900
Views
35
CrossRef citations to date
0
Altmetric
Review Article

Diacetyl and 2,3-pentanedione exposures associated with cigarette smoking: implications for risk assessment of food and flavoring workers

, , , &
Pages 420-435 | Received 12 Aug 2013, Accepted 08 Jan 2014, Published online: 17 Mar 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Daniel L. Overbeek, Alexandra P. Kass, Laura E. Chiel, Edward W. Boyer & Alicia M. H. Casey. (2020) A review of toxic effects of electronic cigarettes/vaping in adolescents and young adults. Critical Reviews in Toxicology 50:6, pages 531-538.
Read now

Articles from other publishers (32)

Antje Prasse, Caroline Quartucci, Gernot Zissel, Gian Kayser, Joachim Müller-Quernheim & Björn Christian Frye. 2023. Orphan Lung Diseases. Orphan Lung Diseases 641 669 .
Shinji Kumagai & Ippei Mori. (2022) Obstructive lung disease among workers exposed to diacetylジアセチル曝露労働者に発症した閉塞性肺疾患. SANGYO EISEIGAKU ZASSHI 64:4, pages 211-220.
Crossref
Anne Havermans, Nadja Mallock, Efthimios Zervas, Stéphanie Caillé-Garnier, Thibault Mansuy, Cécile Michel, Jeroen Pennings, Thomas Schulz, Per Schwarze, Renata Solimini, Jean-Pol Tassin, Constantine Vardavas, Miguel Merino, Charlotte Pauwels, Lotte van Nierop, Claude Lambré & Anette Bolling. (2022) Review of industry reports on EU priority tobacco additives part A: Main outcomes and conclusions. Tobacco Prevention & Cessation 8:July, pages 1-18.
Crossref
Juan Wang, So-Young Kim, Emma House, Heather M. Olson, Carl J. Johnston, David Chalupa, Eric Hernady, Thomas J. Mariani, Gérémy Clair, Charles Ansong, Wei-Jun Qian, Jacob N. Finkelstein & Matthew D. McGraw. (2021) Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology. Archives of Toxicology 95:7, pages 2469-2483.
Crossref
Konstantinos Farsalinos. 2021. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure 617 643 .
Randall J. Nett, R. Reid Harvey & Kristin J. Cummings. (2020) Occupational Bronchiolitis. Clinics in Chest Medicine 41:4, pages 661-686.
Crossref
Matt S. Melvin, Karen C. Avery, Regina M. Ballentine, Jason W. Flora, William Gardner, Georgios D. Karles, Yezdi B. Pithawalla, Donna C. Smith, Kimberly D. Ehman & Karl A. Wagner. (2020) Formation of Diacetyl and Other α-Dicarbonyl Compounds during the Generation of E-Vapor Product Aerosols. ACS Omega 5:28, pages 17565-17575.
Crossref
Matthew D. McGraw, So-Young Kim, Christina Reed, Eric Hernady, Irfan Rahman, Thomas J. Mariani & Jacob N. Finkelstein. (2020) Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure. Toxicology Letters 325, pages 25-33.
Crossref
Kyung-Taek Rim & Soo-Jin Kim. (2019) A toxicogenomics study of two chemicals in coffee roasting process. Molecular & Cellular Toxicology 16:1, pages 25-38.
Crossref
Evan M. Beckett, William D. Cyrs, Anders Abelmann, Andrew D. Monnot, Shannon H. Gaffney & Brent L. Finley. (2019) Derivation of an occupational exposure limit for diacetyl using dose‐response data from a chronic animal inhalation exposure study. Journal of Applied Toxicology 39:5, pages 688-701.
Crossref
Zaid Al‐Faham, Ryan F. LeBouf & Randall J. Nett. (2018) Tobacco and other occupational exposures among hookah bar workers. American Journal of Industrial Medicine 61:6, pages 543-544.
Crossref
Konstantinos Farsalinos. (2017) Electronic cigarettes: an aid in smoking cessation, or a new health hazard?. Therapeutic Advances in Respiratory Disease 12, pages 175346581774496.
Crossref
Serban C. Moldoveanu, Amanda G. Hudson & Andrew Harrison. (2017) The Determination of Diacetyl and Acetylpropionyl in Aerosols From Electronic Smoking Devices Using Gas Chromatography Triple Quad Mass Spectrometry. Beiträge zur Tabakforschung International/Contributions to Tobacco Research 27:7, pages 145-153.
Crossref
John B. Hallagan. (2017) The use of diacetyl (2,3-butanedione) and related flavoring substances as flavorings added to foods—Workplace safety issues. Toxicology 388, pages 1-6.
Crossref
M.W. Anders. (2017) Diacetyl and related flavorant α-Diketones: Biotransformation, cellular interactions, and respiratory-tract toxicity. Toxicology 388, pages 21-29.
Crossref
Kathleen Kreiss. (2017) Recognizing occupational effects of diacetyl: What can we learn from this history?. Toxicology 388, pages 48-54.
Crossref
Andrea Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 135 160 .
K.E. Farsalinos. 2017. Analytical Assessment of E-Cigarettes. Analytical Assessment of E-Cigarettes 75 122 .
Ann F. Hubbs, Kara L. Fluharty, Rebekah J. Edwards, Jamie L. Barnabei, John T. Grantham, Scott M. Palmer, Francine Kelly, Linda M. Sargent, Steven H. Reynolds, Robert R. Mercer, Madhusudan P. Goravanahally, Michael L. Kashon, John C. Honaker, Mark C. Jackson, Amy M. Cumpston, William T. Goldsmith, Walter McKinney, Jeffrey S. Fedan, Lori A. Battelli, Tiffany Munro, Winnie Bucklew-Moyers, Kimberly McKinstry, Diane Schwegler-Berry, Sherri Friend, Alycia K. Knepp, Samantha L. Smith & Krishnan Sriram. (2016) Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. The American Journal of Pathology 186:11, pages 2887-2908.
Crossref
A. Hartwig. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 2525 2570 .
Daniel L. Morgan, Micheal P. Jokinen, Crystal L. Johnson, Herman C. Price, William M. Gwinn, Ronald W. Bousquet & Gordon P. Flake. (2016) Chemical Reactivity and Respiratory Toxicity of the α-Diketone Flavoring Agents. Toxicologic Pathology 44:5, pages 763-783.
Crossref
Jennifer S. Pierce, Anders Abelmann & Brent L. Finley. (2016) Comment on “Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes”. Environmental Health Perspectives 124:6.
Crossref
Joseph G. Allen, Skye S. Flanigan, Mallory LeBlanc, Jose Vallarino, Piers MacNaughton, James H. Stewart & David C. Christiani. (2016) Response to “Comment on ‘Flavoring Chemicals in E-Cigarettes: Diacetyl, 2,3-Pentanedione, and Acetoin in a Sample of 51 Products, Including Fruit-, Candy-, and Cocktail-Flavored E-Cigarettes’”. Environmental Health Perspectives 124:6.
Crossref
Van K. Holden & Stella E. Hines. (2016) Update on flavoring-induced lung disease. Current Opinion in Pulmonary Medicine 22:2, pages 158-164.
Crossref
Konstantinos E. Farsalinos, Kurt A. Kistler, Gene Gillman & Vassilis Voudris. (2015) Why We Consider the NIOSH-Proposed Safety Limits for Diacetyl and Acetyl Propionyl Appropriate in the Risk Assessment of Electronic Cigarette Liquid Use: A Response to Hubbs et al.. Nicotine & Tobacco Research 17:10, pages 1290-1291.
Crossref
Ann F. Hubbs, Kristin J. Cummings, Lauralynn Taylor McKernan, David A. Dankovic, Robert M. Park & Kathleen Kreiss. (2015) Comment on Farsalinos et al., “Evaluation of Electronic Cigarette Liquids and Aerosol for the Presence of Selected Inhalation Toxins”. Nicotine & Tobacco Research 17:10, pages 1288-1289.
Crossref
Stephanie ClarkCarl K. Winter. (2015) Diacetyl in Foods: A Review of Safety and Sensory Characteristics. Comprehensive Reviews in Food Science and Food Safety 14:5, pages 634-643.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 42 .
Konstantinos E. Farsalinos, Kurt A. Kistler, Gene Gillman & Vassilis Voudris. (2015) Evaluation of Electronic Cigarette Liquids and Aerosol for the Presence of Selected Inhalation Toxins. Nicotine & Tobacco Research 17:2, pages 168-174.
Crossref
Jennifer S. Pierce, Anders Abelmann, Jason T. Lotter, Chris Comerford, Kara Keeton & Brent L. Finley. (2015) Characterization of naturally occurring airborne diacetyl concentrations associated with the preparation and consumption of unflavored coffee. Toxicology Reports 2, pages 1200-1208.
Crossref
Shannon H. Gaffney, Anders Abelmann, Jennifer S. Pierce, Meghan E. Glynn, John L. Henshaw, Lauren A. McCarthy, Jason T. Lotter, Monty Liong & Brent L. Finley. (2015) Naturally occurring diacetyl and 2,3-pentanedione concentrations associated with roasting and grinding unflavored coffee beans in a commercial setting. Toxicology Reports 2, pages 1171-1181.
Crossref
Brent D. Kerger, Kerry A. Thuett & Brent L. Finley. (2014) Evaluation of four α-diketones for toll-like receptor-4 (TLR-4) activation in a human transfected cell line. Food and Chemical Toxicology 74, pages 117-119.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.