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ORIGINAL ARTICLE

Lycopene protects pancreatic acinar cells against severe acute pancreatitis by abating the oxidative stress through JNK pathway

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Pages 151-163 | Received 30 Jun 2014, Accepted 12 Nov 2014, Published online: 11 Dec 2014

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Mustafa B. A. Djamgoz & Valerie Jentzsch. (2022) Integrative Management of Pancreatic Cancer (PDAC): Emerging Complementary Agents and Modalities. Nutrition and Cancer 74:4, pages 1139-1162.
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Jiyong Yang, Zhen Ye, Dan Mei, Honggang Gu & Jingzhe Zhang. (2019) Long noncoding RNA DLX6-AS1 promotes tumorigenesis by modulating miR-497-5p/FZD4/FZD6/Wnt/β-catenin pathway in pancreatic cancer. Cancer Management and Research 11, pages 4209-4221.
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Xue-Fang Du, Li-Li Zhang, De-Zhong Zhang, Lu Yang, Ying-Ying Fan & Shu-Ping Dong. (2018) Clinical significance of serum total oxidant/antioxidant status in patients with operable and advanced gastric cancer. OncoTargets and Therapy 11, pages 6767-6775.
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Articles from other publishers (16)

Tao Zhang, Guangquan Zhang, Wenbo Yang, Hongze Chen, Jisheng Hu, Zhongjie Zhao, Chundong Cheng, Guanqun Li, Yu Xie, Yilong Li, Rui Kong, Yongwei Wang, Gang Wang, Hua Chen, Xue-Wei Bai, Shangha Pan, Bei Sun & Le Li. (2021) Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis. Cell Death & Disease 12:11.
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Jaeeun Lee, Joo Weon Lim & Hyeyoung Kim. (2021) Lycopene Inhibits Oxidative Stress-Mediated Inflammatory Responses in Ethanol/Palmitoleic Acid-Stimulated Pancreatic Acinar AR42J Cells. International Journal of Molecular Sciences 22:4, pages 2101.
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Suyun Choi & Hyeyoung Kim. (2020) The Remedial Potential of Lycopene in Pancreatitis through Regulation of Autophagy. International Journal of Molecular Sciences 21:16, pages 5775.
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Xu Fu, Peiwu Li, Wen Yin, Li Ma, Bei Zhang, Lingling Zhen, Yanfei Meng, Li Han & Yingzhen Wang. (2020) Overexpression of Nrf2 Protects Against Lipopolysaccharide and Cerulein-Induced Pancreatitis In Vitro and In Vivo. Pancreas 49:3, pages 420-428.
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Peng-yu Duan, Yuan Ma, Xi-na Li, Feng-zhi Qu, Liang Ji, Xiao-yu Guo, Wang-jun Zhang, Fan Xiao, Le Li, Ji-sheng Hu, Bei Sun & Gang Wang. (2019) Inhibition of RIPK1-dependent regulated acinar cell necrosis provides protection against acute pancreatitis via the RIPK1/NF-κB/AQP8 pathway. Experimental & Molecular Medicine 51:8, pages 1-17.
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Małgorzata Grabowska, Dariusz Wawrzyniak, Katarzyna Rolle, Piotr Chomczyński, Stefan Oziewicz, Stefan Jurga & Jan Barciszewski. (2019) Let food be your medicine: nutraceutical properties of lycopene. Food & Function 10:6, pages 3090-3102.
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Longfei Pan, Lei Yu, Liming Wang, Juntao He, Jiangli Sun, Xiaobo Wang, Hai Wang, Zhenghai Bai, Hui Feng & Honghong Pei. (2018) Inflammatory stimuli promote oxidative stress in pancreatic acinar cells via Toll-like receptor 4/nuclear factor-κB pathway. International Journal of Molecular Medicine.
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Le Li, Gang Wang, Ji-Sheng Hu, Guang-Quan Zhang, Hong-Ze Chen, Yue Yuan, Yi-Long Li, Xin-Jian Lv, Feng-Yu Tian, Shang-Ha Pan, Xue-Wei Bai & Bei Sun. (2018) RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis. Cell Death & Disease 9:10.
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Qing-Xing Huang, Jun Ma & Yu-Sheng Wang. (2018) Significance of preoperative ischemia- modified albumin in operable and advanced gastric cancer. Cancer Biomarkers 22:3, pages 477-485.
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Nahla E. El-Ashmawy, Naglaa F. Khedr, Hoda A. El-Bahrawy & Omnia B. Hamada. (2018) Suppression of inducible nitric oxide synthase and tumor necrosis factor-alpha level by lycopene is comparable to methylprednisolone in acute pancreatitis. Digestive and Liver Disease 50:6, pages 601-607.
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Nian Wang, Fen Zhang, Liu Yang, Jiang Zou, Hao Wang, Ke Liu, Meidong Liu, Huali Zhang, Xianzhong Xiao & Kangkai Wang. (2017) Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1. International Journal of Molecular Medicine 40:2, pages 427-437.
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Liang Ji, Le Li, Fengzhi Qu, Guangquan Zhang, Yongwei Wang, Xuewei Bai, Shangha Pan, Dongbo Xue, Gang Wang & Bei Sun. (2016) Hydrogen sulphide exacerbates acute pancreatitis by over‐activating autophagy via AMPK / mTOR pathway . Journal of Cellular and Molecular Medicine 20:12, pages 2349-2361.
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Le Li, Hua Chen, Yue Gao, Yong-Wei Wang, Guang-Quan Zhang, Shang-Ha Pan, Liang Ji, Rui Kong, Gang Wang, Yue-Hui Jia, Xue-Wei Bai & Bei Sun. (2016) Long Noncoding RNA MALAT1 Promotes Aggressive Pancreatic Cancer Proliferation and Metastasis via the Stimulation of Autophagy. Molecular Cancer Therapeutics 15:9, pages 2232-2243.
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CHUNSHENG FENG, TIANFEI LUO, SHUYAN ZHANG, KAI LIU, YANHONG ZHANG, YINAN LUO & PENGFEI GE. (2016) Lycopene protects human SH-SY5Y neuroblastoma cells against hydrogen peroxide-induced death via inhibition of oxidative stress and mitochondria-associated apoptotic pathways. Molecular Medicine Reports 13:5, pages 4205-4214.
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XIAOFENG LEI, LIJIAN LEI, ZHELIN ZHANG & YAN CHENG. (2016) Neuroprotective effects of lycopene pretreatment on transient global cerebral ischemia-reperfusion in rats: The role of the Nrf2/HO-1 signaling pathway. Molecular Medicine Reports 13:1, pages 412-418.
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Seyed Abbas Mirmalek, Ala Gholamrezaei Boushehrinejad, Hassan Yavari, Bahareh Kardeh, Yekta Parsa, Seyed Alireza Salimi-Tabatabaee, Soheila Yadollah-Damavandi, Tina Parsa, Ehsan Shahverdi & Ehsan Jangholi. (2016) Antioxidant and Anti-Inflammatory Effects of Coenzyme Q10 on L-Arginine-Induced Acute Pancreatitis in Rat. Oxidative Medicine and Cellular Longevity 2016, pages 1-8.
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