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Harvard Review of Psychiatry Volume 19, 2011 - Issue 5
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REVIEW

Quality of Life: The Ultimate Outcome Measure of Interventions in Major Depressive Disorder

Waguih William IsHakFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).Correspondence[email protected]
, MD, FAPA , MD,
Jared Matt GreenbergFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).
, MD,
Konstantin BalayanFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).
, MD,
Nina KapitanskiFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).
, MD,
Jessica JeffreyFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).
, MD, MPH, MBA,
Hassan FathyFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).
, MD,
Hala FakhryFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).
, MD &
Mark Hyman RapaportFrom the University of California, Los Angeles Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine (Drs. IsHak, Greenberg, Jeffrey, and Rapaport); Department of Psychiatry and Behavioral Neurosciences, Cedars-Sinai Medical Center, Los Angeles, CA (Drs. IsHak, Balayan, and Rapaport); Department of Psychiatry, Stanford University School of Medicine (Dr. Kapitanski); Department of Psychiatry, State University of New York, Brooklyn School of Medicine (Dr. Fathy); Department of Psychiatry, Faculty of Medicine, Cairo University, Cairo, Egypt (Dr. Fakhry).
, MD show all
Pages 229-239 | Received 02 Jul 2010, Accepted 27 Mar 2011, Published online: 15 Sep 2011

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Maegan M. Paxton Willing, Larissa L. Tate, Patricia T. Spangler, David M. Benedek & David S. Riggs. (2022) Anxiety and Depression Mediate the Relationship of Medication-Resistant PTSD to Quality of Life in Service Members. Military Behavioral Health 10:4, pages 319-327.
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Katharina E. Renz, Matthias Pillny & Tania M. Lincoln. (2022) Increasing motivation in effort-based decision-making tasks: effects of salience and reward expectancy manipulations. Cognitive Neuropsychiatry 27:1, pages 20-34.
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Abdolhadi Jahanfar, Zhila Fereidouni, Mohammad Behnammoghadam, Azizallah Dehghan & Somayeh Bashti. (2020) Efficacy of Eye Movement Desensitization and Reprocessing on the Quality of Life in Patients with Major Depressive Disorder: A Randomized Clinical Trial. Psychology Research and Behavior Management 13, pages 11-17.
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Gang Wang, Kristin Hui Xian Tan, Hongye Ren & Lene Hammer-Helmich. (2020) Impact of Cognitive Symptoms on Health-Related Quality of Life and Work Productivity in Chinese Patients with Major Depressive Disorder: Results from the PROACT Study. Neuropsychiatric Disease and Treatment 16, pages 749-759.
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Jonna Levola, Saana Eskelinen & Tuuli Pitkänen. (2020) Associations between self-rated health, quality of life and symptoms of depression among Finnish inpatients with alcohol and substance use disorders. Journal of Substance Use 25:2, pages 128-134.
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Qijing Bo, Lu Tian, Feng Li, Zhen Mao, Zhimin Wang, Xin Ma & Chuanyue Wang. (2019) Quality of life in euthymic patients with unipolar major depressive disorder and bipolar disorder. Neuropsychiatric Disease and Treatment 15, pages 1649-1657.
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Delphine Saragoussi, Michael Cronquist Christensen, Lene Hammer-Helmich, Benoît Rive, Maëlys Touya & Josep Maria Haro. (2018) Long-term follow-up on health-related quality of life in major depressive disorder: a 2-year European cohort study. Neuropsychiatric Disease and Treatment 14, pages 1339-1350.
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Roni Oren-Yagoda, Thröstur Björgvinsson & Idan M. Aderka. (2018) The relationship between positive affect and negative affect during treatment for major depressive disorder. Psychotherapy Research 28:6, pages 958-968.
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Yuichi Esaki, Tsuyoshi Kitajima, Ippei Takeuchi, Soji Tsuboi, Osamu Furukawa, Masatsugu Moriwaki, Kiyoshi Fujita & Nakao Iwata. (2017) Effect of blue-blocking glasses in major depressive disorder with sleep onset insomnia: A randomized, double-blind, placebo-controlled study. Chronobiology International 34:6, pages 753-761.
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Merijn van de Laar, Dirk Pevernagie, Petra van Mierlo & Sebastiaan Overeem. (2017) Correlates of general quality of life are different in patients with primary insomnia as compared to patients with insomnia and psychiatric comorbidity. Psychology, Health & Medicine 22:2, pages 172-183.
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Michaela Holubova, Jan Prasko, Marie Ociskova, Marketa Marackova, Ales Grambal & Milos Slepecky. (2016) Self-stigma and quality of life in patients with depressive disorder: a cross-sectional study. Neuropsychiatric Disease and Treatment 12, pages 2677-2687.
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Jihyung Hong, Diego Novick, William Montgomery, Maria Victoria Moneta, Héctor Dueñas, Xiaomei Peng & Josep Maria Haro. (2015) Health-related quality of life in patients with depression treated with duloxetine or a selective serotonin reuptake inhibitor in a naturalistic outpatient setting. Patient Preference and Adherence 9, pages 1481-1490.
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Zheng-Yi Zhou, Shawn Sun, Pooja Chopra, Yichen Zhong, Todor Totev & James Signorovitch. (2015) Health resource use and costs of vilazodone and other selective serotonin re-uptake inhibitors in treating major depressive disorder. Journal of Medical Economics 18:11, pages 919-929.
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Diego Novick, William Montgomery, Maria Victoria Moneta, Xiaomei Peng, Roberto Brugnoli & Josep Maria Haro. (2015) Chinese patients with major depression: Do concomitant pain symptoms affect quality of life independently of severity of depression?. International Journal of Psychiatry in Clinical Practice 19:3, pages 174-181.
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Waguih William IsHak, James Mirocha, Sarah Pi, Gabriel Tobia, Bret Becker, Eric D. Peselow & Robert M. Cohen. (2014) Patient-reported outcomes before and after treatment of major depressive disorder. Dialogues in Clinical Neuroscience 16:2, pages 171-183.
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Monika Bullinger & Julia Quitmann. (2014) Quality of life as patient-reported outcomes: principles of assessment. Dialogues in Clinical Neuroscience 16:2, pages 137-145.
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Yoshihiro Satomura, Ryu Takizawa, Shinsuke Koike, Shingo Kawasaki, Akihide Kinoshita, Eisuke Sakakibara, Yukika Nishimura & Kiyoto Kasai. (2014) Potential biomarker of subjective quality of life: Prefrontal activation measurement by near-infrared spectroscopy. Social Neuroscience 9:1, pages 63-73.
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Diego Novick, William Montgomery, Zbigniew Kadziola, Victoria Moneta, Xiaomei Peng, Roberto Brugnoli & Josep Maria Haro. (2013) Do concomitant pain symptoms in patients with major depression affect quality of life even when taking into account baseline depression severity?. Patient Preference and Adherence 7, pages 463-470.
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Maiko Marini, Taciana Madruga Schnornberger, Giovana Bertassi Brandalise, Mônica Bergozza & Elizeth Heldt. (2013) Quality of Life Determinants in Patients of a Psychosocial Care Center for Alcohol and other Drug Users. Issues in Mental Health Nursing 34:7, pages 524-530.
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Judith Renaud & Emmanuelle Bédard. (2013) Depression in the elderly with visual impairment and its association with quality of life. Clinical Interventions in Aging 8, pages 931-943.
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Patrícia Cavalcanti-Ribeiro, Mônica Andrade-Nascimento, Mychelle Morais-de-Jesus, Givaldo Melquíades de Medeiros, Renato Daltro-Oliveira, Jenisson Oliveira Conceição, Marlos Fernando Rocha, Ângela Miranda-Scippa, Karestan Chase Koenen & Lucas Castro Quarantini. (2012) Post-traumatic stress disorder as a comorbidity: impact on disease outcomes. Expert Review of Neurotherapeutics 12:8, pages 1023-1037.
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Waguih William IsHak, Khanh Ha, Nina Kapitanski, Kara Bagot, Hassan Fathy, Brian Swanson, Jennice Vilhauer, Konstantin Balayan, Nestor Ian Bolotaulo & Mark Hyman Rapaport. (2011) The Impact of Psychotherapy, Pharmacotherapy, and Their Combination on Quality of Life in Depression. Harvard Review of Psychiatry 19:6, pages 277-289.
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