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Review Article

Nanotechnology-mediated nose to brain drug delivery for Parkinson's disease: a mini review

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Pages 775-788 | Received 01 Dec 2014, Accepted 16 Feb 2015, Published online: 11 Mar 2015

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Zhiren Wang, Mengru Cao, Hongling Xiang, Wei Wang, Xing Feng & Xiaoping Yang. (2019) WBQ5187, a Multitarget Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer’s Disease and Modulates Cerebral β-Amyloid, Gliosis, cAMP Levels, and Neurodegeneration. ACS Chemical Neuroscience 10:12, pages 4787-4799.
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Vedanti R. Salvi & Pravin Pawar. (2019) Nanostructured lipid carriers (NLC) system: A novel drug targeting carrier. Journal of Drug Delivery Science and Technology 51, pages 255-267.
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Crossref
Sally Vanden-Hehir, William Tipping, Martin Lee, Valerie Brunton, Anna Williams & Alison Hulme. (2019) Raman Imaging of Nanocarriers for Drug Delivery. Nanomaterials 9:3, pages 341.
Crossref
Chandrakantsing V. Pardeshi, Veena S. Belgamwar & Sanjay J. Surana. 2019. Nanobiotechnology in Neurodegenerative Diseases. Nanobiotechnology in Neurodegenerative Diseases 163 175 .
Chandrakantsing V. Pardeshi & Veena S. Belgamwar. (2018) N,N,N‑trimethyl chitosan modified flaxseed oil based mucoadhesive neuronanoemulsions for direct nose to brain drug delivery. International Journal of Biological Macromolecules 120, pages 2560-2571.
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Architha Aithal & P. S. Aithal. (2018) The Concept of Ideal Drug &its Realization Opportunity using Nanopharmaceutical Research Scenario. International Journal of Health Sciences and Pharmacy, pages 11-26.
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Stella Gänger & Katharina Schindowski. (2018) Tailoring Formulations for Intranasal Nose-to-Brain Delivery: A Review on Architecture, Physico-Chemical Characteristics and Mucociliary Clearance of the Nasal Olfactory Mucosa. Pharmaceutics 10:3, pages 116.
Crossref
Daniel Hernandez-Baltazar, Rasajna Nadella, Maria de Jesus Rovirosa-Hernandez, Laura Mireya Zavala-Flores & Christian de Jesus Rosas Jarquin. 2018. Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy. Experimental Animal Models of Human Diseases - An Effective Therapeutic Strategy.
Fabio Sonvico, Adryana Clementino, Francesca Buttini, Gaia Colombo, Silvia Pescina, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann & Sara Nicoli. (2018) Surface-Modified Nanocarriers for Nose-to-Brain Delivery: From Bioadhesion to Targeting. Pharmaceutics 10:1, pages 34.
Crossref
Shadab Md, Subrat K. Bhattmisra, Farrukh Zeeshan, Naiyer Shahzad, Md Ali Mujtaba, Venkata Srikanth Meka, Ammu Radhakrishnan, Prashant Kesharwani, Sanjula Baboota & Javed Ali. (2018) Nano-carrier enabled drug delivery systems for nose to brain targeting for the treatment of neurodegenerative disorders. Journal of Drug Delivery Science and Technology 43, pages 295-310.
Crossref
Ioannis N. Mavridis, Maria Meliou, Efstratios-Stylianos Pyrgelis & Eleni Agapiou. 2018. Design of Nanostructures for Versatile Therapeutic Applications. Design of Nanostructures for Versatile Therapeutic Applications 1 29 .
Anujit Ghosal, Arti Vashist, Shivani Tiwari, Eram Sharmin, Sharif Ahmad & Jaydeep Bhattacharya. 2017. Advances in Personalized Nanotherapeutics. Advances in Personalized Nanotherapeutics 25 40 .
Gabriel Henrique Hawthorne, Marcelo Picinin Bernuci, Mariza Bortolanza, Vitor Tumas, Ana Carolina Issy & Elaine Del-Bel. (2016) Nanomedicine to Overcome Current Parkinson’s Treatment Liabilities: A Systematic Review. Neurotoxicity Research 30:4, pages 715-729.
Crossref
Abhijeet D. Kulkarni, Yogesh H. Vanjari, Karan H. Sancheti, Harun M. Patel, Veena S. Belgamwar, Sanjay J. Surana & Chandrakantsing V. Pardeshi. (2016) New nasal nanocomplex self-assembled from charged biomacromolecules: N,N,N-Trimethyl chitosan and dextran sulfate. International Journal of Biological Macromolecules 88, pages 476-490.
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