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Leukemia & Lymphoma Volume 55, 2014 - Issue 5
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Research Article

Methylenetetrahydrofolate reductase gene haplotypes affect toxicity during maintenance therapy for childhood acute lymphoblastic leukemia in Japanese patients

Yoichi TanakaDepartment of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, Tokyo, JapanCorrespondence[email protected]
,
Atsushi ManabeDepartment of Pediatrics, St. Luke's International Hospital, Tokyo, Japan
,
Hisaya NakadateDepartment of General Pediatrics and Interdisciplinary Medicine, National Center for Child Health and Development, Tokyo, Japan
,
Kensuke KondohDepartment of Pediatrics, St. Marianna University School of Medicine, Kanagawa, Japan
,
Kozue NakamuraDepartment of Pediatrics, Teikyo University Hospital, Tokyo, Japan
,
Katsuyoshi KohDepartment of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan
,
Akira KikuchiDepartment of Pediatrics, Teikyo University Hospital, Tokyo, Japan
&
Takako KomiyamaDepartment of Clinical Pharmacy, Center for Clinical Pharmacy and Sciences, School of Pharmacy, Kitasato University, Tokyo, Japan
 show all
Pages 1126-1131 | Received 05 Feb 2013, Accepted 11 Jul 2013, Published online: 03 Sep 2013

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Dimitri Maamari, Habib El-Khoury, Omran Saifi, Samar A Muwakkit & Nathalie K Zgheib. (2020) Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia. Pharmacogenomics and Personalized Medicine 13, pages 295-317.
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Maitane Umerez, Ángela Gutierrez-Camino, Carmen Muñoz-Maldonado, Idoia Martin-Guerrero & Africa Garcia-Orad. (2017) MTHFR polymorphisms in childhood acute lymphoblastic leukemia: influence on methotrexate therapy. Pharmacogenomics and Personalized Medicine 10, pages 69-78.
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Articles from other publishers (13)

Kun‐yin Qiu, Jia‐yi Wang, Li‐bin Huang, Chang‐gang Li, Lu‐hong Xu, Ri‐yang Liu, Hui‐qin Chen, Yong‐sheng Ruan, Zi‐jun Zhen, Chi‐kong Li & Jian‐pei Fang. (2023) Vincristine and dexamethasone pulses in addition to maintenance therapy among pediatric acute lymphoblastic leukemia ( GD‐ALL ‐2008): An open‐label, multicentre, randomized, phase III clinical trial . American Journal of Hematology 98:6, pages 869-880.
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O. D. Gurieva, M. I. Savelyeva & T. T. Valiev. (2022) Genetic basis of clinical variants of chemotherapy toxicity in children with acute lymphoblastic leukemia (literature review). Russian Journal of Pediatric Hematology and Oncology 8:4, pages 60-70.
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Maša Vidmar Golja, Alenka Šmid, Nataša Karas Kuželički, Jurij Trontelj, Ksenija Geršak & Irena Mlinarič-Raščan. (2020) Folate Insufficiency Due to MTHFR Deficiency Is Bypassed by 5-Methyltetrahydrofolate. Journal of Clinical Medicine 9:9, pages 2836.
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Yue Zhou, Li Wang, Xiao‐Ying Zhai, Li Wen, Fang Tang, Fan Yang, Xi‐Ting Liu, Lei Dong, Li‐Juan Zhi, Hai‐Yan Shi, Guo‐Xiang Hao, Yi Zheng, Evelyne Jacqz‐Aigrain, Tian‐You Wang & Wei Zhao. (2020) Precision therapy of 6‐mercaptopurine in Chinese children with acute lymphoblastic leukaemia. British Journal of Clinical Pharmacology 86:8, pages 1519-1527.
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Guillermo Gervasini & Sonia Mota-Zamorano. (2019) Clinical Implications of Methotrexate Pharmacogenetics in Childhood Acute Lymphoblastic Leukaemia. Current Drug Metabolism 20:4, pages 313-330.
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Nirmalya Roy Moulik, Archana Kumar, Suraksha Agrawal & Abbas Ali Mahdi. (2018) Folate deficiency in north Indian children undergoing maintenance chemotherapy for acute lymphoblastic leukemia-Implications and outcome. Pediatric Blood & Cancer 65:1, pages e26730.
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Rochelle R. Maxwell & Peter D. Cole. (2017) Pharmacogenetic Predictors of Treatment-Related Toxicity Among Children With Acute Lymphoblastic Leukemia. Current Hematologic Malignancy Reports 12:3, pages 176-186.
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Shoshana Rudin, Marcus Marable & R. Stephanie Huang. (2017) The Promise of Pharmacogenomics in Reducing Toxicity During Acute Lymphoblastic Leukemia Maintenance Treatment. Genomics, Proteomics & Bioinformatics 15:2, pages 82-93.
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Y Kakuta, T Naito, M Onodera, M Kuroha, T Kimura, H Shiga, K Endo, K Negoro, Y Kinouchi & T Shimosegawa. (2015) NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD. The Pharmacogenomics Journal 16:3, pages 280-285.
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S.M. Naushad, P. Dorababu & R. Digumarti. 2016. Handbook of nutrition and diet in leukemia and blood disease therapy. Handbook of nutrition and diet in leukemia and blood disease therapy 291 302 .
Ewelina Kałużna, Ewa Strauss, Olga Zając-Spychała, Ewelina Gowin, Bogna Świątek-Kościelna, Jerzy Nowak, Marta Fichna, Przemysław Mańkowski & Danuta Januszkiewicz-Lewandowska. (2015) Functional variants of gene encoding folate metabolizing enzyme and methotrexate-related toxicity in children with acute lymphoblastic leukemia. European Journal of Pharmacology 769, pages 93-99.
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Lin Mei, Evelena P. Ontiveros, Elizabeth A. Griffiths, James E. Thompson, Eunice S. Wang & Meir Wetzler. (2015) Pharmacogenetics predictive of response and toxicity in acute lymphoblastic leukemia therapy. Blood Reviews 29:4, pages 243-249.
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H-R He, S-Y Chen, H-S You, S-S Hu, J-Y Sun, Y-L Dong & J Lu. (2014) Association between methylenetetrahydrofolate reductase polymorphisms and the relapse of acute lymphoblastic leukemia: a meta-analysis. The Pharmacogenomics Journal 14:5, pages 432-438.
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