Advanced search
Publication Cover
Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 5
Submit an article Journal homepage
822
Views
29
CrossRef citations to date
0
Altmetric
Research Article

1-(3-Aminomethyl-4-hydroxyphenyl)-3-pyridinyl-2-propen-1-ones: A novel group of tumour-selective cytotoxins

Sinan BilginerDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, Turkey
,
Halise Inci GulDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Ataturk University, Erzurum, TurkeyCorrespondence[email protected]
,
Ebru MeteDepartment of Chemistry, Faculty of Sciences, Ataturk University, Erzurum, Turkey
,
Umashankar DasDrug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
,
Hiroshi SakagamiDivision of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan
,
Naoki UmemuraDivision of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama 350-0283, Japan
&
Jonathan Richard DimmockDrug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
 show all
Pages 974-980 | Received 10 Apr 2012, Accepted 31 May 2012, Published online: 18 Jul 2012

Citations (29)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Halise Inci Gul, Cem Yamali, Fatma Yesilyurt, Hiroshi Sakagami, Kaan Kucukoglu, Ilhami Gulcin, Mustafa Gul & Claudiu T. Supuran. (2017) Microwave-assisted synthesis and bioevaluation of new sulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 369-374.
Read now
Halise Inci Gul, Ebru Mete, Sakip Emre Eren, Hiroshi Sakagami, Cem Yamali & Claudiu T. Supuran. (2017) Designing, synthesis and bioactivities of 4-[3-(4-hydroxyphenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 32:1, pages 169-175.
Read now
Cem Yamali, Halise Inci Gul, Hiroshi Sakagami & Claudiu T. Supuran. (2016) Synthesis and bioactivities of halogen bearing phenolic chalcones and their corresponding bis Mannich bases. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 125-131.
Read now
Kaan Kucukoglu, Fatih Oral, Tevfik Aydin, Cem Yamali, Oztekin Algul, Hiroshi Sakagami, Ilhami Gulcin, Claudiu T. Supuran & Halise Inci Gul. (2016) Synthesis, cytotoxicity and carbonic anhydrase inhibitory activities of new pyrazolines. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup4, pages 20-24.
Read now
Elif Unluer, Halise Inci Gul, Alkan Demirtas, Hiroshi Sakagami, Naoki Umemura, Muhammet Tanc, Cavit Kazaz & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies of 1-aryl-3-(2-hydroxyethylthio)-1-propanones. Journal of Enzyme Inhibition and Medicinal Chemistry 31:sup3, pages 105-109.
Read now
Halise Inci Gul, Mehtap Tugrak, Hiroshi Sakagami, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2016) Synthesis and bioactivity studies on new 4-(3-(4-Substitutedphenyl)-3a,4-dihydro-3H-indeno[1,2-c]pyrazol-2-yl) benzenesulfonamides. Journal of Enzyme Inhibition and Medicinal Chemistry 31:6, pages 1619-1624.
Read now
Mehtap Tugrak, Cem Yamali, Hiroshi Sakagami & Halise Inci Gul. (2016) Synthesis of mono Mannich bases of 2-(4-hydroxybenzylidene)-2,3-dihydroinden-1-one and evaluation of their cytotoxicities. Journal of Enzyme Inhibition and Medicinal Chemistry 31:5, pages 818-823.
Read now
Halise Inci Gul, Mehtap Tugrak & Hiroshi Sakagami. (2016) Synthesis of some acrylophenones with N-methylpiperazine and evaluation of their cytotoxicities. Journal of Enzyme Inhibition and Medicinal Chemistry 31:1, pages 147-151.
Read now

Articles from other publishers (21)

Aline Bernardes, Mónika Kuzma, Attila Almási, Mátyás Mayer, Caridad Noda Pérez & Pál Perjési. (2022) HPLC and HPLC-MS Analysis of Intestinal Elimination and Phase 2 Metabolism of 4'-hydroxy-4-Methoxychalcone and its Bis-Mannich Analog In The Rat. The Open Medicinal Chemistry Journal 16:1.
Crossref
Yolande Ikala Openda, Balaji Babu & Tebello Nyokong. (2022) Novel cationic-chalcone phthalocyanines for photodynamic therapy eradication of S. aureus and E. coli bacterial biofilms and MCF-7 breast cancer. Photodiagnosis and Photodynamic Therapy 38, pages 102863.
Crossref
Cem YAMALI & Halise İnci GÜL. (2021) Cytotoxic effects of Mannich bases via induction of caspase-3 pathway on human oral squamous cell carcinoma. Journal of the Turkish Chemical Society Section A: Chemistry 8:1, pages 187-194.
Crossref
Padmini TR, Vagdevi HM, Usha Jinendra & Ravikiran B. (2021) Synthesis of benzoxazole derivatives by Mannich reaction and invitro cytotoxic, antimicrobial and docking studies. Chemical Data Collections 31, pages 100628.
Crossref
Murat Demirol, Lütfiye Sirka, Eray Çalışkan, Fatih Biryan, Kenan Koran, Ahmet Orhan Görgülü & Fahrettin Yakuphanoğlu. (2020) Synthesis and photodiode properties of chalcone substituted metallo-phthalocyanine. Journal of Molecular Structure 1219, pages 128571.
Crossref
K. Kucukoglu, H. I. Gul & H. Sakagami. (2020) Evaluation of Cytotoxic Properties of N,N'-bis[(1-aryl-3-heteroaryl)propylidene]-hydrazine dihydrochlorides. Pharmaceutical Chemistry Journal 54:8, pages 784-787.
Crossref
Sinan Bilginer, Halise I. Gul, Feyza S. Erdal, Hiroshi Sakagami & Ilhami Gulcin. (2020) New halogenated chalcones with cytotoxic and carbonic anhydrase inhibitory properties: 6‐(3‐Halogenated phenyl‐2‐propen‐1‐oyl)‐2(3 H )‐benzoxazolones . Archiv der Pharmazie 353:6, pages 1900384.
Crossref
Sinan BİLGİNER. (2020) Benzoksazolon Türevi Şalkon Bileşiklerinin Sentezi ve Biyoaktivitelerinin AraştırılmasıSynthesis and Bioactivities of Benzoxazolone Derivative Chalcone Compounds. Erzincan Üniversitesi Fen Bilimleri Enstitüsü Dergisi 13:1, pages 334-347.
Crossref
Mehtap Tugrak, Halise Inci Gul, Kenjiro Bandow, Hiroshi Sakagami, Ilhami Gulcin, Yusuf Ozkay & Claudiu T. Supuran. (2019) Synthesis and biological evaluation of some new mono Mannich bases with piperazines as possible anticancer agents and carbonic anhydrase inhibitors. Bioorganic Chemistry 90, pages 103095.
Crossref
Kaan Kucukoglu, Halise Inci Gul, Parham Taslimi, Ilhami Gulcin & Claudiu T. Supuran. (2019) Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes. Bioorganic Chemistry 86, pages 316-321.
Crossref
Mehtap Tugrak, Halise Inci Gul, Hiroshi Sakagami, Ilhami Gulcin & Claudiu T. Supuran. (2018) New azafluorenones with cytotoxic and carbonic anhydrase inhibitory properties: 2-Aryl-4-(4-hydroxyphenyl)-5H-indeno[1,2-b]pyridin-5-ones. Bioorganic Chemistry 81, pages 433-439.
Crossref
Kaan Kucukoglu, Mustafa Gul, Halise Inci Gul, Rengul Cetin-Atalay & Bernard Geny. (2018) Cytotoxicities of novel hydrazone compounds with pyrrolidine moiety: inhibition of mitochondrial respiration may be a possible mechanism of action for the cytotoxicity of new hydrazones. Medicinal Chemistry Research 27:9, pages 2116-2124.
Crossref
Sunil Dutt Durgapal, Rina Soni, Shweta Umar, Balakrishnan Suresh & Shubhangi S. Soman. (2018) 3-Aminomethyl pyridine chalcone derivatives: Design, synthesis, DNA binding and cytotoxic studies. Chemical Biology & Drug Design 92:1, pages 1279-1287.
Crossref
Fatma Yesilyurt, Abdullah Aydin, Halise Inci Gul, Mehmet Akkurt & Nefise Dilek Ozcelik. (2018) Crystal structure and theoretical study of (2 E )-1-[4-hydroxy-3-(morpholin-4-ylmethyl)phenyl]-3-(thiophen-2-yl)prop-2-en-1-one . Acta Crystallographica Section E Crystallographic Communications 74:7, pages 960-963.
Crossref
Halise Inci Gul, Cem Yamali, Hiroshi Sakagami, Andrea Angeli, Janis Leitans, Andris Kazaks, Kaspars Tars, Dilan Ozmen Ozgun & Claudiu T. Supuran. (2018) New anticancer drug candidates sulfonamides as selective hCA IX or hCA XII inhibitors. Bioorganic Chemistry 77, pages 411-419.
Crossref
Cem Yamali, Dilan Ozmen Ozgun, Halise Inci Gul, Hiroshi Sakagami, Cavit Kazaz & Noriyuki Okudaira. (2017) Synthesis and structure elucidation of 1-(2,5/3,5-difluorophenyl)-3-(2,3/2,4/2,5/3,4-dimethoxyphenyl)-2-propen-1-ones as anticancer agents. Medicinal Chemistry Research 26:9, pages 2015-2023.
Crossref
Mehtap Tugrak, Halise Inci Gul, Hiroshi Sakagami & Ebru Mete. (2017) Synthesis and anticancer properties of mono Mannich bases containing vanillin moiety. Medicinal Chemistry Research 26:7, pages 1528-1534.
Crossref
Mehtap Tugrak, Abdullah Aydin, Halise Inci Gul, Ertan Sahin & Mehmet Akkurt. (2017) Crystal structure of ( E )-2-({4-hydroxy-5-methoxy-3-[(4-methyl-1-piperazinyl)methyl]phenyl} methylidene)-1-indanone, C 23 H 26 N 2 O 3 . Zeitschrift für Kristallographie - New Crystal Structures 232:1, pages 113-115.
Crossref
K. Kucukoglu, M. Tugrak, A. Demirtas, H. Sakagami & H. I. Gul. (2016) Synthesis and Cytotoxic Activity of (4-Substituted-benzylidene)-(3-Phenyl-1,2,4-Oxadiazol-5-YL)Methylamines. Pharmaceutical Chemistry Journal 50:4, pages 234-238.
Crossref
Abdullah Aydın, Mehmet Akkurt, Halise Inci Gul, Kadir Ozden Yerdelen & Raziye Catak Celik. (2016) Crystal structure of 1-{4-hydroxy-3-[(pyrrolidin-1-yl)methyl]phenyl}-3-phenylprop-2-en-1-one. Acta Crystallographica Section E Crystallographic Communications 72:5, pages 696-698.
Crossref
Gheorghe Roman. (2015) Mannich bases in medicinal chemistry and drug design. European Journal of Medicinal Chemistry 89, pages 743-816.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.