1,859
Views
33
CrossRef citations to date
0
Altmetric
Research Article

Novel flavonoid-based biodegradable nanoparticles for effective oral delivery of etoposide by P-glycoprotein modulation: an in vitro, ex vivo and in vivo investigations

, , , , , & show all
Pages 500-511 | Received 03 Mar 2014, Accepted 09 May 2014, Published online: 17 Jun 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (4)

Xiaoming Zhong, Jianqiong Yang, Hongyan Liu, Zhiwen Yang & Ping Luo. (2023) Potential lipid-based strategies of amphotericin B designed for oral administration in clinical application. Drug Delivery 30:1.
Read now
Shadab Md, Nabil A. Alhakamy, Priyanka Sharma, Mohammad Shahnawaze Ansari & Bapi Gorain. (2022) Nanocarrier-based co-delivery approaches of chemotherapeutics with natural P-glycoprotein inhibitors in the improvement of multidrug resistance cancer therapy. Journal of Drug Targeting 30:8, pages 801-818.
Read now
Zhe Ma, Yuqi Fan, Yumei Wu, Dereje Kebebe, Bing Zhang, Peng Lu, Jiaxin Pi & Zhidong Liu. (2019) Traditional Chinese medicine-combination therapies utilizing nanotechnology-based targeted delivery systems: a new strategy for antitumor treatment. International Journal of Nanomedicine 14, pages 2029-2053.
Read now
Min Liu, Meiwan Chen & Zhiwen Yang. (2017) Design of amphotericin B oral formulation for antifungal therapy. Drug Delivery 24:1, pages 1-9.
Read now

Articles from other publishers (29)

Priya Gupta, Shwetakshi Sharma, Yub Raj Neupane, Zafar Khan, Shahnawaz Ahmad, Nasr A. Emad, Mohd Aqil, Kanchan Kohli & Yasmin Sultana. (2023) Co-delivery of exemestane and thymoquinone via nanostructured lipid carriers for efficient breast cancer therapy. Journal of Drug Delivery Science and Technology 88, pages 104892.
Crossref
Ghulam Mustafa, Dilawar Hassan, Gustavo Ruiz-Pulido, Mehrab Pourmadadi, Mohammad Mahdi Eshaghi, Razieh Behzadmehr, Fatemeh Soltani Tehrani, Abbas Rahdar, Dora Iliana Medina & Sadanand Pandey. (2023) Nanoscale drug delivery systems for cancer therapy using paclitaxel— A review of challenges and latest progressions. Journal of Drug Delivery Science and Technology 84, pages 104494.
Crossref
Gianni Pecorini, Elisabetta Ferraro & Dario Puppi. (2023) Polymeric Systems for the Controlled Release of Flavonoids. Pharmaceutics 15:2, pages 628.
Crossref
Muhammad Shafique, Maqsood Ur Rehman, Zul Kamal, Rami M. Alzhrani, Sameer Alshehri, Ali H. Alamri, Mohammed Ali Bakkari, Fahad Y. Sabei, Awaji Y. Safhi, Ahmed M. Mohammed, Mohamed A. El Hamd & Saud Almawash. (2023) Formulation development of lipid polymer hybrid nanoparticles of doxorubicin and its in-vitro, in-vivo and computational evaluation. Frontiers in Pharmacology 14.
Crossref
Iram Khan, Jayamanti Pandit, Shakeeb Ahmed, Saima Zameer, Nikita, Saeem Ahmad, Shahnaj Bano, Mohd Danish Ansari, Pavitra Solanki, Rao Nargis Jahan, Ayesha Waheed, Mohd Aqil & Yasmin Sultana. (2022) Development and evaluation of biodegradable polymeric lomustine nanofibres for the efficient tumor targeting: In vitro characterization, ex vivo permeation and degradation study. Journal of Drug Delivery Science and Technology 75, pages 103685.
Crossref
Alok Ranjan & Prateek K. Jha. (2021) Recent Advances in Dissolution Testing and Their Use to Improve In Vitro–In Vivo Correlations in Oral Drug Formulations. Journal of Pharmaceutical Innovation 17:3, pages 1011-1026.
Crossref
Morgane Renault–Mahieux, Nathalie Mignet, Johanne Seguin, Khair Alhareth, Muriel Paul & Karine Andrieux. (2022) Co–encapsulation of flavonoids with anti–cancer drugs: A challenge ahead. International Journal of Pharmaceutics 623, pages 121942.
Crossref
Carina Cassini, Pedro Henrique Zatti, Valéria Weiss Angeli, Catia Santos Branco & Mirian Salvador. (2022) Mutual Effects of Free and Nanoencapsulated Phenolic Compounds on Human Microbiota. Current Medicinal Chemistry 29:18, pages 3160-3178.
Crossref
Ali Sartaj, Zufika Qamar, Farheen Fatima Qizilbash, Annu, Shadab Md, Nabil A. Alhakamy, Sanjula Baboota & Javed Ali. (2021) Polymeric Nanoparticles: Exploring the Current Drug Development and Therapeutic Insight of Breast Cancer Treatment and Recommendations. Polymers 13:24, pages 4400.
Crossref
Agnese Gagliardi, Silvia Voci, Sonia Bonacci, Giuseppe Iriti, Antonio Procopio, Massimo Fresta & Donato Cosco. (2021) SCLAREIN (SCLAREol contained in zeIN) nanoparticles: Development and characterization of an innovative natural nanoformulation. International Journal of Biological Macromolecules 193, pages 713-720.
Crossref
Agnese Gagliardi, Silvia Voci, Elena Giuliano, Maria Cristina Salvatici, Marilena Celano, Massimo Fresta & Donato Cosco. (2021) Phospholipid/zein hybrid nanoparticles as promising carriers for the protection and delivery of all-trans retinoic acid. Materials Science and Engineering: C 128, pages 112331.
Crossref
Thi-Thao-Linh Nguyen, Van-An Duong & Han-Joo Maeng. (2021) Pharmaceutical Formulations with P-Glycoprotein Inhibitory Effect as Promising Approaches for Enhancing Oral Drug Absorption and Bioavailability. Pharmaceutics 13:7, pages 1103.
Crossref
Wan-Yi Liu, Chia-Chen Lin, Yun-Shan Hsieh & Yu-Tse Wu. (2021) Nanoformulation Development to Improve the Biopharmaceutical Properties of Fisetin Using Design of Experiment Approach. Molecules 26:10, pages 3031.
Crossref
Paola Aiello, Sara Consalvi, Giovanna Poce, Anna Raguzzini, Elisabetta Toti, Maura Palmery, Mariangela Biava, Marco Bernardi, Mohammad A. Kamal, George Perry & Ilaria Peluso. (2021) Dietary flavonoids: Nano delivery and nanoparticles for cancer therapy. Seminars in Cancer Biology 69, pages 150-165.
Crossref
Delaram Babadi, Simin Dadashzadeh, Mahraz Osouli, Maryam Sadat Daryabari & Azadeh Haeri. (2020) Nanoformulation strategies for improving intestinal permeability of drugs: A more precise look at permeability assessment methods and pharmacokinetic properties changes. Journal of Controlled Release 321, pages 669-709.
Crossref
Yi Peng, Lu Chen, Sheng Ye, Yu Kang, Junqing Liu, Su Zeng & Lushan Yu. (2020) Research and development of drug delivery systems based on drug transporter and nano-formulation. Asian Journal of Pharmaceutical Sciences 15:2, pages 220-236.
Crossref
Hira Choudhury, Rahul Maheshwari, Manisha Pandey, Muktika Tekade, Bapi Gorain & Rakesh Kumar Tekade. (2020) Advanced nanoscale carrier-based approaches to overcome biopharmaceutical issues associated with anticancer drug ‘Etoposide’. Materials Science and Engineering: C 106, pages 110275.
Crossref
Sabya Sachi Das, P. R. P. Verma, Sweta Kar & Sandeep Kumar Singh. 2020. Nanomedicine for Bioactives. Nanomedicine for Bioactives 155 183 .
Francesco Lai, Michele Schlich, Rosa Pireddu, Anna Maria Fadda & Chiara Sinico. (2019) Nanocrystals as Effective Delivery Systems of Poorly Water-soluble Natural Molecules. Current Medicinal Chemistry 26:24, pages 4657-4680.
Crossref
Reza Baradaran Eftekhari, Niloufar Maghsoudnia, Shabnam Samimi, Ali Zamzami & Farid Abedin Dorkoosh. (2019) Co-Delivery Nanosystems for Cancer Treatment: A Review. Pharmaceutical Nanotechnology 7:2, pages 90-112.
Crossref
Niyaz Ahmad, Rizwan Ahmad, Md Aftab Alam & Farhan Jalees Ahmad. (2018) Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles. Chemistry Central Journal 12:1.
Crossref
Lubna Siddiqui, Harshita Mishra, Pawan Kumar Mishra, Zeenat Iqbal & Sushama Talegaonkar. (2018) Novel 4-in-1 strategy to combat colon cancer, drug resistance and cancer relapse utilizing functionalized bioinspiring lignin nanoparticle. Medical Hypotheses 121, pages 10-14.
Crossref
Shilu Mathew, Asmaa A. Al Thani & Hadi M. Yassine. (2018) Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors. PLOS ONE 13:9, pages e0203148.
Crossref
Shao-Qing Chen, Cheng Wang, Shan Tao, Yun-Xin Wang, Fu-Qiang Hu & Hong Yuan. (2018) Rational Design of Redox-Responsive and P-gp-Inhibitory Lipid Nanoparticles with High Entrapment of Paclitaxel for Tumor Therapy. Advanced Healthcare Materials 7:17, pages 1800485.
Crossref
Md. K. Anwer, Ramadan Al-Shdefat, Essam Ezzeldin, Saad M. Alshahrani, Abdullah S. Alshetaili & Muzaffar Iqbal. (2017) Preparation, Evaluation and Bioavailability Studies of Eudragit Coated PLGA Nanoparticles for Sustained Release of Eluxadoline for the Treatment of Irritable Bowel Syndrome. Frontiers in Pharmacology 8.
Crossref
Md. Khalid Anwer, Mohammed A. Al-Mansoor, Shahid Jamil, Ramadan Al-Shdefat, Mohammad Nazam Ansari & Faiyaz Shakeel. (2016) Development and evaluation of PLGA polymer based nanoparticles of quercetin. International Journal of Biological Macromolecules 92, pages 213-219.
Crossref
Arindam Dey, Abhirup Dasgupta, Vijay Kumar, Aakriti Tyagi & Anita Kamra Verma. (2015) Evaluation of the of antibacterial efficacy of polyvinylpyrrolidone (PVP) and tri-sodium citrate (TSC) silver nanoparticles. International Nano Letters 5:4, pages 223-230.
Crossref
Naseem Akhtar, Sushama Talegaonkar, Abdul Ahad, Rook K. Khar & Manu Jaggi. (2015) Potential of a novel self nanoemulsifying carrier system to overcome P-glycoprotein mediated efflux of etoposide: In vitro and ex vivo investigations. Journal of Drug Delivery Science and Technology 28, pages 18-27.
Crossref
Sobiya Zafar, Lalit Mohan Negi, Anita Kamra Verma, Vijay Kumar, Aakriti Tyagi, Pratibha Singh, Zeenat Iqbal & Sushama Talegaonkar. (2014) Sterically stabilized polymeric nanoparticles with a combinatorial approach for multi drug resistant cancer: In vitro and in vivo investigations. International Journal of Pharmaceutics 477:1-2, pages 454-468.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.