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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 26, 2011 - Issue 2
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Research Article

The preparation, in vitro screening and molecular docking of symmetrical bisquaternary cholinesterase inhibitors containing a but-(2E)-en-1,4-diyl connecting linkage

Kamil MusilekCorrespondence[email protected]
,
Ruzena PavlikovaUniversity of Defence, Faculty of Military Health Sciences, Department of Toxicology, Trebesska 1575, Hradec Kralove, Czech Republic
,
Jan MarekUniversity of Defence, Faculty of Military Health Sciences, Department of Toxicology, Trebesska 1575, Hradec Kralove, Czech Republic
,
Marketa KomloovaCharles University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry and Drug Control, Heyrovskeho 1203, Hradec Kralove, Czech Republic
,
Ondrej HolasCharles University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry and Drug Control, Heyrovskeho 1203, Hradec Kralove, Czech Republic
,
Martina HrabinovaUniversity of Defence, Faculty of Military Health Sciences, Centre of Advanced Studies, Trebesska 1575, Hradec Kralove, Czech Republic
,
Miroslav PohankaUniversity of Defence, Faculty of Military Health Sciences, Centre of Advanced Studies, Trebesska 1575, Hradec Kralove, Czech Republic
,
Vlastimil DohnalUniversity of Jan Evangelista Purkynje, Faculty of Science, Department of Chemistry, Ceske mladeze 8, Usti nad Labem, Czech Republic
,
Martin DolezalCharles University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry and Drug Control, Heyrovskeho 1203, Hradec Kralove, Czech Republic
,
Frank Gunn-MooreUniversity of St. Andrews, School of Biology, Bute Building, St. Andrews, Fife, UK
&
Kamil Kuca
 show all
Pages 245-253 | Received 08 Feb 2010, Accepted 24 May 2010, Published online: 15 Mar 2011

Citations (9)

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Kamil Kuca, Jana Zdarova Karasova, Ondrej Soukup, Jiri Kassa, Eva Novotna, Vendula Sepsova, Anna Horova, Jaroslav Pejchal, Martina Hrabinova, Eva Vodakova, Daniel Jun, Eugenie Nepovimova, Martin Valis & Kamil Musilek. (2018) Development of small bisquaternary cholinesterase inhibitors as drugs for pre-treatment of nerve agent poisonings. Drug Design, Development and Therapy 12, pages 505-512.
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Articles from other publishers (8)

Rabail Ujan, Pervaiz Ali Channar, Ali Bahadur, Qamar Abbas, Mazloom Shah, S.G. Rashid, Shahid Iqbal, Aamer Saeed, Hisham S.M. Abd-Rabboh, Hussain Raza, Mubashir Hassan, Ali Nawaz Siyal, Parvez Ali Mahesar, Bhajan Lal, Kashif Ali Channar, Bilal Ahmad Khan, Muhammad Nawaz, Muhammad Shahid Riaz Rajoka & Jung Min Kim. (2021) Synthesis, kinetics and biological assay of some novel aryl bis-thioureas: A potential drug candidates for Alzheimer's disease. Journal of Molecular Structure 1246, pages 131136.
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Mark John P. Mandigma, Michał Domański & Joshua P. Barham. (2020) C-Alkylation of alkali metal carbanions with olefins. Organic & Biomolecular Chemistry 18:39, pages 7697-7723.
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Filipa Siopa, Raquel F. M. Frade, Ana Diniz, Joana M. Andrade, Marisa Nicolai, Ana Meirinhos, Susana D. Lucas, Filipa Marcelo, Carlos A. M. Afonso & Patrícia Rijo. (2018) Acetylcholinesterase Choline-Based Ionic Liquid Inhibitors: In Vitro and in Silico Molecular Docking Studies. ACS Omega 3:12, pages 17145-17154.
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Veronika Hrabcova, Jan Korabecny, Brigita Manyova, Lenka Matouskova, Tomas Kucera, Rafael Dolezal, Kamil Musilek, Lukas Gorecki, Eugenie Nepovimova, Kamil Kuca & Daniel Jun. (2017) Bis-isoquinolinium and bis-pyridinium acetylcholinesterase inhibitors: in vitro screening of probes for novel selective insecticides. RSC Advances 7:62, pages 39279-39291.
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Jana Zdarova Karasova, Milos Hroch, Kamil Musilek & Kamil Kuca. (2015) Small Quaternary Inhibitors K298 and K524: Cholinesterases Inhibition, Absorption, Brain Distribution, and Toxicity. Neurotoxicity Research 29:2, pages 267-274.
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Aamer Saeed, Sumera Zaib, Saba Ashraf, Javeria Iftikhar, Muhammad Muddassar, Kam Y.J. Zhang & Jamshed Iqbal. (2015) Synthesis, cholinesterase inhibition and molecular modelling studies of coumarin linked thiourea derivatives. Bioorganic Chemistry 63, pages 58-63.
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Roney Anderson Nascimento de Aquino, Luzia Valentina Modolo, Rosemeire Brondi Alves & Ângelo de Fátima. (2013) Synthesis, kinetic studies and molecular modeling of novel tacrine dimers as cholinesterase inhibitors. Organic & Biomolecular Chemistry 11:48, pages 8395.
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Kamil Musilek, Jan Roder, Marketa Komloova, Ondrej Holas, Martina Hrabinova, Miroslav Pohanka, Vlastimil Dohnal, Veronika Opletalova, Kamil Kuca & Young-Sik Jung. (2011) Preparation, in vitro screening and molecular modelling of symmetrical 4-tert-butylpyridinium cholinesterase inhibitors—Analogues of SAD-128. Bioorganic & Medicinal Chemistry Letters 21:1, pages 150-154.
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