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Research Article

Evaluation of in Vitro Release Rate and in Vivo Absorption Characteristics of Four Metoprolol Tartrate Immediate-Release Tablet Formulations

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Pages 11-24 | Received 27 Mar 1996, Accepted 26 Sep 1996, Published online: 27 Sep 2008

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Aleksander Mendyk, Paweł K Tuszyński, Sebastian Polak & Renata Jachowicz. (2013) Generalized in vitro-in vivo relationship (IVIVR) model based on artificial neural networks. Drug Design, Development and Therapy 7, pages 223-232.
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Paul R. Seo, Vinod P. Shah & James E. Polli. (2002) Novel Metrics to Compare Dissolution Profiles. Pharmaceutical Development and Technology 7:2, pages 257-265.
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Natalie D. Eddington, Muhammad Ashraf, Larry L. Augsburger, James L. Leslie, Michael J. Fossler, Lawrence J. Lesko, Vinod P. Shah & Gurvinder Singh Rekhi. (1998) Identification of Formulation and Manufacturing Variables That Influence In Vitro Dissolution and In Vivo Bioavailability of Propranolol Hydrochloride Tablets. Pharmaceutical Development and Technology 3:4, pages 535-547.
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Hans Lennernäs & Bertil Abrahamsson. (2005) The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension. Journal of Pharmacy and Pharmacology 57:3, pages 273-285.
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Saeed A Qureshi & Javad Shabnam. (2003) Applications of a new device (spindle) for improved characterization of drug release (dissolution) of pharmaceutical products. European Journal of Pharmaceutical Sciences 19:4, pages 291-297.
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Marilyn N. Martinez & Gordon L. Amidon. (2013) A Mechanistic Approach to Understanding the Factors Affecting Drug Absorption: A Review of Fundamentals. The Journal of Clinical Pharmacology 42:6, pages 620-643.
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Samar Al-Behaisi, István Antal, György Morovján, József Szúnyog, Sándor Drabant, Sylvia Marton & Imre Klebovich. (2002) In vitro simulation of food effect on dissolution of deramciclane film-coated tablets and correlation with in vivo data in healthy volunteers. European Journal of Pharmaceutical Sciences 15:2, pages 157-162.
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Bipin Mistry, James L. Leslie & Natalie D. Eddington. (2002) Influence of input rate on the stereospecific and nonstereospecific first pass metabolism and pharmacokinetics of metoprolol extended release formulations. Chirality 14:4, pages 297-304.
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Kimberley Jackson, David Young & Sonia Pant. (2000) Drug–excipient interactions and their affect on absorption. Pharmaceutical Science & Technology Today 3:10, pages 336-345.
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H. Mahayni, G.S. Rekhi, R.S. Uppoor, P. Marroum, A.S. Hussain, L.L. Augsburger & N.D. Eddington. (2000) Evaluation of “External” Predictability of an In Vitro–In Vivo Correlation for an Extended‐Release Formulation Containing Metoprolol Tartrate. Journal of Pharmaceutical Sciences 89:10, pages 1354-1361.
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Natalie D. Eddington, Guvinder Singh Rekhi, Larry J. Lesko & Larry L. Augsburger. (2015) Scale-up effects on dissolution and bioavailability of propranolol hydrochloride and metoprolol tartrate tablet formulations. AAPS PharmSciTech 1:2, pages 63-71.
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Natalie D. Eddington, Guvinder Singh Rekhi, Larry J. Lesko & Larry L. Augsburger. (2000) Scale-up effects on dissolution and bioavailability of propranolol hydrochloride and metoprolol tartrate tablet formulations. AAPS PharmSciTech 1:2, pages 63-71.
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Mark J. Ginski, Rajneesh Taneja & James E. Polli. (1999) Prediction of dissolution-absorption relationships from a continuous dissolution/Caco-2 system. AAPS PharmSci 1:2, pages 27-38.
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James E. Polli, G. Singh Rekhi, Larry L. Augsburger & Vinod P. Shah. (1997) Methods to Compare Dissolution Profiles and a Rationale for Wide Dissolution Specifications for Metoprolol Tartrate tablets†. Journal of Pharmaceutical Sciences 86:6, pages 690-700.
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