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Research Article

Application of active layering and coating techniques in the development of a multiparticulate, controlled release dosage form of a high-dose, highly soluble drug

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Pages 556-564 | Received 06 May 2013, Accepted 07 May 2013, Published online: 14 Jun 2013

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Yuli Wang, Jiahui Yang, Yong Qian, Meiyan Yang, Yan Qiu, Wei Huang, Li Shan & Chunsheng Gao. (2015) Novel ethylcellulose-coated pellets for controlled release of metoprolol succinate without lag phase: characterization, optimization and in vivo evaluation. Drug Development and Industrial Pharmacy 41:7, pages 1120-1129.
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Nikolett Kállai-Szabó, Miléna Lengyel, Dóra Farkas, Ádám Tibor Barna, Christian Fleck, Bálint Basa & István Antal. (2022) Review on Starter Pellets: Inert and Functional Cores. Pharmaceutics 14:6, pages 1299.
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Daniel Zakowiecki, Maja Frankiewicz, Tobias Hess, Krzysztof Cal, Maciej Gajda, Justyna Dabrowska, Bartlomiej Kubiak, Jadwiga Paszkowska, Marcela Wiater, Dagmara Hoc, Grzegorz Garbacz & Dorota Haznar-Garbacz. (2021) Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets. Pharmaceutics 13:6, pages 805.
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Chao Pi, Ting Feng, Jing Liang, Hao Liu, Dongmei Huang, Chenglin Zhan, Jiyuan Yuan, Robert J. Lee, Ling Zhao & Yumeng Wei. (2018) Polymer blends used to develop felodipine-loaded hollow microspheres for improved oral bioavailability. International Journal of Biological Macromolecules 112, pages 1038-1047.
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Felipe L. Lopez, Alexandra Bowles, Mine Orlu Gul, David Clapham, Terry B. Ernest & Catherine Tuleu. (2016) Effect of formulation variables on oral grittiness and preferences of multiparticulate formulations in adult volunteers. European Journal of Pharmaceutical Sciences 92, pages 156-162.
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Yuli Wang, Jingjing Dai, Xinyi Chang, Meiyan Yang, Ruifang Shen, Li Shan, Yong Qian & Chunsheng Gao. (2014) Model Drug as Pore Former for Controlled Release of Water-Soluble Metoprolol Succinate from Ethylcellulose-Coated Pellets Without Lag Phase: Opportunities and Challenges. AAPS PharmSciTech 16:1, pages 35-44.
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