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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 5
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Research Article

Characterization of nimbidiol as a potent intestinal disaccharidase and glucoamylase inhibitor present in Azadirachta indica (neem) useful for the treatment of diabetes

Abhishek MukherjeeDepartment of Biotechnology, Heritage Institute of Technology, Kolkata, India
&
Subhabrata SenguptaDepartment of Biotechnology, Heritage Institute of Technology, Kolkata, IndiaCorrespondence[email protected]
Pages 900-910 | Received 15 Feb 2012, Accepted 15 May 2012, Published online: 18 Jul 2012

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Usharani Pingali, Mohammed Abid Ali, Srinivas Gundagani & Chandrasekhar Nutalapati. (2020) Evaluation of the Effect of an Aqueous Extract of Azadirachta indica (Neem) Leaves and Twigs on Glycemic Control, Endothelial Dysfunction and Systemic Inflammation in Subjects with Type 2 Diabetes Mellitus – A Randomized, Double-Blind, Placebo-Controlled Clinical Study. Diabetes, Metabolic Syndrome and Obesity 13, pages 4401-4412.
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Articles from other publishers (22)

Roggers Gang, Motlalepula Matsabisa, Denis Okello & Youngmin Kang. (2023) Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda. Applied Biological Chemistry 66:1.
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Somdatta Giri, Jayaprakash Sahoo, Ayan Roy, Sadishkumar Kamalanathan & Dukhabandhu Naik. (2023) Treatment on Nature’s lap: Use of herbal products in the management of hyperglycemia. World Journal of Diabetes 14:4, pages 412-423.
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Pranob Jyoti BHARALİ, Sushanta Kumar BORDOLOİ, Swarnamoni DAS & Kingshuk LAHON. (2022) Effect of chronic administration of aqueous extract of Neem (Azadirachta indica) leaves on Paracetamol-induced hepatotoxicity in Wistar albino rats. Current Perspectives on Medicinal and Aromatic Plants (CUPMAP).
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Subir Kumar Juin, Sathnur Pushpakumar, Suresh C. Tyagi & Utpal Sen. (2022) Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes. Scientific Reports 12:1.
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Narmin Hamaamin Hussen, Aso Hameed Hasan, Joazaizulfazli Jamalis, Sonam Shakya, Subhash Chander, Harsha Kharkwal, Sankaranaryanan Murugesan, Virupaksha Ajit Bastikar & Pramodkumar Pyarelal Gupta. (2022) Potential inhibitory activity of phytoconstituents against black fungus: In silico ADMET, molecular docking and MD simulation studies. Computational Toxicology 24, pages 100247.
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Michela I. Simone, Adam Wood, David Campkin, Milton J. Kiefel & Todd A. Houston. (2022) Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency. European Journal of Medicinal Chemistry 235, pages 114282.
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Jie Sun, Jiangong Ren, Xuejian Hu, Yuanhua Hou & Yan Yang. (2021) Therapeutic effects of Chinese herbal medicines and their extracts on diabetes. Biomedicine & Pharmacotherapy 142, pages 111977.
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Ranendra Pratap Biswal, Durga Prasad Patnana, Sujith Kumar Pulukool, Venketesh Sivaramakrishnan, Ashish Pargaonkar & Rajesh Babu Dandamudi. (2021) Triterpene Profiling of Neem Exudate (Toddy) Using UHPLC-QTOF-MS and its Anti-inflammatory Activity. Planta Medica International Open 8:01, pages e25-e33.
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Anu Rahal, Dinesh Kumar & Jitendra K. Malik. 2021. Nutraceuticals. Nutraceuticals 945 958 .
Qingxia Gan, Jin Wang, Ju Hu, Guanhua Lou, Haijun Xiong, Chengyi Peng, Song Zheng & Qinwan Huang. (2020) The role of diosgenin in diabetes and diabetic complications. The Journal of Steroid Biochemistry and Molecular Biology 198, pages 105575.
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Richa Dubey, Ketaki Patil, Sarath C. DantuDevika M. Sardesai, Parnika Bhatia, Nikita Malik, Jhankar D. Acharya, Soham Sarkar, Soumadwip Ghosh, Rajarshi Chakrabarti, Shilpy Sharma & Ashutosh Kumar. (2019) Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity. Biochemical Journal 476:5, pages 889-907.
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S. Cesa, F. Sisto, G. Zengin, D. Scaccabarozzi, A.K. Kokolakis, M.M. Scaltrito, R. Grande, M. Locatelli, F. Cacciagrano, L. Angiolella, C. Campestre, A. Granese, P. Chimenti & N. Basilico. (2019) Phytochemical analyses and pharmacological screening of Neem oil. South African Journal of Botany 120, pages 331-337.
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Muddasarul Hoda, Shanmugam Hemaiswarya & Mukesh DobleMuddasarul Hoda, Shanmugam Hemaiswarya & Mukesh Doble. 2019. Role of Phenolic Phytochemicals in Diabetes Management. Role of Phenolic Phytochemicals in Diabetes Management 45 82 .
Anu Rahal, Dinesh Kumar & Jitendra K. Malik. 2019. Nutraceuticals in Veterinary Medicine. Nutraceuticals in Veterinary Medicine 37 50 .
Soumicha Mahdjour, Juan J. Guardia, Fernando Rodríguez-Serrano, José Manuel Garrido, Isabel Blancas López-Barajas, Nuria Mut-Salud, Rachid Chahboun & Enrique Alvarez-Manzaneda. (2018) Synthesis and antiproliferative activity of podocarpane and totarane derivatives. European Journal of Medicinal Chemistry 158, pages 863-873.
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Subash Chandra Gupta, Sahdeo Prasad, Amit K. Tyagi, Ajaikumar B. Kunnumakkara & Bharat B. Aggarwal. (2017) Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis. Phytomedicine 34, pages 14-20.
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Xuehua Zheng, Siyuan Zhou, Chen Zhang, Deyan Wu, Hai-Bin Luo & Yinuo Wu. (2017) Docking-assisted 3D-QSAR studies on xanthones as α-glucosidase inhibitors. Journal of Molecular Modeling 23:9.
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Santhosh Kumar Venugopalan, Shanmugarajan T.S.Navaratnam V.Mansor S.M.Ramanathan S.. (2016) Dexamethasone provoked mitochondrial perturbations in thymus: Possible role of N-acetylglucosamine in restoration of mitochondrial function. Biomedicine & Pharmacotherapy 83, pages 1485-1492.
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Rakhi Chakraborty, Swarnendu Roy & Vivekananda Mandal. (2016) Assessment of traditional knowledge of the antidiabetic plants of Darjeeling and Sikkim Himalayas in the context of recent phytochemical and pharmacological advances. Journal of Integrative Medicine 14:5, pages 336-358.
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S. Esakkimuthu, S. Mutheeswaran, S. Arvinth, M. Gabriel Paulraj, P. Pandikumar & S. Ignacimuthu. (2016) Quantitative ethnomedicinal survey of medicinal plants given for cardiometabolic diseases by the non-institutionally trained siddha practitioners of Tiruvallur district, Tamil Nadu, India. Journal of Ethnopharmacology 186, pages 329-342.
Crossref
Dinesh Kumar, Anu Rahal & Jitendra K. Malik. 2016. Nutraceuticals. Nutraceuticals 585 597 .
Ruchi Tiwari, Amit Kumar Verma, Sandip Chakrabort, Kuldeep Dhama & Shoor Vir Singh. (2014) Neem (Azadirachta indica) and its Potential for Safeguarding Health of Animals and Humans: A Review. Journal of Biological Sciences 14:2, pages 110-123.
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