Advanced search
Publication Cover
Leukemia & Lymphoma Volume 32, 1998 - Issue 1-2
Submit an article Journal homepage
71
Views
47
CrossRef citations to date
0
Altmetric
Review Article

Es Nucleoside Transporter Content of Acute Leukemia Cells: Role in Cell Sensitivity to Cytarabine (araC)

Wendy P. Gatiac Department of Pharmacology, Edmonton, Alberta, Canada, T6G 2H7; Department of the Oncology, Edmonton, Alberta, Canada, T6G 2H7
,
Alan R.P. Patersona Department of Pharmacology, Edmonton, Alberta, Canada, T6G 2H7; Department of the Oncology, Edmonton, Alberta, Canada, T6G 2H7
,
Andrew R. Belch Department of the Medicine, Edmonton, Alberta, Canada, T6G 2H7; Department of the Oncology, Edmonton, Alberta, Canada, T6G 2H7
,
Vera Chlumecky Faculty of Medicine Confocal Microscope Facility, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada, T6G 2H7
,
Loree M. Larratt Department of the Medicine, Edmonton, Alberta, Canada, T6G 2H7; Department of the Oncology, Edmonton, Alberta, Canada, T6G 2H7
,
Michael J. Mant Department of the Medicine, Edmonton, Alberta, Canada, T6G 2H7
&
A. Robert Turner Department of the Medicine, Edmonton, Alberta, Canada, T6G 2H7; Department of the Oncology, Edmonton, Alberta, Canada, T6G 2H7
 show all
Pages 45-54 | Received 20 Mar 1998, Published online: 01 Jul 2009

Citations (47)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (12)

Niamh Keane, Ciara Freeman, Ronan Swords & Francis J Giles. (2013) Elacytarabine: lipid vector technology under investigation in acute myeloid leukemia. Expert Review of Hematology 6:1, pages 9-24.
Read now
VijayaL. Damaraju, Delores Mowles, Sylvia Yao, Amy Ng, JamesD. Young, CarolE. Cass & Zeen Tong. (2012) Role of Human Nucleoside Transporters in the Uptake and Cytotoxicity of Azacitidine and Decitabine. Nucleosides, Nucleotides & Nucleic Acids 31:3, pages 236-255.
Read now
VijayaL. Damaraju, MichaelB. Sawyer, JohnR. Mackey, JamesD. Young & CarolE. Cass. (2009) Human Nucleoside Transporters: Biomarkers for Response to Nucleoside Drugs. Nucleosides, Nucleotides & Nucleic Acids 28:5-7, pages 450-463.
Read now
Stephen Spurgeon, Margaret Yu, John D Phillips & Elliot M Epner. (2009) Cladribine: not just another purine analogue?. Expert Opinion on Investigational Drugs 18:8, pages 1169-1181.
Read now
J. D. Young, S. Y. M. Yao, L. Sun, C. E. Cass & S. A. Baldwin. (2008) Human equilibrative nucleoside transporter (ENT) family of nucleoside and nucleobase transporter proteins. Xenobiotica 38:7-8, pages 995-1021.
Read now
R. Swords & F. Giles. (2007) Troxacitabine in acute leukemia. Hematology 12:3, pages 219-227.
Read now
Ronan Swords, Effrosyni Apostolidou & Francis Giles. (2006) Troxacitabine in leukemia. Hematology 11:5-6, pages 321-329.
Read now
Sharon K. Wu, David K. Ann, Kwang-Jin Kim & Vincent H. L. Lee. (2005) Fine tuning of rabbit equilibrative nucleoside transporter activity by an alternatively spliced variant. Journal of Drug Targeting 13:8-9, pages 521-533.
Read now
Emeline Cros, Lars Jordheim, Charles Dumontet & Carlos M Galmarini. (2004) Problems Related to Resistance to Cytarabine in Acute Myeloid Leukemia. Leukemia & Lymphoma 45:6, pages 1123-1132.
Read now
Carlos M Galmarini, Lars Jordheim & Charles Dumontet. (2003) Pyrimidine nucleoside analogs in cancer treatment. Expert Review of Anticancer Therapy 3:5, pages 717-728.
Read now
Kourosh Lotfi, Gunnar Juliusson & Freidoun Albertioni. (2003) Pharmacological Basis for Cladribine Resistance. Leukemia & Lymphoma 44:10, pages 1705-1712.
Read now
Francis J Giles. (2002) Troxacitabine-based therapy of refractory leukemia. Expert Review of Anticancer Therapy 2:3, pages 261-266.
Read now

Articles from other publishers (35)

Ai-Mei Liao, Bangrong Cai, Ji-Hong Huang, Ming Hui, Kyung-Ku Lee, Kwang Youl Lee & ChangJu Chun. (2021) Synthesis, anticancer activity and potential application of diosgenin modified cancer chemotherapeutic agent cytarabine. Food and Chemical Toxicology 148, pages 111920.
Crossref
Erich H. Schneider, Olga Hofmeister, Solveig Kälble & Roland Seifert. (2020) Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells. Naunyn-Schmiedeberg's Archives of Pharmacology 393:7, pages 1251-1267.
Crossref
Svetlana V. Vasilyeva, Alexander A. Shtil, Albina S. Petrova, Sergei M. Balakhnin, Polina Y. Achigecheva, Dmitry A. Stetsenko & Vladimir N. Silnikov. (2017) Conjugates of phosphorylated zalcitabine and lamivudine with SiO2 nanoparticles: Synthesis by CuAAC click chemistry and preliminary assessment of anti-HIV and antiproliferative activity. Bioorganic & Medicinal Chemistry 25:5, pages 1696-1702.
Crossref
Thulani H. Senanayake, Galya Warren, Xin Wei & Serguei V. Vinogradov. (2013) Application of activated nucleoside analogs for the treatment of drug-resistant tumors by oral delivery of nanogel-drug conjugates. Journal of Controlled Release 167:2, pages 200-209.
Crossref
Trinidad D. Montero, Dusan Racordon, Loreto Bravo, Gareth I. Owen, Miguel L. Bronfman & Andrea V. Leisewitz. (2012) PPAR? and PPAR? regulate the nucleoside transporter hENT1. Biochemical and Biophysical Research Communications 419:2, pages 405-411.
Crossref
Ireneusz Nowak, Vijaya L. Damaraju, Carol E. Cass, James D. Young & Morris J. Robins. (2011) Autofluorescent fused-pyrimidine nucleosides: Synthesis and evaluation as permeants and inhibitors of human nucleoside transporters. Collection of Czechoslovak Chemical Communications 76:12, pages 1395-1412.
Crossref
Daniele Santini, Bruno Vincenzi, Maria Elisabetta Fratto, Giuseppe Perrone, Raymond Lai, Vincenzo Catalano, Carol Cass, Pier Adelchi Ruffini, Chiara Spoto, Pietro Muretto, Sergio Rizzo, Andrea Onetti Muda, John R. Mackey, Antonio Russo, Giuseppe Tonini & Francesco Graziano. (2010) Prognostic role of human equilibrative transporter 1 (hENT1) in patients with resected gastric cancer. Journal of Cellular Physiology, pages n/a-n/a.
Crossref
Marçal Pastor‐Anglada, Míriam Molina‐Arcas, Pedro Cano‐Soldado & Francisco Javier Casado. 2009. Transporters as Drug Carriers. Transporters as Drug Carriers 49 80 .
Jatinder K Lamba. (2009) Genetic factors influencing cytarabine therapy. Pharmacogenomics 10:10, pages 1657-1674.
Crossref
Jing Zhang, Frank Visser, Karen M. King, Stephen A. Baldwin, James D. Young & Carol E. Cass. (2007) The role of nucleoside transporters in cancer chemotherapy with nucleoside drugs. Cancer and Metastasis Reviews 26:1, pages 85-110.
Crossref
Marçal Pastor-Anglada & F. Javier Casado. 2007. Deoxynucleoside Analogs In Cancer Therapy. Deoxynucleoside Analogs In Cancer Therapy 1 28 .
Míriam Molina-Arcas, Gema Moreno-Bueno, Pedro Cano-Soldado, Héctor Hernández-Vargas, F. Javier Casado, José Palacios & Marçal Pastor-Anglada. (2006) Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5′-DFUR in breast cancer MCF7 cells. Biochemical Pharmacology 72:12, pages 1646-1656.
Crossref
Peter L. Bonate, Larry Arthaud, William R. CantrellJr.Jr., Katherine Stephenson, John A. SecristIIIIII & Steve Weitman. (2006) Discovery and development of clofarabine: a nucleoside analogue for treating cancer. Nature Reviews Drug Discovery 5:10, pages 855-863.
Crossref
Alan Kambiz Fotoohi, Malin Lindqvist, Curt Peterson & Freidoun Albertioni. (2006) Involvement of the concentrative nucleoside transporter 3 and equilibrative nucleoside transporter 2 in the resistance of T-lymphoblastic cell lines to thiopurines. Biochemical and Biophysical Research Communications 343:1, pages 208-215.
Crossref
Jeffrey E. Rubnitz, Bassem I. Razzouk & Raul C. Ribeiro. 2010. Childhood Leukemias. Childhood Leukemias 499 539 .
Michael P. Draper, Graham K. Jones, Christopher J. Gould & David E. Modrak. 2005. Frontiers in Antimicrobial Resistance. Frontiers in Antimicrobial Resistance 473 499 .
Malancha Sarkar, Tieran Han, Vijaya Damaraju, Pat Carpenter, Carol E. Cass & Ram P. Agarwal. (2005) Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells. Biochemical Pharmacology 70:3, pages 426-432.
Crossref
Laura Chow, Raymond Lai, Laith Dabbagh, Andrew Belch, James D Young, Carol E Cass & John R Mackey. (2005) Analysis of human equilibrative nucleoside transporter 1 (hENT1) protein in non-Hodgkin's lymphoma by immunohistochemistry. Modern Pathology 18:4, pages 558-564.
Crossref
John R. MackeyCarlos M. GalmariniKathryn A. GrahamAnil A. JoyAlain DelmerLaith DabbaghDarryl GlubrechtLawrence D. JewellRaymond LaiThack LangJohn HansonJames D. YoungHelene Merle-BéralJacques L. BinetCarol E. CassCharles Dumontet. (2005) Quantitative analysis of nucleoside transporter and metabolism gene expression in chronic lymphocytic leukemia (CLL): identification of fludarabine-sensitive and -insensitive populations. Blood 105:2, pages 767-774.
Crossref
Xavier Farré, Elena Guillén-Gómez, Lydia Sánchez, David Hardisson, Yolanda Plaza, Jorge Lloberas, F. Javier Casado, José Palacios & Marçal Pastor-Anglada. (2004) Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors. International Journal of Cancer 112:6, pages 959-966.
Crossref
Jennifer Spratlin, Randeep Sangha, Darryl Glubrecht, Laith Dabbagh, James D. Young, Charles Dumontet, Carol Cass, Raymond Lai & John R. Mackey. (2004) The Absence of Human Equilibrative Nucleoside Transporter 1 Is Associated with Reduced Survival in Patients With Gemcitabine-Treated Pancreas Adenocarcinoma. Clinical Cancer Research 10:20, pages 6956-6961.
Crossref
Hiroyuki Achiwa, Tetsuya Oguri, Shigeki Sato, Hiroyoshi Maeda, Takashi Niimi & Ryuzo Ueda. (2005) Determinants of sensitivity and resistance to gemcitabine: The roles of human equilibrative nucleoside transporter 1 and deoxycytidine kinase in non‐small cell lung cancer. Cancer Science 95:9, pages 753-757.
Crossref
M Pastor-Anglada, M Molina-Arcas, F J Casado, B Bellosillo, D Colomer & J Gil. (2004) Nucleoside transporters in chronic lymphocytic leukaemia. Leukemia 18:3, pages 385-393.
Crossref
Francis J. Giles, Eric J. Feldman, Gail J. Roboz, Richard A. Larson, Steven W. Mamus, Jorge E. Cortes, Srdan Verstovsek, Stefan Faderl, Moshe Talpaz, Miloslav Beran, Maher Albitar, Susan M. O’Brien & Hagop M. Kantarjian. (2003) Phase II study of troxacitabine, a novel dioxolane nucleoside analog, in patients with untreated or imatinib mesylate-resistant chronic myelogenous leukemia in blastic phase. Leukemia Research 27:12, pages 1091-1096.
Crossref
Vijaya L Damaraju, Sambasivarao Damaraju, James D Young, Stephen A Baldwin, John Mackey, Michael B Sawyer & Carol E Cass. (2003) Nucleoside anticancer drugs: the role of nucleoside transporters in resistance to cancer chemotherapy. Oncogene 22:47, pages 7524-7536.
Crossref
Lara M Mangravite, Ilaria Badagnani & Kathleen M Giacomini. (2003) Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney. European Journal of Pharmacology 479:1-3, pages 269-281.
Crossref
Francis J. GilesStefan FaderlDeborah A. ThomasJorge E. CortesGuillermo Garcia-ManeroDan DouerAlexandra M. LevineCharles A. KollerSima S. JehaSusan M. O’BrienElihu H. EsteyHagop M. Kantarjian. (2003) Randomized Phase I/II Study of Troxacitabine Combined With Cytarabine, Idarubicin, or Topotecan in Patients With Refractory Myeloid Leukemias. Journal of Clinical Oncology 21:6, pages 1050-1056.
Crossref
Xin Lu, Shimei Gong, Anne Monks, Daniel Zaharevitz & Jeffrey A. Moscow. (2002) Correlation of Nucleoside and Nucleobase Transporter Gene Expression with Antimetabolite Drug Cytotoxicity. Journal of Experimental Therapeutics and Oncology 2:4, pages 200-212.
Crossref
Carlos M Galmarini, John R Mackey & Charles Dumontet. (2002) Nucleoside analogues and nucleobases in cancer treatment. The Lancet Oncology 3:7, pages 415-424.
Crossref
Carlos M. Galmarini, Xavier Thomas, Fabien Calvo, Philippe Rousselot, Assia El Jafaari, Emeline Cros & Charles Dumontet. (2002) Potential mechanisms of resistance to cytarabine in AML patients. Leukemia Research 26:7, pages 621-629.
Crossref
Francis J. GilesGuillermo Garcia-ManeroJorge E. CortesSharyn D. BakerCarol B. MillerSusan M. O'BrienDeborah A. ThomasMichael AndreeffCarol BivinsJacques JolivetHagop M. Kantarjian. (2002) Phase II Study of Troxacitabine, a Novel Dioxolane Nucleoside Analog, in Patients With Refractory Leukemia. Journal of Clinical Oncology 20:3, pages 656-664.
Crossref
S.A. Baldwin, C.E. Cass & J.D. Young. 2002. Wiley Encyclopedia of Molecular Medicine. Wiley Encyclopedia of Molecular Medicine.
Marilyn L. Clarke, John R. Mackey, Stephen A. Baldwin, James D. Young & Carol E. Cass. 2002. Clinically Relevant Resistance in Cancer Chemotherapy. Clinically Relevant Resistance in Cancer Chemotherapy 27 47 .
Sophie Curbo, Chaoyong Zhu, Magnus Johansson, Jan Balzarini & Anna Karlsson. (2001) Dual Mechanisms of 9-?--Arabinofuranosylguanine Resistance in CEM T-Lymphoblast Leukemia Cells. Biochemical and Biophysical Research Communications 285:1, pages 40-45.
Crossref
CM Galmarini, JR Mackey & C Dumontet. (2001) Nucleoside analogues: mechanisms of drug resistance and reversal strategies. Leukemia 15:6, pages 875-890.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.