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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 28, 2013 - Issue 5
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Research Article

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

Laura De LucaDipartimento Farmaco-Chimico, Università di Messina, Messina, ItalyCorrespondence[email protected]
,
Stefania FerroDipartimento Farmaco-Chimico, Università di Messina, Messina, Italy
,
Francesca MorrealeDipartimento Farmaco-Chimico, Università di Messina, Messina, Italy
,
Frauke ChristMolecular Virology and Gene Therapy KU Leuven and IRC KULAK, Leuven, Flanders, Belgium
,
Zeger DebyserMolecular Virology and Gene Therapy KU Leuven and IRC KULAK, Leuven, Flanders, Belgium
,
Alba ChimirriDipartimento Farmaco-Chimico, Università di Messina, Messina, Italy
&
Rosaria GittoDipartimento Farmaco-Chimico, Università di Messina, Messina, Italy
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Pages 1002-1009 | Received 10 May 2012, Accepted 12 Jun 2012, Published online: 18 Jul 2012

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Zhimin Zhang, Lili Gu, Beibei Wang, Wenhai Huang, Yanmin Zhang, Zhen Ma, Shenxin Zeng & Zhengrong Shen. (2019) Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping. Journal of Enzyme Inhibition and Medicinal Chemistry 34:1, pages 808-817.
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Articles from other publishers (10)

Sheng Han, Yali Sang, Yan Wu, Yuan Tao, Christophe Pannecouque, Erik De Clercq, Chunlin Zhuang & Fen-Er Chen. (2020) Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors. European Journal of Medicinal Chemistry 185, pages 111874.
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Mihai Ciubotaru, Mihaela Georgiana Musat, Marius Surleac, Elena Ionita, Andrei Jose Petrescu, Edgars Abele & Ramona Abele. (2019) The Design of New HIV-IN Tethered Bifunctional Inhibitors Using Multiple Microdomain Targeted Docking. Current Medicinal Chemistry 26:15, pages 2574-2600.
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Yan Wang, Huang-Quan Lin, Ping Wang, Jian-Shu Hu, Tsz-Ming Ip, Liu-Meng Yang, Yong-Tang Zheng & David Chi-Cheong Wan. (2017) Discovery of a Novel HIV-1 Integrase/p75 Interacting Inhibitor by Docking Screening, Biochemical Assay, and in Vitro Studies. Journal of Chemical Information and Modeling 57:9, pages 2336-2343.
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Fatima E. Agharbaoui, Ashley C. Hoyte, Stefania Ferro, Rosaria Gitto, Maria Rosa Buemi, James R. Fuchs, Mamuka Kvaratskhelia & Laura De Luca. (2016) Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase. European Journal of Medicinal Chemistry 123, pages 673-683.
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Yung-Ping Lee, Tzong-Fu Kuo & Shoei-Sheng Lee. (2015) Identification of the metabolites of TCM prescription Sinisan, found in miniature pig urine via intragastric administration. Journal of Pharmaceutical and Biomedical Analysis 111, pages 311-319.
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Stefania Ferro, Laura De Luca, Fatima Ezzahra Agharbaoui, Frauke Christ, Zeger Debyser & Rosaria Gitto. (2015) Optimization of rhodanine scaffold for the development of protein–protein interaction inhibitors. Bioorganic & Medicinal Chemistry 23:13, pages 3208-3214.
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Ming-Zhi Zhang, Qiong Chen & Guang-Fu Yang. (2015) A review on recent developments of indole-containing antiviral agents. European Journal of Medicinal Chemistry 89, pages 421-441.
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Kevin B. Teuscher & Haitao Ji. 2015. Fragment-Based Methods in Drug Discovery. Fragment-Based Methods in Drug Discovery 57 73 .
Theresa Tiefenbrunn & C. David Stout. (2014) Towards novel therapeutics for HIV through fragment-based screening and drug design. Progress in Biophysics and Molecular Biology 116:2-3, pages 124-140.
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Stefania Ferro, Laura De Luca, Giuseppa Lo Surdo, Francesca Morreale, Frauke Christ, Zeger Debyser, Rosaria Gitto & Alba Chimirri. (2014) A new potential approach to block HIV-1 replication via protein–protein interaction and strand-transfer inhibition. Bioorganic & Medicinal Chemistry 22:7, pages 2269-2279.
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