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Original Article

2-Chlorodeoxyadenosine (2-CdA): A Potent Chemotherapeutic and Immunosuppressive Nucleoside

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Pages 1-8 | Received 20 Jan 1991, Published online: 01 Jul 2009

References

  • Giblett E. R., Anderson J. E., Cohen F., Pollara B., Meuwissen H. J. Adenosine deaminase deficiency in two patients with severely impaired cellular immunity. Lancet 1972; 2: 1067–1069
  • Carson D. A., Kaye J., Seegmiller J. E. Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency, Possible role of nucleo-side kinase(s). Proc. Natl. Acad. Sci. USA 1977; 74: 5677–5681
  • Agarwal R. P., Crabtree G. W., Parks R. E., Jr., Nelson J. A., Keightley R., Parkman R., Rosen F. S., Stern R. C., Polmar S. H. Purine nucleoside metabolism in the erythrocytes of patients with adenosine deaminase deficiency and severe combined immunodeficiency. J. Clin. Invest 1976; 57: 1025–1035
  • Carson D. A., Wasson D. B., Kaye J., Ullman B., Martin D. W., Jr., Robins R. K., Montgomery J. A. Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc. Natl. Acad. Sci. USA 1980; 77: 6865–6869
  • Seto S., Carrera C. J., Kubota M., Wasson D. B., Carson D. A. Mechanism of deoxyadenosine and 2-chlorodeox-yadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest 1985; 75: 377–383
  • Carson D. A., Wasson D. B., Taetle R., Yu A. Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes. Blood 1983; 62: 737–743
  • Carson D. A., Wasson D. B., Beutler E. Antileukemic and immunosuppressive activity of 2-chloro-2′-deoxyadenosine. Proc. Natl. Acad. Sci. USA 1984; 81: 2232–2236
  • Juliusson G., Liliemark J. 2-Chlorodeoxyadenosine (CdA) in lymphoproliferative diseases, Clinical and pharmaco-kinetic studies. Blood (Suppl I) 1990; 76: 354a
  • Carrera C. J., Terai C., Lotz M., Curd J. G., Piro L. D., Beutler E., Carson D. A. Potent toxicity of 2-chlorodeoxyadenosine towards human monocytes in vitro and in vivo, A novel approach to immunosuppressive therapy. J. Clin. Invest 1990; 86: 1480–1488
  • Carson D. A., Wasson D. B., Lamon J., Beutler E. A potent new anti-lymphocyte agent, 2-chlorodeoxyadenosine. Blood 1982; 60, (Supplement 1)
  • Saven A., Carrera C. J., Carson D. A., Beutler E., Piro L. D. 2-Chlorodeoxyadenosine, An active agent in the treatment of cutaneous T-cell lymphoma. Blood 1989; 74: 239a
  • Piro L. D., Carrera C. J., Beutler E., Carson D. A. 2-Chlorodeoxyadenosine, An effective new agent for the treatment of chronic lymphocytic leukemia. Blood 1988; 72: 1069–1973
  • Saven A., Carrera C. J., Carson D. A., Beutler E., Piro L. D. Phase II trial update of 2-chlorodeoxyadenosine treatment of advanced chronic lymphocytic leukemia. Proc. Am. Soc. Clin. Oncol 1990; 9: 212a
  • Cheson B. D., Bennett J. M., Rai K. R., Grever M. R., Kay N. E., Schiffer C. A., Oken M. M., Keating M. J., Boldt D. H., Kempin S. J., Foon K. A. Guidelines for clinical protocols for chronic lymphocytic leukemia. Recommendations of the National Cancer Institute-sponsored Working Group. Am. J. Hematol 1988; 29: 152–163
  • Kay A. C., Carrera C. J., Carson D. A., Beutler E., Piro L. D. Phase II trial of 2-chlorodeoxyadenosine in low-grade lymphoma. Blood 1989; 74: 121a
  • Piro L. D., Miller W. E., Carrera C. J., Carson D. A., Beutler E. Hairy-cell leukemia. N. Engl. J. Med 1987; 317: 901
  • Piro L. D., Carrera C. J., Carson D. A., Beutler E. Lasting remissions in hairy cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N. Engl. J. Med 1990; 322: 1117–1121
  • Carrera C. J., Piro L. D., Saven A., Cox K., Beutler E., Carson D. A., Kipps T. J. Restoration of lymphocyte subsets following 2-chlorodeoxyadenosine remission induction in hairy cell leukemia. Blood 1990; 76: 260A, (Suppl)
  • Carson D. A., Kaye J., Wasson D. B. The potential importance of soluble deoxynucleotidase activity in mediating deoxyadenosine toxicity in human lymphoblasts. J. Immunol 1981; 126: 348–352
  • Agarwal R. P., Spector T., Parks R. E., Jr. Tight-binding inhibitors—IV. Inhibition of adenosine deaminases by various inhibitors. Biochem. Pharmacol 1976; 26: 359–367
  • Lembersky B. C., Ratain M. J., Westbrook C., Colomb H. M. Rapid response to 2′-deoxycoformycin in advanced hairy cell leukemia after failure of interferons alpha and gamma. Am. J. Hematol 1988; 27: 60–62
  • Johnston J. B., Eisenhauer E., Corbett W. E., Scott J. G., Zaentz S. D. Efficacy of 2′-deoxycoformycin in hairy-cell leukemia, a study of the National Cancer Institute of Canada Clinical Trials Group. JNCI 1988; 80: 765–769
  • Spiers A. S., Parekh S. J. The treatment of hairy cell leukemia with 2′-deoxycoformycin, results in India and in the United States. Leukemia 1987; 1: 347–350
  • Blick M., Lepe-Zuniga J. L., Doig R., Quesada J. R. Durable complete remissions after 2′-deoxycoformycin treatment in patients with hairy cell leukemia resistant to interferon alpha. Am. J. Hematol 1990; 33: 205–209
  • Dillman R. O., Yu A. L., Qiao C.-N. Repeated pentostatin (2′-deoxycoformycin)-induced remissions in a patient with advanced chronic lymphocytic leukemia. West. J. Med 1988; 148: 334–337
  • Kraut E. H., Neff J. C., Bouroncle B. A., Gochnour D., Grever M. R. Immunosuppressive effects of pentostatin. J. Clin. Oncol 1990; 8: 848–855
  • Lindley C. M., Bernard S. A., Robertson J. D. Vomiting associated with pentostatin and pentostatin plus alpha-interferon, unique pattern and potential mechanisms. J. Pain Symptom. Manage 1990; 5: 262–264
  • Keating M. J., Kantarjian H., Talpaz M., Redman J., Koller C., Barlogie B., Velasquez W., Plunkett W., Freireich E. J., McCredie K. B. Fludarabine, A new agent with major activity against chronic lymphocytic leukemia. Blood 1989; 74: 19–25
  • Kantarjian H. M., Schachner J., Keating M. J. Fludarabine therapy in hairy cell leukemia. Cancer 1991; 67: 1291–1293

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