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Pharmaceutical Development and Technology Volume 19, 2014 - Issue 8
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Research Article

Trehalose is not a universal solution for solid lipid nanoparticles freeze-drying

Slavomira DoktorovovaInstitute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro (IBB/CGB-UTAD) Vila-RealPortugal;Department of Pharmaceutics, Biopharmaceutics & NutriCosmetics, Institute of Pharmacy, Freie Universität Berlin BerlinGermany
,
Ranjita ShegokarDepartment of Pharmaceutics, Biopharmaceutics & NutriCosmetics, Institute of Pharmacy, Freie Universität Berlin BerlinGermany
,
Lisete FernandesElectron Microscopy Unit, University of Trás-os-Montes and Alto Douro Vila RealPortugal
,
Paula Martins-LopesInstitute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro (IBB/CGB-UTAD) Vila-RealPortugal
,
Amélia M. SilvaCentre for the Research and Technology of Agro-Environmental and Biological Sciences, University of Trás-os-Montes and Alto Douro (CITAB-UTAD) Vila RealPortugal;Department of Biology and Environment, School of Life and Environmental Sciences (ECVA, UTAD), University of Trás-os-Montes and Alto Douro Vila RealPortugal
,
Rainer H. MüllerDepartment of Pharmaceutics, Biopharmaceutics & NutriCosmetics, Institute of Pharmacy, Freie Universität Berlin BerlinGermany
&
Eliana B. SoutoInstitute of Biotechnology and Bioengineering, Centre of Genomics and Biotechnology, University of Trás-os-Montes and Alto Douro (IBB/CGB-UTAD) Vila-RealPortugal;Faculty of Health Sciences, Fernando Pessoa University PortoPortugalCorrespondence[email protected]
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Pages 922-929 | Received 20 Jun 2013, Accepted 23 Aug 2013, Published online: 07 Oct 2013

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Marianne Joseph Naguib, Amira Moustafa Kamel, Ahmed Thabet Negmeldin, Ahmed Hassen Elshafeey & Ibrahim Elsayed. (2020) Molecular docking and statistical optimization of taurocholate-stabilized galactose anchored bilosomes for the enhancement of sofosbuvir absorption and hepatic relative targeting efficiency. Drug Delivery 27:1, pages 996-1009.
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Marie Rouquette, Karine Ser-Le Roux, Mélanie Polrot, Claudie Bourgaux, Jean-Philippe Michel, Fabienne Testard, Frédéric Gobeaux & Sinda Lepetre-Mouelhi. (2019) Towards a clinical application of freeze-dried squalene-based nanomedicines. Journal of Drug Targeting 27:5-6, pages 699-708.
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Joana R. Campos, Ana R. Fernandes, Raquel Sousa, Joana F. Fangueiro, Prapaporn Boonme, Maria Luisa Garcia, Amelia M. Silva, Beatriz C. Naveros & Eliana B. Souto. (2019) Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial design, release profile and cytotoxicity in human Colon adenocarcinoma cell line. Pharmaceutical Development and Technology 24:5, pages 616-622.
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Lulu Wang, Yingying Ma, Yu Gu, Yangyang Liu, Juan Zhao, Beibei Yan & Yancai Wang. (2018) Cryoprotectant choice and analyses of freeze-drying drug suspension of nanoparticles with functional stabilisers. Journal of Microencapsulation 35:3, pages 241-248.
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Arun B.Narendar D.Kishan Veerabrahma. (2018) Development of olmesartan medoxomil lipid-based nanoparticles and nanosuspension: preparation, characterization and comparative pharmacokinetic evaluation. Artificial Cells, Nanomedicine, and Biotechnology 46:1, pages 126-137.
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Jagruti Desai & Hetal Thakkar. (2016) Effect of particle size on oral bioavailability of darunavir-loaded solid lipid nanoparticles. Journal of Microencapsulation 33:7, pages 669-678.
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Rohan Shah, Daniel Eldridge, Enzo Palombo & Ian HardingRohan Shah, Daniel Eldridge, Enzo Palombo & Ian Harding. 2015. Lipid Nanoparticles: Production, Characterization and Stability. Lipid Nanoparticles: Production, Characterization and Stability 23 43 .
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