Advanced search
Publication Cover
Critical Reviews in Toxicology Volume 43, 2013 - Issue 1
Submit an article Journal homepage
1,164
Views
107
CrossRef citations to date
0
Altmetric
Review Article

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

Helinor JohnstonNano Safety Research Group, Heriot-Watt University, School of Life Sciences, Edinburgh, UKCorrespondence[email protected]
,
Giulio PojanaDepartment of Environmental Sciences, Informatics and Statistics-DAIS, University Ca’ Foscari Venice, Venice, Italy
,
Stefano ZuinVenice Research Consortium, Via della Libertà 12, Scientific and Technological Park of Venice, Venice, Italy
,
Nicklas Raun JacobsenNational Research Centre for the Working Environment, Lersø Parkalle 105, Copenhagen, Denmark
,
Peter MøllerDepartment of Public Health, Section of Environment Health, University of Copenhagen, Øster Farimagsgade 5A, Copenhagen, Denmark
,
Steffen LoftDepartment of Public Health, Section of Environment Health, University of Copenhagen, Øster Farimagsgade 5A, Copenhagen, Denmark
,
Manuela Semmler-BehnkeComprehensive Pneumology Center – Institute of Lung Biology and Disease, and Focus Network Nanoparticles and Health, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
,
Catherine McGuinessMRC/University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory Queen’s Medical Research Institute, Edinburgh, UK
,
Dominique BalharryNano Safety Research Group, Heriot-Watt University, School of Life Sciences, Edinburgh, UK
,
Antonio MarcominiDepartment of Environmental Sciences, Informatics and Statistics-DAIS, University Ca’ Foscari Venice, Venice, Italy
,
Håkan WallinNational Research Centre for the Working Environment, Lersø Parkalle 105, Copenhagen, Denmark
,
Wolfgang KreylingComprehensive Pneumology Center – Institute of Lung Biology and Disease, and Focus Network Nanoparticles and Health, Helmholtz Zentrum München – German Research Center for Environmental Health, Neuherberg, Germany
,
Ken DonaldsonMRC/University of Edinburgh Centre for Inflammation Research, ELEGI Colt Laboratory Queen’s Medical Research Institute, Edinburgh, UK
,
Lang TranInstitute of Occupational Medicine, Research Park North, Edinburgh, UK
&
Vicki StoneNano Safety Research Group, Heriot-Watt University, School of Life Sciences, Edinburgh, UK
 show all
Pages 1-20 | Received 21 Dec 2011, Accepted 05 Oct 2012, Published online: 06 Nov 2012

Citations (107)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (21)

Sabina Halappanavar, James D. Ede, Indrani Mahapatra, Harald F. Krug, Eileen D. Kuempel, Iseult Lynch, Rob J. Vandebriel & Jo Anne Shatkin. (2021) A methodology for developing key events to advance nanomaterial-relevant adverse outcome pathways to inform risk assessment. Nanotoxicology 15:3, pages 289-310.
Read now
Yi-Hsien Cheng, Jim E. Riviere, Nancy A. Monteiro-Riviere & Zhoumeng Lin. (2018) Probabilistic risk assessment of gold nanoparticles after intravenous administration by integrating in vitro and in vivo toxicity with physiologically based pharmacokinetic modeling. Nanotoxicology 12:5, pages 453-469.
Read now
Peter Møller & Nicklas Raun Jacobsen. (2017) Weight of evidence analysis for assessing the genotoxic potential of carbon nanotubes. Critical Reviews in Toxicology 47:10, pages 871-888.
Read now
William K. Boyes, Luka L. Thornton, Souhail R. Al-Abed, Christian P. Andersen, Dermont C. Bouchard, Robert M. Burgess, Elaine A. Cohen Hubal, Kay T. Ho, Michael F. Hughes, Kirk Kitchin, Jay R. Reichman, Kim R. Rogers, Jeffrey A. Ross, Paul T. Rygiewicz, Kirk G. Scheckel, Sheau-Fung Thai, Richard G. Zepp & Robert M. Zucker. (2017) A comprehensive framework for evaluating the environmental health and safety implications of engineered nanomaterials. Critical Reviews in Toxicology 47:9, pages 771-814.
Read now
Cristina Cerrillo, Gotzone Barandika, Amaya Igartua, Olatz Areitioaurtena & Gemma Mendoza. (2017) Key challenges for nanotechnology: Standardization of ecotoxicity testing. Journal of Environmental Science and Health, Part C 35:2, pages 104-126.
Read now
Rune Hjorth, Lilian van Hove & Fern Wickson. (2017) What can nanosafety learn from drug development? The feasibility of “safety by design”. Nanotoxicology 11:3, pages 305-312.
Read now
Laura Vila, Laura Rubio, Balasubramanyam Annangi, Alba García-Rodríguez, Ricard Marcos & Alba Hernández. (2017) Frozen dispersions of nanomaterials are a useful operational procedure in nanotoxicology. Nanotoxicology 11:1, pages 31-40.
Read now
Eileen D. Kuempel, Marie-Claude Jaurand, Peter Møller, Yasuo Morimoto, Norihiro Kobayashi, Kent E. Pinkerton, Linda M. Sargent, Roel C. H. Vermeulen, Bice Fubini & Agnes B. Kane. (2017) Evaluating the mechanistic evidence and key data gaps in assessing the potential carcinogenicity of carbon nanotubes and nanofibers in humans. Critical Reviews in Toxicology 47:1, pages 1-58.
Read now
Tian Zhou, Qinglei Dong, Yang Shen, Wei Wu, Haide Wu, Xianglin Luo, Xiaoling Liao & Guixue Wang. (2016) PEG-b-PCL polymeric nano-micelle inhibits vascular angiogenesis by activating p53-dependent apoptosis in zebrafish. International Journal of Nanomedicine 11, pages 6517-6531.
Read now
Khalil B. Ramadi, Yassir A. Mohamed, Ashraf Al-Sbiei, Saeeda Almarzooqi, Ghada Bashir, Aisha Al Dhanhani, Dhanya Sarawathiamma, Shahnaz Qadri, Javed Yasin, Abderrahim Nemmar, Maria J. Fernandez-Cabezudo, Yousef Haik & Basel K. Al-Ramadi. (2016) Acute systemic exposure to silver-based nanoparticles induces hepatotoxicity and NLRP3-dependent inflammation. Nanotoxicology 10:8, pages 1061-1074.
Read now
Wendel Wohlleben, Marc D. Driessen, Simon Raesch, Ulrich F. Schaefer, Christine Schulze, Bernhard von Vacano, Antje Vennemann, Martin Wiemann, Christian A. Ruge, Herbert Platsch, Sarah Mues, Rainer Ossig, Janina M. Tomm, Jürgen Schnekenburger, Thomas A.J. Kuhlbusch, Andreas Luch, Claus-Michael Lehr & Andrea Haase. (2016) Influence of agglomeration and specific lung lining lipid/protein interaction on short-term inhalation toxicity. Nanotoxicology 10:7, pages 970-980.
Read now
Claudia Coll, Dominic Notter, Fadri Gottschalk, Tianyin Sun, Claudia Som & Bernd Nowack. (2016) Probabilistic environmental risk assessment of five nanomaterials (nano-TiO2, nano-Ag, nano-ZnO, CNT, and fullerenes). Nanotoxicology 10:4, pages 436-444.
Read now
Ali Kermanizadeh, Ilse Gosens, Laura MacCalman, Helinor Johnston, Pernille H. Danielsen, Nicklas R. Jacobsen, Anke-Gabriele Lenz, Teresa Fernandes, Roel P. F. Schins, Flemming R. Cassee, Håkan Wallin, Wolfgang Kreyling, Tobias Stoeger, Steffen Loft, Peter Møller, Lang Tran & Vicki Stone. (2016) A Multilaboratory Toxicological Assessment of a Panel of 10 Engineered Nanomaterials to Human Health—ENPRA Project—The Highlights, Limitations, and Current and Future Challenges. Journal of Toxicology and Environmental Health, Part B 19:1, pages 1-28.
Read now
Adriana Albini, Arianna Pagani, Laura Pulze, Antonino Bruno, Elisa Principi, Terenzio Congiu, Elisabetta Gini, Annalisa Grimaldi, Barbara Bassani, Silvio De Flora, Magda de Eguileor & Douglas M Noonan. (2015) Environmental impact of multi-wall carbon nanotubes in a novel model of exposure: systemic distribution, macrophage accumulation, and amyloid deposition. International Journal of Nanomedicine 10, pages 6133-6145.
Read now
Ali Kermanizadeh, Dominique Balharry, Håkan Wallin, Steffen Loft & Peter Møller. (2015) Nanomaterial translocation–the biokinetics, tissue accumulation, toxicity and fate of materials in secondary organs–a review. Critical Reviews in Toxicology 45:10, pages 837-872.
Read now
Nadine Haberl, Stephanie Hirn, Martin Holzer, Gabriele Zuchtriegel, Markus Rehberg & Fritz Krombach. (2015) Effects of acute systemic administration of TiO2, ZnO, SiO2, and Ag nanoparticles on hemodynamics, hemostasis and leukocyte recruitment. Nanotoxicology 9:8, pages 963-971.
Read now
Mohamed Alaraby, Alba Hernández, Balasubramanyam Annangi, Esref Demir, Jordi Bach, Laura Rubio, Amadeu Creus & Ricard Marcos. (2015) Antioxidant and antigenotoxic properties of CeO2 NPs and cerium sulphate: Studies with Drosophila melanogaster as a promising in vivo model. Nanotoxicology 9:6, pages 749-759.
Read now
Ratna Tantra, Ceyda Oksel, Tomasz Puzyn, Jian Wang, Kenneth N. Robinson, Xue Z. Wang, Cai Y. Ma & Terry Wilkins. (2015) Nano(Q)SAR: Challenges, pitfalls and perspectives. Nanotoxicology 9:5, pages 636-642.
Read now
Sara Correia Carreira, Laura Walker, Kai Paul & Margaret Saunders. (2015) The toxicity, transport and uptake of nanoparticles in the in vitro BeWo b30 placental cell barrier model used within NanoTEST. Nanotoxicology 9:sup1, pages 66-78.
Read now
David E. Lefebvre, Koen Venema, Lourdes Gombau, Luis G. Valerio$suffix/text()$suffix/text(), Jayadev Raju, Genevieve S. Bondy, Hans Bouwmeester, R. Paul Singh, Amy J. Clippinger, Eva-Maria Collnot, Rekha Mehta & Vicki Stone. (2015) Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices. Nanotoxicology 9:4, pages 523-542.
Read now
Agnes G. Oomen, Peter M. J. Bos, Teresa F. Fernandes, Kerstin Hund-Rinke, Diana Boraschi, Hugh J. Byrne, Karin Aschberger, Stefania Gottardo, Frank von der Kammer, Dana Kühnel, Danail Hristozov, Antonio Marcomini, Lucia Migliore, Janeck Scott-Fordsmand, Peter Wick & Robert Landsiedel. (2014) Concern-driven integrated approaches to nanomaterial testing and assessment – report of the NanoSafety Cluster Working Group 10. Nanotoxicology 8:3, pages 334-348.
Read now

Articles from other publishers (86)

Zhangjian Chen, Shuo Han, Pai Zheng, Jiahe Zhang, Shupei Zhou & Guang Jia. (2022) Landscape of lipidomic metabolites in gut-liver axis of Sprague–Dawley rats after oral exposure to titanium dioxide nanoparticles. Particle and Fibre Toxicology 19:1.
Crossref
Mohammed A. Sharaf & Andrzej Kloczkowski. 2022. Nanocomposite Materials for Biomedical and Energy Storage Applications. Nanocomposite Materials for Biomedical and Energy Storage Applications.
Jiangnan Yi, Yuanliang Li, Qianying Mai, Yaxuan Li, Yingying Lin, Xiaoshan Weng, Zhu Ai, Mingze Li, Peng Shang, Mujahid Iqbal, Khalid Mehmood, Yung-Fu Chang, Zhaoxin Tang, Hui Zhang & Ying Li. (2022) Hepatotoxicity and the role of the gut–liver axis in dogs after oral administration of zinc oxide nanoparticles. Metallomics 14:11.
Crossref
Faiza Jabbar, Young-Su Kim & Sang Ho Lee. (2022) Biological Influence of Pulmonary Disease Conditions Induced by Particulate Matter on Microfluidic Lung Chips. BioChip Journal 16:3, pages 305-316.
Crossref
Laura Maria Azzurra Camassa, Elisabeth Elje, Espen Mariussen, Eleonora Marta Longhin, Maria Dusinska, Shan Zienolddiny-Narui & Elise Rundén-Pran. (2022) Advanced Respiratory Models for Hazard Assessment of Nanomaterials—Performance of Mono-, Co- and Tricultures. Nanomaterials 12:15, pages 2609.
Crossref
Kelison Venício Brito Alves, Diego Stéfani T. Martinez, Oswaldo L. Alves & Edison Barbieri. (2022) Co-exposure of carbon nanotubes with carbofuran pesticide affects metabolic rate in Palaemon pandaliformis (shrimp). Chemosphere 288, pages 132359.
Crossref
Irini Furxhi, Finbarr Murphy, Craig A. Poland, Martin Cunneen & Martin Mullins. (2021) Precaution as a Risk in Data Gaps and Sustainable Nanotechnology Decision Support Systems: a Case Study of Nano-Enabled Textiles Production. NanoEthics 15:3, pages 245-270.
Crossref
Peter Møller, Regitze Sølling Wils, Emilio Di Ianni, Claudia Andrea Torero Gutierrez, Martin Roursgaard & Nicklas Raun Jacobsen. (2021) Genotoxicity of multi-walled carbon nanotube reference materials in mammalian cells and animals. Mutation Research/Reviews in Mutation Research 788, pages 108393.
Crossref
Adrián García-Salvador, Alberto Katsumiti, Elena Rojas, Carol Aristimuño, Mónica Betanzos, Marta Martínez-Moro, Sergio E. Moya & Felipe Goñi-de-Cerio. (2021) A Complete In Vitro Toxicological Assessment of the Biological Effects of Cerium Oxide Nanoparticles: From Acute Toxicity to Multi-Dose Subchronic Cytotoxicity Study. Nanomaterials 11:6, pages 1577.
Crossref
R.J.A. Vibhavari, Gautam Kumar, Vanishree Rao, Sri Pragnya Cheruku & Nitesh Kumar. 2021. Nano-Pharmacokinetics and Theranostics. Nano-Pharmacokinetics and Theranostics 117 152 .
Zhangjian Chen, Pai Zheng, Shuo Han, Jiahe Zhang, Zejun Li, Shupei Zhou & Guang Jia. (2020) Tissue-specific oxidative stress and element distribution after oral exposure to titanium dioxide nanoparticles in rats. Nanoscale 12:38, pages 20033-20046.
Crossref
Luna Rahman, Andrew Williams, Krishna Gelda, Jake Nikota, Dongmei Wu, Ulla Vogel & Sabina Halappanavar. (2020) 21st Century Tools for Nanotoxicology: Transcriptomic Biomarker Panel and Precision‐Cut Lung Slice Organ Mimic System for the Assessment of Nanomaterial‐Induced Lung Fibrosis. Small 16:36, pages 2000272.
Crossref
Zhangjian Chen, Shuo Han, Pai Zheng, Shupei Zhou & Guang Jia. (2020) Combined effect of titanium dioxide nanoparticles and glucose on the blood glucose homeostasis in young rats after oral administration. Journal of Applied Toxicology 40:9, pages 1284-1296.
Crossref
Aleksandra Zielińska, Beatriz Costa, Maria V. Ferreira, Diogo Miguéis, Jéssica M. S. Louros, Alessandra Durazzo, Massimo Lucarini, Piotr Eder, Marco V. Chaud, Margreet Morsink, Niels Willemen, Patrícia Severino, Antonello Santini & Eliana B. Souto. (2020) Nanotoxicology and Nanosafety: Safety-by-Design and Testing at a Glance. International Journal of Environmental Research and Public Health 17:13, pages 4657.
Crossref
Robert J. Hamers. (2020) Energy Storage Materials as Emerging Nano-contaminants. Chemical Research in Toxicology 33:5, pages 1074-1081.
Crossref
Zhangjian Chen, Shuo Han, Shupei Zhou, Huimin Feng, Ying Liu & Guang Jia. (2020) Review of health safety aspects of titanium dioxide nanoparticles in food application. NanoImpact 18, pages 100224.
Crossref
Zhangjian Chen, Shuo Han, Pai Zheng, Di Zhou, Shupei Zhou & Guang Jia. (2020) Effect of oral exposure to titanium dioxide nanoparticles on lipid metabolism in Sprague-Dawley rats. Nanoscale 12:10, pages 5973-5986.
Crossref
Sara T. Humes & Tara Sabo-Attwood. 2020. Information Resources in Toxicology. Information Resources in Toxicology 425 436 .
V. Ananthi, K. Mohanrasu, T. Boobalan, K. Anand, M. Sudhakar, Anil Chuturgoon, V. Balasubramanian, R. Yuvakkumar & A. Arun. 2020. Integrative Nanomedicine for New Therapies. Integrative Nanomedicine for New Therapies 113 146 .
Zhangjian Chen, Di Zhou, Shuo Han, Shupei Zhou & Guang Jia. (2019) Hepatotoxicity and the role of the gut-liver axis in rats after oral administration of titanium dioxide nanoparticles. Particle and Fibre Toxicology 16:1.
Crossref
Alba García-Rodríguez, Liliya Kazantseva, Laura Vila, Laura Rubio, Antonia Velázquez, María José Ramírez, Ricard Marcos & Alba Hernández. (2019) Micronuclei Detection by Flow Cytometry as a High-Throughput Approach for the Genotoxicity Testing of Nanomaterials. Nanomaterials 9:12, pages 1677.
Crossref
Alba García-Rodríguez, Laura Rubio, Laura Vila, Noel Xamena, Antonia Velázquez, Ricard Marcos & Alba Hernández. (2019) The Comet Assay as a Tool to Detect the Genotoxic Potential of Nanomaterials. Nanomaterials 9:10, pages 1385.
Crossref
Todd A. StueckleJenny R. Roberts. (2019) Perspective on Current Alternatives in Nanotoxicology Research. Applied In Vitro Toxicology 5:3, pages 111-113.
Crossref
Zhangjian Chen, Di Zhou, Shupei Zhou & Guang Jia. (2019) Gender difference in hepatic toxicity of titanium dioxide nanoparticles after subchronic oral exposure in Sprague‐Dawley rats. Journal of Applied Toxicology 39:5, pages 807-819.
Crossref
Sabina Halappanavar, Luna Rahman, Jake Nikota, Sarah S. Poulsen, Yaobo Ding, Petra Jackson, Hakan Wallin, Otmar Schmid, Ulla Vogel & Andrew Williams. (2019) Ranking of nanomaterial potency to induce pathway perturbations associated with lung responses. NanoImpact 14, pages 100158.
Crossref
Enrico Bergamaschi, Mary Gulumian, Jun Kanno & Kai Savolainen. 2019. Biomarkers in Toxicology. Biomarkers in Toxicology 735 755 .
. 2018. New Technologies and the Law in War and Peace. New Technologies and the Law in War and Peace.
H. L. Aaltonen, J. K. Jakobsson, S. Diaz, S. Zackrisson, E. Piitulainen, J. Löndahl & P. Wollmer. (2018) Deposition of inhaled nanoparticles is reduced in subjects with COPD and correlates with the extent of emphysema: proof of concept for a novel diagnostic technique. Clinical Physiology and Functional Imaging 38:6, pages 1008-1014.
Crossref
Tiziana Tosco & Rajandrea Sethi. (2018) Human health risk assessment for nanoparticle-contaminated aquifer systems. Environmental Pollution 239, pages 242-252.
Crossref
Swapna Upadhyay & Lena Palmberg. (2018) Air-Liquid Interface: Relevant In Vitro Models for Investigating Air Pollutant-Induced Pulmonary Toxicity. Toxicological Sciences 164:1, pages 21-30.
Crossref
Zhangjian Chen, Yun Wang, Xiang Wang, Lin Zhuo, Shi Chen, Shichuan Tang, Lin Zhao, Xianguo Luan & Guang Jia. (2018) Effect of titanium dioxide nanoparticles on glucose homeostasis after oral administration. Journal of Applied Toxicology 38:6, pages 810-823.
Crossref
Daiana Silva Ávila, Juliana Fredo Roncato & Maurício Tavares Jacques. (2018) Nanotoxicology assessment in complementary/alternative models. Energy, Ecology and Environment 3:2, pages 72-80.
Crossref
Laura Vila, Alba García-Rodríguez, Constanza Cortés, Antonia Velázquez, Noel Xamena, Adriana Sampayo-Reyes, Ricard Marcos & Alba Hernández. (2018) Effects of cerium oxide nanoparticles on differentiated/undifferentiated human intestinal Caco-2 cells. Chemico-Biological Interactions 283, pages 38-46.
Crossref
Nasim Ganji, Iftheker A. Khan & Geoffrey D. Bothun. (2018) Surface Activity of Poly(ethylene glycol)-Coated Silver Nanoparticles in the Presence of a Lipid Monolayer. Langmuir 34:5, pages 2039-2045.
Crossref
David B Warheit. (2018) Hazard and risk assessment strategies for nanoparticle exposures: how far have we come in the past 10 years?. F1000Research 7, pages 376.
Crossref
Natalie Burden, Karin Aschberger, Qasim Chaudhry, Martin J.D. Clift, Paul Fowler, Helinor Johnston, Robert Landsiedel, Joanna Rowland, Vicki Stone & Shareen H. Doak. (2017) Aligning nanotoxicology with the 3Rs: What is needed to realise the short, medium and long-term opportunities?. Regulatory Toxicology and Pharmacology 91, pages 257-266.
Crossref
Vicki Stone, Mark R. Miller, Martin J.D. Clift, Alison Elder, Nicholas L. Mills, Peter Møller, Roel P.F. Schins, Ulla Vogel, Wolfgang G. Kreyling, Keld Alstrup Jensen, Thomas A.J. Kuhlbusch, Per E. Schwarze, Peter Hoet, Antonio Pietroiusti, Andrea De Vizcaya-Ruiz, Armelle Baeza-Squiban, João Paulo Teixeira, C. Lang Tran & Flemming R. Cassee. (2017) Nanomaterials Versus Ambient Ultrafine Particles: An Opportunity to Exchange Toxicology Knowledge. Environmental Health Perspectives 125:10.
Crossref
Nicklas Raun Jacobsen, Peter Møller, Per Axel Clausen, Anne Thoustrup Saber, Christian Micheletti, Keld Alstrup Jensen, Håkan Wallin & Ulla Vogel. (2017) Biodistribution of Carbon Nanotubes in Animal Models. Basic & Clinical Pharmacology & Toxicology 121, pages 30-43.
Crossref
Mark R. Miller, Jennifer B. Raftis, Jeremy P. Langrish, Steven G. McLean, Pawitrabhorn Samutrtai, Shea P. Connell, Simon Wilson, Alex T. Vesey, Paul H. B. Fokkens, A. John F. Boere, Petra Krystek, Colin J. Campbell, Patrick W. F. Hadoke, Ken Donaldson, Flemming R. Cassee, David E. Newby, Rodger Duffin & Nicholas L. Mills. (2017) Inhaled Nanoparticles Accumulate at Sites of Vascular Disease. ACS Nano 11:5, pages 4542-4552.
Crossref
Irit Allon, Ahmi Ben-Yehudah, Raz Dekel, Jan-Helge Solbakk, Klaus-Michael Weltring & Gil Siegal. (2016) Ethical issues in nanomedicine: Tempest in a teapot?. Medicine, Health Care and Philosophy 20:1, pages 3-11.
Crossref
Jo Anne Shatkin, Kimberly Ong & James Ede. 2017. Metrology and Standardization of Nanotechnology. Metrology and Standardization of Nanotechnology 381 408 .
G.M. Mortimer & R.F. Minchin. 2017. Micro and Nanotechnology in Vaccine Development. Micro and Nanotechnology in Vaccine Development 373 392 .
J. Li & F.L. Martin. 2017. Neurotoxicity of Nanomaterials and Nanomedicine. Neurotoxicity of Nanomaterials and Nanomedicine 75 98 .
Thomas Loret, Emmanuel Peyret, Marielle Dubreuil, Olivier Aguerre-Chariol, Christophe Bressot, Olivier le Bihan, Tanguy Amodeo, Bénédicte Trouiller, Anne Braun, Christophe Egles & Ghislaine Lacroix. (2016) Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions. Particle and Fibre Toxicology 13:1.
Crossref
Finbarr Murphy, Barry Sheehan, Martin Mullins, Hans Bouwmeester, Hans J. P. Marvin, Yamine Bouzembrak, Anna L. Costa, Rasel Das, Vicki Stone & Syed A. M. Tofail. (2016) A Tractable Method for Measuring Nanomaterial Risk Using Bayesian Networks. Nanoscale Research Letters 11:1.
Crossref
Aleksandr Käkinen, Anne Kahru, Helen Nurmsoo, Anna-Liisa Kubo & Olesja M. Bondarenko. (2016) Solubility-driven toxicity of CuO nanoparticles to Caco2 cells and Escherichia coli : Effect of sonication energy and test environment. Toxicology in Vitro 36, pages 172-179.
Crossref
Huadong Xu, Lin Zhao, Zhangjian Chen, Jingwen Zhou, Shichuan Tang, Fanling Kong, Xinwei Li, Ling Yan, Ji Zhang & Guang Jia. (2016) Exposure assessment of workplace manufacturing titanium dioxide particles. Journal of Nanoparticle Research 18:10.
Crossref
Baoshan Xing, Chad D. Vecitis & Nicola SenesiKarin Aschberger, Frans M. Christensen, Kirsten Rasmussen & Keld A. Jensen. 2016. Engineered Nanoparticles and the Environment: Biophysicochemical Processes and Toxicity. Engineered Nanoparticles and the Environment: Biophysicochemical Processes and Toxicity 409 441 .
El-Sayed Belal & Hassan El-Ramady. 2016. Nanoscience in Food and Agriculture 2. Nanoscience in Food and Agriculture 2 311 358 .
Matthew S. P. Boyles, Christina Ranninger, Roland Reischl, Marc Rurik, Richard Tessadri, Oliver Kohlbacher, Albert Duschl & Christian G. Huber. (2016) Copper oxide nanoparticle toxicity profiling using untargeted metabolomics. Particle and Fibre Toxicology 13:1.
Crossref
Zhangjian Chen, Yun Wang, Lin Zhuo, Shi Chen, Lin Zhao, Xianguo Luan, Haifang Wang & Guang Jia. (2015) Effect of titanium dioxide nanoparticles on the cardiovascular system after oral administration. Toxicology Letters 239:2, pages 123-130.
Crossref
Heinz Langhals, Moritz Eberspächer & Alexander Hofer. (2015) Learning about Structural and Optical Properties of Organic Compounds through Preparation of Functional Nanomicelles while Avoiding Hazardous Chemicals or Complicated Apparatus. Journal of Chemical Education 92:10, pages 1725-1729.
Crossref
Vinayak Pachapur, Satinder Kaur Brar, Mausam Verma & Rao Y. Surampalli. 2015. Nanomaterials in the Environment. Nanomaterials in the Environment 421 437 .
Junko Nakanishi, Yasuo Morimoto, Isamu Ogura, Norihiro Kobayashi, Masato Naya, Makoto Ema, Shigehisa Endoh, Manabu Shimada, Akira Ogami, Toshihiko Myojyo, Takako Oyabu, Masashi Gamo, Atsuo Kishimoto, Takuya Igarashi & Sosuke Hanai. (2015) Risk Assessment of the Carbon Nanotube Group. Risk Analysis 35:10, pages 1940-1956.
Crossref
Zhangjian Chen, Yun Wang, Lin Zhuo, Shi Chen, Lin Zhao, Tian Chen, Yang Li, Wenxiao Zhang, Xin Gao, Ping Li, Haifang Wang & Guang Jia. (2015) Interaction of titanium dioxide nanoparticles with glucose on young rats after oral administration. Nanomedicine: Nanotechnology, Biology and Medicine 11:7, pages 1633-1642.
Crossref
Helen Bridle, Dominique Balharry, Birgit Gaiser & Helinor Johnston. (2015) Exploitation of Nanotechnology for the Monitoring of Waterborne Pathogens: State-of-the-Art and Future Research Priorities. Environmental Science & Technology 49:18, pages 10762-10777.
Crossref
Saber M. Hussain, David B. Warheit, Sheung P. Ng, Kristen K. Comfort, Christin M. Grabinski & Laura K. Braydich-Stolle. (2015) At the Crossroads of Nanotoxicology in vitro : Past Achievements and Current Challenges . Toxicological Sciences 147:1, pages 5-16.
Crossref
Shona O’Rourke, Vicki Stone, Björn Stolpe & Teresa F. Fernandes. (2015) Assessing the acute hazards of zinc oxide nanomaterials to Lumbriculus variegatus. Ecotoxicology 24:6, pages 1372-1384.
Crossref
Georgia Miller & Fern Wickson. (2015) Risk Analysis of Nanomaterials: Exposing Nanotechnology's Naked Emperor. Review of Policy Research 32:4, pages 485-512.
Crossref
Ilaria Fratoddi, Iole Venditti, Cesare Cametti & Maria Vittoria Russo. (2015) How toxic are gold nanoparticles? The state-of-the-art. Nano Research 8:6, pages 1771-1799.
Crossref
Tobias Walser, David Meyer, Wouter Fransman, Harrie Buist, Eelco Kuijpers & Derk Brouwer. (2015) Life-cycle assessment framework for indoor emissions of synthetic nanoparticles. Journal of Nanoparticle Research 17:6.
Crossref
Sandra Suppi, Kaja Kasemets, Angela Ivask, Kai Künnis-Beres, Mariliis Sihtmäe, Imbi Kurvet, Villem Aruoja & Anne Kahru. (2015) A novel method for comparison of biocidal properties of nanomaterials to bacteria, yeasts and algae. Journal of Hazardous Materials 286, pages 75-84.
Crossref
Josje H.E. Arts, Mackenzie Hadi, Muhammad-Adeel Irfan, Athena M. Keene, Reinhard Kreiling, Delina Lyon, Monika Maier, Karin Michel, Thomas Petry, Ursula G. Sauer, David Warheit, Karin Wiench, Wendel Wohlleben & Robert Landsiedel. (2015) A decision-making framework for the grouping and testing of nanomaterials (DF4nanoGrouping). Regulatory Toxicology and Pharmacology 71:2, pages S1-S27.
Crossref
Ali Kermanizadeh, Caroline Chauché, David M. Brown, Steffen Loft & Peter Møller. (2015) The role of intracellular redox imbalance in nanomaterial induced cellular damage and genotoxicity: A review. Environmental and Molecular Mutagenesis 56:2, pages 111-124.
Crossref
Vanessa Valdiglesias, Gözde Kiliç, Carla Costa, Natalia Fernández-Bertólez, Eduardo Pásaro, João Paulo Teixeira & Blanca Laffon. (2015) Effects of iron oxide nanoparticles: Cytotoxicity, genotoxicity, developmental toxicity, and neurotoxicity. Environmental and Molecular Mutagenesis 56:2, pages 125-148.
Crossref
Peter Møller, Ditte Marie Jensen, Daniel Vest Christophersen, Ali Kermanizadeh, Nicklas Raun Jacobsen, Jette Gjerke Hemmingsen, Pernille Høgh Danielsen, Dorina Gabriela Karottki, Martin Roursgaard, Yi Cao, Kim Jantzen, Henrik Klingberg, Lars-Georg Hersoug & Steffen Loft. (2015) Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. Environmental and Molecular Mutagenesis 56:2, pages 97-110.
Crossref
Anja Silge, Katharina Bräutigam, Thomas Bocklitz, Petra Rösch, Antje Vennemann, Inge Schmitz, Jürgen Popp & Martin Wiemann. (2015) ZrO 2 nanoparticles labeled via a native protein corona: detection by fluorescence microscopy and Raman microspectroscopy in rat lungs . The Analyst 140:15, pages 5120-5128.
Crossref
John H. Priester, Laurie C. Van De Werfhorst, Yuan Ge, Adeyemi S. Adeleye, Shivira Tomar, Lauren M. Tom, Yvette M. Piceno, Gary L. Andersen & Patricia A. Holden. (2014) Effects of TiO 2 and Ag Nanoparticles on Polyhydroxybutyrate Biosynthesis By Activated Sludge Bacteria . Environmental Science & Technology 48:24, pages 14712-14720.
Crossref
Nagarjun Konduru, Jana Keller, Lan Ma-Hock, Sibylle Gröters, Robert Landsiedel, Thomas C Donaghey, Joseph D Brain, Wendel Wohlleben & Ramon M Molina. (2014) Biokinetics and effects of barium sulfate nanoparticles. Particle and Fibre Toxicology 11:1.
Crossref
Hermann M. Bolt. (2014) Current developments in toxicology. Archives of Toxicology.
Crossref
Lina Ghibelli & Sanjay Mathur. (2014) Biological interactions of oxide nanoparticles: The good and the evil. MRS Bulletin 39:11, pages 949-954.
Crossref
O. D. Hendrickson, A. V. Zherdev, I. V. Gmoshinskii & B. B. Dzantiev. (2014) Fullerenes: In vivo studies of biodistribution, toxicity, and biological action. Nanotechnologies in Russia 9:11-12, pages 601-617.
Crossref
José AriasJosé Arias. 2014. Nanotechnology and Drug Delivery, Volume One. Nanotechnology and Drug Delivery, Volume One 1 27 .
Andrew Owen, Christine Dufès, Davide Moscatelli, Eric Mayes, Jonathan F Lovell, Kattesh V Katti, Konstantin Sokolov, Mariarosa Mazza, Olivier Fontaine, Steve Rannard & Vicki Stone. (2014) The application of nanotechnology in medicine: treatment and diagnostics. Nanomedicine 9:9, pages 1291-1294.
Crossref
Zhangjian Chen, Yun Wang, Te Ba, Yang Li, Ji Pu, Tian Chen, Yanshuang Song, Yongen Gu, Qin Qian, Jinglin Yang & Guang Jia. (2014) Genotoxic evaluation of titanium dioxide nanoparticles in vivo and in vitro. Toxicology Letters 226:3, pages 314-319.
Crossref
Ben Forbes, Raegan O'Lone, Philippa Pribul Allen, Anthony Cahn, Chris Clarke, Mark Collinge, Lea Ann Dailey, Louise E. Donnelly, Joseph Dybowski, David Hassall, Deon Hildebrand, Rhys Jones, Joanne Kilgour, Jan Klapwijk, Curtis C. Maier, Tim McGovern, Kristen Nikula, Joel D. Parry, Matthew D. Reed, Ian Robinson, Lindsay Tomlinson & Alison Wolfreys. (2014) Challenges for inhaled drug discovery and development: Induced alveolar macrophage responses. Advanced Drug Delivery Reviews 71, pages 15-33.
Crossref
David E. Lefebvre, Bevan Pearce, Jason H. Fine, Emily Chomyshyn, Nikia Ross, Sabina Halappanavar, Azam F. Tayabali, Ivan Curran & Genevieve S. Bondy. (2014) In Vitro Enhancement of Mouse T Helper 2 Cell Sensitization to Ovalbumin Allergen by Carbon Black Nanoparticles. Toxicological Sciences 138:2, pages 322-332.
Crossref
Yevgen Nazarenko, Paul J. Lioy & Gediminas Mainelis. (2014) Quantitative assessment of inhalation exposure and deposited dose of aerosol from nanotechnology-based consumer sprays. Environmental Science: Nano 1:2, pages 161.
Crossref
Daniela Tiedemann, Ulrike Taylor, Christoph Rehbock, Jurij Jakobi, Sabine Klein, Wilfried A. Kues, Stephan Barcikowski & Detlef Rath. (2014) Reprotoxicity of gold, silver, and gold–silver alloy nanoparticles on mammalian gametes. The Analyst 139:5, pages 931-942.
Crossref
Lise K. Vesterdal, Pernille H. Danielsen, Janne K. Folkmann, Line F. Jespersen, Karin Aguilar-Pelaez, Martin Roursgaard, Steffen Loft & Peter Møller. (2014) Accumulation of lipids and oxidatively damaged DNA in hepatocytes exposed to particles. Toxicology and Applied Pharmacology 274:2, pages 350-360.
Crossref
Matthew S. Hull & Diana M. Bowman. 2014. Nanotechnology Environmental Health and Safety. Nanotechnology Environmental Health and Safety 3 8 .
Enrico Bergamaschi, Mary Gulumian, Jun Kanno & Kai Savolainen. 2014. Biomarkers in Toxicology. Biomarkers in Toxicology 697 716 .
D.W. Hobson & R.C. Guy. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 434 436 .
Lucia Vecchione, Micol Massimiani, Antonella Camaioni, Luna Sifrani, Andrea Magrini, Antonio Pietroiusti & Luisa Campagnolo. (2013) A comparative study of metal oxide nanoparticles embryotoxicity using the embryonic stem cell test. BioNanoMaterials 14:1-2, pages 61-64.
Crossref
Diego Stéfani Teodoro Martinez & Oswaldo Luiz Alves. (2013) Interação de nanomateriais com biossistemas e a nanotoxicologia: na direção de uma regulamentação. Ciência e Cultura 65:3, pages 32-36.
Crossref
Victoria Sherwood, Desirè Di Silvio & Francesca Baldelli Bombelli. 2016. Personalized Medicine with a Nanochemistry Twist. Personalized Medicine with a Nanochemistry Twist 29 54 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.