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The Aging Male Volume 19, 2016 - Issue 2
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Original Article

Testofen, a specialised Trigonella foenum-graecum seed extract reduces age-related symptoms of androgen decrease, increases testosterone levels and improves sexual function in healthy aging males in a double-blind randomised clinical study

Amanda RaoDepartment of Medicine, University of Sydney, Sydney, Australia, Correspondence[email protected]
,
Elizabeth SteelsIntegrated Health Group, Clinical Research, Brisbane, Australia,
,
Warrick J. InderDepartment of Diabetes and Endocrinology, Princess Alexandra Hospital, Brisbane, Australia, and
,
Suzanne AbrahamDepartment of Medicine, University of Sydney, Sydney, Australia,
&
Luis VitettaDepartment of Medicine, University of Sydney, Sydney, Australia, ;Medlab Pty Ltd, Sydney, Australia
Pages 134-142 | Received 24 Sep 2015, Accepted 19 Dec 2015, Published online: 20 Jan 2016

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S. N. Sankhwar, Pawan Kumar, Manashi Bagchi, Mehul Rungta & Debasis Bagchi. (2023) Safety and Efficacy of Furosap®, a Patented Trigonella foenum-graecum Seed Extract, in Boosting Testosterone Level, Reproductive Health and Mood Alleviation in Male Volunteers. Journal of the American Nutrition Association 42:1, pages 27-35.
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İlhan Özen & Xungai Wang. (2023) Biomedicine: electrospun nanofibrous hormonal therapies through skin/tissue—a review. International Journal of Polymeric Materials and Polymeric Biomaterials 72:1, pages 21-39.
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Sachiko Kubo, Toshiyuki Yasui, Yukie Matsuura & Masahito Tomotake. (2020) Differences in male climacteric symptoms with aging among rotating night shift workers. The Aging Male 23:5, pages 995-1003.
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Rafal Mlynarski, Agnieszka Mlynarska & Krzysztof S. Golba. (2020) Attitude towards sexuality and sexual behaviors among men with heart rhythm disorders. The Aging Male 23:5, pages 764-769.
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Dongning Yao, Bingyu Zhang, Jianfan Zhu, Qianru Zhang, Yuanjia Hu, Shengpeng Wang, Yitao Wang, Hui Cao & Jianbo Xiao. (2020) Advances on application of fenugreek seeds as functional foods: Pharmacology, clinical application, products, patents and market. Critical Reviews in Food Science and Nutrition 60:14, pages 2342-2352.
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David R. Hooper, Adam S. Tenforde & Anthony C. Hackney. (2018) Treating exercise-associated low testosterone and its related symptoms. The Physician and Sportsmedicine 46:4, pages 427-434.
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Chad M. Kerksick, Colin D. Wilborn, Michael D. Roberts, Abbie Smith-Ryan, Susan M. Kleiner, Ralf Jäger, Rick Collins, Mathew Cooke, Jaci N. Davis, Elfego Galvan, Mike Greenwood, Lonnie M. Lowery, Robert Wildman, Jose Antonio & Richard B. Kreider. (2018) ISSN exercise & sports nutrition review update: research & recommendations. Journal of the International Society of Sports Nutrition 15:1.
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Articles from other publishers (35)

Eduard Isenmann, Pijus Alisauskas, Ulrich Flenker, Jan Schalla & Patrick Diel. (2023) The Anabolic Effect of Fenugreek: A Systematic Review with Meta-analysis. International Journal of Sports Medicine 44:10, pages 692-703.
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Dengjianyi Xu, Yucong Zhang, Jian Bai, Huixing Yuan, Tao Wang, Jihong Liu, Wen Song & Delin Ma. (2023) Botanical drugs for treating erectile dysfunction: clinical evidence. Frontiers in Pharmacology 14.
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Amanda Rao, Paul Clayton & David Briskey. (2023) Libifem® (Trigonella foenum-graecum) in conjunction with exercise on muscle strength, power, endurance, and body composition in females aged between 25 and 45 years. Frontiers in Sports and Active Living 5.
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Waleed I. Albaker. (2023) Fenugreek and Its Effects on Muscle Performance: A Systematic Review. Journal of Personalized Medicine 13:3, pages 427.
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Laleh Fakhr, Fatemeh Chehregosha, Meysam Zarezadeh, Maryam Chaboksafar & Ali Tarighat-Esfanjani. (2023) Effects of fenugreek supplementation on the components of metabolic syndrome: A systematic review and dose-response meta-analysis of randomized clinical trials. Pharmacological Research 187, pages 106594.
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Lucas de Souza Ortolan, Karina Ferrazzolli Devienne Vicentine & Simone Acrani. (2022) Effects of fenugreek (Trigonella foenum-graecum) on daily sperm production, epididymal transit and sperm morphology of pubertal Wistar rats. Brazilian Journal of Science 1:11, pages 65-72.
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Giulia Villa, Mattia Boarin, Debora Rosa, Serena Togni, Duilio F. Manara, Loris Bonetti & Stefano Terzoni. (2022) Phytotherapy in urological benign disease: A systematic review. International Journal of Urological Nursing 16:3, pages 174-195.
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Marne Louters, Michelle Pearlman, Emily Solsrud & Amy Pearlman. (2021) Functional hypogonadism among patients with obesity, diabetes, and metabolic syndrome. International Journal of Impotence Research 34:7, pages 714-720.
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Adam Shepherd, Oliver Brunckhorst, Kamran Ahmed & Qihe Xu. (2022) Botanicals in health and disease of the testis and male fertility: A scoping review. Phytomedicine 106, pages 154398.
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Adrian Andres Aguilar-Morgan, Abraham Morgentaler & Luis Antonio Reyes-Vallejo. (2022) Testosterone Boosters: How Real Are Their Effects?. Androgens: Clinical Research and Therapeutics 3:1, pages 69-76.
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. 2022. The Chemistry inside Spices & Herbs: Research and Development – Volume II. The Chemistry inside Spices & Herbs: Research and Development – Volume II 162 192 .
Neetu Singh, Surender Singh Yadav, Sanjiv Kumar & Balasubramaniam Narashiman. (2022) Ethnopharmacological, phytochemical and clinical studies on Fenugreek (Trigonella foenum-graecum L.). Food Bioscience 46, pages 101546.
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Azita Sadogh, Narjes Gorji & Reihaneh Moeini. (2022) Herbal foodstuffs in Avicenna’s recommended diet to improve sperm quality and increase male fertility; an evidence-based approach. Journal of Complementary and Integrative Medicine 19:1, pages 47-70.
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Anuradha Patel, Sanjesh Tiwari, Neeraj Pandey, Divya Gupta & Sheo Mohan Prasad. 2022. Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals. Research Anthology on Recent Advancements in Ethnopharmacology and Nutraceuticals 616 648 .
Jean M. Bokelmann. 2022. Medicinal Herbs in Primary Care. Medicinal Herbs in Primary Care 341 349 .
Jai Malik, Sunayna Choudhary, Subhash C. Mandal, Prerna Sarup & Sonia Pahuja. 2022. Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Oxidative Stress and Toxicity in Reproductive Biology and Medicine 137 159 .
Valerie Jia-En Sin, Ganesh Srinivasan Anand & Hwee-Ling Koh. (2021) Botanical Medicine and Natural Products Used for Erectile Dysfunction. Sexual Medicine Reviews 9:4, pages 568-592.
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Heather A. Hausenblas, Kara L. Conway, Kevin R.M. Coyle, Emily Barton, Lacie D. Smith, Michael Esposito, Charles Harvey, Dennis Oakes & David R. Hooper. (2021) Efficacy of fenugreek seed extract on men's psychological and physical health: a randomized placebo-controlled double-blind clinical trial. Journal of Complementary and Integrative Medicine 18:2, pages 445-448.
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Stephen J Smith, Adrian L Lopresti, Shaun Y M Teo & Timothy J Fairchild. (2021) Examining the Effects of Herbs on Testosterone Concentrations in Men: A Systematic Review. Advances in Nutrition 12:3, pages 744-765.
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Masato Shirai, Yuto Miyoshi, Taiki Ogasa, Miho Miyoshi, Keisuke Ishikawa, Ippei Hiramatsu, Yuka Uesaka, Taiji Nozaki, Taro Koyama & Akira Tsujimura. (2021) Oral Testofen, L-Citrulline, Resveratrol, and Caffeine Supplement Drink Improves Sexual Function in Men with Phosphodiesterase 5 Inhibitors: Randomized, Double-Blind, Placebo-Controlled Crossover Pilot Study. The World Journal of Men's Health 39:4, pages 733.
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Muhammad Akram, Muhammad Daniyal, Sabira Sultana, Aymen Owais, Naheed Akhtar, Rabia Zahid, Fahad Said, Abdelhakim Bouyahya, Evgeny Ponomarev, Mohammad Ali Shariat & Muthu Thiruvengadam. (2021) Traditional and modern management strategies for rheumatoid arthritis. Clinica Chimica Acta 512, pages 142-155.
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Annie George & Eckehard Liske. 2021. Herbal Medicine in Andrology. Herbal Medicine in Andrology 215 225 .
Ayah Rebhi Hilles & Syed Mahmood. 2021. Fenugreek. Fenugreek 503 522 .
Amanda J. Rao, Alistair R. Mallard & Ross Grant. (2020) Testofen ® (Fenugreek extract) increases strength and muscle mass compared to placebo in response to calisthenics. A randomized control trial . Translational Sports Medicine 3:4, pages 374-380.
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Anthony C. Hackney. (2020) Hypogonadism in Exercising Males: Dysfunction or Adaptive-Regulatory Adjustment?. Frontiers in Endocrinology 11.
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Anuradha Patel, Sanjesh Tiwari, Neeraj Pandey, Divya Gupta & Sheo Mohan Prasad. 2020. Ethnopharmacological Investigation of Indian Spices. Ethnopharmacological Investigation of Indian Spices 5 35 .
Frank Cloutier, Pauline Roumaud, Sabrina Ayoub-Charette, Subrata Chowdhury & Luc J. Martin. (2020) The intake of an extract from seeds of Tamarindus indica L. modulates the endocrine function of adult male mice under a high fat diet. Heliyon 6:1, pages e03310.
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Heitor O. Santos, Scott Howell & Filipe J. Teixeira. (2019) Beyond tribulus (Tribulus terrestris L.): The effects of phytotherapics on testosterone, sperm and prostate parameters. Journal of Ethnopharmacology 235, pages 392-405.
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Amit D. Kandhare, Prasad A. Thakurdesai, Pralhad Wangikar & Subhash L. Bodhankar. (2019) A systematic literature review of fenugreek seed toxicity by using ToxRTool: evidence from preclinical and clinical studies. Heliyon 5:4, pages e01536.
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Solomon Habtemariam. 2019. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases. Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases 579 637 .
Lesław Bernard Lahuta, Joanna Szablińska, Monika Ciak & Ryszard Józef Górecki. (2018) The occurrence and accumulation of d-pinitol in fenugreek (Trigonella foenum graecum L.). Acta Physiologiae Plantarum 40:8.
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Hyun Jun Park, Kyeong Soo Lee, Eun Kyoung Lee & Nam Cheol Park. (2018) Efficacy and Safety of a Mixed Extract of Trigonella foenum-graecum Seed and Lespedeza cuneata in the Treatment of Testosterone Deficiency Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial . The World Journal of Men's Health 36:3, pages 230.
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D. Sureshkumar, Shamshad Begum, N.M. Johannah, Balu Maliakel & I.M. Krishnakumar. (2018) Toxicological evaluation of a saponin-rich standardized extract of fenugreek seeds (FenuSMART®): Acute, sub-chronic and genotoxicity studies. Toxicology Reports 5, pages 1060-1068.
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Jorge M. Alves-Silva, Abderrahmane Romane, Thomas Efferth & Lígia Salgueiro. (2017) North African Medicinal Plants Traditionally Used in Cancer Therapy. Frontiers in Pharmacology 8.
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Kalyan C. Nagulapalli Venkata, Anand Swaroop, Debasis Bagchi & Anupam Bishayee. (2017) A small plant with big benefits: Fenugreek ( Trigonella foenum-graecum Linn.) for disease prevention and health promotion . Molecular Nutrition & Food Research 61:6, pages 1600950.
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