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ORIGINAL CONTRIBUTIONS

Prehospital Transfusion of Plasma and Red Blood Cells in Trauma Patients

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Read on this site (3)

Cherisse Berry, John M. Gallagher, Jeffrey M. Goodloe, Warren C. Dorlac, Jimm Dodd & Peter E. Fischer. (2023) Prehospital Hemorrhage Control and Treatment by Clinicians: A Joint Position Statement. Prehospital Emergency Care 27:5, pages 544-551.
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Eva V. Zadorozny, Tyler Weigel, Andre Stone, Danielle S. Gruen, Samuel M. Galvagno$suffix/text()$suffix/text(), Mark H. Yazer, Joshua B. Brown & Francis X. Guyette. (2022) Prehospital Lactate is Associated with the Need for Blood in Trauma. Prehospital Emergency Care 26:4, pages 590-599.
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Joshua B. Brown, Francis X. Guyette, Matthew D. Neal, Jeffrey A. Claridge, Brian J. Daley, Brian G. Harbrecht, Richard S. Miller, Herb A. Phelan, Peter W. Adams, Barbara J. Early, Andrew B. Peitzman, Timothy R. Billiar & Jason L. Sperry. (2015) Taking the Blood Bank to the Field: The Design and Rationale of the Prehospital Air Medical Plasma (PAMPer) Trial. Prehospital Emergency Care 19:3, pages 343-350.
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Articles from other publishers (138)

Gianluca Facchetti, Marilisa Facchetti, Mariette Schmal, Ronan Lee, Silvia Fiorelli, Tommaso Fabrizio Marzano, Cristian Lupi, Francesco Daminelli, Giovanni Sbrana, Domenico Massullo & Franco Marinangeli. (2023) Prehospital Blood Transfusion in Helicopter Emergency Medical Services: An Italian Survey. Air Medical Journal.
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Dominik A. Jakob, Martin Müller, Sebastian Jud, Roland Albrecht, Wolf Hautz & Urs Pietsch. (2023) The forgotten cohort-lessons learned from prehospital trauma death: a retrospective cohort study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 31:1.
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Yann Daniel, Clément Derkenne, Simon‐Pierre Corcostegui, Daniel Jost, Christophe Martinaud, Stéphane Travers & Jean‐Jacques Lataillade. (2023) Mobile blood depots in ground ambulances in compliance with French legislation: A feasibility study. Transfusion 63:8, pages 1481-1487.
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. (2023) Prehospital Hemorrhage Control and Treatment by Clinicians: A Joint Position Statement. Annals of Emergency Medicine 82:1, pages e1-e8.
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Robert T. Russell & Samantha M. Koenig. (2023) Prehospital Transfusion in Pediatric Trauma—The Clock Is Ticking. JAMA Pediatrics 177:7, pages 663.
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Katrina M. Morgan, Elissa Abou-Khalil, Stephen Strotmeyer, Ward M. Richardson, Barbara A. Gaines & Christine M. Leeper. (2023) Association of Prehospital Transfusion With Mortality in Pediatric Trauma. JAMA Pediatrics 177:7, pages 693.
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Weiqin Chee, Claire R. Sharp & Corrin J. Boyd. (2023) Clinical Use of Canine Thawed Refrigerated Plasma: A Historical Case Series. Animals 13:12, pages 2040.
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Daniel W. Bougie, Sarah E. Reese, Rebecca J. Birch, Deborah B. Bookwalter, Patrick K. Mitchell, David Roh, Lisa Baumann Kreuziger, Ritchard G. Cable, Ruchika Goel, Jerome Gottschall, Ronald George Hauser, Jeanne E. Hendrickson, Eldad A. Hod, Cassandra D. Josephson, Stacie Kahn, Steven H. Kleinman, Alan E. Mast, Paul M. Ness, Nareg H. Roubinian & Steven Sloan. (2023) Associations between ABO non‐identical platelet transfusions and patient outcomes—A multicenter retrospective analysis . Transfusion 63:5, pages 960-972.
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Andrew-Paul Deeb, Francis X. Guyette, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Brian J. Eastridge, Bellal Joseph, Raminder Nirula, Gary A. Vercruysse, Jason L. Sperry & Joshua B. Brown. (2023) Time to early resuscitative intervention association with mortality in trauma patients at risk for hemorrhage. Journal of Trauma and Acute Care Surgery 94:4, pages 504-512.
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Armin Krösbacher, Dietmar Fries & Markus Thaler. (2023) Unkontrollierbare Blutungen prähospital – Retten Blutprodukte Leben?. NOTARZT 39:01, pages 37-46.
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Stefania Cimbanassi, Roberto Bini & Osvaldo Chiara. 2023. The High-risk Surgical Patient. The High-risk Surgical Patient 699 702 .
Heidi Yliharju, Timo Jama & Hilla Nordquist. (2022) Initial experiences of prehospital blood product transfusions between 2016 and 2020 in Päijät-Häme hospital district, Finland. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 30:1.
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N. R. E. Schneider, F. Weilbacher, T. Maurer, A. M. Würmell, A. Leo, M. A. Weigand & E. Popp. (2021) Präklinische Bluttransfusion bei lebensbedrohlicher Blutung – erweiterte lebensrettende Therapieoptionen durch das Konzept Medical Intervention CarPreclinical blood transfusion in life-threatening hemorrhage—advanced therapeutic options provided by the “medical intervention car” concept. Notfall + Rettungsmedizin 25:8, pages 552-560.
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Emily E Clarke, James Hamm, Andrew D Fisher, Michael D April, Brit J Long, Kennedy S Mdaki, Ronnie Hill, James A Bynum & Steven G Schauer. (2022) Trends in Prehospital Blood, Crystalloid, and Colloid Administration in Accordance With Changes in Tactical Combat Casualty Care Guidelines. Military Medicine 187:11-12, pages e1265-e1270.
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Maxwell A. Braverman, Allison A. Smith, Angelo V. Ciaraglia, Jason S. Radowsky, Steven G. Schauer, Valerie G. Sams, Leslie J. Greebon, Michael D. Shiels, Rachelle Babbitt Jonas, Samantha Ngamsuntikul, Elizabeth Waltman, Eric Epley, Tracee Rose, James A. Bynum, Andre P. Cap, Brian J. Eastridge, Ronald M. Stewart, Donald H. Jenkins & Susannah E. Nicholson. (2022) The regional whole blood program in San Antonio, TX : A 3 ‐year update on prehospital and in‐hospital transfusion practices for traumatic and n on‐traumatic hemorrhage . Transfusion 62:S1.
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Andrew-Paul Deeb, Lara Hoteit, Shimena Li, Francis X. Guyette, Brian J. Eastridge, Raminder Nirula, Gary A. Vercruysse, Terence O’Keeffe, Bellal Joseph, Matthew D. Neal, Jason L. Sperry & Joshua B. Brown. (2022) Prehospital synergy: Tranexamic acid and blood transfusion in patients at risk for hemorrhage. Journal of Trauma and Acute Care Surgery 93:1, pages 52-58.
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Marco Tartaglione, Luca Carenzo, Lorenzo Gamberini, Cristian Lupi, Aimone Giugni, Carlo Alberto Mazzoli, Valentina Chiarini, Silvia Cavagna, Davide Allegri, John B Holcomb, David Lockey, Giovanni Sbrana, Giovanni Gordini & Carlo Coniglio. (2022) Multicentre observational study on practice of prehospital management of hypotensive trauma patients: the SPITFIRE study protocol. BMJ Open 12:5, pages e062097.
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Marie Csete. (2022) Prehospital Blood Transfusion for Severe Trauma: Translating Experience From the Military to the Civilian Setting Is Not Always Straightforward. Anesthesia & Analgesia 134:4, pages 675-677.
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Roman Dudaryk, Catherine Heim, Kurt Ruetzler & Evan G. Pivalizza. (2022) Pro-Con Debate: Prehospital Blood Transfusion—Should It Be Adopted for Civilian Trauma?. Anesthesia & Analgesia 134:4, pages 678-682.
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Oscar Sáenz-Morales, Mayra Murillo-Gomez, Jorge Russi-Lozano, Francisco Viera-Molina, Dafna García, Catalina Torres & Manuel Garay-Fernandez. (2022) Coagulopatía inducida por trauma. Revisión basada en la evidencia y propuesta de manejo. Acta Colombiana de Cuidado Intensivo 22:2, pages 115-126.
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Harriet Tucker, Pascale Avery, Karim Brohi, Ross Davenport, Joanne Griggs, Anne Weaver & Laura Green. (2021) Outcome measures used in clinical research evaluating prehospital blood component transfusion in traumatically injured bleeding patients: A systematic review. Journal of Trauma and Acute Care Surgery 91:6, pages 1018-1024.
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Marcus Rudolph, Nicole Sitzmann, Joerg Braun, Berthold Henkel & Florian Reifferscheid. (2021) Präklinische Therapie mit Blutprodukten – das Projekt „HeliBlut“. Der Notarzt 37:06, pages 319-324.
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Stephanie M. Armocida, Bryan A. Cotton & Elliott R. Haut. (2021) CHEERS to You on a Well-done Cost-effectiveness Analysis of Prehospital Plasma for Helicopter Resuscitation of Patients With Traumatic Shock. JAMA Surgery 156:12, pages 1139.
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Harriet Tucker, Ross Davenport & Laura Green. (2021) The Role of Plasma Transfusion in Pre-Hospital Haemostatic Resuscitation. Transfusion Medicine Reviews 35:4, pages 91-95.
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Mark A. Popovsky & Nathan White. (2021) Spray‐dried plasma: A post‐traumatic blood “bridge” for life‐saving resuscitation . Transfusion 61:S1.
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Henry T. Peng, Shawn G. Rhind, Dana Devine, Craig Jenkins & Andrew Beckett. (2021) Ex vivo hemostatic and immuno‐inflammatory profiles of freeze‐dried plasma. Transfusion 61:S1.
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Stephen P. Canton, Waseem Lutfi, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Francis X. Guyette, Jason L. Sperry & Joshua B. Brown. (2021) Lactate as a mediator of prehospital plasma mortality reduction in hemorrhagic shock. Journal of Trauma and Acute Care Surgery 91:1, pages 186-191.
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Jonathan A. Black, Virginia S. Pierce, Kavina Juneja & John B. Holcomb. (2021) Complications of Hemorrhagic Shock and Massive Transfusion—a Comparison Before and After the Damage Control Resuscitation Era. Shock 56:1, pages 42-51.
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Karoline Sætre Michalsen, Leif Rognås, Mads Vandborg, Christian Erikstrup & Christian Fenger-Eriksen. (2020) Prehospital Transfusion of Red Blood Cells and Plasma by an Urban Ground-Based Critical Care Team. Prehospital and Disaster Medicine 36:2, pages 170-174.
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Shiming Yang, Colin F. Mackenzie, Peter Rock, Chienyu Lin, Doug Floccare, Thomas Scalea, Florian Stumpf, Christopher Winans, Samuel Galvagno, Catriona Miller, Deborah Stein & Peter F. Hu. (2021) Comparison of massive and emergency transfusion prediction scoring systems after trauma with a new Bleeding Risk Index score applied in-flight. Journal of Trauma and Acute Care Surgery 90:2, pages 268-273.
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Francis X. Guyette, Jason L. Sperry, Andrew B. Peitzman, Timothy R. Billiar, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Tyler Putnam, Therese M. Duane, Herb A. Phelan & Joshua B. Brown. (2021) Prehospital Blood Product and Crystalloid Resuscitation in the Severely Injured Patient. Annals of Surgery 273:2, pages 358-364.
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Alec D Emerling, William Bianchi, Michael Krzyzaniak, Travis Deaton, Darin Via, Benjamin Archer, Jared Sutherland, Kaeley Shannon, Judy L Dye, Mary Clouser & Jonathan D Auten. (2021) Rapid Sequence Induction Strategies Among Critically Injured U.S. Military During the Afghanistan and Iraq Conflicts. Military Medicine 186:Supplement_1, pages 316-323.
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Mark Walsh, Ernest E. Moore, Hunter B. Moore, Scott Thomas, Hau C. Kwaan, Jacob Speybroeck, Mathew Marsee, Connor M. Bunch, John Stillson, Anthony V. Thomas, Annie Grisoli, John Aversa, Daniel Fulkerson, Stefani Vande Lune, Lucas Sjeklocha & Quincy K. Tran. (2021) Whole Blood, Fixed Ratio, or Goal-Directed Blood Component Therapy for the Initial Resuscitation of Severely Hemorrhaging Trauma Patients: A Narrative Review. Journal of Clinical Medicine 10:2, pages 320.
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Kathleen Selleng, Marcel Baschin, Berthold Henkel, Gregor Jenichen, Karl-Christian Thies, Marcus Rudolph, Florian Reifferscheid, Jörg Braun, Malte Hannich, Theresa Winter, Klaus Hahnenkamp & Andreas Greinacher. (2021) Blood Product Supply for a Helicopter Emergency Medical Service. Transfusion Medicine and Hemotherapy 48:6, pages 332-341.
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Marie-Christine Wright, Chikezie N. Okeagu, Alaina L. Broussard, Keith P. Delaune, Shukan Patel, Elyse M. Cornett & Alan David Kaye. 2021. Essentials of Blood Product Management in Anesthesia Practice. Essentials of Blood Product Management in Anesthesia Practice 357 368 .
Anthony E. Pusateri & Richard B. Weiskopf. 2021. Trauma Induced Coagulopathy. Trauma Induced Coagulopathy 705 718 .
Andrew-Paul Deeb & Joshua B. Brown. 2021. Trauma Induced Coagulopathy. Trauma Induced Coagulopathy 495 512 .
Krista J. Stephenson, Kyle J. Kalkwarf & John B. Holcomb. 2021. Trauma Induced Coagulopathy. Trauma Induced Coagulopathy 473 486 .
Jason B. Brill, Bryan A. Cotton & Ryan A. Lawless. 2021. Trauma Induced Coagulopathy. Trauma Induced Coagulopathy 353 371 .
Hiroki Nagasawa, Keita Shibahashi, Kazuhiko Omori & Youichi Yanagawa. (2021) The effect of prehospital intravenous access in traumatic shock: a Japanese nationwide cohort study. Acute Medicine & Surgery 8:1.
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Daniel Jost, Sabine Lemoine, Frederic Lemoine, Vincent Lanoe, Olga Maurin, Clément Derkenne, Marilyn Franchin Frattini, Maëlle Delacote, Edouard Seguineau, Anne Godefroy, Nicolas Hervault, Ludovic Delhaye, Nicolas Pouliquen, Emilie Louis-Delauriere, Julie Trichereau, Florian Roquet, Marina Salomé, Catherine Verret, René Bihannic, Romain Jouffroy, Benoit Frattini, Vivien Hong Tuan Ha, Pascal Dang-Minh, Stéphane Travers, Michel Bignand, Christophe Martinaud, Eliane Garrabe, Sylvain Ausset, Bertrand Prunet, Anne Sailliol & Jean Pierre Tourtier. (2020) French lyophilized plasma versus normal saline for post-traumatic coagulopathy prevention and correction: PREHO-PLYO protocol for a multicenter randomized controlled clinical trial. Trials 21:1.
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Pauli Vuorinen, Joonas-Eemeli Kiili, Piritta Setälä, Antti Kämäräinen & Sanna Hoppu. (2020) Prehospital administration of blood products: experiences from a Finnish physician-staffed helicopter emergency medical service. BMC Emergency Medicine 20:1.
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Danielle S. Gruen, Francis X. Guyette, Joshua B. Brown, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Mark H. Yazer, Matthew D. Neal, Brian S. Zuckerbraun & Jason L. Sperry. (2020) Characterization of unexpected survivors following a prehospital plasma randomized trial. Journal of Trauma and Acute Care Surgery 89:5, pages 908-914.
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Christine M. Leeper, Mark H. Yazer, Darrell J. Triulzi, Matthew D. Neal & Barbara A. Gaines. (2020) Whole Blood is Superior to Component Transfusion for Injured Children. Annals of Surgery 272:4, pages 590-594.
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Scott Assen, Jessica Cardenas, Mitchell George, Yao-Wei Wang, Charles E. Wade, David Meyer & Bryan A. Cotton. (2020) Hemostatic potential of cold-stored non-leukoreduced whole blood over time: An assessment of platelet function and thrombin generation for optimal shelf life. Journal of Trauma and Acute Care Surgery 89:3, pages 429-434.
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Juan Duchesne, David McGreevy, Kristofer Nilsson, Joseph DuBose, Todd E. Rasmussen, Megan Brenner, Tomas Jacome, Tal Hörer & Danielle Tatum. (2020) Delta Systolic Blood Pressure (SBP) Can be a Stronger Predictor of Mortality Than Pre-Aortic Occlusion SBP in Non-Compressible Torso Hemorrhage; an Abotrauma and AORTA Analysis. Shock Publish Ahead of Print.
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Danielle S. Gruen, Joshua B. Brown, Francis X. Guyette, Yoram Vodovotz, Pär I. Johansson, Jakob Stensballe, Derek A. Barclay, Jinling Yin, Brian J. Daley, Richard S. Miller, Brian G. Harbrecht, Jeffrey A. Claridge, Herb A. Phelan, Matthew D. Neal, Brian S. Zuckerbraun, Timothy R. Billiar & Jason L. Sperry. (2020) Prehospital plasma is associated with distinct biomarker expression following injury. JCI Insight 5:8.
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Elisabeth C. Turenhout, Sebastiaan M. Bossers, Stephan A. Loer, Georgios F. Giannakopoulos, Lothar A. Schwarte & Patrick Schober. (2020) Pre‐hospital transfusion of red blood cells. Part 1: A scoping review of current practice and transfusion triggers. Transfusion Medicine 30:2, pages 86-105.
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Elisabeth C. Turenhout, Sebastiaan M. Bossers, Stephan A. Loer, Georgios F. Giannakopoulos, Lothar A. Schwarte & Patrick Schober. (2020) Pre‐hospital transfusion of red blood cells. Part 2: A systematic review of treatment effects on outcomes. Transfusion Medicine 30:2, pages 106-133.
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Natalie J. Koons, Betty Nguyen, Mithun R. Suresh, Carmen Hinojosa-Laborde & Victor A. Convertino. (2020) Tracking DO2 with Compensatory Reserve During Whole Blood Resuscitation in Baboons. Shock 53:3, pages 327-334.
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James Williams, Nicholas Merutka, David Meyer, Yu Bai, Samuel Prater, Rodolfo Cabrera, John B. Holcomb, Charles E. Wade, Joseph D. Love & Bryan A. Cotton. (2020) Safety profile and impact of low-titer group O whole blood for emergency use in trauma. Journal of Trauma and Acute Care Surgery 88:1, pages 87-93.
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Mouayyad Zaza, Kyle J. Kalkwarf & John B. Holcomb. 2020. Damage Control Resuscitation. Damage Control Resuscitation 145 162 .
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Anirban Sen Gupta. (2019) Hemoglobin-based Oxygen Carriers: Current State-of-the-art and Novel Molecules. Shock 52:1S, pages 70-83.
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Chase Krook, Domhnall O’Dochartaigh, Doug Martin, Zoë Piggott, Ryan Deedo, Sarah Painter, Gennifer van Werkhoven, Darcy McKay, Dennis Nesdoly & JN Armstrong. (2018) Blood on board: The development of a prehospital blood transfusion program in a Canadian helicopter emergency medical service. CJEM 21:3, pages 365-373.
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Tim W.H. Rijnhout, Kimberley E. Wever, Roy H.A.R. Marinus, Nico Hoogerwerf, Leo M.G GeeraedtsJr.Jr. & Edward C.T.H. Tan. (2019) Is prehospital blood transfusion effective and safe in haemorrhagic trauma patients? A systematic review and meta-analysis. Injury 50:5, pages 1017-1027.
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Anthony E. Pusateri, Frank K. Butler, Stacy A. Shackelford, Jason L. Sperry, Ernest E. Moore, Andrew P. Cap, Audra L. Taylor, Mary J. Homer, W. Keith Hoots, Richard B. Weiskopf & Michael R. Davis. (2019) The need for dried plasma – a national issue. Transfusion 59:S2, pages 1587-1592.
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Joost H. Peters, Pascal S.H. Smulders, Xavier R.J. Moors, Stef J.M. Bouman, Claartje M.E.M. Meijs, Nico Hoogerwerf & Michael J.R. Edwards. (2019) Are on-scene blood transfusions by a helicopter emergency medical service useful and safe? A multicentre case–control study. European Journal of Emergency Medicine 26:2, pages 128-132.
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L.J. Terceros-Almanza, C. García-Fuentes, S. Bermejo-Aznárez, I.J. Prieto del Portillo, C. Mudarra-Reche, H. Domínguez-Aguado, R. Viejo-Moreno, J. Barea-Mendoza, R. Gómez-Soler, I. Casado-Flores & M. Chico-Fernández. (2019) Prediction of massive bleeding in a prehospital setting: Validation of six scoring systems. Medicina Intensiva (English Edition) 43:3, pages 131-138.
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L.J. Terceros-Almanza, C. García-Fuentes, S. Bermejo-Aznárez, I.J. Prieto del Portillo, C. Mudarra-Reche, H. Domínguez-Aguado, R. Viejo-Moreno, J. Barea-Mendoza, R. Gómez-Soler, I. Casado-Flores & M. Chico-Fernández. (2019) Predicción de hemorragia masiva a nivel extrahospitalario: validación de seis escalas. Medicina Intensiva 43:3, pages 131-138.
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I. M. Smith, N. Crombie, J. R. Bishop, A. McLaughlin, D. N. Naumann, M. Herbert, J. M. Hancox, G. Slinn, N. Ives, M. Grant, G. D. Perkins, H. Doughty & M. J. Midwinter. (2018) RePHILL: protocol for a randomised controlled trial of pre-hospital blood product resuscitation for trauma. Transfusion Medicine 28:5, pages 346-356.
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Kohsuke Hagisawa, Manabu Kinoshita, Bonpei Takase, Kenichi Hashimoto, Daizoh Saitoh, Shuhji Seki, Yasuhiro Nishida & Hiromi Sakai. (2018) Efficacy of Resuscitative Transfusion With Hemoglobin Vesicles in the Treatment of Massive Hemorrhage in Rabbits With Thrombocytopenic Coagulopathy and Its Effect on Hemostasis by Platelet Transfusion. Shock 50:3, pages 324-330.
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Richard M. Lyon, Eleanor de Sausmarez, Emily McWhirter, Gary Wareham, Magnus Nelson, Ashley Matthies, Anthony Hudson, Leigh Curtis & Malcolm Q. Russell. (2017) Pre-hospital transfusion of packed red blood cells in 147 patients from a UK helicopter emergency medical service. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 25:1.
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Jakob Stensballe, Hanne H. Henriksen & Pär I. Johansson. (2017) Early haemorrhage control and management of trauma-induced coagulopathy. Current Opinion in Critical Care 23:6, pages 503-510.
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