Es Nucleoside Transporter Content of Acute Leukemia Cells: Role in Cell Sensitivity to Cytarabine (araC)

References

• Chabner B. A. Cytidine analogues. Cancer Chemotherapy and Biotherapy, 2nd edn, B. A. Chabner, D. L. Longo. Lippincott-Raven, Philadelphia 1996; 213–233
   Google Scholar
• Hoelzer D. Acute lymphoblastic leukemia in adults. Leukemia, 6th edn, E. S. Henderson, T. A. Lister, M. F. Greaves. W.B. Saunders Company, Philadelphia 1996; 446–478
   Google Scholar
• Beutler E., Piro L. D., Saven A., Kay A. C., McMillan R., Longmire R., Carrera C. J., Morin P., Carson D. 2-Chlorodeoxyadenosine (2-CdA): A potent chemotherapeutic and immunosuppressive nucleoside. Leukemia and Lymphoma 1991; 5: 1–8
   PubMed Web of Science ®Google Scholar
• Keating M. J., O'Brien S., Plunkett W., Robertson L. E., Gandhi V., Estey E., Dimopoulos M., Cabanillas E, Kemena A., Kantarjian H. Fludarabine phosphate: A new active agent in hematologic malignancies. Semin. Hematol. 1994; 31: 28–39
   PubMed Web of Science ®Google Scholar
• Kufe D. W., Major P. P., Egan E. M., Beardsley G. P. Correlation of cytotoxicity with incorporation of ara-C into DNA. J. Biol. Chem. 1980; 255: 8997–9000
   PubMed Web of Science ®Google Scholar
• Seto S., Carrera C. J., Kubota M., Wasson D. B., Carson D. A. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 1985; 75: 377–383
   PubMed Web of Science ®Google Scholar
• Plunkett W., Huang P., Gandhi V. Metabolism and action of fludarabine phosphate. Semin. Oncol. 1990; 17: 3–17
   PubMed Web of Science ®Google Scholar
• Hannun Y. A. Apoptosis and the dilemma of cancer chemotherapy. Blood 1997; 89: 1845–1853
   PubMed Web of Science ®Google Scholar
• Oliver J. M., Paterson A. RP. Nucleoside transport. I. A mediated process in human erythrocytes. Can. J. Biochem. 1971; 49: 262–270
   PubMedGoogle Scholar
• Paterson A. R.P., Clanachan A. S., Craik J. D., Gati W. P, Jakobs E. S., Wiley J. S., Cass C. E. Plasma membrane transport of nucleosides, nucleobases and nucleotides: an overview. Role of adenosine and adenine nucleotides in the biological system, S. Imai, M. Nakazawa. Elsevier, Tokyo 1991; 133–149
   Google Scholar
• Belt J. A., Marina N. M., Phelps D. A., Crawford C. R. Nucleoside transport in normal and neoplastic cells. Advan. Enzyme Regul. 1993; 33: 235–252
   PubMedGoogle Scholar
• Cass C. E. Nucleoside transport. Drug Transport in Antimicrobial Therapy and Anticancer Therapy, N. Georgopapadakou. Marcel Dekker, New York 1995; 403–451
   Google Scholar
• Griffith D. A., Jarvis S. M. Nucleoside and nucleobase transport systems of mammalian cells. Biochim. Biophys. Acta 1996; 1286: 153–181
   PubMed Web of Science ®Google Scholar
• Paterson A. RP., Oliver J. M. Nucleoside transport. II. Inhibition by p-nitrobenzylthioguanosine and related compounds. Can. J. Biochem. 1971; 49: 271–274
   PubMedGoogle Scholar
• Belt J. A. Heterogeneity of nucleoside transport in mammalian cells. Two types of transport activity in L1210 and other cultured neoplastic cells. Mol. Pharmacol. 1983; 24: 479–484
   PubMed Web of Science ®Google Scholar
• Huang Q.-Q., Yao S. Y.M., Ritzel M. W.L., Paterson A. RP, Cass C. E., Young J. D. Cloning and functional expression of a complementary DNA encoding a mammalian nucleoside transport protein. J. Biol. Chem. 1994; 269: 17757–17760
   PubMed Web of Science ®Google Scholar
• Che M., Ortiz D. F., Arias I. M. Primary structure and functional expression of a cDNA encoding the bile canalicular, purine-specific Na+-nucleoside co-transporter. J. Biol. Chem. 1995; 270: 13596–13599
   PubMed Web of Science ®Google Scholar
• Griffiths M., Beaumont N., Yao S. Y.M., Sundaram M., Boumah C. E., Davies A., Kwong F. Y.P., Coe I., Cass C. E., Young J. D., Baldwin S. A. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nature Medicine 1997; 3: 89–93
   PubMed Web of Science ®Google Scholar
• Crawford C., Patel D., Belt J. isolation of a human cDNA that confers equilibrative, nitrobenzylmercaptopurine riboside-insensitive nucleoside transport activity (ei), to a transport deficient human leukemia cell line. Proc. Amer. Assoc. Cancer Res. 1997; 38: 60
   Google Scholar
• Griffiths M., Yao S. Y.M., Abidi F., Phillips S. E.V., Cass C. E., Young J. D., Baldwin S. A. Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei), equilibrative nucleoside transporter from human placenta. Biochem. J. 1997; 328: 739–743
   PubMed Web of Science ®Google Scholar
• Dagnino L., Bennett L. L., Jr., Paterson A. R.P. Substrate specificity, kinetics, and stoichiometry of sodium dependent adenosine transport in L1210/AM mouse leukemia cells. J. Biol. Chem. 1991; 266: 6312–6317
   PubMed Web of Science ®Google Scholar
• Crawford C. R, Ng C. Y.C., Noel D., Belt J. A. Nucleoside transport in L1210 murine leukemia cells. Evidence for three transporters. J. Biol. Chem. 1990; 265: 9732–9736
   PubMed Web of Science ®Google Scholar
• Uzerman A. P., Voorschuur A. H. The relationship between ionization and affinity of nucleoside transport inhibitors. Naunyn-Schmiedeherg's Arch. Pharmacol. 1990; 342: 336–341
   PubMed Web of Science ®Google Scholar
• Beukers M. W., Kerkhof C. J.M., Uzerman A. P., Soudijn W. Nucleoside transport inhibition and platelet aggregation in human blood: R75231 and its enantiomers, draflazine and R88016. Eur. J. Pharmacol. 1994; 266: 57–62
   PubMed Web of Science ®Google Scholar
• Griffith D. A., Conant A. R., Jarvis S. M. Differential inhibition of nucleoside transport systems in mammalian cells by a new series of compounds related to lidoflazine and mioflazine. Biochem. Pharmacol. 1990; 40: 2297–2303
   PubMed Web of Science ®Google Scholar
• Cass C. E., Gaudette L. A., Paterson A. R.P. Mediated transport of nucleosides in human erythrocytes: specific binding of the inhibitor nitrobenzylthioinosine to nucleoside transport sites in the erythrocyte membrane. Biochim. Biophys. Acta 1974; 345: 1–10
   PubMed Web of Science ®Google Scholar
• Paterson A. RP, Jakobs E. S., Harley E. R, Cass C. E., Robins M. J. Inhibitors of nucleoside transport as probes and drugs. Development of Target-Oriented Anticancer Drugs, Y.-C. Cheng, B. Goz, M. Minkofff. Raven Press, New York 1983; 41–56
   Google Scholar
• Wiley J. S., Jones S. P., Sawyer W. H., Paterson A. R.P. Cytosine arabinoside influx and nucleoside transport sites in acute leukemia. J. Clin. Invest. 1982; 69: 479–489
   PubMed Web of Science ®Google Scholar
• White J. C., Rathmell J. P., Capizzi R. L. Membrane transport influences the rate of accumulation of cytosine arabinoside in human leukemia cells. J. Clin. Invest. 1987; 79: 380–387
   PubMed Web of Science ®Google Scholar
• Agbanyo F. R, Vijakalakshmi D., Craik J. D., Gati W. P., McAdam D. P., Asakura J., Robins M. J., Paterson A. R.P., Cass C. E. SAENTA, a novel ligand with high affinity for polypeptides associated with nucleoside transport: partial purification of the nitrobenzylthioinosine-binding protein of pig erythrocytes by affinity chromatography. Biochem. J. 1990; 270: 605–614
   PubMed Web of Science ®Google Scholar
• Wiley J. S., Brocklebank A. M., Snook M. B., Jamieson G. P., Sawyer W. H., Craik J. D., Cass C. E., Robins M. J., McAdam D. P., Paterson A. R.P. A new fluorescent probe for the equilibrative inhibitor-sensitive nucleoside transporter. Biochem. J. 1991; 273: 667–672
   PubMed Web of Science ®Google Scholar
• Buolamwinl J. K., Craik J. D., Robins M. J., Gati W. P., Cass C. E., Paterson A. R.P. Conjugates of fluorescein and SAENTA (5′-S-(2-aminoethyl)-N6-(4-nitroben-zyl)-5′-thioadenosine): flow cytometry probes for the es, nucleoside transporter elements of the plasma membrane. Nucleosides and Nucleotides 1994; 13: 737–751
   Google Scholar
• Wiley J. S., Cebon J. S., Jamieson G. P., Szer J., Gibson J., Woodruff R. K., McKendrick J. J., Sheridan W. P., Biggs J. C., Snook M. B., Brocklebank A. M., Railings M. C., Paterson A. R.P. Assessment of proliferative responses to granulocyte-macrophage colony-stimulating factor (GM-CSF) in acute myeloid leukaemia using a fluorescent ligand for the nucleoside transporter. Leukemia 1994; 8: 181–185
   PubMed Web of Science ®Google Scholar
• Wiley J. S., Taupin J., Jamieson G. P., Snook M., Sawyer W. H., Finch L. R. Cytosine arabinoside transport and metabolism in acute leukemias and T cell lymphoblastic lymphoma. J. Clin. Invest. 1985; 75: 632–642
   PubMed Web of Science ®Google Scholar
• J Wiley J. S., Smith C. L., Jamieson G. P. Transport of 2′-deoxycoformycin in human leukemia and lymphoma cells. Biochem. Pharmacol. 1991; 42: 708–710
   PubMed Web of Science ®Google Scholar
• Gati W. P., Paterson A. RP, Larratt L. M., Turner A. R., Belch A. R. Sensitivity of acute leukemia cells to cytarabine is a correlate of cellular es, nucleoside transporter site content measured by flow cytometry with SAENTA-fluorescein. Blood 1997; 90: 346–353
   PubMed Web of Science ®Google Scholar
• Sargent J. M., Taylor C. G. Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia. Br. J. Cancer 1989; 60: 206–210
   PubMed Web of Science ®Google Scholar
• Gati W. P., Paterson A. R.P, Belch A. R., Larratt L. M., Turner A. R. Role of membrane transport in resistance of leukemic blasts to nucleoside drugs. Frontiers of Malignant Hematology. Leukemia Research Fund of Canada, Toronto 1997; 96
   Google Scholar
• The study in progress is a companion to a clinical trial in chemotherapy of AML conducted by the Canadian Leukemia Study Group, Our study uses leukemic cells from newly-diagnosed AML patients who had not been treated for their disease at the time of sampling
   Google Scholar
• Tattersall M. H.N., Ganeshaguru K., Hoffbrand A. V. Mechanisms of resistance of human acute leukaemia cells to cytosine arabinoside. Br. J. Haematol. 1974; 27: 39–46
   PubMed Web of Science ®Google Scholar
• Steuart C. D., Burke P. J. Cytidine deaminase and the development of resistance to arabinosyl cytosine. Nature New Biol. 1971; 233: 109–110
   PubMedGoogle Scholar
• Lacombe R, Durrieu F., Briais A., Dumain P., Belloc R, Bascans E., Reiffers J., Boisseau MR, Bernard Ph. Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia. Leukemia 1997; 11: 1878–1886
   PubMed Web of Science ®Google Scholar
• Bonnet D., Dick J. E. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nature Med. 1997; 3: 730–737
   PubMed Web of Science ®Google Scholar
• Darzynkiewicz Z., Bruno S., Del Bino G., Gorczyca W., Hotz M. A., Lassota P., Traganos R. Features of apoptotic cells measured by flow cytometry. Cytometry 1992; 13: 795–808
   PubMedGoogle Scholar