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Amyloid
The Journal of Protein Folding Disorders
Volume 10, 2003 - Issue 2
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Original Article

A model for amyloid fibril formation in immunoglobulin light chains based on comparison of amyloidogenic and benign proteins and specific antibody binding

Ritu Khurana Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
,
Pierre O. Souillac Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
,
Alisa C. Coats Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
,
Lauren Minert Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
,
Cristian Ionescu-zanetti Department of Physics, University of California, Santa Cruz, CA, 95064, USA
,
Sue A. Carter Department of Physics, University of California, Santa Cruz, CA, 95064, USA
,
Alan Solomon Human Immunology and Cancer Program, Department of Medicine, University of Tennessee Graduate School of Medicine, Knoxville, TN, USA
&
Anthony L. Fink Department of Chemistry and Biochemistry, University of California, Santa Cruz, CA 95064, USA
 show all
Pages 97-109 | Received 07 Oct 2002, Accepted 24 Apr 2003, Published online: 06 Jul 2009

Citations (20)

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Alan Solomon. (2022) Management of AL amyloidosis in 2021+. Amyloid 29:1, pages 66-66.
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Articles from other publishers (19)

Laetitia F. Heid, Tatsiana Kupreichyk, Marie P. Schützmann, Walfried Schneider, Matthias Stoldt & Wolfgang Hoyer. (2023) Nucleation of α-Synuclein Amyloid Fibrils Induced by Cross-Interaction with β-Hairpin Peptides Derived from Immunoglobulin Light Chains. International Journal of Molecular Sciences 24:22, pages 16132.
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Ramona M. Absmeier, Georg J. Rottenaicher, Hristo L. Svilenov, Pamina Kazman & Johannes Buchner. (2022) Antibodies gone bad – the molecular mechanism of light chain amyloidosis. The FEBS Journal 290:6, pages 1398-1419.
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Kieran Hand, Mark C. Wilkinson & Jillian Madine. (2018) Isolation and purification of recombinant immunoglobulin light chain variable domains from the periplasmic space of Escherichia coli. PLOS ONE 13:10, pages e0206167.
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Sujoy Mukherjee, Simon P. Pondaven, Kieran Hand, Jillian Madine & Christopher P. Jaroniec. (2017) Effect of amino acid mutations on the conformational dynamics of amyloidogenic immunoglobulin light-chains: A combined NMR and in silico study. Scientific Reports 7:1.
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Emily B. Martin, Angela Williams, Craig Wooliver, R. Eric Heidel, Sarah Adams, John Dunlap, Marina Ramirez-Alvarado, Luis M. Blancas-Mejia, Ronald H. Lands, Stephen J. Kennel & Jonathan S. Wall. (2017) Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils—A metric for predicting amyloid propensity. PLOS ONE 12:3, pages e0174152.
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Cardine N. Nokwe, Manuel Hora, Martin Zacharias, Hisashi Yagi, Jirka Peschek, Bernd Reif, Yuji Goto & Johannes Buchner. (2016) A Stable Mutant Predisposes Antibody Domains to Amyloid Formation through Specific Non-Native Interactions. Journal of Molecular Biology 428:6, pages 1315-1332.
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Luis M. Blancas-MejíaMarina Ramirez-Alvarado. (2013) Systemic Amyloidoses. Annual Review of Biochemistry 82:1, pages 745-774.
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Sujoy Mukherjee, Simon P. Pondaven & Christopher P. Jaroniec. (2011) Conformational Flexibility of a Human Immunoglobulin Light Chain Variable Domain by Relaxation Dispersion Nuclear Magnetic Resonance Spectroscopy: Implications for Protein Misfolding and Amyloid Assembly. Biochemistry 50:26, pages 5845-5857.
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Emma Rhiannon Simpson, Eva Maria Herold & Johannes Buchner. (2009) The Folding Pathway of the Antibody VL Domain. Journal of Molecular Biology 392:5, pages 1326-1338.
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Daizo Hamada, Toshiki Tanaka, Gian Gaetano Tartaglia, Amol Pawar, Michele Vendruscolo, Mei Kawamura, Atsuo Tamura, Naoki Tanaka & Christopher M. Dobson. (2009) Competition between Folding, Native-State Dimerisation and Amyloid Aggregation in β-Lactoglobulin. Journal of Molecular Biology 386:3, pages 878-890.
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Kostandinos Sideras & Morie A. Gertz. 2009. Advances in Clinical Chemistry Volume 47. Advances in Clinical Chemistry Volume 47 1 44 .
Xiaoyun Meng, Anthony L. Fink & Vladimir N. Uversky. (2008) The Effect of Membranes on the In Vitro Fibrillation of an Amyloidogenic Light-Chain Variable-Domain SMA. Journal of Molecular Biology 381:4, pages 989-999.
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Marina Ramirez-Alvarado. 2008. Molecular Biology of Protein Folding, Part B. Molecular Biology of Protein Folding, Part B 115 160 .
X Meng, A Fink & M Zhu. 2007. XIth International Symposium on Amyloidosis. XIth International Symposium on Amyloidosis 3 6 .
Zhijie Qin, Dongmei Hu, Min Zhu & Anthony L. Fink. (2007) Structural Characterization of the Partially Folded Intermediates of an Immunoglobulin Light Chain Leading to Amyloid Fibrillation and Amorphous Aggregation. Biochemistry 46:11, pages 3521-3531.
Crossref
Brian O'Nuallain, Amy Allen, Stephen J. Kennel, Deborah T. Weiss, Alan Solomon & Jonathan S. Wall. (2007) Localization of a Conformational Epitope Common to Non-Native and Fibrillar Immunoglobulin Light Chains. Biochemistry 46:5, pages 1240-1247.
Crossref
Fred J. Stevens. 2005. Amyloid Proteins. Amyloid Proteins 527 569 .
Jonathan S. Wall, Vibha Gupta, Matthew Wilkerson, Maria Schell, Remy Loris, Paul Adams, Alan Solomon, Fred Stevens & Chris Dealwis. (2004) Structural basis of light chain amyloidogenicity: comparison of the thermodynamic properties, fibrillogenic potential and tertiary structural features of four V λ 6 proteins . Journal of Molecular Recognition 17:4, pages 323-331.
Crossref
Min Zhu, Shubo Han, Feimeng Zhou, Sue A. Carter & Anthony L. Fink. (2004) Annular Oligomeric Amyloid Intermediates Observed by in Situ Atomic Force Microscopy. Journal of Biological Chemistry 279:23, pages 24452-24459.
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