, Tanii Y, Shibata R, Kurachi M. 1993. Differential effects of tight and loose 2-hour restraint stress on extracellular concentrations of dopamine in nucleus accumbens and anteromedial frontal cortex. Jpn J Psychiatr Neurol. 47 1: 57–61.
  • Kvetnanský R, Pacák K, Fukuhara K, Viskupic E, Hiremagalur B, Nankova B, Goldstein DS, Sabban EL, Kopin IJ. 1995. Sympathoadrenal system in stress: Interaction with the hypothalamic–pituitary–adrenocortical system. Ann N Y Acad Sci. 771:131–158.
  • Lowry OH, Rosenborough NJ, Farr AL, Randall RJ. 1951. Protein measurement with folin phenol reagent. J Biol Chem. 193:265–275.
  • Marinelli M, Piazza PV. 2002. Interaction between glucocorticoid hormones, stress and psychostimulant drugs. Eur J Neurosci. 16:387–394.
  • Maroun M, Richter-Levin G. 2003. Exposure to acute stress blocks the induction of long-term potentiation of the amygdala-prefrontal cortex pathway in vivo. J Neurosci. 23 11: 4406–4409.
  • McEwen BS. 2000. The neurobiology of stress: From serendipity to clinical relevance. Brain Res. 886 1–2: 172–189.
  • McQuade R, Stanford SC. 2000. A microdialysis study of the noradrenergic response in rat frontal cortex and hypothalamus to a conditioned cue for aversive, naturalistic environmental stimuli. Psychopharmacology. 148:201–208.
  • Mitchell SN, Thomas PJ. 1988. Effect of restraint stress and anxiolytics on 5-HT turnover in rat brain. Pharmacology. 37 2: 105–113.
  • Müller M, Pape HC, Speckmann EJ, Gorji A. 2006. Effect of eugenol on spreading depression and epileptiform discharges in rat neocortical and hippocampal tissues. Neuroscience. 140 2: 743–751.
  • Pacák K, Palkovits M, Kvetnanský R, Fukuhara K, Armando I, Kopin IJ, Goldstein DS. 1993. Effects of single or repeated immobilization on release of norepinephrine and its metabolites in the central nucleus of the amygdala in conscious rats. Neuroendocrinology. 57 4: 626–633.
  • Palkovits M, Brownstein MJ. 1988. Maps and guide to microdissection of the rat brain. New York: Elsevier.
  • Pfaff H. 2006. Health care research: The last mile in sight. Dtsch Med Wochenschr. 131 25-26: 1488–1490.
  • Phillips LJ, McGorry PD, Garner B, Thompson KN, Pantelis C, Wood SJ, Berger G. 2006. Stress, the hippocampus and the hypothalamic–pituitary–adrenal axis: Implications for the development of psychotic disorders. Aus N Z J Psychiatry. 40:725–741.
  • Popova NK, Gilinsky MA, Amstislavskaya TG, Morosova EA, Seif I, De Maeyer E. 2001. Regional serotonin metabolism in the brain of transgenic mice lacking monoamine oxidase A. J Neurosci Res. 66 3: 423–427.
  • Richardson JS. 1984. Brain part monoamines in the neuroendocrine mechanisms activated by immobilization stress in the rat. Int J Neurosci. 23 1: 57–67.
  • Sairam K, Priyambada S, Aryya NC, Goel RK. 2003. Gastroduodenal ulcer protective activity of Asparagus racemosus: An experimental, biochemical and histological study. J Ethnopharmacol. 86 1: 1–10.
  • Sapolsky RM, Krey LC, McEwen BS. 1986. The neuroendocrinology of stress and aging: The glucocorticoid cascade hypothesis. Endocr Rev. 7 3: 284–301.
  • Sastre B, Nicolay A, Bruguerolle B, Portugal H. 2004. Method for simultaneous measurement of norepinephrine, 3-methoxy-4-hydroxyphenylglycol and 3,4-dihydroxyphenylglycol by liquid chromatography with electrochemical detection: Application in rat cerebral cortex and plasma after lithium chloride treatment. J Chromatogr B Analyt Technol Biomed Life Sci. 801 2: 205–211.
  • Selye H. 1936. A Syndrome Produced by Diverse Nocuous Agents. Nature. 138:32.
  • Sen P, Maiti PC, Puri S, Ray A, Audulov NA, Valdman AV. 1992. Mechanism of anti-stress activity of Ocimum sanctum Linn, eugenol and Tinospora malabarica in experimental animals. Indian J Exp Biol. 30 7: 592–596.
  • Shah ZA, Gilani RA, Sharma P, Vohora SB. 2004. Attenuation of stress-elicited brain catecholamines, serotonin and plasma corticosterone levels by calcined gold preparations used in Indian system of medicine. Basic Clin Pharmacol Toxicol. 96:469–474.
  • Sheikh N, Ahmad A, Siripurapu KB, Kuchibhotla VK, Singh S, Palit G. 2007. Effect of Bacopa monniera on stress induced changes in plasma corticosterone and brain monoamines in rats. J Ethnopharmacol. 111:671–676.
  • Stevenson CW, Sullivan RM, Gratton A. 2003. Effects of basolateral amygdala dopamine depletion on the nucleus accumbens and medial prefrontal cortical dopamine responses to stress. Neuroscience. 116 1: 285–293.
  • Tao G, Irie Y, Li DJ, Keung WM. 2005. Eugenol and its structural analogs inhibit monoamine oxidase A and exhibit antidepressant-like activity. Bioorg Med Chem. 13 15: 4777–4788.
  • Van De Kar LD, Blair ML. 1999. Forebrain pathways mediating stress-induced hormone secretion. Front Neuroendocrinol. 20:1–48.
  • Varel VH, Miller DN. 2004. Plant oils thymol and eugenol affect cattle and swine waste emissions differently. Water Sci Technol. 50 4: 207–213.
  • Viljoen M, Panzer A. 2007. The central noradrenergic system: An overview. Afr J Psychiatry. 10:135–141.
  • Westerink BHC. 1985. Sequence and significance of dopamine metabolism in the rat-brain. Neurochem Int. 7:221–227.
  • Wie MB, Won MH, Lee KH, Shin JH, Lee JC, Suh HW, Song DK, Kim YH. 1997. Eugenol protects neuronal cells from excitotoxic and oxidative injury in primary cortical cultures. Neurosci Lett. 225 2: 93–96.
  • Won MH, Lee JC, Kim YH, Song DK, Suh HW, Oh YS, Kim JH, Shin TK, Lee YJ, Wie MB. 1998. Postischemic hypothermia induced by eugenol protects hippocampal neurons from global ischemia in gerbils. Neurosci Lett. 254 2: 101–104.
  • Woodward CJ, Emery PW. 1987. Determination of plasma corticosterone using high-performance liquid chromatography. J Chromatogr. 419:280–284.
  • Yazaki K. 1989. Study of behavioral pharmacology on rats. Tranquilizing effects induced by endogenous or exogenous bradykinin. Shikwa Gakuho. 89 10: 1529–1548.
  • Ziegler DR, Cass WA, Herman JP. 1999. Excitatory influence of the locus coeruleus in hypothalamic–pituitary–adrenocortical axis responses to stress. J Neuroendocrinol. 11:361–369.

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