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Original Articles: Research

The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma

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Pages 1085-1097 | Received 05 May 2010, Accepted 09 Jan 2011, Published online: 21 Mar 2011

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Read on this site (3)

Yi-Pin Chen, Yen-Wei Liu, Demei Lee, Jiantai Timothy Qiu, Tzung-Yan Lee & Shih-Jung Liu. (2019) Biodegradable andrographolide-eluting nanofibrous membranes for the treatment of cervical cancer. International Journal of Nanomedicine 14, pages 421-429.
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Chang-Liang He, Peng-Fei Yi, Qiao-Jia Fan, Hai-Qing Shen, Xiao-Lin Jiang, Qian-Qian Qin, Zhou Song, Cui Zhang, Shuai-Cheng Wu, Xu-Bin Wei, Ying-Lun Li & Ben-Dong Fu. (2013) Xiang-Qi-Tang and its active components exhibit anti-inflammatory and anticoagulant properties by inhibiting MAPK and NF-κB signaling pathways in LPS-treated rat cardiac microvascular endothelial cells. Immunopharmacology and Immunotoxicology 35:2, pages 215-224.
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Malgorzata Czyz, Kamila Koprowska & Malgorzata Sztiller-Sikorska. (2013) Parthenolide reduces the frequency of ABCB5-positive cells and clonogenic capacity of melanoma cells from anchorage independent melanospheres. Cancer Biology & Therapy 14:2, pages 135-145.
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Articles from other publishers (60)

Wenxia Li, Hangjie Fu, Liuyuan Fang, Hui Chai, Bin Ding & Shenxian Qian. (2023) Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway. Archives of Biochemistry and Biophysics 742, pages 109622.
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Joana Jorge, Joana Neves, Raquel Alves, Catarina Geraldes, Ana Cristina Gonçalves & Ana Bela Sarmento-Ribeiro. (2023) Parthenolide Induces ROS-Mediated Apoptosis in Lymphoid Malignancies. International Journal of Molecular Sciences 24:11, pages 9167.
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Sipin Zhu, Ping Sun, Samuel Bennett, Oscar Charlesworth, Renxiang Tan, Xing Peng, Qiang Gu, Omar Kujan & Jiake Xu. (2023) The therapeutic effect and mechanism of parthenolide in skeletal disease, cancers, and cytokine storm. Frontiers in Pharmacology 14.
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Yi-Ju Chou, Ching-Cheng Lin, Ya-Chi Hsu, Jia-Ling Syu, Ling-Ming Tseng, Jen-Hwey Chiu, Jeng-Fan Lo, Chao-Hsiung Lin & Shu-Ling Fu. (2022) Andrographolide suppresses the malignancy of triple-negative breast cancer by reducing THOC1-promoted cancer stem cell characteristics. Biochemical Pharmacology 206, pages 115327.
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Xingchen LIU & Xiaobing WANG. (2022) Recent advances on the structural modification of parthenolide and its derivatives as anticancer agents. Chinese Journal of Natural Medicines 20:11, pages 814-829.
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Jiao Qu, Qianqian Liu, Guoquan You, Ling Ye, Yiguang Jin, Lingdong Kong, Wenjie Guo, Qiang Xu & Yang Sun. (2021) Advances in ameliorating inflammatory diseases and cancers by andrographolide: Pharmacokinetics, pharmacodynamics, and perspective. Medicinal Research Reviews 42:3, pages 1147-1178.
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Lei Xuan, Jing-hai Hu, Ran Bi, Si-qi Liu & Chun-xi Wang. (2022) Andrographolide Inhibits Proliferation and Promotes Apoptosis in Bladder Cancer Cells by Interfering with NF- κ B and PI3K/AKT Signaling In Vitro and In Vivo. Chinese Journal of Integrative Medicine 28:4, pages 349-356.
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Daniela Carlisi, Marianna Lauricella, Antonella D’Anneo, Anna De Blasio, Adriana Celesia, Giovanni Pratelli, Antonietta Notaro, Giuseppe Calvaruso, Michela Giuliano & Sonia Emanuele. (2022) Parthenolide and Its Soluble Analogues: Multitasking Compounds with Antitumor Properties. Biomedicines 10:2, pages 514.
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S. Yasri & V. Wiwanitkit. 2022. Nutraceuticals and Functional Foods in Immunomodulators. Nutraceuticals and Functional Foods in Immunomodulators 271 289 .
Sharuti Mehta, Anil Kumar Sharma & Rajesh K. Singh. (2021) Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update. Phytomedicine Plus 1:4, pages 100085.
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Divya Jain, Yogesh Murti, Wasi Ullah Khan, Rajib Hossain, Mohammad Nabil Hossain, Krishn Kumar Agrawal, Rana Azeem Ashraf, Muhammad Torequl Islam, Pracheta Janmeda, Yasaman Taheri, Mohammed M. Alshehri, Sevgi Durna Daştan, Balakyz Yeskaliyeva, Aliya Kipchakbayeva, Javad Sharifi-Rad & William C. Cho. (2021) Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma. Oxidative Medicine and Cellular Longevity 2021, pages 1-31.
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Karin Jöhrer & Serhat Sezai Ҫiҫek. (2021) Multiple Myeloma Inhibitory Activity of Plant Natural Products. Cancers 13:11, pages 2678.
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Hiroki Doi, Taei Matsui, Johannes M. Dijkstra, Atsushi Ogasawara, Yuki Higashimoto, Seiji Imamura, Tamae Ohye, Hiromu Takematsu, Itsuro Katsuda & Hidehiko Akiyama. (2022) Andrographolide, isolated from Andrographis paniculata, induces apoptosis in monocytic leukemia and multiple myeloma cells via augmentation of reactive oxygen species production. F1000Research 10, pages 542.
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Hiroki Doi, Taei Matsui, Johannes M. Dijkstra, Atsushi Ogasawara, Yuki Higashimoto, Seiji Imamura, Tamae Ohye, Hiromu Takematsu, Itsuro Katsuda & Hidehiko Akiyama. (2021) Andrographolide, isolated from Andrographis paniculata, induces apoptosis in monocytic leukemia and multiple myeloma cells via augmentation of reactive oxygen species production. F1000Research 10, pages 542.
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Yu Gao, Mingtan Tang, Euphemia Leung, Darren Svirskis, Andrew Shelling & Zimei Wu. (2020) Dual or multiple drug loaded nanoparticles to target breast cancer stem cells. RSC Advances 10:32, pages 19089-19105.
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Shanoo Suroowan & Mohamad Fawzi Mahomoodally. 2020. Urban Health Risk and Resilience in Asian Cities. Urban Health Risk and Resilience in Asian Cities 367 387 .
Hon Liong Soo, Shun Ying Quah, Ibrahim Sulaiman, Sreenivasa Rao Sagineedu, Jonathan Chee Woei Lim & Johnson Stanslas. (2019) Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents. Drug Discovery Today 24:9, pages 1890-1898.
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Jan Skoda, Karolina Borankova, Patric J. Jansson, Michael L.-H. Huang, Renata Veselska & Des R. Richardson. (2019) Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti-cancer therapies. Pharmacological Research 139, pages 298-313.
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Danila Cianciosi, Alfonso Varela-Lopez, Tamara Y. Forbes-Hernandez, Massimiliano Gasparrini, Sadia Afrin, Patricia Reboredo-Rodriguez, JiaoJiao Zhang, José L. Quiles, Seyed F. Nabavi, Maurizio Battino & Francesca Giampieri. (2018) Targeting molecular pathways in cancer stem cells by natural bioactive compounds. Pharmacological Research 135, pages 150-165.
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Yung-Hsing Huang, Ommoleila Molavi, Abdulraheem Alshareef, Moinul Haque, Qian Wang, Michael Chu, Christopher Venner, Irwindeep Sandhu, Anthea Peters, Afsaneh Lavasanifar & Raymond Lai. (2018) Constitutive Activation of STAT3 in Myeloma Cells Cultured in a Three-Dimensional, Reconstructed Bone Marrow Model. Cancers 10:6, pages 206.
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Changmin Kim, Hyo-Sook Song, Hojung Park & Bonglee Kim. (2018) Activation of ER Stress-Dependent miR-216b Has a Critical Role in Salvia miltiorrhiza Ethanol-Extract-Induced Apoptosis in U266 and U937 Cells. International Journal of Molecular Sciences 19:4, pages 1240.
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Muhammad Torequl Islam, Eunüs S. Ali, Shaikh Jamal Uddin, Md. Amirul Islam, Subrata Shaw, Ishaq N. Khan, Seyed Soheil Saeedi Saravi, Saheem Ahmad, Shahnawaz Rehman, Vijai Kumar Gupta, Mihnea-Alexandru Găman, Amelia Maria Găman, Santosh Yele, Asish Kumar Das, João Marcelo de Castro e Sousa, Sandra Maria Mendes de Moura Dantas, Hercília Maria Lins Rolim, Ana Amélia de Carvalho Melo-Cavalcante, Mohammad S. Mubarak, Nagendra Sastry Yarla, Jamil A. Shilpi, Siddhartha Kumar Mishra, Atanas G. Atanasov & Mohammad Amjad Kamal. (2018) Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer. Cancer Letters 420, pages 129-145.
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Jung‐Sun Moon, Hyun‐Mi Ko, Ji‐Il Park, Jae‐Hyung Kim, Sun‐Hun Kim & Min‐Seok Kim. (2017) Inhibition of human mesenchymal stem cell proliferation via Wnt signaling activation. Journal of Cellular Biochemistry 119:2, pages 1670-1678.
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Hua Li, Hang Lu, Meng Lv, Qingsheng Wang & Yuping Sun. (2018) Parthenolide facilitates apoptosis and reverses drug-resistance of human gastric carcinoma cells by inhibiting the STAT3 signaling pathway. Oncology Letters.
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