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Review Article

Strategies for oral delivery and mitochondrial targeting of CoQ10

Pages 1868-1881 | Received 13 Oct 2014, Accepted 27 Nov 2014, Published online: 29 Dec 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Amin Gasmi, Geir Bjørklund, Pavan Kumar Mujawdiya, Yuliya Semenova, Salva Piscopo & Massimiliano Peana. (2022) Coenzyme Q10 in aging and disease. Critical Reviews in Food Science and Nutrition 0:0, pages 1-13.
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Eduarda Fernandes, Sofia Benfeito, Fernando Cagide, Hugo Gonçalves, Sigrid Bernstorff, Jana B Nieder, M Elisabete CD Real Oliveira, Fernanda Borges & Marlene Lúcio. (2021) Lipid Nanosystems and Serum Protein as Biomimetic Interfaces: Predicting the Biodistribution of a Caffeic Acid-Based Antioxidant. Nanotechnology, Science and Applications 14, pages 7-27.
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Mikayla E. Raddysh & Diego H. Delgado. (2021) Integrating supplementation in the management of patients with heart failure: an evidence-based review. Expert Review of Cardiovascular Therapy 19:10, pages 891-905.
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Nadia Turton, Nathan Bowers, Sam Khajeh, Iain P Hargreaves & Robert A Heaton. (2021) Coenzyme Q10 and the exclusive club of diseases that show a limited response to treatment. Expert Opinion on Orphan Drugs 9:5, pages 151-160.
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Vanessa Jane Banun, Prarthana Rewatkar, Zanib Chaudhary, Zhi Qu, Taskeen Janjua, Anuja Patil, Yuao Wu, Hang T. Ta, Nidhi Bansal, Jared A. Miles, Benjamin P. Ross, Tushar Kumeria & Amirali Popat. (2021) Protein Nanoparticles for Enhanced Oral Delivery of Coenzyme-Q10: in Vitro and in Silico Studies . ACS Biomaterials Science & Engineering 9:6, pages 2846-2856.
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Yasuharu Kashiwagura, Shota Takusagawa, Yasuyuki Ikematsu, Shimako Tanaka, Noriyuki Namiki & Shinya Uchida. (2023) Tablet characteristics and pharmacokinetics of orally disintegrating tablets containing coenzyme Q10 granules prepared by different methods. Acta Pharmaceutica 73:1, pages 107-119.
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Torsak Tippairote, Geir Bjørklund, Amin Gasmi, Yuliya Semenova, Massimiliano Peana, Salvatore Chirumbolo & Tony Hangan. (2022) Combined Supplementation of Coenzyme Q10 and Other Nutrients in Specific Medical Conditions. Nutrients 14:20, pages 4383.
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Theresa Staufer, Mirja L. Schulze, Oliver Schmutzler, Christian Körnig, Vivienne Welge, Thorsten Burkhardt, Jens-Peter Vietzke, Alexandra Vogelsang, Julia M. Weise, Thomas Blatt, Oliver Dabrowski, Gerald Falkenberg, Dennis Brückner, Carlos Sanchez-Cano & Florian Grüner. (2022) Assessing Cellular Uptake of Exogenous Coenzyme Q10 into Human Skin Cells by X-ray Fluorescence Imaging. Antioxidants 11:8, pages 1532.
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Victoria Maneu, Pedro Lax, Antonio Miguel G. De Diego, Nicolás Cuenca & Antonio G. García. (2022) Combined drug triads for synergic neuroprotection in retinal degeneration. Biomedicine & Pharmacotherapy 149, pages 112911.
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Jieqiong Xie, Jiayang Jiang & Qiwei Guo. (2022) Primary Coenzyme Q10 Deficiency-7 and Pathogenic COQ4 Variants: Clinical Presentation, Biochemical Analyses, and Treatment. Frontiers in Genetics 12.
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Nicola Rizzardi, Irene Liparulo, Giorgia Antonelli, Francesca Orsini, Antonella Riva, Christian Bergamini & Romana Fato. (2021) Coenzyme Q10 Phytosome Formulation Improves CoQ10 Bioavailability and Mitochondrial Functionality in Cultured Cells. Antioxidants 10:6, pages 927.
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Chary López-Pedrera, José Manuel Villalba, Alejandra Mª Patiño-Trives, Maria Luque-Tévar, Nuria Barbarroja, Mª Ángeles Aguirre, Alejandro Escudero-Contreras & Carlos Pérez-Sánchez. (2021) Therapeutic Potential and Immunomodulatory Role of Coenzyme Q10 and Its Analogues in Systemic Autoimmune Diseases. Antioxidants 10:4, pages 600.
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Žane Temova Rakuša, Albin Kristl & Robert Roškar. (2021) Stability of Reduced and Oxidized Coenzyme Q10 in Finished Products. Antioxidants 10:3, pages 360.
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Joyce N. Amajuoyi, Margaret O. Ilomuanya, Yaa Asantewaa-Osei, Chukwuemeka P. Azubuike, Samson O. Adeosun & Cecilia I. Igwilo. (2020) Development of electrospun keratin/coenzyme Q10/poly vinyl alcohol nanofibrous scaffold containing mupirocin as potential dressing for infected wounds. Future Journal of Pharmaceutical Sciences 6:1.
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Carmen J. Pastor-Maldonado, Juan M. Suárez-Rivero, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, Irene Villalón-García, Manuel Munuera-Cabeza, Alejandra Suárez-Carrillo, Marta Talaverón-Rey & José A. Sánchez-Alcázar. (2020) Coenzyme Q10: Novel Formulations and Medical Trends. International Journal of Molecular Sciences 21:22, pages 8432.
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Josef Jampilek & Katarina Kralova. (2020) Potential of Nanonutraceuticals in Increasing Immunity. Nanomaterials 10:11, pages 2224.
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Lídia Bofill, Dafne de Sande, Rafael Barbas & Rafel Prohens. (2020) New Cocrystal of Ubiquinol with High Stability to Oxidation. Crystal Growth & Design 20:8, pages 5583-5588.
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Phiwayinkosi V. Dludla, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Ilenia Cirilli, Tawanda M. Nyambuya, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Bongani B. Nkambule, Rabia Johnson, Sithandiwe E. Mazibuko-Mbeje, Christo J. F. Muller, Johan Louw & Luca Tiano. (2020) Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. International Journal of Molecular Sciences 21:9, pages 3247.
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Asad Ali, Usama Ahmad, Juber Akhtar, Badruddeen & Mohd Muazzam Khan. (2019) Engineered nano scale formulation strategies to augment efficiency of nutraceuticals. Journal of Functional Foods 62, pages 103554.
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Huan-Chieh Chen, Chi-Chang Huang, Tien-Jen Lin, Mei-Chich Hsu & Yi-Ju Hsu. (2019) Ubiquinol Supplementation Alters Exercise Induced Fatigue by Increasing Lipid Utilization in Mice. Nutrients 11:11, pages 2550.
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Giovanna Petrangolini, Massimo Ronchi, Elisabetta Frattini, Eric De Combarieu, Pietro Allegrini & Antonella Riva. (2019) A New Food-grade Coenzyme Q10 Formulation Improves Bioavailability: Single and Repeated Pharmacokinetic Studies in Healthy Volunteers. Current Drug Delivery 16:8, pages 759-767.
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Zafar, Quarta, Marradi & Ragusa. (2019) Recent Developments in the Reduction of Oxidative Stress through Antioxidant Polymeric Formulations. Pharmaceutics 11:10, pages 505.
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Cristina Cerqua, Alberto Casarin, Fabien Pierrel, Luis Vazquez Fonseca, Giampiero Viola, Leonardo Salviati & Eva Trevisson. (2019) Vitamin K2 cannot substitute Coenzyme Q10 as electron carrier in the mitochondrial respiratory chain of mammalian cells. Scientific Reports 9:1.
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Mayumi Takahashi & Kazuhide Takahashi. (2019) Water-soluble CoQ10 as A Promising Anti-aging Agent for Neurological Dysfunction in Brain Mitochondria. Antioxidants 8:3, pages 61.
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Luis Vitetta, Andrea Leong, Joyce Zhou, Serena Dal Forno, Sean Hall & David Rutolo. (2018) The Plasma Bioavailability of Coenzyme Q10 Absorbed from the Gut and the Oral Mucosa. Journal of Functional Biomaterials 9:4, pages 73.
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Isabel González-Mariscal, Alejandro Martin-Montalvo, Luis Vazquez-Fonseca, Teresa Pomares-Viciana, Ana Sánchez-Cuesta, Daniel José Fernández-Ayala, Placido Navas & Carlos Santos-Ocana. (2018) The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis. Biochimica et Biophysica Acta (BBA) - Bioenergetics 1859:11, pages 1235-1248.
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Arrigo F. G. Cicero, Federica Fogacci & Alessandro Colletti. (2018) Commentary to: “The Effects of Coenzyme Q10 Supplementation on Blood Pressures Among Patients with Metabolic Diseases: A Systematic Review and Meta-analysis of Randomized Controlled Trials”. High Blood Pressure & Cardiovascular Prevention 25:1, pages 51-52.
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Benkai Qin, Lei Liu, Yangyang Pan, Yingchun Zhu, Xiaohe Wu, Shiyong Song & Guang Han. (2017) PEGylated Solanesol for Oral Delivery of Coenzyme Q 10 . Journal of Agricultural and Food Chemistry 65:16, pages 3360-3367.
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Jerzy Jankowski, Katarzyna Korzeniowska, Artur Cieślewicz & Anna Jabłecka. (2016) Coenzyme Q10 – A new player in the treatment of heart failure?. Pharmacological Reports 68:5, pages 1015-1019.
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Gye Hwa Shin, Jun Tae Kim & Hyun Jin Park. (2015) Recent developments in nanoformulations of lipophilic functional foods. Trends in Food Science & Technology 46:1, pages 144-157.
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