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Research Article

Bioactivation of Halogenated Hydrocarbons by Cytochrome P4502E1

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Pages 1-20 | Published online: 25 Sep 2008

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Samuel M. Cohen, Christopher Bevan, Bhaskar Gollapudi & James E. Klaunig. (2023) Evaluation of the carcinogenicity of carbon tetrachloride. Journal of Toxicology and Environmental Health, Part B 26:6, pages 342-370.
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Yoshio Ijiri, Ryuji Kato, Maiko Sadamatsu, Mina Takano, Yuki Yasuda, Fumiaki Tanaka, Chiyo Oishi, Hideki Imano, Yoshikatsu Okada, Kazuhiko Tanaka & Tetsuya Hayashi. (2018) Contributions of caspase-8 and -9 to liver injury from CYP2E1-produced metabolites of halogenated hydrocarbons. Xenobiotica 48:1, pages 60-72.
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Showkat Ahmad Ganie, Tanveer Ali Dar, Sabuhi Zargar, Aashiq Hussain Bhat, Khalid Bashir Dar, Akbar Masood & Mohammad Afzal Zargar. (2016) Crataegus songarica methanolic extract accelerates enzymatic status in kidney and heart tissue damage in albino rats and its in vitro cytotoxic activity. Pharmaceutical Biology 54:7, pages 1246-1254.
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Andrea Trevisan, Federica Chiara, Michele Mongillo, Luigi Quintieri & Patrizia Cristofori. (2012) Sex-related differences in renal toxicodynamics in rodents. Expert Opinion on Drug Metabolism & Toxicology 8:9, pages 1173-1188.
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Dimitrios T Trafalis, Eleftheria S Panteli, Anastasios Grivas, Christos Tsigris & Petros N Karamanakos. (2010) CYP2E1 and risk of chemically mediated cancers. Expert Opinion on Drug Metabolism & Toxicology 6:3, pages 307-319.
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Pat Neafsey, Gary Ginsberg, Dale Hattis, Douglas O. Johns, Kathryn Z. Guyton & Babasaheb Sonawane. (2009) Genetic Polymorphism in CYP2E1: Population Distribution of CYP2E1 Activity. Journal of Toxicology and Environmental Health, Part B 12:5-6, pages 362-388.
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AngelaS. Burke, Kelly Redeker, RichardC. Kurten, LauraP. James & JackA. Hinson. (2007) Mechanisms of Chloroform-Induced Hepatotoxicity: Oxidative Stress and Mitochondrial Permeability Transition in Freshly Isolated Mouse Hepatocytes. Journal of Toxicology and Environmental Health, Part A 70:22, pages 1936-1945.
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Miyoung Yoon, MichaelC. Madden & HughA. Barton. (2007) Extrahepatic Metabolism by CYP2E1 in PBPK Modeling of Lipophilic Volatile Organic Chemicals: Impacts on Metabolic Parameter Estimation and Prediction of Dose Metrics. Journal of Toxicology and Environmental Health, Part A 70:18, pages 1527-1541.
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Ying-Shan Jin, Min-Jae Lee, Woong Han, Seong-Il Heo, Soo In Sohn & Myeong-Hyeon Wang. (2006) Antioxidant effects and hepatoprotective activity of 2,5-dihydroxy-4,3′-di(β-d-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots on CCl4-induced liver damage. Free Radical Research 40:9, pages 986-992.
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Jose M Jimenez-Lopez & Arthur I Cederbaum. (2005) CYP2E1-dependent oxidative stress and toxicity: role in ethanol-induced liver injury. Expert Opinion on Drug Metabolism & Toxicology 1:4, pages 671-685.
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S. Muzeeb, M. K. Pasha, S. J. S. Basha, R. Mullangi & N. R. Srinivas. (2005) Effect of 1-aminobenzotriazole on the in vitro metabolism and single-dose pharmacokinetics of chlorzoxazone, a selective CYP2E1 substrate in Wistar rats. Xenobiotica 35:8, pages 825-838.
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Ernest Hodgson & Randy L. Rose. (2005) Human Metabolism and Metabolic Interactions of Deployment-Related Chemicals. Drug Metabolism Reviews 37:1, pages 1-39.
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Ying-Shan Jin, Ying-Shan Jin, Seong-Il Heo, Ying-Shan Jin, Seong-Il Heo, Min-Jae Lee, HaE-IK Rhee & Myeong-Hyeon Wang. (2005) Free radical scavenging and hepatoprotective actions of Quercus aliena acorn extract against CCl4-induced liver. Free Radical Research 39:12, pages 1351-1358.
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Jack A. Hinson, Angela B. Reid, Sandra S. McCullough & Laura P. James. (2004) Acetaminophen‐Induced Hepatotoxicity: Role of Metabolic Activation, Reactive Oxygen/Nitrogen Species, and Mitochondrial Permeability Transition. Drug Metabolism Reviews 36:3-4, pages 805-822.
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Lutz W. D. Weber, Meinrad Boll & Andreas Stampfl. (2003) Hepatotoxicity and Mechanism of Action of Haloalkanes: Carbon Tetrachloride as a Toxicological Model. Critical Reviews in Toxicology 33:2, pages 105-136.
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AmyL. Lavin, CatherineF. Jacobson & JohnM. DeSesso. (2000) An Assessment of the Carcinogenic Potential of Trichloroethylene in Humans. Human and Ecological Risk Assessment: An International Journal 6:4, pages 575-641.
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Jane Ellen Simmons. (1997) The Hepatic Interaction of Aliphatic Alcohols with Halogenated Hydrocarbons. Drug Metabolism Reviews 29:1-2, pages 123-136.
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C. Nebbia, M. Dacasto, L. Ceppa, S. Bosia, E. Burdino, R. F. Witkamp & G. Ugazio. (1996) Gender differences in ethanol oxidation and cytochrome P4502E1 content and functions in hepatic microsomes from alcohol-preferring and non-preferring rats. Xenobiotica 26:11, pages 1121-1129.
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A. Irizar & C. Ioannides. (1995) Extrahepatic expression of P450 proteins in insulin-dependent diabetes mellitus. Xenobiotica 25:9, pages 941-949.
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