Citations (166)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (9)
Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher & Vikas Kumar. (2020) An integrative translational framework for chemical induced neurotoxicity – a systematic review. Critical Reviews in Toxicology 50:5, pages 424-438.
Read now
Read now
Harvey J. Clewell$suffix/text()$suffix/text(), Jerry L. Campbell, Cynthia Van Landingham, Allison Franzen, Miyoung Yoon, Darol E. Dodd, Melvin E. Andersen & P. Robinan Gentry. (2019) Incorporation of in vitro metabolism data and physiologically based pharmacokinetic modeling in a risk assessment for chloroprene. Inhalation Toxicology 31:13-14, pages 468-483.
Read now
Read now
Laura Hedges, Susan Brown, A. Kenneth MacLeod, Audrey Vardy, Edward Doyle, Gina Song, Marjory Moreau, Miyoung Yoon, Thomas G. Osimitz & Brian G. Lake. (2019) Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes. Xenobiotica 49:5, pages 521-527.
Read now
Read now
Ulrika Carlander, Tshepo Paulsen Moto, Anteneh Assefa Desalegn, Robert A Yokel & Gunnar Johanson. (2018) Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics. International Journal of Nanomedicine 13, pages 2631-2646.
Read now
Read now
Virunya S. Bhat, M.E. (Bette) Meek, Mathieu Valcke, Caroline English, Alan Boobis & Richard Brown. (2017) Evolution of chemical-specific adjustment factors (CSAF) based on recent international experience; increasing utility and facilitating regulatory acceptance. Critical Reviews in Toxicology 47:9, pages 733-753.
Read now
Read now
C. M. Willson & O. Grundmann. (2017) In vitro assays in natural products research – a matter of concentration and relevance to in vivo administration using resveratrol, α-mangostin/γ-mangostin and xanthohumol as examples. Natural Product Research 31:5, pages 492-506.
Read now
Read now
Mirjam Luijten, Evelyn D. Olthof, Betty C. Hakkert, Emiel Rorije, Jan-Willem van der Laan, Ruud A. Woutersen & Jan van Benthem. (2016) An integrative test strategy for cancer hazard identification. Critical Reviews in Toxicology 46:7, pages 615-639.
Read now
Read now
Susan P. Felter, George P. Daston, Susan Y. Euling, Aldert H. Piersma & Melissa S. Tassinari. (2015) Assessment of health risks resulting from early-life exposures: Are current chemical toxicity testing protocols and risk assessment methods adequate?. Critical Reviews in Toxicology 45:3, pages 219-244.
Read now
Read now
Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
Read now
Read now
Articles from other publishers (157)
Harvey J. Clewell, Matthew W. Linakis & Miyoung Yoon. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology
513
519
.
Leona D. Scanlan & Svetlana E. Koshlukova. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology
499
511
.
Jacqueline Miller‐Holt, Holger Behrsing, Ian Crooks, Rodger Curren, Kubilay Demir, Jeremie Gafner, Gene Gillman, Michael Hollings, Robert Leverette, Michael Oldham, Liam Simms, Leon F. StankowskiJrJr, David Thorne, Roman Wieczorek & Martha M. Moore. (2022) Key challenges for in vitro testing of tobacco products for regulatory applications: Recommendations for dosimetry. Drug Testing and Analysis 15:10, pages 1175-1188.
Crossref
Crossref
Mina Jahandideh, Erfan Ebrahimi, Mohammad Hosein Farzaei & Ebrahim Barzegari. (2023) The effect of chronic lithium treatment on hippocampal progenitor cells: Transcriptomic analysis and systems pharmacology. Brain and Behavior.
Crossref
Crossref
Barnett A. Rattner, Thomas G. Bean, Val R. Beasley, Philippe Berny, Karen M. Eisenreich, John E. Elliott, Margaret L. Eng, Phyllis C. Fuchsman, Mason D. King, Rafael Mateo, Carolyn B. Meyer, Jason M. O'Brien & Christopher J. Salice. (2023) Wildlife ecological risk assessment in the 21st century: Promising technologies to assess toxicological effects. Integrated Environmental Assessment and Management.
Crossref
Crossref
Rebecca A. Clewell & Harvey J. ClewellIIIIII. 2003. Patty's Toxicology. Patty's Toxicology
1
18
.
Kai Huang, Wei Zhou, Jie Fu, Qun Zhang, Yunhe Teng, Luyao Gu, Yilin Fu, Boyuan Hu, Yang Mei, Haiyan Zhang, Aiqian Zhang, Jianjie Fu & Guibin Jiang. (2023) Linking Transthyretin-Binding Chemicals and Free Thyroid Hormones: In Vitro to In Vivo Extrapolation Based on a Competitive Binding Model. Environmental Science & Technology 57:25, pages 9130-9139.
Crossref
Crossref
Dunja Dimitrijevic, Eric Fabian, Dorothee Funk-Weyer & Robert Landsiedel. (2023) Rapid equilibrium dialysis, ultrafiltration or ultracentrifugation? Evaluation of methods to quantify the unbound fraction of substances in plasma. Biochemical and Biophysical Research Communications 651, pages 114-120.
Crossref
Crossref
Amith Sadananda Maroli & Robert Powers. (2021) Closing the gap between in vivo and in vitro omics: using QA/QC to strengthen ex vivo NMR metabolomics. NMR in Biomedicine 36:4.
Crossref
Crossref
Styliani Fragki, Aldert H. Piersma, Joost Westerhout, Anne Kienhuis, Nynke I. Kramer & Marco J. Zeilmaker. (2022) Applicability of generic PBK modelling in chemical hazard assessment: A case study with IndusChemFate. Regulatory Toxicology and Pharmacology 136, pages 105267.
Crossref
Crossref
Abdulkarim Najjar, Ans Punt, John Wambaugh, Alicia Paini, Corie Ellison, Styliani Fragki, Enrica Bianchi, Fagen Zhang, Joost Westerhout, Dennis Mueller, Hequn Li, Quan Shi, Timothy W. Gant, Phil Botham, Rémi Bars, Aldert Piersma, Ben van Ravenzwaay & Nynke I. Kramer. (2022) Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment. Archives of Toxicology 96:12, pages 3407-3419.
Crossref
Crossref
Rongrui Liu, Tim R. Zacharewski, Rory B. Conolly & Qiang Zhang. (2022) A Physiologically Based Pharmacokinetic (PBPK) Modeling Framework for Mixtures of Dioxin-like Compounds. Toxics 10:11, pages 700.
Crossref
Crossref
Marjory Moreau, Jeff Fisher, Melvin E. Andersen, Asayah Barnwell, Sage Corzine, Aarati Ranade, Patrick D. McMullen & Scott D. Slattery. (2022) NAM-based prediction of point-of-contact toxicity in the lung: A case example with 1,3-dichloropropene. Toxicology 481, pages 153340.
Crossref
Crossref
Jianing Hu, Yueyue Zhu, Jinwen Zhang, Yichi Xu, Jiayi Wu, Weihong Zeng, Yi Lin & Xiaorui Liu. (2022) The potential toxicity of polystyrene nanoplastics to human trophoblasts in vitro. Environmental Pollution 311, pages 119924.
Crossref
Crossref
Rebecca A. Clewell, Harvey J. ClewellIIIIII, Matthew W. Linakis, Charles A. EasleyIVIV, Jacqueline N. Langmo, Joshua Salley, Robinan Gentry & Thomas Rücker. (2022) An in vitro approach to determine the human relevance of anti-spermatogenic effects of 4-methylmorpholine 4-oxide, monohydrate (NMMO) in rat reproductive toxicity studies. Toxicology in Vitro 82, pages 105365.
Crossref
Crossref
Andrew C. Harris, Peter Muelken, Aleksandra Alcheva, Irina Stepanov & Mark G. LeSage. (2022) Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase in vitro and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats. Frontiers in Neuroscience 16.
Crossref
Crossref
Karolina Jagiello & Krzesimir Ciura. (2022)
In vitro
to
in vivo
extrapolation to support the development of the next generation risk assessment (NGRA) strategy for nanomaterials
. Nanoscale 14:18, pages 6735-6742.
Crossref
Crossref
Xiaoqing Chang, Yu-Mei Tan, David G. Allen, Shannon Bell, Paul C. Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti J. Hakkinen, Shruti V. Kabadi, Nicole C. Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather A. Pangburn, Elijah J. Petersen, Emily N. Reinke, Alexandre J. S. Ribeiro, Nisha Sipes, Lisa M. Sweeney, John F. Wambaugh, Ronald Wange, Barbara A. Wetmore & Moiz Mumtaz. (2022) IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making. Toxics 10:5, pages 232.
Crossref
Crossref
Hequn Li, Joe Reynolds, Ian Sorrell, David Sheffield, Ruth Pendlington, Richard Cubberley & Beate Nicol. (2022) PBK modelling of topical application and characterisation of the uncertainty of Cmax estimate: A case study approach. Toxicology and Applied Pharmacology 442, pages 115992.
Crossref
Crossref
Marjory Moreau, Pankajini Mallick, Marci Smeltz, Saad Haider, Chantel I. Nicolas, Salil N. Pendse, Jeremy A. Leonard, Matthew W. Linakis, Patrick D. McMullen, Rebecca A. Clewell, Harvey J. Clewell & Miyoung Yoon. (2022) Considerations for Improving Metabolism Predictions for In Vitro to In Vivo Extrapolation. Frontiers in Toxicology 4.
Crossref
Crossref
Romi Singh Maharjan, Ajay Vikram Singh, Javaria Hanif, Daniel Rosenkranz, Rashad Haidar, Amruta Shelar, Shubham Pratap Singh, Aditya Dey, Rajendra Patil, Paolo Zamboni, Peter Laux & Andreas Luch. (2022) Investigation of the Associations between a Nanomaterial’s Microrheology and Toxicology. ACS Omega 7:16, pages 13985-13997.
Crossref
Crossref
David E. Hines, Shannon Bell, Xiaoqing Chang, Kamel Mansouri, David Allen & Nicole Kleinstreuer. (2022) Application of an Accessible Interface for Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation. Frontiers in Pharmacology 13.
Crossref
Crossref
Nicola Antonio di Meo, Davide Loizzo, Savio Domenico Pandolfo, Riccardo Autorino, Matteo Ferro, Camillo Porta, Alessandro Stella, Cinzia Bizzoca, Leonardo Vincenti, Felice Crocetto, Octavian Sabin Tataru, Monica Rutigliano, Michele Battaglia, Pasquale Ditonno & Giuseppe Lucarelli. (2022) Metabolomic Approaches for Detection and Identification of Biomarkers and Altered Pathways in Bladder Cancer. International Journal of Molecular Sciences 23:8, pages 4173.
Crossref
Crossref
Fan Yu, Kathryn Rudd, Sarah Jean PourEdgar Trelles StickenOle DethloffRoman WieczorekThomas Nahde, Liam SimmsFiona ChapmanLukasz CzekalaMatthew Stevenson & Grant O'Connell. (2022)
Preclinical Assessment of Tobacco-Free Nicotine Pouches Demonstrates Reduced
In Vitro
Toxicity Compared with Tobacco Snus and Combustible Cigarette Smoke
. Applied In Vitro Toxicology 8:1, pages 24-35.
Crossref
Crossref
George Loizou, Kevin McNally, Alicia Paini & Alex Hogg. (2022) Derivation of a Human In Vivo Benchmark Dose for Bisphenol A from ToxCast In Vitro Concentration Response Data Using a Computational Workflow for Probabilistic Quantitative In Vitro to In Vivo Extrapolation. Frontiers in Pharmacology 12.
Crossref
Crossref
Abdulkarim Najjar, Andreas Schepky, Christopher-Tilman Krueger, Matthew Dent, Sophie Cable, Hequn Li, Sebastien Grégoire, Laurene Roussel, Audrey Noel-Voisin, Nicola J. Hewitt & Estefania Cardamone. (2022) Use of Physiologically-Based Kinetics Modelling to Reliably Predict Internal Concentrations of the UV Filter, Homosalate, After Repeated Oral and Topical Application. Frontiers in Pharmacology 12.
Crossref
Crossref
Ewa Bednarczyk, Yanfei Lu, Alicia Paini, Sofia Batista Leite, Leo A. van Grunsven, Andrew Worth & Maurice Whelan. (2022) Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model. Alternatives to Laboratory Animals 50:1, pages 45-56.
Crossref
Crossref
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology
593
623
.
Yu-Mei Tan, Hugh A. Barton, Alan Boobis, Rachel Brunner, Harvey Clewell, Rhian Cope, Jeffrey Dawson, Jeanne Domoradzki, Peter Egeghy, Pankaj Gulati, Brandall Ingle, Nicole Kleinstreuer, Kelly Lowe, Anna Lowit, Elizabeth Mendez, David Miller, Jeffrey Minucci, James Nguyen, Alicia Paini, Monique Perron, Katherine Phillips, Hua Qian, Tharacad Ramanarayanan, Fiona Sewell, Philip Villanueva, John Wambaugh & Michelle Embry. (2021) Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment. Regulatory Toxicology and Pharmacology 127, pages 105070.
Crossref
Crossref
Lara M. Schuijt, Feng-Jiao Peng, Sanne J.P. van den Berg, Milou M.L. Dingemans & Paul J. Van den Brink. (2021) (Eco)toxicological tests for assessing impacts of chemical stress to aquatic ecosystems: Facts, challenges, and future. Science of The Total Environment 795, pages 148776.
Crossref
Crossref
Yaoxing Wu, Zidong Song, John C. Little, Min Zhong, Hongwan Li & Ying Xu. (2021) An integrated exposure and pharmacokinetic modeling framework for assessing population-scale risks of phthalates and their substitutes. Environment International 156, pages 106748.
Crossref
Crossref
Alish B. Palmos, Rodrigo R. R. Duarte, Demelza M. Smeeth, Erin C. Hedges, Douglas F. Nixon, Sandrine Thuret & Timothy R. Powell. (2021) Lithium treatment and human hippocampal neurogenesis. Translational Psychiatry 11:1.
Crossref
Crossref
Gulsah Dogruer, Nynke I. Kramer, Iris L. Schaap, Henner Hollert, Caroline Gaus & Jason P. van de Merwe. (2021) An integrative approach to define chemical exposure threshold limits for endangered sea turtles. Journal of Hazardous Materials 420, pages 126512.
Crossref
Crossref
Alan Valdiviezo, Yu-Syuan Luo, Zunwei Chen, Weihsueh A Chiu & Ivan Rusyn. (2021)
Quantitative
In Vitro
-to-
In Vivo
Extrapolation for Mixtures: A Case Study of Superfund Priority List Pesticides
. Toxicological Sciences 183:1, pages 60-69.
Crossref
Crossref
Hequn Li, Haitao Yuan, Alistair Middleton, Jin Li, Beate Nicol, Paul Carmichael, Jiabin Guo, Shuangqing Peng & Qiang Zhang. (2021) Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling – A case study of doxorubicin with dose metrics considerations. Toxicology in Vitro 74, pages 105171.
Crossref
Crossref
Sherry R. Black, John W. Nichols, Kellie A. Fay, Sharlene R. Matten & Scott G. Lynn. (2021) Evaluation and comparison of in vitro intrinsic clearance rates measured using cryopreserved hepatocytes from humans, rats, and rainbow trout. Toxicology 457, pages 152819.
Crossref
Crossref
Francesca Pistollato, Federica Madia, Raffaella Corvi, Sharon Munn, Elise Grignard, Alicia Paini, Andrew Worth, Anna Bal-Price, Pilar Prieto, Silvia Casati, Elisabet Berggren, Stephanie K Bopp & Valérie Zuang. (2021) Current EU regulatory requirements for the assessment of chemicals and cosmetic products: challenges and opportunities for introducing new approach methodologies. Archives of Toxicology 95:6, pages 1867-1897.
Crossref
Crossref
Luise Henneberger, Julia Huchthausen, Niklas Wojtysiak & Beate I. Escher. (2021)
Quantitative
In Vitro
-to-
In Vivo
Extrapolation: Nominal versus Freely Dissolved Concentration
. Chemical Research in Toxicology 34:4, pages 1175-1182.
Crossref
Crossref
Hanumantha Rao Balaji Raghavendran, Elango Natarajan, Saktiswaren Mohan, Genasan Krishnamurithy, Malliga Raman Murali, S. Parasuraman, Simmrat Singh & Tunku Kamarul. (2021) The functionalization of the electrospun PLLA fibrous scaffolds reduces the hydrogen peroxide induced cytokines secretion in vitro. Materials Today Communications 26, pages 101812.
Crossref
Crossref
Ans Punt, Nicole Pinckaers, Ad Peijnenburg & Jochem Louisse. (2020) Development of a Web-Based Toolbox to Support Quantitative In-Vitro-to-In-Vivo Extrapolations (QIVIVE) within Nonanimal Testing Strategies. Chemical Research in Toxicology 34:2, pages 460-472.
Crossref
Crossref
Sebastian Lungu-Mitea, Carolina Vogs, Gunnar Carlsson, Maximiliane Montag, Kim Frieberg, Agneta Oskarsson & Johan Lundqvist. (2020) Modeling Bioavailable Concentrations in Zebrafish Cell Lines and Embryos Increases the Correlation of Toxicity Potencies across Test Systems. Environmental Science & Technology 55:1, pages 447-457.
Crossref
Crossref
Ying Shao, Andreas Schiwy, Lisa Glauch, Luise Henneberger, Maria König, Marie Mühlenbrink, Hongxia Xiao, Beat Thalmann, Rita Schlichting, Henner Hollert & Beate I. Escher. (2020) Optimization of a pre-metabolization procedure using rat liver S9 and cell-extracted S9 in the Ames fluctuation test. Science of The Total Environment 749, pages 141468.
Crossref
Crossref
Chantel I. Nicolas, Kevin Bronson, Salil N. Pendse, Alina Efremenko, Jeremy M. Fitzpatrick, Melyssa S. Minto, Kamel Mansouri, Miyoung Yoon, Martin B. Phillips, Rebecca A. Clewell, Melvin E. Andersen, Harvey J. ClewellIIIIII & Patrick D. McMullen. (2020) The TTC Data Mart: An interactive browser for threshold of toxicological concern calculations. Computational Toxicology 15, pages 100128.
Crossref
Crossref
Paul A. Walker, Stephanie Ryder, Andrea Lavado, Clive Dilworth & Robert J. Riley. (2020) The evolution of strategies to minimise the risk of human drug-induced liver injury (DILI) in drug discovery and development. Archives of Toxicology 94:8, pages 2559-2585.
Crossref
Crossref
Yitong Liu, Mapa S.T. Mapa & Robert L. Sprando. (2020) Liver toxicity of anthraquinones: A combined in vitro cytotoxicity and in silico reverse dosimetry evaluation. Food and Chemical Toxicology 140, pages 111313.
Crossref
Crossref
Courtney Perry, Grace Davis, Todd M. Conner & Tao Zhang. (2020) Utilization of Physiologically Based Pharmacokinetic Modeling in Clinical Pharmacology and Therapeutics: an Overview. Current Pharmacology Reports 6:3, pages 71-84.
Crossref
Crossref
Paulette Clancy. (2020) Balancing Multiple Goals and Making It Work for Materials Research. ACS Central Science 6:4, pages 464-466.
Crossref
Crossref
Jose Zavala, Anastasia N. Freedman, John T. Szilagyi, Ilona Jaspers, John F. Wambaugh, Mark Higuchi & Julia E. Rager. (2020) New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing. International Journal of Environmental Research and Public Health 17:6, pages 2124.
Crossref
Crossref
Thomas E. Moxon, Hequn Li, Mi-Young Lee, Przemyslaw Piechota, Beate Nicol, Juliette Pickles, Ruth Pendlington, Ian Sorrell & Maria Teresa Baltazar. (2020) Application of physiologically based kinetic (PBK) modelling in the next generation risk assessment of dermally applied consumer products. Toxicology in Vitro 63, pages 104746.
Crossref
Crossref
Qiang Li, Heng Dong, Guangwen Yang, Yuxian Song, Yongbin Mou & Yanhong Ni. (2020) Mouse Tumor-Bearing Models as Preclinical Study Platforms for Oral Squamous Cell Carcinoma. Frontiers in Oncology 10.
Crossref
Crossref
Salil N. Pendse, Alina Efremenko, C. Eric Hack, Marjory Moreau, Pankajini Mallick, Michael Dzierlenga, Chantel I. Nicolas, Miyoung Yoon, Harvey J. Clewell & Patrick D. McMullen. (2020) Population Life-course exposure to health effects model (PLETHEM): An R package for PBPK modeling. Computational Toxicology 13, pages 100115.
Crossref
Crossref
Pankajini Mallick, Marjory Moreau, Gina Song, Alina Y Efremenko, Salil N Pendse, Moire R Creek, Thomas G Osimitz, Ronald N Hines, Paul Hinderliter, Harvey J Clewell, Brian G Lake & Miyoung Yoon. (2020) Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans. Toxicological Sciences 173:1, pages 86-99.
Crossref
Crossref
Miyoung Yoon. 2020. Physiologically Based Pharmacokinetic (PBPK) Modeling. Physiologically Based Pharmacokinetic (PBPK) Modeling
301
321
.
Zhoumeng Lin, Yi-Hsien Cheng, Wei-Chun Chou & Miao Li. 2020. Physiologically Based Pharmacokinetic (PBPK) Modeling. Physiologically Based Pharmacokinetic (PBPK) Modeling
243
279
.
Ling Jin, Guibin Jiang & Xiangdong Li. 2020. A New Paradigm for Environmental Chemistry and Toxicology. A New Paradigm for Environmental Chemistry and Toxicology
263
276
.
Miyoung Yoon, Gina Song, Harvey Clewell & Bas Blaauboer. 2019. Big Data in Predictive Toxicology. Big Data in Predictive Toxicology
331
358
.
Marjory Moreau & Andy Nong. (2019) Evaluating hexabromocyclododecane (HBCD) toxicokinetics in humans and rodents by physiologically based pharmacokinetic modeling. Food and Chemical Toxicology 133, pages 110785.
Crossref
Crossref
Jeremy A. Leonard & Yu-Mei Tan. (2019) Tiered approaches for screening and prioritizing chemicals through integration of pharmacokinetics and exposure information with in vitro dose-response data. Computational Toxicology 12, pages 100101.
Crossref
Crossref
Krittika Mittal, Doug Crump & Niladri Basu. (2019) A comparative study of 3 alternative avian toxicity testing methods: Effects on hepatic gene expression in the chicken embryo. Environmental Toxicology and Chemistry 38:11, pages 2546-2555.
Crossref
Crossref
Kyle C. Ferguson, Yu-Syuan Luo, Ivan Rusyn & Weihsueh A. Chiu. (2019) Comparative analysis of Rapid Equilibrium Dialysis (RED) and solid phase micro-extraction (SPME) methods for In Vitro-In Vivo extrapolation of environmental chemicals. Toxicology in Vitro 60, pages 245-251.
Crossref
Crossref
Anne Marie Gannon, Marjory Moreau, Reza Farmahin, Russell S. Thomas, Tara S. Barton-Maclaren, Andy Nong, Ivan Curran & Carole L. Yauk. (2019) Hexabromocyclododecane (HBCD): A case study applying tiered testing for human health risk assessment. Food and Chemical Toxicology 131, pages 110581.
Crossref
Crossref
Patrick D. McMullen, Salil N. Pendse, Michael B. Black, Kamel Mansouri, Saad Haider, Melvin E. Andersen & Rebecca A. Clewell. (2019) Addressing systematic inconsistencies between in vitro and in vivo transcriptomic mode of action signatures. Toxicology in Vitro 58, pages 1-12.
Crossref
Crossref
Nichola Gellatly & Fiona Sewell. (2019) Regulatory acceptance of in silico approaches for the safety assessment of cosmetic-related substances. Computational Toxicology 11, pages 82-89.
Crossref
Crossref
Ans Punt, Aafke Aartse, Toine F. H. Bovee, Arjen Gerssen, Stefan P. J. van Leeuwen, Ron L. A. P. Hoogenboom & Ad A. C. M. Peijnenburg. (2019) Quantitative in vitro-to-in vivo extrapolation (QIVIVE) of estrogenic and anti-androgenic potencies of BPA and BADGE analogues. Archives of Toxicology 93:7, pages 1941-1953.
Crossref
Crossref
Gina Song, Marjory Moreau, Alina Efremenko, Brian G Lake, Huali Wu, James V Bruckner, Catherine A White, Thomas G Osimitz, Moire R Creek, Paul M Hinderliter, Harvey J Clewell & Miyoung Yoon. (2019) Evaluation of Age-Related Pyrethroid Pharmacokinetic Differences in Rats: Physiologically-Based Pharmacokinetic Model Development Using In Vitro Data and In Vitro to In Vivo Extrapolation. Toxicological Sciences 169:2, pages 365-379.
Crossref
Crossref
Marco E. Franco & Ramon Lavado. (2019) Applicability of in vitro methods in evaluating the biotransformation of polycyclic aromatic hydrocarbons (PAHs) in fish: Advances and challenges. Science of The Total Environment 671, pages 685-695.
Crossref
Crossref
Heather L. Ciallella & Hao Zhu. (2019) Advancing Computational Toxicology in the Big Data Era by Artificial Intelligence: Data-Driven and Mechanism-Driven Modeling for Chemical Toxicity. Chemical Research in Toxicology 32:4, pages 536-547.
Crossref
Crossref
Daniel P. Russo, Judy Strickland, Agnes L. Karmaus, Wenyi Wang, Sunil Shende, Thomas Hartung, Lauren M. Aleksunes & Hao Zhu. (2019) Nonanimal Models for Acute Toxicity Evaluations: Applying Data-Driven Profiling and Read-Across. Environmental Health Perspectives 127:4.
Crossref
Crossref
Barbara A. Wetmore, Rebecca A. Clewell, Brian Cholewa, Bethany Parks, Salil N. Pendse, Michael B. Black, Kamel Mansouri, Saad Haider, Ellen L. Berg, Richard S. Judson, Keith A. Houck, Matthew Martin, Harvey J. ClewellIIIIII, Melvin E. Andersen, Russell S. Thomas & Patrick D. McMullen. (2019) Assessing bioactivity-exposure profiles of fruit and vegetable extracts in the BioMAP profiling system. Toxicology in Vitro 54, pages 41-57.
Crossref
Crossref
A. Paini, J.A. Leonard, E. Joossens, J.G.M. Bessems, A. Desalegn, J.L. Dorne, J.P. Gosling, M.B. Heringa, M. Klaric, T. Kliment, N.I. Kramer, G. Loizou, J. Louisse, A. Lumen, J.C. Madden, E.A. Patterson, S. Proença, A. Punt, R.W. Setzer, N. Suciu, J. Troutman, M. Yoon, A. Worth & Y.M. Tan. (2019) Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making. Computational Toxicology 9, pages 61-72.
Crossref
Crossref
Daniela Rodrigues, Joana Pinto, Ana Araújo, Carmen Jerónimo, Rui Henrique, Maria Bastos, Paula Guedes de Pinho & Márcia Carvalho. (2019) GC-MS Metabolomics Reveals Distinct Profiles of Low- and High-Grade Bladder Cancer Cultured Cells. Metabolites 9:1, pages 18.
Crossref
Crossref
Mark T.D. Cronin & Miyoung Yoon. 2019. The History of Alternative Test Methods in Toxicology. The History of Alternative Test Methods in Toxicology
287
300
.
Ângelo C. Salvador, Ricardo J. R. Guilherme, Armando J. D. Silvestre & Sílvia M. Rocha. 2019. Bioactive Molecules in Food. Bioactive Molecules in Food
2261
2295
.
Zhongyu Wang & Jingwen Chen. 2019. Advances in Computational Toxicology. Advances in Computational Toxicology
15
36
.
Qiang Zhang, Jin Li, Alistair Middleton, Sudin Bhattacharya & Rory B. Conolly. (2018) Bridging the Data Gap From in vitro Toxicity Testing to Chemical Safety Assessment Through Computational Modeling. Frontiers in Public Health 6.
Crossref
Crossref
Martin B. PhillipsPergentino Balbuena-VenancioJeffrey R. EndersRachel L. NoriniYoo-Sik ShimErin BurgunderLavanya RaoDavid BillingsJenny PedersenJeffrey M. MacdonaldMelvin AndersenHarvey J. ClewellIIIIIIMiyoung Yoon. (2018) Xenobiotic Metabolism in Alginate-Encapsulated Primary Human Hepatocytes Over Long Timeframes. Applied In Vitro Toxicology 4:3, pages 238-247.
Crossref
Crossref
D. Gholobova, M. Gerard, L. Decroix, L. Desender, N. Callewaert, P. Annaert & L. Thorrez. (2018) Human tissue-engineered skeletal muscle: a novel 3D in vitro model for drug disposition and toxicity after intramuscular injection. Scientific Reports 8:1.
Crossref
Crossref
John F Wambaugh, Michael F Hughes, Caroline L Ring, Denise K MacMillan, Jermaine Ford, Timothy R Fennell, Sherry R Black, Rodney W Snyder, Nisha S Sipes, Barbara A Wetmore, Joost Westerhout, R Woodrow Setzer, Robert G Pearce, Jane Ellen Simmons & Russell S Thomas. (2018) Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. Toxicological Sciences 163:1, pages 152-169.
Crossref
Crossref
Amy J. Clippinger, David Allen, Annie M. Jarabek, Marco Corvaro, Marianna Gaça, Sean Gehen, Jon A. Hotchkiss, Grace Patlewicz, Jodie Melbourne, Paul Hinderliter, Miyoung Yoon, Dongeun Huh, Anna Lowit, Barbara Buckley, Michael Bartels, Kelly BéruBé, Daniel M. Wilson, Ian Indans & Mathieu Vinken. (2018) Alternative approaches for acute inhalation toxicity testing to address global regulatory and non-regulatory data requirements: An international workshop report. Toxicology in Vitro 48, pages 53-70.
Crossref
Crossref
Ans Punt, Hans Bouwmeester, Marie-Jeanne W.A. Schiffelers & Ad A.C.M. Peijnenburg. (2018) Expert opinions on the acceptance of alternative methods in food safety evaluations: Formulating recommendations to increase acceptance of non-animal methods for kinetics. Regulatory Toxicology and Pharmacology 92, pages 145-151.
Crossref
Crossref
Aldert H. Piersma, Jan van Benthem, Janine Ezendam & Anne S. Kienhuis. (2018) Validation redefined. Toxicology in Vitro 46, pages 163-165.
Crossref
Crossref
Cory L. Strope, Kamel Mansouri, Harvey J. ClewellIIIIII, James R. Rabinowitz, Caroline Stevens & John F. Wambaugh. (2018) High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling. Science of The Total Environment 615, pages 150-160.
Crossref
Crossref
Jorge M. Naciff. 2018. In Vitro Toxicology. In Vitro Toxicology
111
126
.
J.P. Bressler, A. Maertens & P Locke. 2018. Comprehensive Toxicology. Comprehensive Toxicology
119
126
.
Ângelo C. Salvador, Ricardo J. R. Guilherme, Armando J. D. Silvestre & Sílvia M. Rocha. 2017. Sweeteners. Sweeteners
1
35
.
Francois Pognan. 2018. Drug-Induced Liver Toxicity. Drug-Induced Liver Toxicity
21
43
.
J.V. Sala Benito, Alicia Paini, Andrea-Nicole Richarz, Thorsten Meinl, Michael R. Berthold, Mark T.D. Cronin & Andrew P. Worth. (2017) Automated workflows for modelling chemical fate, kinetics and toxicity. Toxicology in Vitro 45, pages 249-257.
Crossref
Crossref
Gabriella F. Schirinzi, Ignacio Pérez-Pomeda, Josep Sanchís, Cesare Rossini, Marinella Farré & Damià Barceló. (2017) Cytotoxic effects of commonly used nanomaterials and microplastics on cerebral and epithelial human cells. Environmental Research 159, pages 579-587.
Crossref
Crossref
Shweta Sinha, Phulen Sarma, Rakesh Sehgal & Bikash Medhi. (2017) Development in Assay Methods for in Vitro Antimalarial Drug Efficacy Testing: A Systematic Review. Frontiers in Pharmacology 8.
Crossref
Crossref
Weixiao Cheng & Carla A. Ng. (2017) A Permeability-Limited Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctanoic acid (PFOA) in Male Rats. Environmental Science & Technology 51:17, pages 9930-9939.
Crossref
Crossref
Ksenia J. Groh & Jane Muncke. (2017)
In Vitro
Toxicity Testing of Food Contact Materials: State-of-the-Art and Future Challenges
. Comprehensive Reviews in Food Science and Food Safety 16:5, pages 1123-1150.
Crossref
Crossref
JuKyung Lee, SuRyon Shin, Anna Desalvo, Geonhui Lee, Jeong Yoon Lee, Alessandro Polini, Sukyoung Chae, Hobin Jeong, Jonghan Kim, Haksoo Choi & HeaYeon Lee. (2017) Nonmediated, Label-Free Based Detection of Cardiovascular Biomarker in a Biological Sample. Advanced Healthcare Materials 6:17, pages 1700231.
Crossref
Crossref
Paul A. Lapchak & John H. Zhang. (2016) The High Cost of Stroke and Stroke Cytoprotection Research. Translational Stroke Research 8:4, pages 307-317.
Crossref
Crossref
Jessica LundqvistChristina SvenssonKristina AttoffAnna Forsby. (2017) Altered mRNA Expression and Cell Membrane Potential in the Differentiated C17.2 Cell Model as Indicators of Acute Neurotoxicity. Applied In Vitro Toxicology 3:2, pages 154-162.
Crossref
Crossref
Frank A.P.C. Gobas, S.Victoria Otton, Laura F. Tupper-Ring, Meara A. Crawford, Kathryn E. Clark & Michael G. Ikonomou. (2017) Chemical activity-based environmental risk analysis of the plasticizer di-ethylhexyl phthalate and its main metabolite mono-ethylhexyl phthalate. Environmental Toxicology and Chemistry 36:6, pages 1483-1492.
Crossref
Crossref
Fabian C. Fischer, Luise Henneberger, Maria König, Kai Bittermann, Lukas Linden, Kai-Uwe Goss & Beate I. Escher. (2017)
Modeling Exposure in the Tox21
in Vitro
Bioassays
. Chemical Research in Toxicology 30:5, pages 1197-1208.
Crossref
Crossref
Gina Song, Xueying Sun, Ronald N. Hines, D. Gail McCarver, Brian G. Lake, Thomas G. Osimitz, Moire R. Creek, Harvey J. Clewell & Miyoung Yoon. (2017) Determination of Human Hepatic CYP2C8 and CYP1A2 Age-Dependent Expression to Support Human Health Risk Assessment for Early Ages. Drug Metabolism and Disposition 45:5, pages 468-475.
Crossref
Crossref
Anxo Fernández-FerreiroMaría Santiago-VarelaMaría Gil-MartínezMiguel González-BarciaAndrea Luaces-RodríguezVictoria Díaz-TomeMaría PardoJosé Blanco MéndezAntonio Piñeiro-CesMaría Teresa Rodríguez-AresMaria Jesus LamasFrancisco J. Otero-Espinar. (2017)
In Vitro
Evaluation of the Ophthalmic Toxicity Profile of Chlorhexidine and Propamidine Isethionate Eye Drops
. Journal of Ocular Pharmacology and Therapeutics 33:3, pages 202-209.
Crossref
Crossref
Jochem Louisse, Karsten Beekmann & Ivonne M.C.M. Rietjens. (2016) Use of Physiologically Based Kinetic Modeling-Based Reverse Dosimetry to Predict in Vivo Toxicity from in Vitro Data. Chemical Research in Toxicology 30:1, pages 114-125.
Crossref
Crossref
Paul A. Lapchak & Paul D. Boitano. 2017. Neuroprotective Therapy for Stroke and Ischemic Disease. Neuroprotective Therapy for Stroke and Ischemic Disease
3
71
.
Martin Wagner, Cornelia Kienle, Etiënne L. M. Vermeirssen & Jörg Oehlmann. 2017. In vitro Environmental Toxicology - Concepts, Application and Assessment. In vitro Environmental Toxicology - Concepts, Application and Assessment
1
58
.
Alexander Gosslau. 2016. Food Toxicology. Food Toxicology
11
34
.
N. Michel, M. Freese, M. Brinkmann, J.-D. Pohlmann, H. Hollert, U. Kammann, M. Haarich, N. Theobald, W. Gerwinski, W. Rotard & R. Hanel. (2016) Fipronil and two of its transformation products in water and European eel from the river Elbe. Science of The Total Environment 568, pages 171-179.
Crossref
Crossref
Delyan P. Ivanov, Beth Coyle, David A. Walker & Anna M. Grabowska. (2016) In vitro models of medulloblastoma: Choosing the right tool for the job. Journal of Biotechnology 236, pages 10-25.
Crossref
Crossref
Harish K. Handral, Huei Jinn Tong, Intekhab Islam, Gopu Sriram, Vinicus Rosa & Tong Cao. (2016)
Pluripotent stem cells: An
in vitro
model for nanotoxicity assessments
. Journal of Applied Toxicology 36:10, pages 1250-1258.
Crossref
Crossref
Ahmad Rezaei Kolahchi, Nima Khadem Mohtaram, Hassan Pezeshgi Modarres, Mohammad Mohammadi, Armin Geraili, Parya Jafari, Mohsen Akbari & Amir Sanati-Nezhad. (2016) Microfluidic-Based Multi-Organ Platforms for Drug Discovery. Micromachines 7:9, pages 162.
Crossref
Crossref
Alexander Gosslau. (2016) Assessment of food toxicology. Food Science and Human Wellness 5:3, pages 103-115.
Crossref
Crossref
Daniela Rodrigues, Carmen Jerónimo, Rui Henrique, Luís Belo, Maria de Lourdes Bastos, Paula Guedes de Pinho & Márcia Carvalho. (2016)
Biomarkers in bladder cancer: A metabolomic approach using
in vitro
and
ex vivo
model systems
. International Journal of Cancer 139:2, pages 256-268.
Crossref
Crossref
Alexander V. LyubimovCarolina Garcia‐Canton & Emmanuel Minet. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions
1
31
.
John W. Wills, George E. Johnson, Shareen H. Doak, Lya G. Soeteman-Hernández, Wout Slob & Paul A. White. (2016)
Empirical analysis of BMD metrics in genetic toxicology part I:
in vitro
analyses to provide robust potency rankings and support MOA determinations
. Mutagenesis 31:3, pages 255-263.
Crossref
Crossref
Bas J. Blaauboer, Alan R. Boobis, Bobbie Bradford, Andrew Cockburn, Anne Constable, Mardas Daneshian, Gareth Edwards, Jossie A. Garthoff, Brett Jeffery, Cyrille Krul & Jeroen Schuermans. (2016) Considering new methodologies in strategies for safety assessment of foods and food ingredients. Food and Chemical Toxicology 91, pages 19-35.
Crossref
Crossref
Patrick Poulin. 2016. Drug Discovery Toxicology. Drug Discovery Toxicology
67
81
.
Martijn J. Wilmer, Chee Ping Ng, Henriëtte L. Lanz, Paul Vulto, Laura Suter-Dick & Rosalinde Masereeuw. (2016) Kidney-on-a-Chip Technology for Drug-Induced Nephrotoxicity Screening. Trends in Biotechnology 34:2, pages 156-170.
Crossref
Crossref
Patrick Poulin, Frank J. Burczynski & Sami Haddad. (2016) The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro -to- In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research. Journal of Pharmaceutical Sciences 105:2, pages 497-508.
Crossref
Crossref
Miyoung Yoon & Harvey J. Clewell. (2016) Addressing Early Life Sensitivity Using Physiologically Based Pharmacokinetic Modeling and In Vitro to In Vivo Extrapolation. Toxicological Research 32:1, pages 15-20.
Crossref
Crossref
Birendra Kumar SinghSeok Hoon ParkHyang-Bok LeeYoung-Aae GooHyoung Shik KimSeung Hee ChoJeong Hun LeeGhe Whan AhnJin Pyo KimSu Myoung KangEun-Ki Kim. (2016) Kojic Acid Peptide: A New Compound with Anti-Tyrosinase Potential. Annals of Dermatology 28:5, pages 555.
Crossref
Crossref
Kunal Roy & Supratik Kar. 2016. In Silico Methods for Predicting Drug Toxicity. In Silico Methods for Predicting Drug Toxicity
237
304
.
Markus Brinkmann, Thomas G. Preuss & Henner Hollert. 2017. In vitro Environmental Toxicology - Concepts, Application and Assessment. In vitro Environmental Toxicology - Concepts, Application and Assessment
293
317
.
Mauro Fà, Hong Zhang, Agnieszka Staniszewski, Faisal Saeed, Li W. Shen, Isaac T. Schiefer, Marton I. Siklos, Subhasish Tapadar, Vladislav A. Litosh, Jenny Libien, Pavel A. Petukhov, Andrew F. Teich, Gregory R.J. Thatcher & Ottavio Arancio. (2015) Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease. Journal of Alzheimer's Disease 49:3, pages 707-721.
Crossref
Crossref
Jessica J.W. Broeders, Joop L.M. Hermens, Bas J. Blaauboer & Marie-Gabrielle Zurich. (2015) The in vitro biokinetics of chlorpromazine and diazepam in aggregating rat brain cell cultures after repeated exposure. Toxicology in Vitro 30:1, pages 185-191.
Crossref
Crossref
Markus Brinkmann, Marko Freese, Jan-Dag Pohlmann, Ulrike Kammann, Thomas G. Preuss, Sebastian Buchinger, Georg Reifferscheid, Anne Beiermeister, Reinhold Hanel & Henner Hollert. (2015) A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel ( Anguilla anguilla ). Science of The Total Environment 536, pages 279-287.
Crossref
Crossref
Yuri Dancik, Paul L. Bigliardi & Mei Bigliardi-Qi. (2015) What happens in the skin? Integrating skin permeation kinetics into studies of developmental and reproductive toxicity following topical exposure. Reproductive Toxicology 58, pages 252-281.
Crossref
Crossref
Elaina M. Kenyon & Harvey J. ClewellIIIIII. 2015. Arsenic. Arsenic
495
509
.
Sieto Bosgra & Joost Westerhout. (2015) Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics. Reproductive Toxicology 55, pages 73-80.
Crossref
Crossref
Elisa C.M. Tonk, Jeroen L.A. Pennings & Aldert H. Piersma. (2015) An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis. Reproductive Toxicology 55, pages 104-113.
Crossref
Crossref
Jerry Campbell, Cynthia Van Landingham, Susan Crowell, Robinan Gentry, Debra Kaden, Stacy Fiebelkorn, Anne Loccisano & Harvey Clewell. (2015) A preliminary regional PBPK model of lung metabolism for improving species dependent descriptions of 1,3-butadiene and its metabolites. Chemico-Biological Interactions 238, pages 102-110.
Crossref
Crossref
Lars Ole Schwen, Arne Schenk, Clemens Kreutz, Jens Timmer, María Matilde Bartolomé Rodríguez, Lars Kuepfer & Tobias Preusser. (2015) Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations. PLOS ONE 10:7, pages e0133653.
Crossref
Crossref
Patrick Poulin. (2015) A Paradigm Shift in Pharmacokinetic–Pharmacodynamic (PKPD) Modeling: Rule of Thumb for Estimating Free Drug Level in Tissue Compared with Plasma to Guide Drug Design. Journal of Pharmaceutical Sciences 104:7, pages 2359-2368.
Crossref
Crossref
Katherine von Stackelberg, Elizabeth Guzy, Tian Chu & Birgit Claus Henn. (2015) Exposure to Mixtures of Metals and Neurodevelopmental Outcomes: A Multidisciplinary Review Using an Adverse Outcome Pathway Framework. Risk Analysis 35:6, pages 971-1016.
Crossref
Crossref
Laura Suter-DickPaula M. AlvesBas J. BlaauboerKlaus-Dieter BremmCatarina BritoSandra CoeckeBurkhard FlickPaul FowlerJürgen HeschelerMagnus Ingelman-SundbergPaul JenningsJens M. KelmIrene ManouPratibha MistryAngelo MorettoAdrian RothDonald StedmanBob van de WaterMario Beilmann. (2015) Stem Cell-Derived Systems in Toxicology Assessment. Stem Cells and Development 24:11, pages 1284-1296.
Crossref
Crossref
Kevin McNally, Richard Cotton, Alex Hogg & George Loizou. (2015) Reprint of PopGen: A virtual human population generator. Toxicology 332, pages 77-93.
Crossref
Crossref
Iwona Wilk-Zasadna, Camilla Bernasconi, Olavi Pelkonen & Sandra Coecke. (2015) Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data. Toxicology 332, pages 8-19.
Crossref
Crossref
Miyoung Yoon, Gregory L. Kedderis, Grace Zhixia Yan & Harvey J. ClewellIIIIII. (2015) Use of in vitro data in developing a physiologically based pharmacokinetic model: Carbaryl as a case study. Toxicology 332, pages 52-66.
Crossref
Crossref
Michael Gülden, Jeannine Schreiner & Hasso Seibert. (2015) In vitro toxicity testing with microplate cell cultures: Impact of cell binding. Toxicology 332, pages 41-51.
Crossref
Crossref
M.-E. Willemin, A. Kadar, G. de Sousa, E. Leclerc, R. Rahmani & C. Brochot. (2015) In vitro human metabolism of permethrin isomers alone or as a mixture and the formation of the major metabolites in cryopreserved primary hepatocytes. Toxicology in Vitro 29:4, pages 803-812.
Crossref
Crossref
Patrick Poulin. (2015) Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research. Journal of Pharmaceutical Sciences 104:6, pages 2110-2118.
Crossref
Crossref
James T. MacGregor, Roland Frötschl, Paul A. White, Kenny S. Crump, David A. Eastmond, Shoji Fukushima, Melanie Guérard, Makoto Hayashi, Lya G. Soeteman-Hernández, George E. Johnson, Toshio Kasamatsu, Dan D. Levy, Takeshi Morita, Lutz Müller, Rita Schoeny, Maik J. Schuler & Véronique Thybaud. (2015) IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 783, pages 66-78.
Crossref
Crossref
Donald J. Versteeg & Jorge M. Naciff. (2015)
In Response
: Ecotoxicogenomics addressing future needs: An industry perspective
. Environmental Toxicology and Chemistry 34:4, pages 704-706.
Crossref
Crossref
Andreas M Svennebring. (2015)
How to report and discuss ADME data in medicinal chemistry publications:
in vitro
data or
in vivo
extrapolations?
. Future Medicinal Chemistry 7:3, pages 259-267.
Crossref
Crossref
Dominique R. Talbert, Kimberly R. Doherty, Patricia B. Trusk, Diarmuid M. Moran, Scott A. Shell & Sarah Bacus. (2015) A Multi-parameter In Vitro Screen in Human Stem Cell-Derived Cardiomyocytes Identifies Ponatinib-Induced Structural and Functional Cardiac Toxicity. Toxicological Sciences 143:1, pages 147-155.
Crossref
Crossref
Daniel José Barbosa, João Paulo Capela, Maria de Lourdes Bastos & Félix Carvalho. (2015) In vitro models for neurotoxicology research. Toxicology Research 4:4, pages 801-842.
Crossref
Crossref
Daniel Krewski, Margit Westphal, Melvin E. Andersen, Gregory M. Paoli, Weihsueh A. Chiu, Mustafa Al-Zoughool, Maxine C. Croteau, Lyle D. Burgoon & Ila Cote. (2014) A Framework for the Next Generation of Risk Science. Environmental Health Perspectives 122:8, pages 796-805.
Crossref
Crossref
. (2014) Modern methodologies and tools for human hazard assessment of chemicals. EFSA Journal 12:4.
Crossref
Crossref
Markus Brinkmann, Kathrin Eichbaum, Sebastian Buchinger, Georg Reifferscheid, Thuy Bui, Andreas Schäffer, Henner Hollert & Thomas G. Preuss. (2014)
Understanding Receptor-Mediated Effects in Rainbow Trout:
In Vitro
–
in Vivo
Extrapolation Using Physiologically Based Toxicokinetic Models
. Environmental Science & Technology 48:6, pages 3303-3309.
Crossref
Crossref
Miyoung Yoon, Alina Efremenko, Bas J. Blaauboer & Harvey J. Clewell. (2014) Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds. Toxicology in Vitro 28:2, pages 164-170.
Crossref
Crossref
C. Downey, F. Daly & K.M. O’Boyle. (2014) An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine. Toxicology in Vitro 28:2, pages 231-239.
Crossref
Crossref
Jos G. Bessems, George Loizou, Kannan Krishnan, Harvey J. ClewellIIIIII, Camilla Bernasconi, Frederic Bois, Sandra Coecke, Eva-Maria Collnot, Walter Diembeck, Lucian Romeo Farcal, Liesbeth Geraets, Ursula Gundert-Remy, Nynke Kramer, Gabriele Küsters, Sofia B. Leite, Olavi R. Pelkonen, Klaus Schröder, Emanuela Testai, Iwona Wilk-Zasadna & José-Manuel Zaldívar-Comenges. (2014) PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment. Regulatory Toxicology and Pharmacology 68:1, pages 119-139.
Crossref
Crossref
Kevin McNally, Richard Cotton, Alex Hogg & George Loizou. (2014) PopGen: A virtual human population generator. Toxicology 315, pages 70-85.
Crossref
Crossref
Oscar L. Volger. 2014. Toxicogenomics-Based Cellular Models. Toxicogenomics-Based Cellular Models
89
124
.
Nadia Quignot, Jérémy Hamon & Frederic Y. Bois. 2014. In Vitro Toxicology Systems. In Vitro Toxicology Systems
531
550
.
Bas J. Blaauboer. 2014. In Vitro Toxicology Systems. In Vitro Toxicology Systems
521
530
.
Joanna Jaworska, Yuri Dancik, Petra Kern, Frank Gerberick & Andreas Natsch. (2013) Bayesian integrated testing strategy to assess skin sensitization potency: from theory to practice. Journal of Applied Toxicology 33:11, pages 1353-1364.
Crossref
Crossref
Yuri Dancik, John A Troutman & Joanna Jaworska. (2013) A framework incorporating the impact of exposure scenarios and application conditions on risk assessment of chemicals applied to skin. In Silico Pharmacology 1:1.
Crossref
Crossref
Alexandre R.R. Péry, Céline Brochot, Florence A. Zeman, Enrico Mombelli, Sophie Desmots, Manuela Pavan, Elena Fioravanzo & José-Manuel Zaldívar. (2013) Prediction of dose-hepatotoxic response in humans based on toxicokinetic/toxicodynamic modeling with or without in vivo data: A case study with acetaminophen. Toxicology Letters 220:1, pages 26-34.
Crossref
Crossref
Miyoung Yoon, Harvey J. ClewellIIIIII & Melvin E. Andersen. (2013) Deriving an explicit hepatic clearance equation accounting for plasma protein binding and hepatocellular uptake. Toxicology in Vitro 27:1, pages 11-15.
Crossref
Crossref
Steve Gutsell & Paul Russell. (2013) The role of chemistry in developing understanding of adverse outcome pathways and their application in risk assessment. Toxicology Research 2:5, pages 299.
Crossref
Crossref
J Lippert, M Brosch, O von Kampen, M Meyer, H.‐U Siegmund, C Schafmayer, T Becker, B Laffert, L Görlitz, S Schreiber, PJ Neuvonen, M Niemi, J Hampe & L Kuepfer. (2012) A Mechanistic, Model‐Based Approach to Safety Assessment in Clinical Development. CPT: Pharmacometrics & Systems Pharmacology 1:11, pages 1-8.
Crossref
Crossref