1,626
Views
17
CrossRef citations to date
0
Altmetric
Research Article

Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms

, , &
Pages 331-339 | Received 12 Mar 2009, Accepted 27 May 2009, Published online: 29 Oct 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Sandhya Kortagere. (2012) Screening for small molecule inhibitors of Toxoplasma gondii . Expert Opinion on Drug Discovery 7:12, pages 1193-1206.
Read now

Articles from other publishers (16)

Mike dos Santos, Andréia Luiza Oliveira Costa, Guilherme Henrique de Souza Vaz, Gabriela Carolina Alves de Souza, Ricardo Wagner de Almeida Vitor & Érica S. Martins-Duarte. (2023) Medicines for Malaria Venture Pandemic Box In Vitro Screening Identifies Compounds Highly Active against the Tachyzoite Stage of Toxoplasma gondii. Tropical Medicine and Infectious Disease 8:12, pages 510.
Crossref
Tayyebeh Koneshlou, Morteza Rouhani, Hamid Saeidian & Javad Mokhtari Aliabad. (2023) Biguanide-dihydropyrimidine dual scaffolds with impressive basicities according to DFT calculations. Computational and Theoretical Chemistry 1225, pages 114178.
Crossref
Jarunee Vanichtanankul, Aphisit Yoomuang, Supannee Taweechai, Thanaya Saeyang, Jutharat Pengon, Jirundon Yuvaniyama, Bongkoch Tarnchompoo, Yongyuth Yuthavong & Sumalee Kamchonwongpaisan. (2022) Structural Insight into Effective Inhibitors’ Binding to Toxoplasma gondii Dihydrofolate Reductase Thymidylate Synthase . ACS Chemical Biology 17:7, pages 1691-1702.
Crossref
Jiamiao Fu, Siyu Liu, Minqiang Hu, Ximing Liao, Xiaoquan Wang, Zhengshuang Xu, Qinkai Li & Junmin Quan. (2022) Biguanide MC001, a Dual Inhibitor of OXPHOS and Glycolysis, Shows Enhanced Antitumor Activity Without Increasing Lactate Production. ChemMedChem 17:6.
Crossref
Deepika Kathuria, Akshay D. Raul, Pravin Wanjari & Prasad V. Bharatam. (2021) Biguanides: Species with versatile therapeutic applications. European Journal of Medicinal Chemistry 219, pages 113378.
Crossref
Deepika Kathuria, Apoorva A. Bankar & Prasad V. Bharatam. (2018) “What's in a structure?” The story of biguanides. Journal of Molecular Structure 1152, pages 61-78.
Crossref
Scott A. Gabel, Michael R. Duff, Lars C. Pedersen, Eugene F. DeRose, Juno M. Krahn, Elizabeth E. Howell & Robert E. London. (2017) A Structural Basis for Biguanide Activity. Biochemistry 56:36, pages 4786-4798.
Crossref
Madalyn M. McFarland, Sydney J. Zach, Xiaofang Wang, Lakshmi-Prasad Potluri, Andrew J. Neville, Jonathan L. Vennerstrom & Paul H. Davis. (2016) Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity. Antimicrobial Agents and Chemotherapy 60:12, pages 7017-7034.
Crossref
Rupesh U. Shelke, Mariam S. Degani, Archana Raju, Mukti Kanta Ray & Mysore G. R. Rajan. (2016) Fragment Discovery for the Design of Nitrogen Heterocycles as Mycobacterium tuberculosis Dihydrofolate Reductase Inhibitors . Archiv der Pharmazie 349:8, pages 602-613.
Crossref
Arundhati C. Lele, Archana Raju, Mihir P. Khambete, M. K. Ray, M. G. R. Rajan, Manisha A. Arkile, Nandadeep J. Jadhav, Dhiman Sarkar & Mariam S. Degani. (2015) Design and Synthesis of a Focused Library of Diamino Triazines as Potential Mycobacterium tuberculosis DHFR Inhibitors . ACS Medicinal Chemistry Letters 6:11, pages 1140-1144.
Crossref
Nilesh R Tawari, Seema Bag, Archana Raju, Arundhati C Lele, Ranjeet Bairwa, Mukti Kanta Ray, MGR Rajan, Laxman U Nawale, Dhiman Sarkar & Mariam S Degani. (2015) Rational drug design, synthesis and biological evaluation of dihydrofolate reductase inhibitors as antituberculosis agents. Future Medicinal Chemistry 7:8, pages 979-988.
Crossref
Surekha Shridhar, Kolaleh Hassan, David J. Sullivan, Gerardo R. Vasta & José A. Fernández Robledo. (2013) Quantitative assessment of the proliferation of the protozoan parasite Perkinsus marinus using a bioluminescence assay for ATP content. International Journal for Parasitology: Drugs and Drug Resistance 3, pages 85-92.
Crossref
R. D. SHARMA, S. BAG, N. R. TAWARI, M. S. DEGANI, K. GOSWAMI & M. V. R. REDDY. (2013) Exploration of 2, 4-diaminopyrimidine and 2, 4-diamino-s-triazine derivatives as potential antifilarial agents. Parasitology 140:8, pages 959-965.
Crossref
Nilesh R. Tawari, Ranjeet Bairwa, M.K. Ray, M.G.R. Rajan & Mariam S. Degani. (2010) Design, synthesis, and biological evaluation of 4-(5-nitrofuran-2-yl)prop-2-en-1-one derivatives as potent antitubercular agents. Bioorganic & Medicinal Chemistry Letters 20:21, pages 6175-6178.
Crossref
Seema Bag, Nilesh R. Tawari, Mariam S. Degani & Sherry F. Queener. (2010) Design, synthesis, biological evaluation and computational investigation of novel inhibitors of dihydrofolate reductase of opportunistic pathogens. Bioorganic & Medicinal Chemistry 18:9, pages 3187-3197.
Crossref
Seema Bag, Nilesh R. Tawari, Richa Sharma, Kalyan Goswami, M.V.R. Reddy & Mariam S. Degani. (2010) In vitro biological evaluation of biguanides and dihydrotriazines against Brugia malayi and folate reversal studies. Acta Tropica 113:1, pages 48-51.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.