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Pharmaceutical Development and Technology Volume 1, 1996 - Issue 2
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Research Article

Compaction Simulator Studies of a New Drug Substance: Effect of Particle Size and Shape, and Its Binary Mixtures with Microcrystalline Cellulose

Metin Çelik Pharmaceutical Compaction Research Laboratory and Information Center, Department of Pharmaceutics, College of Pharmacy, Rutgers University, Piscataway, New Jersey
,
John T. H. Ong CoCensys, Inc., Irvine, California
,
Zak T. Chowhan Pharmaceutics International, Hunt Valley, Maryland
&
Glenn J. Samuel Gilead Sciences, Inc., Foster City, California
Pages 119-126 | Received 20 Oct 1995, Accepted 07 Feb 1996, Published online: 27 Sep 2008

Citations (13)

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Read on this site (2)

Vivek S. Dave, Raafat M. Fahmy & Stephen W. Hoag. (2013) Investigation of the physical–mechanical properties of Eudragit® RS PO/RL PO and their mixtures with common pharmaceutical excipients. Drug Development and Industrial Pharmacy 39:7, pages 1113-1125.
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César Viseras, César Iborra Viseras, Africa Yebra & Alberto López-Galindo. (2000) Characteristics of Pharmaceutical Grade Phyllosilicate Compacts. Pharmaceutical Development and Technology 5:1, pages 53-58.
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Articles from other publishers (11)

Nenad Nikolić, Tijana Miletić, Jovana Kovačević, Đorđe Medarević & Svetlana Ibrić. (2022) Usage of compaction simulators for the powder compression characterization: Advantages and limitations. Arhiv za farmaciju 72:6, pages 546-565.
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Yasasvi Bommireddy, Ankit Agarwal, Vikas Yettella, Vikas Tomar & Marcial Gonzalez. (2019) Loading-unloading contact law for micro-crystalline cellulose particles under large deformations. Mechanics Research Communications 99, pages 22-31.
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Daryl M. Simmons. 2019. Chemical Engineering in the Pharmaceutical Industry. Chemical Engineering in the Pharmaceutical Industry 227 243 .
G.E. Amidon, P.J. Meyer & D.M. Mudie. 2017. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 271 293 .
Harvey Lieberman & N. Murti Vemuri. 2015. The Practice of Medicinal Chemistry. The Practice of Medicinal Chemistry 767 791 .
Sarsvatkumar Patel & Arvind Kumar Bansal. (2011) Prediction of mechanical properties of compacted binary mixtures containing high-dose poorly compressible drug. International Journal of Pharmaceutics 403:1-2, pages 109-114.
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Shayne Cox GadKatharina M Picker-Freyer. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Ian J Hardy & Walter G Cook. (2003) Predictive and correlative techniques for the design, optimisation and manufacture of solid dosage forms. Journal of Pharmacy and Pharmacology 55:1, pages 3-18.
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Gregory E. Amidon, Pamela J. Secreast & Deanna Mudie. 2009. Developing Solid Oral Dosage Forms. Developing Solid Oral Dosage Forms 163 186 .
Ching Kim Tye, Changquan (Calvin) Sun & Gregory E. Amidon. (2005) Evaluation of the effects of tableting speed on the relationships between compaction pressure, tablet tensile strength, and tablet solid fraction. Journal of Pharmaceutical Sciences 94:3, pages 465-472.
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Jennifer J. Wang, Micael A. Guillot, Simon D. Bateman & Kenneth R. Morris. (2004) Modeling of adhesion in tablet compression. II. Compaction studies using a compaction simulator and an instrumented tablet press. Journal of Pharmaceutical Sciences 93:2, pages 407-417.
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