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Research Article

Ginsenoside Rb3 ameliorates myocardial ischemia-reperfusion injury in rats

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Pages 900-906 | Received 05 Oct 2010, Accepted 11 Jan 2011, Published online: 19 May 2011

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Read on this site (4)

Fangfei Liu, Yating Shen, Jiabin Li, Lixia Bi, Xiaoli Ye, Yanhong Li & Du Zhi. (2023) Characteristics of ginsenoside Rd-induced effects on rat intestinal contractility with irritable bowel syndrome. Natural Product Research 37:18, pages 3152-3157.
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Amir Hossein Ajzashokouhi, Ramin Rezaee, Navid Omidkhoda & Gholamreza Karimi. (2023) Natural compounds regulate the PI3K/Akt/GSK3β pathway in myocardial ischemia-reperfusion injury. Cell Cycle 22:7, pages 741-757.
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Sun-Joo Oh, Yuri Oh, In Wang Ryu, Kyunghoon Kim & Chang-Jin Lim. (2016) Protective properties of ginsenoside Rb3 against UV-B radiation-induced oxidative stress in HaCaT keratinocytes. Bioscience, Biotechnology, and Biochemistry 80:1, pages 95-103.
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Dapeng Chen, Yongjian Xiong, Chunling Jiang, Bochao Lv, Fangfei Liu, Li Wang & Yuan Lin. (2014) Effects of ginsenosides on rat jejunal contractility. Pharmaceutical Biology 52:2, pages 162-168.
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Articles from other publishers (28)

Gan Chen, Hong Zhang, Jiaming Jiang, Simin Chen, Hongmei Zhang, Gongmin Zhang, Changwu Zheng & Hongxi Xu. (2023) Metabolomics approach to growth‐age discrimination in mountain‐cultivated ginseng ( Panax ginseng C. A. Meyer) using ultra‐high‐performance liquid chromatography coupled with quadrupole‐time‐of‐flight mass spectrometry . Journal of Separation Science 46:22.
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Zekun Cui, Lifei Gu, Tao Liu, Yining Liu, Boyang Yu, Junping Kou, Fang Li & Kun Yang. (2023) Ginsenoside Rd attenuates myocardial ischemia injury through improving mitochondrial biogenesis via WNT5A/Ca2+ pathways. European Journal of Pharmacology 957, pages 176044.
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Xinxin Cao, Fan Yao, Bin Zhang & Xiaobo Sun. (2023) Mitochondrial dysfunction in heart diseases: Potential therapeutic effects of Panax ginseng. Frontiers in Pharmacology 14.
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Jinjin Chen, Qingxia Huang, Jing Li, Yao Yao, Weichen Sun, Zepeng Zhang, Hongyu Qi, Zhaoqiang Chen, Jiaqi Liu, Daqing Zhao, Jia Mi & Xiangyan Li. (2023) Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms. Journal of Ethnopharmacology 300, pages 115715.
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WEI LI, YUEYANG DUAN, XIAOTONG YAN, XIANGXIANG LIU, MEILING FAN & ZI WANG. (2022) A mini-review on pharmacological effects of ginsenoside Rb3, a marked saponin from Panax genus. BIOCELL 46:6, pages 1417-1423.
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Chunlian Tian, Yu Chang, Ruxia Wang, Zhiruo Kang, Qi Wang, Zhifan Tong, Aohua Zhou, Cancan Cui & Mingchun Liu. (2021) Optimization of ultrasound extraction of Tribulus terrestris L. leaves saponins and their HPLC-DAD-ESI-MSn profiling, anti-inflammatory activity and mechanism in vitro and in vivo. Journal of Ethnopharmacology 278, pages 114225.
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Yi Zhang, Haixia Ji, Ou Qiao, Zhi Li, Lorenzo Pecoraro, Xueqian Zhang, Xiaoying Han, Wenzhe Wang, Xinyu Zhang, Shuli Man, Juan Wang, Xia Li, Changxiao Liu, Luqi Huang & Wenyuan Gao. (2021) Nanoparticle conjugation of ginsenoside Rb3 inhibits myocardial fibrosis by regulating PPARα pathway. Biomedicine & Pharmacotherapy 139, pages 111630.
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Jianqiang Deng, Huiyun Wang, Xiaodong Mu, Xiuting He, Fenglan Zhao & Qingguo Meng. (2021) Advances in Research on the Preparation and Biological Activity of Maslinic Acid. Mini-Reviews in Medicinal Chemistry 21:1, pages 79-89.
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Ruiying Wang, Min Wang, Jiahui Zhou, Daoshun Wu, Jingxue Ye, Guibo Sun & Xiaobo Sun. (2021) Saponins in Chinese Herbal Medicine Exerts Protection in Myocardial Ischemia–Reperfusion Injury: Possible Mechanism and Target Analysis. Frontiers in Pharmacology 11.
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Min Li, Xuwen Li, Limei Zhou & Yongri Jin. (2020) Effects of total saponins from Panacis majoris Rhizoma and its degradation products on myocardial ischemia-reperfusion injury in rats. Biomedicine & Pharmacotherapy 130, pages 110538.
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Chunlian Tian, Yu Chang, Xin Liu, Zehui Zhang, Yuru Guo, Zhiwei Lan, Peng Zhang & Mingchun Liu. (2020) Anti-inflammatory activity in vitro, extractive process and HPLC-MS characterization of total saponins extract from Tribulus terrestris L. fruits. Industrial Crops and Products 150, pages 112343.
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Mingyan Shao, Dongqing Guo, Wenji Lu, Xu Chen, Lin Ma, Yan Wu, Xuefeng Zhang, Qiyan Wang, Xiaoping Wang, Weili Li, Qian Wang, Wei Wang, Chun Li & Yong Wang. (2020) Identification of the active compounds and drug targets of Chinese medicine in heart failure based on the PPARs-RXRα pathway. Journal of Ethnopharmacology 257, pages 112859.
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Xu Chen, Qiyan Wang, Mingyan Shao, Lin Ma, Dongqing Guo, Yan Wu, Pengrong Gao, Xiaoping Wang, Weili Li, Chun Li & Yong Wang. (2019) Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway. Biomedicine & Pharmacotherapy 120, pages 109487.
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Xiaomin Liu, Yichuan Jiang, Wenwen Fu, Xiaofeng Yu & Dayun Sui. (2019) Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats. International Journal of Molecular Medicine.
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Qianwen Yang, Ning Wang, Jie Zhang, Geng Chen, Hui Xu, Qingguo Meng, Yuan Du, Xin Yang & Huaying Fan. (2019) In vitro and in silico evaluation of stereoselective effect of ginsenoside isomers on platelet P2Y12 receptor. Phytomedicine 64, pages 152899.
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Jing-Yan Han, Quan Li, Chun-Shui Pan, Kai Sun & Jing-Yu Fan. (2019) Effects and mechanisms of QiShenYiQi pills and major ingredients on myocardial microcirculatory disturbance, cardiac injury and fibrosis induced by ischemia-reperfusion. Pharmacological Research 147, pages 104386.
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Hyo-Joong Won, Hyun Il Kim, Taejun Park, Hyeongmin Kim, Kanghee Jo, Hyojin Jeon, Seo Jun Ha, Jung Min Hyun, Aeri Jeong, Jung Sik Kim, Ye Jin Park, Yun Ho Eo & Jaehwi Lee. (2019) Non-clinical pharmacokinetic behavior of ginsenosides. Journal of Ginseng Research 43:3, pages 354-360.
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Xue Han, Mengying Li, Zhifeng Zhao, Yuanyuan Zhang, Jianping Zhang, Xuan Zhang, Ying Zhang, Shengjiang Guan & Li Chu. (2019) Mechanisms underlying the cardio-protection of total ginsenosides against myocardial ischemia in rats in vivo and in vitro: Possible involvement of L-type Ca2+ channels, contractility and Ca2+ homeostasis. Journal of Pharmacological Sciences 139:3, pages 240-248.
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Xiaohong Tracey GanMorris Karmazyn. (2018) Cardioprotection by ginseng: experimental and clinical evidence and underlying mechanisms. Canadian Journal of Physiology and Pharmacology 96:9, pages 859-868.
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Deepika Singh & Prabir Kumar Chaudhuri. (2018) Structural characteristics, bioavailability and cardioprotective potential of saponins. Integrative Medicine Research 7:1, pages 33-43.
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Yichuan Jiang, Min Li, Zeyuan Lu, Yuchen Wang, Xiaofeng Yu, Dayun Sui & Li Fu. (2017) Ginsenoside Rg3 induces ginsenoside Rb1-comparable cardioprotective effects independent of reducing blood pressure in spontaneously hypertensive rats. Experimental and Therapeutic Medicine.
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Jing-Yan Han, Quan Li, Zhi-Zhong Ma & Jing-Yu Fan. (2017) Effects and mechanisms of compound Chinese medicine and major ingredients on microcirculatory dysfunction and organ injury induced by ischemia/reperfusion. Pharmacology & Therapeutics 177, pages 146-173.
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Fanli Meng, Xiaotian Su, Wei Li & Yinan Zheng. (2017) Ginsenoside Rb3 strengthens the hypoglycemic effect through AMPK for inhibition of hepatic gluconeogenesis. Experimental and Therapeutic Medicine 13:5, pages 2551-2557.
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YIPING WANG, ZHAOHUI HU, BING SUN, JIAHONG XU, JINFA JIANG & MING LUO. (2015) Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion injury via Akt/endothelial nitric oxide synthase signaling and the B-cell lymphoma/B-cell lymphoma-associated X protein pathway. Molecular Medicine Reports 11:6, pages 4518-4524.
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Dongying Xu, Ping Huang, Zhaosheng Yu, Daniel H. Xing, Shuai Ouyang & Guoqiang Xing. (2015) Efficacy and Safety of Panax notoginseng Saponin Therapy for Acute Intracerebral Hemorrhage, Meta-Analysis, and Mini Review of Potential Mechanisms of Action. Frontiers in Neurology 5.
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XIAOMIN LIU, YICHUAN JIANG, XIAOFENG YU, WENWEN FU, HONG ZHANG & DAYUN SUI. (2014) Ginsenoside-Rb3 protects the myocardium from ischemia-reperfusion injury via the inhibition of apoptosis in rats. Experimental and Therapeutic Medicine 8:6, pages 1751-1756.
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Youhua Wang, Jinghui Dong, Ping Liu, Chi Wai Lau, Zhen Gao, Duan Zhou, Jingyi Tang, Chi Fai Ng & Yu Huang. (2014) Ginsenoside Rb3 attenuates oxidative stress and preserves endothelial function in renal arteries from hypertensive rats. British Journal of Pharmacology 171:13, pages 3171-3181.
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Yang Wang, Xu Li, Xiaoliang Wang, Waynebond Lau, Yajing Wang, Yuan Xing, Xing Zhang, Xinliang Ma & Feng Gao. (2013) Ginsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β Signaling and Inhibition of the Mitochondria-Dependent Apoptotic Pathway. PLoS ONE 8:8, pages e70956.
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