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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 26, 2011 - Issue 2
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Research Article

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

Jalmira MulchandeMedicinal Chemistry, iMed.UL, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, Lisbon, PortugalCorrespondence[email protected]
,
Sandra I. SimõesNanomedicine & Drug Delivery Systems, iMed.UL, Faculty of Pharmacy, University of Lisbon, Campus of Lumiar, Building F, R/C, Estrada do Paço do Lumiar, Lisbon, Portugal
,
Maria M. GasparNanomedicine & Drug Delivery Systems, iMed.UL, Faculty of Pharmacy, University of Lisbon, Campus of Lumiar, Building F, R/C, Estrada do Paço do Lumiar, Lisbon, Portugal
,
Carla V. EleutérioNanomedicine & Drug Delivery Systems, iMed.UL, Faculty of Pharmacy, University of Lisbon, Campus of Lumiar, Building F, R/C, Estrada do Paço do Lumiar, Lisbon, Portugal
,
Rudi OliveiraMedicinal Chemistry, iMed.UL, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, Lisbon, Portugal
,
Maria E.M. CruzNanomedicine & Drug Delivery Systems, iMed.UL, Faculty of Pharmacy, University of Lisbon, Campus of Lumiar, Building F, R/C, Estrada do Paço do Lumiar, Lisbon, Portugal
,
Rui MoreiraMedicinal Chemistry, iMed.UL, Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, Lisbon, Portugal
&
Jim IleyDepartment of Chemistry and Analytical Sciences, 4The Open University, Milton Keynes, UK
 show all
Pages 169-175 | Received 14 Dec 2009, Accepted 14 Apr 2010, Published online: 14 Jun 2010

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M. Asadollahi-Baboli. (2012) Quantitative structure–activity relationship analysis of human neutrophil elastase inhibitors using shuffling classification and regression trees and adaptive neuro-fuzzy inference systems. SAR and QSAR in Environmental Research 23:5-6, pages 505-520.
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Articles from other publishers (6)

Beata Donarska, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Barbara Zdzisińska, Wojciech Płaziński & Krzysztof Z. Łączkowski. (2023) Thalidomide derivatives as nanomolar human neutrophil elastase inhibitors: Rational design, synthesis, antiproliferative activity and mechanism of action. Bioorganic Chemistry 138, pages 106608.
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Susana Rocha, Rita Félix, Maria João Valente, Andreia Bento-Silva, Rute Rebelo, Célia Gomes Amorim, Alberto da Nova Araújo, Rui Moreira, Alice Santos-Silva & Maria Conceição B. S. M. Montenegro. (2023) Polysulfone Membranes Doped with Human Neutrophil Elastase Inhibitors: Assessment of Bioactivity and Biocompatibility. Membranes 13:1, pages 89.
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Beata Donarska, Marta Świtalska, Joanna Wietrzyk, Wojciech Płaziński, Magdalena Mizerska-Kowalska, Barbara Zdzisińska & Krzysztof Z. Łączkowski. (2022) Discovery of New 3,3-Diethylazetidine-2,4-dione Based Thiazoles as Nanomolar Human Neutrophil Elastase Inhibitors with Broad-Spectrum Antiproliferative Activity. International Journal of Molecular Sciences 23:14, pages 7566.
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Andreia Nunes, Joana Marto, Lídia Maria Gonçalves, Sandra Simões, Rita Félix, Andreia Ascenso, Francisca Lopes & Helena Margarida Ribeiro. (2020) Novel and Modified Neutrophil Elastase Inhibitor Loaded in Topical Formulations for Psoriasis Management. Pharmaceutics 12:4, pages 358.
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Susana D. Lucas, Lídia M. Gonçalves, Luís A. R. Carvalho, Henrique F. Correia, Eduardo M. R. Da Costa, Romina A. Guedes, Rui Moreira & Rita C. Guedes. (2013) Optimization of O 3 -Acyl Kojic Acid Derivatives as Potent and Selective Human Neutrophil Elastase Inhibitors . Journal of Medicinal Chemistry 56:23, pages 9802-9806.
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Peter Sjö. (2012) Neutrophil elastase inhibitors: recent advances in the development of mechanism-based and nonelectrophilic inhibitors. Future Medicinal Chemistry 4:5, pages 651-660.
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