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Pharmaceutical Development and Technology Volume 20, 2015 - Issue 5

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Research Article

Development of eye drops containing antihypertensive drugs: formulation of aqueous irbesartan/γCD eye drops

Phatsawee JansookFaculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand, Correspondence[email protected]

Chutimon MuankaewFaculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland, and

Einar StefánssonDepartment of Ophthalmology, Faculty of Medicine, National University Hospital, University of Iceland, Reykjavik, Iceland

Thorsteinn LoftssonFaculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland, and

Pages 626-632 | Received 27 Feb 2014, Accepted 25 Mar 2014, Published online: 23 Apr 2014

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https://doi.org/10.3109/10837450.2014.910811
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Qiuxiang Wang, Aiwen Zhang, Lu Zhu, Xuewen Yang, Guihua Fang & Bo Tang. (2023) Cyclodextrin-based ocular drug delivery systems: A comprehensive review. Coordination Chemistry Reviews 476, pages 214919.
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Sidhartha Sankar Hota, Souvik Nandi & Subrata Mallick. (2022) Management and control of intraocular pressure applying macitentan hydrogel film formulation: improved effect of surfactant and cosurfactant system. DARU Journal of Pharmaceutical Sciences 30:1, pages 39-47.
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Andrea Mariela Araya-Sibaja, Cinira Fandaruff, Ana María Guevara-Camargo, Felipe Vargas-Huertas, William J. Zamora, José Roberto Vega-Baudrit, Teodolito Guillén-Girón, Mirtha Navarro-Hoyos, Paola Paoli, Patrizia Rossi & William Jones. (2022) Crystal Forms of the Antihypertensive Drug Irbesartan: A Crystallographic, Spectroscopic, and Hirshfeld Surface Analysis Investigation. ACS Omega 7:17, pages 14897-14909.
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Phatsawee Jansook & Thorsteinn Loftsson. (2022) Self-assembled γ-cyclodextrin as nanocarriers for enhanced ocular drug bioavailability. International Journal of Pharmaceutics 618, pages 121654.
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Noriaki Nagai, Fumihiko Ogata, Ayari Ike, Yurisa Shimomae, Hanano Osako, Yosuke Nakazawa, Naoki Yamamoto & Naohito Kawasaki. (2022) Oral Formulation Based on Irbesartan Nanocrystals Improve Drug Solubility, Absorbability, and Efficacy. Pharmaceutics 14:2, pages 387.
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Thorsteinn Loftsson & Einar Stefánsson. (2021) Aqueous eye drops containing drug/cyclodextrin nanoparticles deliver therapeutic drug concentrations to both anterior and posterior segment. Acta Ophthalmologica 100:1, pages 7-25.
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Phatsawee Jansook, Hay Marn Hnin, Pitsiree Praphanwittaya, Thorsteinn Loftsson & Einar Stefansson. (2022) Effect of salt formation on γ-cyclodextrin solubilization of irbesartan and candesartan and the chemical stability of their ternary complexes. Journal of Drug Delivery Science and Technology 67, pages 102980.
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Jing Tian, Ting Ting Meng, Shijie Ma, Ting Gao, Xin Di, Jing Chen & Jianhong Yang. (2022) Spatial-thermodynamic understanding of stabilization mechanism using computational approaches and molecular-level elucidation of the mechanism of crystal transformation in polymorphic irbesartan nanosuspensions. International Journal of Pharmaceutics 612, pages 121350.
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Saori Deguchi, Fumihiko Ogata, Masaki Watanabe, Hiroko Otake, Naoki Yamamoto, Naohito Kawasaki & Noriaki Nagai. (2021) Nanocrystalline Suspensions of Irbesartan Enhance Oral Bioavailability by Improving Drug Solubility and Leading Endocytosis Uptake into the Intestine. Pharmaceutics 13:9, pages 1404.
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Laura Lorenzo‐Soler, Olof Birna Olafsdottir, Gerhard Garhöfer, Phatsawee Jansook, Iris Myrdal Kristinsdottir, Aimin Tan, Thorsteinn Loftsson & Einar Stefansson. (2020) Angiotensin Receptor Blockers in cyclodextrin nanoparticle eye drops: Ocular pharmacokinetics and pharmacologic effect on intraocular pressure. Acta Ophthalmologica 99:4, pages 376-382.
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Martin Kallab, Kornelia Schuetzenberger, Nikolaus Hommer, Bhavapriya Jasmin Schäfer, Doreen Schmidl, Helga Bergmeister, Markus Zeitlinger, Aimin Tan, Phatsawee Jansook, Thorsteinn Loftsson, Einar Stefansson & Gerhard Garhöfer. (2021) Bio-Distribution and Pharmacokinetics of Topically Administered γ-Cyclodextrin Based Eye Drops in Rabbits. Pharmaceuticals 14:5, pages 480.
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Georgios Leonis, Eirini Christodoulou, Dimitrios Ntountaniotis, Maria V. Chatziathanasiadou, Thomas Mavromoustakos, Nikolaos Naziris, Maria Chountoulesi, Costas Demetzos, Georgia Valsami, Dimitrios E. Damalas, Andreas G. Tzakos, Nikolaos S. Thomaidis, Vlasios Karageorgos & Georgios Liapakis. (2020) Antihypertensive activity and molecular interactions of irbesartan in complex with 2‐hydroxypropyl‐β‐cyclodextrin. Chemical Biology & Drug Design 96:1, pages 668-683.
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Blanca Lorenzo-Veiga, Patricia Diaz-Rodriguez, Carmen Alvarez-Lorenzo, Thorsteinn Loftsson & Hakon Hrafn Sigurdsson. (2020) In Vitro and Ex Vivo Evaluation of Nepafenac-Based Cyclodextrin Microparticles for Treatment of Eye Inflammation. Nanomaterials 10:4, pages 709.
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Pitsiree Praphanwittaya, Phennapha Saokham, Phatsawee Jansook & Thorsteinn Loftsson. (2020) Aqueous solubility of kinase inhibitors: II the effect of hexadimethrine bromide on the dovitinib/γ-cyclodextrin complexation. Journal of Drug Delivery Science and Technology 55, pages 101463.
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Saikishore Meruva, Prajwal Thool, Shyam Karki, William Bowen, Indrajit Ghosh & Sumit Kumar. (2019) Downstream processing of irbesartan nanocrystalline suspension and mini-tablet development – Part II. International Journal of Pharmaceutics 568, pages 118509.
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Saikishore Meruva, Prajwal Thool, Shawreen Shah, Shyam Karki, William Bowen, Indrajit Ghosh & Sumit Kumar. (2019) Formulation and performance of Irbesartan nanocrystalline suspension and granulated or bead-layered dried powders – Part I. International Journal of Pharmaceutics 568, pages 118189.
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Blanca Lorenzo-Veiga, Hakon Sigurdsson & Thorsteinn Loftsson. (2019) Nepafenac-Loaded Cyclodextrin/Polymer Nanoaggregates: A New Approach to Eye Drop Formulation. Materials 12:2, pages 229.
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Adrian Julian Marcus, Igor Iezhitsa, Renu Agarwal, Pavel Vassiliev, Alexander Spasov, Olga Zhukovskaya, Vera Anisimova, Bushra Johari & Nafeeza Mohd Ismail. (2018) Intraocular pressure lowering effect and structure-activity relationship of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats: Insight on possible link with hypotensive activity. European Journal of Pharmaceutical Sciences 114, pages 245-254.
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Thorsteinn Loftsson & Einar Stefánsson. (2017) Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye. International Journal of Pharmaceutics 531:2, pages 413-423.
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Αdamantia S. Liossi, Dimitrios Ntountaniotis, Tahsin F. Kellici, Maria V. Chatziathanasiadou, Grigorios Megariotis, Maria Mania, Johanna Becker-Baldus, Manfred Kriechbaum, Andraž Krajnc, Eirini Christodoulou, Clemens Glaubitz, Michael Rappolt, Heinz Amenitsch, Gregor Mali, Doros N. Theodorou, Georgia Valsami, Marinos Pitsikalis, Hermis Iatrou, Andreas G. Tzakos & Thomas Mavromoustakos. (2017) Exploring the interactions of irbesartan and irbesartan–2-hydroxypropyl-β-cyclodextrin complex with model membranes. Biochimica et Biophysica Acta (BBA) - Biomembranes 1859:6, pages 1089-1098.
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Victoria J. Valerón Bergh & Hanne Hjorth Tønnesen. (2017) Interactions and solubilization of 5, 10, 15, 20-tetrakis(4-hydroxyphenyl)porphyrin with poloxamer 407 and β-cyclodextrin-derivatives in binary and ternary systems. Journal of Drug Delivery Science and Technology 37, pages 51-60.
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Chutimon Muankaew, Phatsawee Jansook, Einar Stefánsson & Thorsteinn Loftsson. (2014) Effect of γ-cyclodextrin on solubilization and complexation of irbesartan: Influence of pH and excipients. International Journal of Pharmaceutics 474:1-2, pages 80-90.
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Development of eye drops containing antihypertensive drugs: formulation of aqueous irbesartan/γCD eye drops

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Development of eye drops containing antihypertensive drugs: formulation of aqueous irbesartan/γCD eye drops

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