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Research Article

Formononetin induces the mitochondrial apoptosis pathway in prostate cancer cells via downregulation of the IGF-1/IGF-1R signaling pathway

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Pages 466-470 | Received 10 May 2013, Accepted 04 Sep 2013, Published online: 20 Dec 2013

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Saleh A. Almatroodi, Ahmad Almatroudi, Amjad Ali Khan & Arshad Husain Rahmani. (2023) Potential Therapeutic Targets of Formononetin, a Type of Methoxylated Isoflavone, and Its Role in Cancer Therapy through the Modulation of Signal Transduction Pathways. International Journal of Molecular Sciences 24:11, pages 9719.
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Ji Eon Park, Woo‐Cheol Shin, Hyo‐Jung Lee, Dahye Yoon, Deok Yong Sim, Chi‐Hoon Ahn, Su‐Yeon Park, Bum Sang Shim, So Jung Park, Kyung Seok Kim, Geum Duck Park, Sung‐Hoon Kim & Dae Young Lee. (2022) SH‐PRO extract alleviates benign prostatic hyperplasia via ROS ‐mediated activation of PARP /caspase 3 and inhibition of FOXO3a / AR / PSA signaling in vitro and in vivo . Phytotherapy Research 37:2, pages 452-463.
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Sneha Sivadas, Nandakumar Selvasudha, Pooja Prasad & Hannah R. Vasanthi. 2023. Molecular Nutrition and Mitochondria. Molecular Nutrition and Mitochondria 303 332 .
Bingke Bai, Qianbo Chen, Rui Jing, Xuhui He, Hongrui Wang, Yanfei Ban, Qi Ye, Weiheng Xu & Chengjian Zheng. (2021) Molecular Basis of Prostate Cancer and Natural Products as Potential Chemotherapeutic and Chemopreventive Agents. Frontiers in Pharmacology 12.
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Kai-Ching Tay, Loh Teng-Hern Tan, Chim Kei Chan, Sok Lai Hong, Kok-Gan Chan, Wei Hsum Yap, Priyia Pusparajah, Learn-Han Lee & Bey-Hing Goh. (2019) Formononetin: A Review of Its Anticancer Potentials and Mechanisms. Frontiers in Pharmacology 10.
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Samantha Ong, Muthu Shanmugam, Lu Fan, Sarah Fraser, Frank Arfuso, Kwang Ahn, Gautam Sethi & Anupam Bishayee. (2019) Focus on Formononetin: Anticancer Potential and Molecular Targets. Cancers 11:5, pages 611.
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Xiong Zhang, Qi Ni, Ying Wang, Hongwei Fan & Yingbin Li. (2018) Synergistic Anticancer Effects of Formononetin and Temozolomide on Glioma C6 Cells. Biological and Pharmaceutical Bulletin 41:8, pages 1194-1202.
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Yun Huang, Kenneth Kwan, Ka Leung, Huaiyou Wang, Xiang Kong, Tina Dong & Karl Tsim. (2018) The Extracts and Major Compounds Derived from Astragali Radix Alter Mitochondrial Bioenergetics in Cultured Cardiomyocytes: Comparison of Various Polar Solvents and Compounds. International Journal of Molecular Sciences 19:6, pages 1574.
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Jyoti Gautam, Vikram Khedgikar, Priyanka Kushwaha, Dharmendra Choudhary, Geet Kumar Nagar, Kapil Dev, Preety Dixit, Divya Singh, Rakesh Maurya & Ritu Trivedi. (2017) Formononetin, an isoflavone, activates AMP-activated protein kinase/ β -catenin signalling to inhibit adipogenesis and rescues C57BL/6 mice from high-fat diet-induced obesity and bone loss . British Journal of Nutrition 117:5, pages 645-661.
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Yi Qin, Jichao Ye, Peng Wang, Liangbin Gao, Suwei Wang & Huiyong Shen. (2016) miR-223 contributes to the AGE-promoted apoptosis via down-regulating insulin-like growth factor 1 receptor in osteoblasts. Bioscience Reports 36:2.
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