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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 25, 2010 - Issue 3
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Research Article

Why acetylcholinesterase reactivators do not work in butyrylcholinesterase

Jiří WiesnerNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic
,
Zdeněk KřížNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech Republic
,
Kamil Kuča
,
Daniel Jun
&
Jaroslav KočaNational Centre for Biomolecular Research, Faculty of Science, Masaryk University, Brno, Czech RepublicCorrespondence[email protected]
Pages 318-322 | Received 04 Mar 2009, Accepted 03 Jun 2009, Published online: 29 Oct 2009

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Kamil Musilek, Ruzena Pavlikova, Jan Marek, Marketa Komloova, Ondrej Holas, Martina Hrabinova, Miroslav Pohanka, Vlastimil Dohnal, Martin Dolezal, Frank Gunn-Moore & Kamil Kuca. (2011) The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage. Journal of Enzyme Inhibition and Medicinal Chemistry 26:2, pages 245-253.
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Articles from other publishers (13)

Tatiana N. Pashirova, Andrei Bogdanov & Patrick Masson. (2021) Therapeutic nanoreactors for detoxification of xenobiotics: Concepts, challenges and biotechnological trends with special emphasis to organophosphate bioscavenging. Chemico-Biological Interactions 346, pages 109577.
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Jakub Jończyk, Jędrzej Kukułowicz, Kamil Łątka, Barbara Malawska, Young-Sik Jung, Kamil Musilek & Marek Bajda. (2021) Molecular Modeling Studies on the Multistep Reactivation Process of Organophosphate-Inhibited Acetylcholinesterase and Butyrylcholinesterase. Biomolecules 11:2, pages 169.
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Jorge Estévez, Felipe Rodrigues de Souza, María Romo, Iris Mangas, Tanos Celmar Costa Franca & Eugenio Vilanova. (2019) Interactions of human butyrylcholinesterase with phenylvalerate and acetylthiocholine as substrates and inhibitors: kinetic and molecular modeling approaches. Archives of Toxicology 93:5, pages 1281-1296.
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Kamil Kuca, Daniel Jun, Lucie Junova, Kamil Musilek, Martina Hrabinova, Jorge da Silva, Teodorico Ramalho, Marian Valko, Qinghua Wu, Eugenie Nepovimova & Tanos França. (2018) Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. Molecules 23:5, pages 1103.
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Long Yan, Jia Chen, Bin Xu, Lei Guo, Yan Xie, Jijun Tang & Jianwei Xie. (2016) A liquid chromatography tandem mass spectrometric method on in vitro nerve agents poisoning characterization and reactivator efficacy evaluation by determination of specific peptide adducts in acetylcholinesterase. Journal of Chromatography A 1450, pages 86-93.
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Jacob Atsmon, Einat Brill-Almon, Carmit Nadri-Shay, Raul Chertkoff, Sari Alon, Dimitri Shaikevich, Inna Volokhov, Kirsten Y. Haim, Daniel Bartfeld, Avidor Shulman, Ilya Ruderfer, Tehila Ben-Moshe, Orit Shilovitzky, Hermona Soreq & Yoseph Shaaltiel. (2015) Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R. Toxicology and Applied Pharmacology 287:3, pages 202-209.
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Gabriele Horn, Timo Wille, Kamil Musilek, Kamil Kuca, Horst Thiermann & Franz Worek. (2014) Reactivation kinetics of 31 structurally different bispyridinium oximes with organophosphate-inhibited human butyrylcholinesterase. Archives of Toxicology 89:3, pages 405-414.
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Oussama Cherif, Fatma Allouche, Fakher Chabchoub, Mourad Chioua, Elena Soriano, Matilde Yañez, Ramón Cacabelos, Alejandro RomeroManuela G López  & Jose Marco-Contelles. (2014) Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease. Future Medicinal Chemistry 6:17, pages 1883-1891.
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Julien Renou, Mélanie Loiodice, Mélanie Arboléas, Rachid Baati, Ludovic Jean, Florian Nachon & Pierre-Yves Renard. (2014) Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterases. Chem. Commun. 50:30, pages 3947-3950.
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Carter W. Abney, Jennifer L. S. Knaack, Ahmed A. I. Ali & Rudolph C. Johnson. (2013) Novel Dual-Mode Immunomagnetic Method for Studying Reactivation of Nerve Agent-Inhibited Butyrylcholinesterase. Chemical Research in Toxicology 26:5, pages 775-782.
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Zoran RadićTrevor DaleZrinka Kovarik, Suzana Berend, Edzna GarciaLimin ZhangGabriel Amitai, Carol GreenBožica Radić, Brendan M. DugganDariush AjamiJulius RebekJrJrPalmer Taylor. (2013) Catalytic detoxification of nerve agent and pesticide organophosphates by butyrylcholinesterase assisted with non-pyridinium oximes. Biochemical Journal 450:1, pages 231-242.
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Roney Anderson Nascimento de Aquino, Luzia Valentina Modolo, Rosemeire Brondi Alves & Ângelo de Fátima. (2013) Synthesis, kinetic studies and molecular modeling of novel tacrine dimers as cholinesterase inhibitors. Organic & Biomolecular Chemistry 11:48, pages 8395.
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Daniel Jun, Lucie Musilova, Miroslav Pohanka, Young-Sik Jung, Pavel Bostik & Kamil Kuca. (2010) Reactivation of Human Acetylcholinesterase and Butyrylcholinesterase Inhibited by Leptophos-Oxon with Different Oxime Reactivators in Vitro. International Journal of Molecular Sciences 11:8, pages 2856-2863.
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