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Original Article

2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside

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Pages 1-8 | Received 20 Jan 1991, Published online: 01 Jul 2009

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Holger Scheible, Marc Laisney, Elmar Wimmer, Ana Javornik & Hugues Dolgos. (2013) Comparison of the in vitro and in vivo metabolism of Cladribine (Leustatin, Movectro) in animals and human. Xenobiotica 43:12, pages 1084-1094.
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Darren S Sigal & Alan Saven. (2008) Cladribine in indolent non-Hodgkin’s lymphoma. Expert Review of Anticancer Therapy 8:4, pages 535-545.
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W. N. Wu, L. A. Mckown, M. D. Moyer & W. Cheung. (2004) Metabolism of the antineoplastic and immunosuppressive drug 2-CdA (Leustatin®) in animals and humans. Xenobiotica 34:6, pages 591-606.
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Tadeusz Robak. (2003) Purine Nucleoside Analogues in the Treatment of Myleoid Leukemias. Leukemia & Lymphoma 44:3, pages 391-409.
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Stephen A Johnson. (2001) Nucleoside analogues in the treatment of haematological malignancies. Expert Opinion on Pharmacotherapy 2:6, pages 929-943.
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Eric Van Den Neste, Andre Delannoy, Walter Feremans, Augustin Ferrant & Lucienne Michaux. (2001) Second Primary Tumors and Immune Phenomena After Fludarabine or 2-Chloro-2′-Deoxy adenosine Treatment. Leukemia & Lymphoma 40:5-6, pages 541-550.
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Scott A. Tetreault & Alan Saven. (2000) Delayed Onset of Autoimmune Hemolytic Anemia Complicating Cladribine Therapy for Waldenström Macroglobulinemia. Leukemia & Lymphoma 37:1-2, pages 125-130.
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Wendy P. Gatiac, Alan R.P. Patersona, Andrew R. Belch, Vera Chlumecky, Loree M. Larratt, Michael J. Mant & A. Robert Turner. (1998) Es Nucleoside Transporter Content of Acute Leukemia Cells: Role in Cell Sensitivity to Cytarabine (araC). Leukemia & Lymphoma 32:1-2, pages 45-54.
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T. Robak, J. Gora-Tybor, E. Krykowski, J. A. Walewski, A. Borawska, A. Plubańska, P. Potemski, A. Hellmann, J. M. Zaucha, L. Konopka, B. Ceglarek, T. Durýński, A. Sikorska, K. Michalak, J. Urasiński, J. Opalińska, A. Dmoszyńska, M. B. Adamczyk-Cioch, Z. Kuratowska, J. Dwilewicz-Trojaczek, P. Boguradzki, M. Dere, S. May & P. Grieb. (1997) Activity of 2-chlorodeoxyadenosine (cladribine) in 2-hour intravenous infusion in 94 previously treated patients with low grade non-hodgkin's lymphoma. Leukemia & Lymphoma 26:1-2, pages 99-105.
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K. Warzocha, E. Krykowski, J. Góra-tybor, A. Fronczak & T. Robak. (1996) Fulminant 2-Chlorodeoxyadenosine-Related Peripheral Neuropathy in a Patient with Paraneoplastic Neurological Syndrome Associated with Lymphoma. Leukemia & Lymphoma 21:3-4, pages 343-346.
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M. J. Keating, S. O'brien, H. Kantarjian, L. B. Robertson, C. Koller, M. Beran & E. Estey. (1993) Nucleoside Analogs in Treatment of Chronic Lymphocytic Leukemia. Leukemia & Lymphoma 10:sup1, pages 139-145.
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F. Lauria, D. Benfenati, D. Raspadori, D. Rondelli, P. L. Zinzani & S. Tura. (1993) High Complete Remission Rate in Hairy Cell Leukemia Treated with 2-Chlorodeoxyadenosine. Leukemia & Lymphoma 11:5-6, pages 399-404.
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M. A. Dimopoulos, S. O'brien, H. Kantarjian, E. E. Estey, M. J. Keating & R. Alexanian. (1993) Treatment of Waldenstrom's Macroglobulinemia with Nucleoside Analogues. Leukemia & Lymphoma 11:sup2, pages 105-108.
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Alan Saven & Lawrence D. Piro. (1993) 2-Chlorodeoxyadenosine in the Treatment of Hairy Cell Leukemia. Cancer Investigation 11:5, pages 559-564.
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Marco Montillo, Alessandra Tedeschi, Susan O'Brien, Francesco Di Raimondo, Susan Lerner, Alessandra Ferrajoli, Enrica Morra & Michael J. Keating. (2002) Phase II study of cladribine and cyclophosphamide in patients with chronic lymphocytic leukemia and prolymphocytic leukemia. Cancer 97:1, pages 114-120.
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Gerassimos A. Pangalis, Theodoros P. Vassilakopoulos, Maria N. Dimopoulou, Marina P. Siakantaris, Flora N. Kontopidou & Maria K. Angelopoulou. (2002) B‐chronic lymphocytic leukemia: practical aspects. Hematological Oncology 20:3, pages 103-146.
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Kenneth R. Hande. 2002. Encyclopedia of Cancer. Encyclopedia of Cancer 515 525 .
Stephen A. Johnson. (2000) Clinical Pharmacokinetics of Nucleoside Analogues. Clinical Pharmacokinetics 39:1, pages 5-26.
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H. M. Golomb. 1999. Oncologic Therapies. Oncologic Therapies 411 418 .
M.A Fridrik, G Jäger, H.R Kienzer, H Hausmaninger, P Oppitz, O Krieger, A Zabernigg, A Lang, M Neubauer, G Weidinger, L Schiller, H.L Seewann, A Chott & W Linkesch. (1998) Efficacy and toxicity of 2-chlorodeoxyadenosine (cladribine)—2h infusion for 5 days—as first-line treatment for advanced low grade non-Hodgkin’s lymphoma. European Journal of Cancer 34:10, pages 1560-1564.
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T Robak, M Błasińska-Morawiec, J.Z Błoński, E Krykowski, M Komarnicki, E Trepińska, M Kaźmierczuk, J Hansz, A Dmoszyńska, J Roliński, L Konopka, A.B Skotnicki, W.S Nowak, S Kotlarek-Haus, B Zdziarska & I Urasiński. (1997) The effect of 2-h infusion of 2-chlorodeoxyadenosine (cladribine) with prednisone in previously untreated B-cell chronic lymphocytic leukaemia. European Journal of Cancer 33:14, pages 2347-2351.
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Kimo C. Stine, Robert L. Saylors, Laura L. Williams & David L. Becton. (1997) 2-chlorodeoxyadenosine (2-CDA) for the treatment of refractory or recurrent Langerhans cell histiocytosis (LCH) in pediatric patients. Medical and Pediatric Oncology 29:4, pages 288-292.
Crossref
Ashley K Morris, Jill M Kolesar & John G Kuhn. (2016) Review : Purine nucleoside analogs: fludarabine, entostatin and cladribine. Journal of Oncology Pharmacy Practice 3:2, pages 94-109.
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T. Robak, M. Błasińska‐Morawiec, E. Krykowski, A. Hellmann & L. Konopka. (2009) Autoimmune haemolytic anaemia in patients with chronic lymphocytic eukaemia treated with 2‐chlorodeoxyadenosine (cladribine). European Journal of Haematology 58:2, pages 109-113.
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Alan Saven & Lawrence D. Piro. 1996. Advances in Lymphoma Research. Advances in Lymphoma Research 15 26 .
A. Delannoy. (1996) 2-Chloro-2′-deoxyadenosine: clinical applications in hematology. Blood Reviews 10:3, pages 148-166.
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JC Sipe, JS Romine, JA Koziol, R McMillan, J Zyroff & E Beutler. (2016) Development of cladribine treatment in multiple sclerosis. Multiple Sclerosis Journal 1:6, pages 343-347.
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S.A. Johnson. (1996) Purine analogues in the management of lymphoproliferative diseases. Clinical Oncology 8:5, pages 289-296.
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Jack C. Sipe, J. S. Romine, J. Zyroff, J. Koziol & E. Beutler. 1996. Multiple Sclerosis. Multiple Sclerosis 313 334 .
Henrik Depenbrock, Martin Wenger, Robert Peter, Christian Fellbaum, Thomas Block, Johannes Rastetter & Axel -R. Hanauske. (1995) Investigation of the comparative effects of 2-chlorodeoxyadenosine on tumor colony forming unitsin vitro. Investigational New Drugs 13:2, pages 117-123.
Crossref
C. Pott-Hoeck & W. Hiddemann. (1995) Purine analogs in the treatment of low-grade lymphomas and chronic lymphocytic leukemias. Annals of Oncology 6:5, pages 421-433.
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Viera Reichelov�, Gunnar Juliusson, Tatiana Spasokoukotskaja, Staffan Eriksson & Jan Liliemark. (1995) Interspecies differences in the kinetic properties of deoxycytidine kinase elucidate the poor utility of a phase I pharmacologically directed dose-escalation concept for 2-chloro-2?-deoxyadenosine. Cancer Chemotherapy and Pharmacology 36:6, pages 524-529.
Crossref
H. -J. Guchelaar, D. J. Richel & M. R. Schaafsma. (1994) Clinical and toxicological aspects of the antineoplastic drug cladribine: A review. Annals of Hematology 69:5, pages 223-230.
Crossref
Harvey M. Golomb. (1994) Do we know the treatment of choice for hairy cell leukemia?. Annals of Oncology 5:8, pages 676-677.
Crossref
A. Delannoy, A. Ferrant, P. Martiat, A. Bosly & J.L. Michaux. (2009) 2‐chlorodeoxyadenosine and multiple myeloma. European Journal of Haematology 53:3, pages 181-182.
Crossref
Monika Lechleitner, Bernhard Auer, Udo Zilian, Fritz Hoppichler, Michael Schirmer, Bernhard Föger, Francoise Geisen, Josef R. Patsch & Günther Konwalinka. (1994) The immunosuppressive substance 2-chloro-2-deoxyadenosine modulates lipoprotein metabolism in a murine macrophage cell line (P388 cells). Lipids 29:9, pages 627-633.
Crossref
Ken Kobayashi, Nicholas J. Vogelzang, Sheila M. O'Brien, Richard L. Schilsky, Everett E. Vokes & Mark J. Ratain. (1994) A phase I study of intermittent infusion cladribine in patients with solid tumors. Cancer 74:1, pages 168-173.
Crossref
Alan Saven, Lawrence D. Piro, Robert H. Lemon, Michael L. Figueroa, Michael Kosty, Douglas J. Ellison & Ernest Beutler. (1994) Complete hematologic remissions in chronic-phase, philadelphia-chromosome-positive, chronic myelogenous leukemia after 2-chlorodeoxyadenosine. Cancer 73:12, pages 2953-2963.
Crossref
Carlos J. Carrera, Alan Saven & Lawrence D. Piro. (1994) Purine Metabolism of Lymphocytes: Targets for Chemotherapy Drug Development. Hematology/Oncology Clinics of North America 8:2, pages 357-381.
Crossref
Alastair J.J. Wood, Alan Saven & Lawrence Piro. (1994) Newer Purine Analogues for the Treatment of Hairy-Cell Leukemia. New England Journal of Medicine 330:10, pages 691-697.
Crossref
F. Lauria, D. Rondelli, D. Raspadori, D. Benfenati & S. Tura. (2009) Rapid restoration of natural killer activity following treatment with 2‐chlorodeoxyadenosine in 22 patients with hairy‐cell leukemia. European Journal of Haematology 52:1, pages 16-20.
Crossref
D.C. Betticher, M.F. Fey, A. von Rohr, A. Tobler, H. Jenzer, A. Gratwohl, A. Lohri, P. Pugin, U. Hess, O. Pagani, G. Zulian & T. Cerny. (1994) High incidence of infections after 2-chlorodeoxyadenosine (2-CDA) therapy in patients with malignant lymphomas and chronic and acute leukaemias. Annals of Oncology 5:1, pages 57-64.
Crossref
Maurizio Tonato & Anna Maria Mosconi. 1994. Innovative Antimetabolites in Solid Tumours. Innovative Antimetabolites in Solid Tumours 53 59 .
Alan Saven & Lawrence D. Piro. (1993) The newer purine analogs. Significant therapeutic advance in the management of lymphoid malignancies. Cancer 72:S11, pages 3470-3483.
Crossref
D.C. Betticher, M.F. Fey, M. Rabaglio, T. Cerny, U. Hess, V. Meier, M. Stalder & G. Zulian. (1993) Cladribine and severe myelotoxicity. The Lancet 342:8883, pages 1369.
Crossref
Alan Saven, Michael L. Figueroa, Lawrence D. Piro & Joseph D. Rosenblatt. (1993) 2-Chlorodeoxyadenosine to Treat Refractory Histiocytosis X. New England Journal of Medicine 329:10, pages 734-735.
Crossref
P. L. Zinzani, F. Lauria, D. Rondelli, D. Benfenati, D. Raspadori, M. Bocchia, A. Gozzetti, M. Cavo, T. M. Cirio, F. Zaja, D. Russo, R. Fanin, P. Galieni, R. Algeri, M. Fiacchini & S. Tura. (2009) Fludarabine in patients with advanced and/or resistant B‐chronic lymphocytic leukemia. European Journal of Haematology 51:2, pages 93-97.
Crossref
M. Ryba, P. Grieb, M. Pastuszko, J. Bidziński, J. Andrychowski, C. Dziewiecki, P. Bojarski & L. Królicki. (1993) Successful prevention of neurological deficit in SAH patients with 2-chlorodeoxyadenosine. Acta Neurochirurgica 124:2-4, pages 61-65.
Crossref
Michael J. Keating. (1993) Immunosuppression with purine analogues — the flip side of the gold coin. Annals of Oncology 4:5, pages 347-348.
Crossref
M. Ryba, P. Grieb, M. Walski, J. Sawicki & M. Pastuszko. (1993) 2-Chloro-2? deoxyadenosine prevents angiopathic changes in cerebral arteries in experimental SAH in rabbits. Acta Neurochirurgica 122:1-2, pages 118-121.
Crossref
S. P. Mulligan & D. Catovsky. (2008) The chronic B‐cell leukaemias. Australian and New Zealand Journal of Medicine 23:1, pages 42-50.
Crossref
Alan Saven, Lawrence D. Piro, Carlos J. Carrera, Dennis A. Carson & Ernest Beutler. 1993. Leukemia: Advances in Research and Treatment. Leukemia: Advances in Research and Treatment 15 34 .
Gunnar Juliusson, Annika Elmhorn-Rosenborg & Jan Liliemark. (1992) Response to 2-Chlorodeoxyadenosine in Patients with B-Cell Chronic Lymphocytic Leukemia Resistant to Fludarabine. New England Journal of Medicine 327:15, pages 1056-1061.
Crossref
E Beutler. (1992) Cladribine (2-chlorodeoxyadenosine). The Lancet 340:8825, pages 952-956.
Crossref
AYALEW TEFFERI & ROBERT L. PHYLIKY. (1992) A Clinical Update on Chronic Lymphocytic Leukemia. II. Critical Analysis of Current Chemotherapeutic Modalities. Mayo Clinic Proceedings 67:5, pages 457-461.
Crossref

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